Abstract:
:We report a patient with meningeal gliomatosis who had signs of meningitis, hypoglycorrhachia, and an intracranial mass. Despite suspicion of a primary intracranial neoplasm, repeated CSF cytologies were not diagnostic and led to a brain biopsy for diagnosis. Immunoperoxidase staining for glial fibrillary acidic protein stained CSF cells that had been thought inflammatory on routine cytology. This case and other reports demonstrate that multiple cytologic examinations may be negative despite extensive gliomatous infiltration of the meninges. Immunoperoxidase staining is useful in cases of suspected meningeal spread of glioma when suspicious cells are seen on routine CSF cytology.
journal_name
Neurologyjournal_title
Neurologyauthors
Wechsler LR,Gross RA,Miller DCdoi
10.1212/wnl.34.12.1611subject
Has Abstractpub_date
1984-12-01 00:00:00pages
1611-5issue
12eissn
0028-3878issn
1526-632Xjournal_volume
34pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::The authors describe a case of syphilitic amyotrophy in a 37-year-old man presenting with subacute progressive painless weakness in the right arm. Syphilitic amyotrophy is still an existing differential diagnosis of painless and progressive weakness. The authors explore potential obstacles in the diagnostic workup and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000046584.72672.d3
更新日期:2003-02-11 00:00:00
abstract:OBJECTIVE:To test the hypothesis that accelerated peripheral blood mononuclear cell recovery after alemtuzumab treatment of multiple sclerosis is associated with recurrent disease activity and to investigate the claim that CD4 counts greater than 388.5 × 10(6) cells/mL at 12 months can be used to identify patients who ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000520
更新日期:2014-06-17 00:00:00
abstract::A 25-year-old man with a long history of temporal lobe epilepsy developed right occipital lobe seizures and a progressive right homonymous hemianopia. MRI showed diffuse enhancement of the left temporoparieto-occipital white matter and cortical thickening of the left medial temporal lobe. The resected temporal lobe re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.3.654
更新日期:1999-02-01 00:00:00
abstract::We have studied one family of a pedigree in which bulbospinal muscular atrophy and protanopia were segregated. Genotypes for these disorders were obtained on three generations, and the maximum likelihood estimate of recombination fraction was 0.4 with the lod score method. The results indicated that the two loci are n...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.6.1019
更新日期:1987-06-01 00:00:00
abstract:OBJECTIVE:In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer a higher lesion detection than 1.5T, but it remains unclear whether this affects the fulfilment of the diagnostic criteria for multiple sclerosis (MS). METHODS:We recruited 66 patients with CIS within 6 months...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000005825
更新日期:2018-07-17 00:00:00
abstract:OBJECTIVE:To compare nonadherence to statins in older black and white adults following an ischemic stroke. METHODS:We studied black and white adults ≥66 years of age with Medicare fee-for-service insurance coverage hospitalized for ischemic stroke from 2007 to 2012 who filled a statin prescription within 30 days follo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003910
更新日期:2017-05-09 00:00:00
abstract:OBJECTIVE:To describe the clinical features, neuropathology, and genetic studies in a family with autosomal dominant frontotemporal dementia (FTD). BACKGROUND:Clinical Pick's disease, or FTD with parkinsonism, has been described in several families linked to chromosome 17 (FTDP-17). Most of these have shown tau protei...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.4.818
更新日期:2000-02-22 00:00:00
abstract::In six patients with cryptococcal meningitis, diagnosis was made by routine cytologic examination of cerebrospinal fluid (CSF). A seventh patient had a false-positive cryptococcal antigen titer, and no organism was seen on SCF examination. The patient had herpes simplex encephalitis on brain biopsy. Cytologic examinat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.1.102
更新日期:1980-01-01 00:00:00
abstract::We studied the scalp distribution of auditory event-related potentials (P300), using simultaneously a cephalic (linked ears) and a noncephalic (balanced sternovertebra) reference. The recordings with noncephalic reference showed that infrequent, attended auditory stimuli evoke a negative bitemporal component (N300) as...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.11.1803
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVE:To investigate the lateralization and localization of ictal EEG in focal epilepsy. METHODS:A total of 486 ictal EEG of 72 patients with focal epilepsy arising from the mesial temporal, neocortical temporal, mesial frontal, dorsolateral frontal, parietal, and occipital regions were analyzed. RESULTS:Surface ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.11.2022
更新日期:2001-12-11 00:00:00
abstract:OBJECTIVE:To perform a double-blind, randomized study comparing efficacy and safety of daily and weekend prednisone in boys with Duchenne muscular dystrophy (DMD). METHODS:A total of 64 boys with DMD who were between 4 and 10 years of age were randomized at 1 of 12 centers of the Cooperative International Neuromuscula...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e318227b164
更新日期:2011-08-02 00:00:00
abstract:OBJECTIVE:To assess the determinants of amyotrophic lateral sclerosis (ALS) phenotypes in a population-based cohort. METHODS:The study population included 2,839 patients with ALS diagnosed in Piemonte, Italy (1995-2015). Patients were classified according to motor (classic, bulbar, flail arm, flail leg, predominantly ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008869
更新日期:2020-02-25 00:00:00
abstract:BACKGROUND:Extrapyramidal signs (EPS) are common in Alzheimer disease (AD) and increase in prevalence as AD advances. The neuropathologic substrate responsible for EPS in AD remains to be fully characterized. METHODS:Subjects had a clinical diagnosis of AD confirmed by neuropathologic examination. EPS during life were...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000158423.05224.7F
更新日期:2005-04-26 00:00:00
abstract:OBJECTIVE:This study explored the association between long-term epilepsy surgery outcome and changes in depressive symptoms. METHODS:Adults were enrolled between 1996 and 2001 in a multicenter prospective study to evaluate outcomes of resective epilepsy surgery. The extent of depressive symptoms and depression case st...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31823a0c90
更新日期:2011-11-29 00:00:00
abstract::A patient with glioblastoma of the rostral brainstem and hypothalamus exhibited bilateral internuclear ophthalmoplegia and vertical nystagmus; he suffered episodes of cataplexy, narcolepsy, and sleep paralysis. A peculiar fluctuation of posture and tone ("limp man syndrome") proved to be a manifestation of continuous ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.10.1115
更新日期:1980-10-01 00:00:00
abstract:OBJECTIVES:Determine the frequency of and the predictive factors for abnormal ocular fundus findings among emergency department (ED) headache patients. METHODS:Cross-sectional study of prospectively enrolled adult patients presenting to our ED with a chief complaint of headache. Ocular fundus photographs were obtained...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0f20
更新日期:2013-01-29 00:00:00
abstract:OBJECTIVE:To investigate whether vitamin D, smoking, and anti-Epstein-Barr virus (EBV) antibody concentrations predict long-term cognitive status and neuroaxonal injury in multiple sclerosis (MS). METHODS:This study was conducted among 278 patients with clinically isolated syndrome who participated in the clinical tri...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000009371
更新日期:2020-05-05 00:00:00
abstract::Evaluating rehabilitation requires rating scales that detect change. The authors examined Barthel Index (BI) data from 1,495 patients at a neurorehabilitation unit to determine whether total scale responsiveness accurately reflects item responsiveness. Total score effect sizes were moderate to large (0.47 to 1.09). It...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000116136.22922.d6
更新日期:2004-05-25 00:00:00
abstract::In a double-blind, placebo-controlled, parallel-group, randomized clinical trial, we studied the efficacy of long-term (1-year) oral treatment with acetyl-L-carnitine in 130 patients with a clinical diagnosis of Alzheimer's disease. We employed 14 outcome measures to assess functional and cognitive impairment. After 1...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.41.11.1726
更新日期:1991-11-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between CSF creatine kinase BB isoenzyme activity (CSF CKBB) and neurologic outcome after cardiac arrest in clinical practice. BACKGROUND:CSF CKBB reflects the extent of brain damage following cardiac arrest. METHODS:To help with prognosis, treating physicians ordered CSF CKBB tes...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.2.352
更新日期:1997-02-01 00:00:00
abstract::A 28-year-old nonimmunocompromised man developed secondary syphilis confirmed by serum and CSF findings. His course was complicated by chorioretinitis, extensive skin lesions, and spastic paraparesis secondary to syphilitic meningomyelitis. MRI of the spinal cord was strikingly abnormal. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.2_part_1.325
更新日期:1991-02-01 00:00:00
abstract::We studied the effect of deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus on voice symptoms in seven patients with essential tremor. All had undergone DBS for management of hand tremor. Five of the patients had received unilateral implants; two were treated bilaterally. Each reported improveme...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.50.3.796
更新日期:1998-03-01 00:00:00
abstract::A decade of empirical work in brain imaging, genomics, and other areas of research has yielded new knowledge about the frequency of incidental findings, investigator responsibility, and risks and benefits of disclosure. Straightforward guidance for handling such findings of possible clinical significance, however, has...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000280469.17461.94
更新日期:2008-01-29 00:00:00
abstract::Clinicians have long suspected an association of classic amyotrophic lateral sclerosis (ALS) with Parkinson's disease (PD), dementia, or both. If proven, this would raise the possibility of a shared genetic susceptibility to the three disorders. To investigate this hypothesis, we compared 151 newly diagnosed ALS patie...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.10.1872
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVE:To determine the effect of clinical and radiologic disease activity on the rate of thinning of the ganglion cell/inner plexiform (GCIP) layer and the retinal nerve fiber layer in patients with multiple sclerosis (MS) using optical coherence tomography (OCT). METHODS:One hundred sixty-four patients with MS an...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827b1a1c
更新日期:2013-01-01 00:00:00
abstract::Revascularization time windows for patients with acute ischemic stroke are generally restricted to 8 hours. Later treatment attempts require more accurate prediction of risk and benefit, as safety and efficacy at these time strata are less well demonstrated. Advanced imaging techniques identify irreversible infarction...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3182695826
更新日期:2012-09-25 00:00:00
abstract:OBJECTIVES:Although small fiber neuropathy (SFN) often occurs without apparent cause, the molecular etiology of idiopathic SFN (I-SFN) has remained enigmatic. Sodium channel Na(v)1.7 is preferentially expressed within dorsal root ganglion (DRG) and sympathetic ganglion neurons and their small-diameter peripheral axons....
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182574f12
更新日期:2012-05-22 00:00:00
abstract::The technique of intrathecal enhancement using metrizamide (Amipaque) combined with CT imaging enables both the morphologic and dynamic (serial) evaluation of the intracranial cerebrospinal fluid pathways. Three distinct metrizamide CT cisternographic patterns (delayed, intermediate, and normal) emerge in pediatric pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.1.71
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVES:Circulating endothelial progenitor cells (EPC) are markers of vascular injury and their numbers decrease in acute stroke. However, the relation of EPC levels to stroke severity has not been quantified. MRI measurements of lesion volume provide an objective method for stroke severity assessment and outcome pr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318200d741
更新日期:2010-12-07 00:00:00
abstract::We compared the number of new gadolinium-enhancing and T2-weighted lesions on six monthly MRI scans in eight patients with relapsing multiple sclerosis before and during treatment with weekly intramuscular interferon beta-1a (Avonex; 30 microg). MRI activity was modestly reduced during treatment (p = 0.016). The treat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.4.874
更新日期:1999-09-11 00:00:00