Human brain, plasma, and cerebrospinal fluid concentration of sodium valproate after 72 hours of therapy.

Abstract:

:Nine neurosurgical patients suffering from a variety of brain tumors were studied. Sodium valproate was given for 3 days before surgery. At craniotomy, sections of brain and samples of cerebrospinal fluid (CSF) and plasma were obtained and assayed for sodium valproate concentrations. Brain levels were 6.8 to 27.9% of plasma concentrations, and CSF levels were 7.6 to 25.0% of plasma levels. There was a significant correlation between brain and CSF levels and plasma on Spearman ranking. These results confirm that valproate is not selectively concentrated in brain fractions, and the concentration in brain is related to the free anticonvulsant level in plasma.

journal_name

Neurology

journal_title

Neurology

authors

Vajda FJ,Donnan GA,Phillips J,Bladin PF

doi

10.1212/wnl.31.4.486

subject

Has Abstract

pub_date

1981-04-01 00:00:00

pages

486-7

issue

4

eissn

0028-3878

issn

1526-632X

journal_volume

31

pub_type

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