Abstract:
:Nine neurosurgical patients suffering from a variety of brain tumors were studied. Sodium valproate was given for 3 days before surgery. At craniotomy, sections of brain and samples of cerebrospinal fluid (CSF) and plasma were obtained and assayed for sodium valproate concentrations. Brain levels were 6.8 to 27.9% of plasma concentrations, and CSF levels were 7.6 to 25.0% of plasma levels. There was a significant correlation between brain and CSF levels and plasma on Spearman ranking. These results confirm that valproate is not selectively concentrated in brain fractions, and the concentration in brain is related to the free anticonvulsant level in plasma.
journal_name
Neurologyjournal_title
Neurologyauthors
Vajda FJ,Donnan GA,Phillips J,Bladin PFdoi
10.1212/wnl.31.4.486subject
Has Abstractpub_date
1981-04-01 00:00:00pages
486-7issue
4eissn
0028-3878issn
1526-632Xjournal_volume
31pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::In six patients with cryptococcal meningitis, diagnosis was made by routine cytologic examination of cerebrospinal fluid (CSF). A seventh patient had a false-positive cryptococcal antigen titer, and no organism was seen on SCF examination. The patient had herpes simplex encephalitis on brain biopsy. Cytologic examinat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.1.102
更新日期:1980-01-01 00:00:00
abstract::Chronic daily headache (CDH) affects approximately 4 to 5% of the population and encompasses a number of different diagnoses, including transformed migraine, chronic tension-type headache (TTH), new-onset daily persistent headache, and hemicrania continua. Although the pathophysiology of CDH is still poorly understood...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.59.5_suppl_2.s8
更新日期:2002-09-10 00:00:00
abstract:OBJECTIVE:To evaluate the safety and efficacy of 60 Hz deep brain stimulation (DBS) of the globus pallidus internus (GPi) in 15 consecutive patients with primary dystonia. METHODS:We conducted a retrospective analysis of clinic charts relative to 15 consecutive patients with medically refractory primary dystonia who u...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000267430.95106.ff
更新日期:2007-08-14 00:00:00
abstract::The authors investigated whether repetitive transcranial magnetic stimulation (rTMS) at 1 Hz (12 minutes; 90% of motor threshold) to the primary motor cortex (M1) leads to changes in diffusion-weighted imaging (DWI). After the rTMS train, there was a temporary small restriction in diffusion within the targeted left M1...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000058903.15205.46
更新日期:2003-05-13 00:00:00
abstract:OBJECTIVE:Hospital readmission is an important quality improvement measure that has not been well-studied in pediatric neurology. We examined predictors of 7-day and 30-day readmissions for pediatric patients hospitalized with a neurologic diagnosis. METHODS:This was a retrospective study of hospital readmission rates...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007280
更新日期:2019-04-16 00:00:00
abstract:OBJECTIVE:To improve clinical recognition and provide research diagnostic criteria for three clinical syndromes associated with frontotemporal lobar degeneration. METHODS:Consensus criteria for the three prototypic syndromes-frontotemporal dementia, progressive nonfluent aphasia, and semantic dementia-were developed b...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章,评审
doi:10.1212/wnl.51.6.1546
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:The NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox) is a comprehensive battery of brief assessment tools. The purpose of this article is to describe plans to establish normative reference values for the NIH Toolbox measures. METHODS:A large sample will be obtained from the US...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182872e70
更新日期:2013-03-12 00:00:00
abstract:OBJECTIVE:To determine whether 24 weeks of high-intensity progressive aerobic exercise (PAE) affects brain MRI measures in people with multiple sclerosis (MS). METHODS:We conducted a randomized, controlled, phase 2 trial (with a crossover follow-up) including an exercise group (supervised PAE followed by self-guided p...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000011241
更新日期:2021-01-12 00:00:00
abstract::We describe a familial disorder consisting of sleep apnea, anosmia, colorblindness, partial complex seizures, and cognitive dysfunction. The phenotypic expression of the syndrome suggests an autosomal dominant inheritance with incomplete penetrance. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.2.190
更新日期:1988-02-01 00:00:00
abstract::We found an antinuclear antibody highly restricted to nuclei of neurons in two patients with subacute sensory neuronopathy complicating oat cell carcinoma of the lung. Serum was tested by indirect immunofluorescence and immunoperoxidase staining. At low concentrations of antibody, only the nuclei of the neurons were s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.4.538
更新日期:1985-04-01 00:00:00
abstract::A 12-year-old girl presented with headache, nausea, decreased level of consciousness, and diplopia. Brain MRI, arteriography (figure e-1 on the Neurology® Web site at www.neurology.org), vasculitic markers, and CSF were normal, as were EEGs and ECGs. Transcranial color-coded ultrasonography of the basilar artery revea...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436064.90018.48
更新日期:2013-11-19 00:00:00
abstract:OBJECTIVE:Evaluating the TBI incidence during the COVID-19 pandemic era compared with similar period in previous year. BACKGROUND:The emergence of SARS-CoV2 influenced the evolution of governmental and hospital policy worldwide, which might eventually impact many aspects. The incidence of many diseases in the Emergenc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000719968.10580.81
更新日期:2020-11-17 00:00:00
abstract:OBJECTIVE:To compare the efficacy, tolerability, and safety of IV methylprednisolone (IV MP) vs oral methylprednisolone (oMP) at equivalent high doses in patients with multiple sclerosis (MS) experiencing a recent relapse. METHODS:Patients with a clinical relapse within the previous 2 weeks and at least 1 gadolinium (...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e3181c3fd5b
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Clostridium botulinum neurotoxin types A, B, and E cause most cases of the paralytic disease botulism. Little is known about the epidemiology, clinical features, or microbiology of botulism type F. METHODS:Cases of adult type F botulism were identified by review of data collected by CDC's National Botulism ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000187127.92446.4c
更新日期:2005-12-13 00:00:00
abstract:OBJECTIVE:There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. METHODS:We assessed a cohort of participants at r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002944
更新日期:2016-08-09 00:00:00
abstract::A 20-year-old woman using an oral diet aid preparation containing phenylpropanolamine presented with an intracerebral hemorrhage and angiographic evidence of cerebral vasculitis. Gas chromatography demonstrated phenylpropanolamine in the urine. Even when used within recommended guidelines, phenylpropanolamine usage sh...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.3.405
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:Functional or psychogenic movement disorders (FMD) present a diagnostic challenge. To diagnose FMD, clinicians must have experience with signs typical of FMD and distinguishing features from other hyperkinetic disorders. The aim of this study was to clarify the decision-making process of expert clinicians whi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003479
更新日期:2017-01-10 00:00:00
abstract:OBJECTIVES:1) To reassess the prevalence of migraine in the United States; 2) to assess patterns of migraine treatment in the population; and 3) to contrast current patterns of preventive treatment use with recommendations for use from an expert headache panel. METHODS:A validated self-administered headache questionna...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000252808.97649.21
更新日期:2007-01-30 00:00:00
abstract::We performed a quantitative immunocytochemical study using a polyclonal antibody directed against choline acetyltransferase (ChAT) in the lower pontine reticular formation in four control subjects and three patients with progressive supranuclear palsy (PSP). In the normal brains, there was detectable ChAT-like immunor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1593
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVE:To verify whether the change in L-dopa plasma levels after a single dose of carbidopa/L-dopa 50/200 (controlled-release) transiently modifies frontal components of somatosensory evoked potentials (SEPs) in patients with PD in parallel with improvement of motor performance. BACKGROUND:Apomorphine, a potent do...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1451
更新日期:1999-10-22 00:00:00
abstract:OBJECTIVE:To investigate whether cognitive function is related to incidence of stroke. METHODS:A population-based cohort of 1551 subjects with no clinical history or signs of stroke, age 75 years and over at baseline, were followed up for 3 years. Individuals with a first-ever stroke event that was recorded in the Sto...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.11.2103
更新日期:2000-06-13 00:00:00
abstract::A 32-year-old patient with seizures experienced decreased right-ear hearing during electrocortical stimulation mapping of the left lateral superior temporal gyrus. Audiometric testing under headphones confirmed a reversible, moderate unilateral hearing loss. Under binaural listening conditions, auditory comprehension ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000149524.11371.B1
更新日期:2005-01-25 00:00:00
abstract::We report a patient with meningeal gliomatosis who had signs of meningitis, hypoglycorrhachia, and an intracranial mass. Despite suspicion of a primary intracranial neoplasm, repeated CSF cytologies were not diagnostic and led to a brain biopsy for diagnosis. Immunoperoxidase staining for glial fibrillary acidic prote...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.12.1611
更新日期:1984-12-01 00:00:00
abstract::We used [18F]-2-fluoro-2-deoxy-D-glucose (FDG) and PET to study regional cerebral glucose utilization in seven patients with fatal familial insomnia (FFI), an inherited prion disease with a mutation at codon 178 of the prion protein gene. Four patients were methionine/methionine homozygotes at codon 129 (symptom durat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.1.126
更新日期:1997-07-01 00:00:00
abstract::Acute global aphasia without hemiparesis has been considered pathognomonic of embolic stroke. During 1 year, we encountered six patients with this syndrome. Two had multiple strokes, probably embolic. One had atrial fibrillation; at autopsy, there were metastases as well as multiple infarcts in the left hemisphere. On...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.2.201
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVE:To assess the pathophysiologic changes in patients with spontaneous intracranial hypotension (SIH) based on measures of CSF dynamics, and on the duration of symptoms, in a retrospective case-controlled study. METHODS:We included consecutive patients investigated for SIH at our department from January 2012 to...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009812
更新日期:2020-07-21 00:00:00
abstract::We studied 25 patients within 6 hours of acute spinal cord injury using magnetically evoked cortical motor evoked potentials (MEPs). The subjects included 16 quadriplegics with cervical spine injuries and eight paraplegics. MEPs were recorded from abductor digiti minimi (ADM), biceps, flexor hallucis brevis, and tibia...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.45.2.303
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVE:To perform a double-blind, randomized study comparing efficacy and safety of daily and weekend prednisone in boys with Duchenne muscular dystrophy (DMD). METHODS:A total of 64 boys with DMD who were between 4 and 10 years of age were randomized at 1 of 12 centers of the Cooperative International Neuromuscula...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e318227b164
更新日期:2011-08-02 00:00:00
abstract:OBJECTIVE:To characterize brain functional connectivity in subjects with prechiasmatic visual system damage and relate functional connectivity features to extent of vision loss. METHODS:In this case-control study, resting-state, eyes-closed EEG activity was recorded in patients with partial optic nerve damage (n = 15)...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000000672
更新日期:2014-08-05 00:00:00
abstract:OBJECTIVE:To determine whether there are distinct thalamic regions statistically associated with either contraversive or ipsiversive disturbance of verticality perception measured by subjective visual vertical (SVV). METHODS:We used modern statistical lesion behavior mapping on a sample of 37 stroke patients with isol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002238
更新日期:2016-01-12 00:00:00