Abstract:
:A decade of empirical work in brain imaging, genomics, and other areas of research has yielded new knowledge about the frequency of incidental findings, investigator responsibility, and risks and benefits of disclosure. Straightforward guidance for handling such findings of possible clinical significance, however, has been elusive. In early work focusing on imaging studies of the brain, we suggested that investigators and institutional review boards must anticipate and articulate plans for handling incidental findings. Here we provide a detailed analysis of different approaches to the problem and evaluate their merits in the context of the goals and setting of the research and the involvement of neurologists, radiologists, and other physicians. Protecting subject welfare and privacy, as well as ensuring scientific integrity, are the highest priorities in making choices about how to handle incidental findings. Forethought and clarity will enable these goals without overburdening research conducted within or outside the medical setting.
journal_name
Neurologyjournal_title
Neurologyauthors
Illes J,Kirschen MP,Edwards E,Bandettini P,Cho MK,Ford PJ,Glover GH,Kulynych J,Macklin R,Michael DB,Wolf SM,Grabowski T,Seto Bdoi
10.1212/01.wnl.0000280469.17461.94subject
Has Abstractpub_date
2008-01-29 00:00:00pages
384-90issue
5eissn
0028-3878issn
1526-632Xpii
70/5/384journal_volume
70pub_type
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