Time course of frontal somatosensory evoked potentials. Relation to L-dopa plasma levels and motor performance in PD.

Abstract:

OBJECTIVE:To verify whether the change in L-dopa plasma levels after a single dose of carbidopa/L-dopa 50/200 (controlled-release) transiently modifies frontal components of somatosensory evoked potentials (SEPs) in patients with PD in parallel with improvement of motor performance. BACKGROUND:Apomorphine, a potent dopamine-agonist drug, transiently increases frontal SEP components, which may be depressed in PD; however, relationships between clinical status, frontal SEPs, and therapy are still unclear. METHODS:Nineteen PD patients (mean age 65.9 years, range 52 to 77, responders to L-dopa therapy, were studied in the same day at times T0 (baseline predose level), T1 (presumed L-dopa peak time), and T2 (end of dose-induced motor response). The following were monitored: L-dopa plasma concentration, tapping test, reaction times, peak latency (with central conduction times), and amplitude of cervical, subcortical, as well as cortical parietal and frontal SEP components elicited by median nerve stimulation of the more clinically affected arm. RESULTS:The average amplitude of frontal components of PD patients was significantly reduced at T0 with respect to control subjects. A significant and transient amplitude increase of frontal SEPs was found at T1, in parallel with the L-dopa peak concentration and improvement in motor performance (tapping and reaction times), without significant changes in amplitude of parietal SEP waves. No latency shifts were observed in brain and spinal waves. CONCLUSIONS:L-Dopa may influence the responsiveness of the parkinsonian brain as assessed by frontal somatosensory evoked potentials. The time course of these modifications coincides with that of the clinical response in the motor performance.

journal_name

Neurology

journal_title

Neurology

authors

Ulivelli M,Rossi S,Pasqualetti P,Rossini PM,Ghiglieri O,Passero S,Battistini N

doi

10.1212/wnl.53.7.1451

subject

Has Abstract

pub_date

1999-10-22 00:00:00

pages

1451-7

issue

7

eissn

0028-3878

issn

1526-632X

journal_volume

53

pub_type

杂志文章
  • Spinal cord infarction: etiology and outcome.

    abstract::We reviewed 44 cases of ischemia and infarction of the spinal cord at two university hospitals. Three patients experienced transient ischemic attacks. Etiologies of completed strokes were diverse and included rupture and surgical repair of aortic aneurysms, aortic dissection, aortic rupture and thrombosis, global isch...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.47.2.321

    authors: Cheshire WP,Santos CC,Massey EW,Howard JF Jr

    更新日期:1996-08-01 00:00:00

  • Estimation of the temporal probability of human immunodeficiency virus (HIV) dementia after risk stratification for HIV-infected persons.

    abstract::We developed a scheme using routinely available data to estimate the risk of human immunodeficiency virus (HIV) dementia in HIV-infected persons over time. We performed a longitudinal review of medical records from more than 100 medical facilities in 11 U.S. cities. A total of 19,462 HIV-infected persons without histo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.2.392

    authors: Qureshi AI,Hanson DL,Jones JL,Janssen RS

    更新日期:1998-02-01 00:00:00

  • Familial occipital calcifications, hemorrhagic strokes, leukoencephalopathy, dementia, and external carotid dysplasia.

    abstract:OBJECTIVE:To describe a new familial association of late-onset dementia, patchy leukoencephalopathy, intracerebral hemorrhages, bilateral occipital calcifications (BOC), and external carotid artery dysplasia (ECAD). METHODS:At age 62, the proband, who was of Spanish descent, had left temporal hemorrhage in a backgroun...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.55.11.1661

    authors: Iglesias S,Chapon F,Baron JC

    更新日期:2000-12-12 00:00:00

  • Thrombolytic therapy in acute ischemic stroke patients with cardiac thrombus.

    abstract::The authors describe the outcome of five patients with a cardiac thrombus selected among 183 patients with stroke (2.7 %) who were given IV tissue plasminogen activator (tPA). No early systemic or cerebral embolism occurred. Two patients made a complete recovery at 3 months. Two patients had a moderate outcome. One pa...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.11.2122

    authors: Derex L,Nighoghossian N,Perinetti M,Honnorat J,Trouillas P

    更新日期:2001-12-11 00:00:00

  • Immediate-release and controlled-release carbidopa/levodopa in PD: a 5-year randomized multicenter study. Carbidopa/Levodopa Study Group.

    abstract:OBJECTIVE:To compare effects of immediate-release (IR) and sustained-release (CR) carbidopa/levodopa in levodopa-naive PD patients. BACKGROUND:It was hypothesized that the long-acting preparation would be associated with fewer long-term complications. METHODS:A total of 618 patients were studied in 36 centers worldwi...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1212/wnl.53.5.1012

    authors: Koller WC,Hutton JT,Tolosa E,Capilldeo R

    更新日期:1999-09-22 00:00:00

  • 3-Methylglutaconic aciduria type I redefined: a syndrome with late-onset leukoencephalopathy.

    abstract:OBJECTIVE:3-Methylglutaconic aciduria type I is a rare inborn error of leucine catabolism. It is thought to present in childhood with nonspecific symptoms; it was even speculated to be a nondisease. The natural course of disease is unknown. METHODS:This is a study on 10 patients with 3-methylglutaconic aciduria type I...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181f39a8a

    authors: Wortmann SB,Kremer BH,Graham A,Willemsen MA,Loupatty FJ,Hogg SL,Engelke UF,Kluijtmans LA,Wanders RJ,Illsinger S,Wilcken B,Cruysberg JR,Das AM,Morava E,Wevers RA

    更新日期:2010-09-21 00:00:00

  • Lyme borreliosis in Bell's palsy. Long Island Neuroborreliosis Collaborative Study Group.

    abstract::Lyme borreliosis (LB) causes a range of neurologic manifestations, the most common of which is facial nerve paralysis. To evaluate nervous system LB, we organized a neurologic collaborative study group in Suffolk County, NY, a region of high LB incidence. Between July and September 1989, LB serologies were performed o...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.7.1268

    authors: Halperin JJ,Golightly M

    更新日期:1992-07-01 00:00:00

  • A prospective study of cognitive impairment in ALS.

    abstract:OBJECTIVE:To characterize prospectively the cognitive profile in ALS. METHODS:Clinically definite ALS patients (11 men, 2 women), age 39.9 to 74.0 years (mean age, 54.2 +/- 9.6 years; mean disease duration, 21.1 +/- 10.5 months) underwent neuropsychologic, language, and speech testing followed by MR 1H spectroscopy (4...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.53.8.1665

    authors: Strong MJ,Grace GM,Orange JB,Leeper HA,Menon RS,Aere C

    更新日期:1999-11-10 00:00:00

  • Brain reserve and cognitive reserve protect against cognitive decline over 4.5 years in MS.

    abstract:OBJECTIVE:Based on the theories of brain reserve and cognitive reserve, we investigated whether larger maximal lifetime brain growth (MLBG) and/or greater lifetime intellectual enrichment protect against cognitive decline over time. METHODS:Forty patients with multiple sclerosis (MS) underwent baseline and 4.5-year fo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000000433

    authors: Sumowski JF,Rocca MA,Leavitt VM,Dackovic J,Mesaros S,Drulovic J,DeLuca J,Filippi M

    更新日期:2014-05-20 00:00:00

  • Predictors of outcome after anterior temporal lobectomy: the intracarotid amobarbital test.

    abstract::The intracarotid amobarbital test (IAT) examines hemispheric memory and language. We set out to determine whether memory performance on the IAT correlated with seizure relief after anterior temporal lobectomy in 117 patients with refractory epilepsy. The IAT assessed recognition memory performance for nine items with ...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章

    doi:10.1212/wnl.44.12.2325

    authors: Sperling MR,Saykin AJ,Glosser G,Moran M,French JA,Brooks M,O'Connor MJ

    更新日期:1994-12-01 00:00:00

  • Morphometry of dermal nerve fibers in human skin.

    abstract:OBJECTIVE:We aimed to assess the innervation density of dermal nerves in human skin biopsies by bright-field immunohistochemistry. METHODS:The size of dermal area where nerve length was quantified was validated in 30 skin biopsy sections (5 controls and 5 patients with small-fiber neuropathy [SFN]). It was obtained di...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318225ab51

    authors: Lauria G,Cazzato D,Porretta-Serapiglia C,Casanova-Molla J,Taiana M,Penza P,Lombardi R,Faber CG,Merkies IS

    更新日期:2011-07-19 00:00:00

  • Registry studies of long-term multiple sclerosis outcomes: description of key registries.

    abstract:BACKGROUND:Multiple sclerosis (MS) registries can provide valuable insights into the natural history of MS. Key observational findings of the registries include MS patient disability progression rate, predictors of increased disability, and changes in lifespan. MS registries have been established in Canada, the United ...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/WNL.0b013e3182050225

    authors: Hurwitz BJ

    更新日期:2011-01-04 00:00:00

  • 31P NMR studies in Duchenne muscular dystrophy: age-related metabolic changes.

    abstract::To evaluate possible progressive metabolic changes in Duchenne muscular dystrophy, we used 31P nuclear magnetic resonance spectroscopy to measure high-energy phosphate compounds and phosphorylated diesters (PDE) in resting gastrocnemius muscle of 14 Duchenne patients and 10 normal boys. The patients had higher inorgan...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.1.165

    authors: Younkin DP,Berman P,Sladky J,Chee C,Bank W,Chance B

    更新日期:1987-01-01 00:00:00

  • Short-term outcomes of skull fracture: a population-based study of survival and neurologic complications.

    abstract::All Olmsted County, Minnesota, residents who experienced brain injury from 1935 through 1979 were identified and their medical records reviewed for survival and neurologic outcome. Minimum inclusion criteria included loss of consciousness or post-traumatic amnesia or neurologic evidence of brain injury or skull fractu...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.39.1.96

    authors: Wiederholt WC,Melton LJ 3rd,Annegers JF,Grabow JD,Laws ER Jr,Ilstrup DM

    更新日期:1989-01-01 00:00:00

  • Disordered swallowing due to a syrinx: correction by shunting.

    abstract::Disturbed deglutition is common in diseases of the brainstem and lower cranial nerves, but little is known about the mechanisms involved. We studied a 49-year-old man with symptoms of syringomyelia and syringobulbia lasting 7 years. Esophageal motility studies showed inability to initiate swallowing, esophageal hypomo...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.11.1497

    authors: Bleck TP,Shannon KM

    更新日期:1984-11-01 00:00:00

  • HTLV-I-associated myelopathy/tropical spastic paraparesis in the United States.

    abstract::HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is endemic in the Caribbean basin and Japan. Because of the close proximity of the United States to the Caribbean and the presence of HTLV-I-seropositive persons in the United States, we sought reports of patients who were HTLV-I seropositive and had ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.41.9.1355

    authors: Janssen RS,Kaplan JE,Khabbaz RF,Hammond R,Lechtenberg R,Lairmore M,Chiasson MA,Punsalang A,Roberts B,McKendall RR

    更新日期:1991-09-01 00:00:00

  • Effects of cannabis on cognitive function in patients with multiple sclerosis.

    abstract:BACKGROUND:While neuropsychological deficits have been reported in healthy individuals who use street cannabis, data in patients with multiple sclerosis (MS) are lacking. Given that MS is associated with cognitive deterioration, the aim of this study was to determine the neuropsychological effects of cannabis use in th...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e318212ab0c

    authors: Honarmand K,Tierney MC,O'Connor P,Feinstein A

    更新日期:2011-03-29 00:00:00

  • Hearing impairment in essential tremor.

    abstract:OBJECTIVE:To assess hearing in patients with essential tremor (ET) vs patients with Parkinson disease (PD) and normal controls. METHODS:The authors assessed demographic and clinical information including use of hearing aids in 250 patients with ET, 127 patients with PD, and 127 normal controls. The authors administere...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000086376.40750.af

    authors: Ondo WG,Sutton L,Dat Vuong K,Lai D,Jankovic J

    更新日期:2003-10-28 00:00:00

  • Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials.

    abstract:OBJECTIVE:To revise the 1999 Airlie House consensus guidelines for the design and implementation of preclinical therapeutic studies and clinical trials in amyotrophic lateral sclerosis (ALS). METHODS:A consensus committee comprising 140 key members of the international ALS community (ALS researchers, clinicians, patie...

    journal_title:Neurology

    pub_type: 共识发展会议,杂志文章

    doi:10.1212/WNL.0000000000007242

    authors: van den Berg LH,Sorenson E,Gronseth G,Macklin EA,Andrews J,Baloh RH,Benatar M,Berry JD,Chio A,Corcia P,Genge A,Gubitz AK,Lomen-Hoerth C,McDermott CJ,Pioro EP,Rosenfeld J,Silani V,Turner MR,Weber M,Brooks BR,Miller

    更新日期:2019-04-02 00:00:00

  • Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding: report of the Quality Standards Subcommittee and Therapeutics and Technology Asses

    abstract:OBJECTIVE:To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of antiepileptic drugs (AE...

    journal_title:Neurology

    pub_type: 杂志文章,实务指引,评审

    doi:10.1212/WNL.0b013e3181a6b325

    authors: Harden CL,Pennell PB,Koppel BS,Hovinga CA,Gidal B,Meador KJ,Hopp J,Ting TY,Hauser WA,Thurman D,Kaplan PW,Robinson JN,French JA,Wiebe S,Wilner AN,Vazquez B,Holmes L,Krumholz A,Finnell R,Shafer PO,Le Guen C,Americ

    更新日期:2009-07-14 00:00:00

  • High-dose monotherapy in treatment of intractable seizures.

    abstract::We evaluated the therapeutic efficacy and toxicity of high-dose monotherapy, using carbamazepine or phenytoin, in patients with previously uncontrolled seizures. Treatment with a single drug was equal to or better than polypharmacy, but only a few patients became free of seizures. Toxicity was mild and associated with...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.34.6.707

    authors: Lesser RP,Pippenger CE,Lüders H,Dinner DS

    更新日期:1984-06-01 00:00:00

  • Obstacles in the diagnosis and treatment of syphilitic amyotrophy.

    abstract::The authors describe a case of syphilitic amyotrophy in a 37-year-old man presenting with subacute progressive painless weakness in the right arm. Syphilitic amyotrophy is still an existing differential diagnosis of painless and progressive weakness. The authors explore potential obstacles in the diagnostic workup and...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000046584.72672.d3

    authors: Etgen T,Bischoff C,Resch M,Winbeck K,Conrad B,Sander D

    更新日期:2003-02-11 00:00:00

  • Insights into the natural history of spontaneous intracranial hypotension from infusion testing.

    abstract:OBJECTIVE:To assess the pathophysiologic changes in patients with spontaneous intracranial hypotension (SIH) based on measures of CSF dynamics, and on the duration of symptoms, in a retrospective case-controlled study. METHODS:We included consecutive patients investigated for SIH at our department from January 2012 to...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000009812

    authors: Häni L,Fung C,Jesse CM,Ulrich CT,Miesbach T,Cipriani DR,Dobrocky T,Z'Graggen WJ,Raabe A,Piechowiak EI,Beck J

    更新日期:2020-07-21 00:00:00

  • Drug-mediated antiepileptogenesis in humans.

    abstract::The goal of pharmacologic therapy for patients with epilepsy is to suppress seizures without side effects. There is growing interest in developing antiepileptogenic drugs capable of preventing the onset of seizures in patients at high risk and inducing a permanent remission of seizures in patients with epilepsy, i.e.,...

    journal_title:Neurology

    pub_type: 杂志文章,评审

    doi:10.1212/wnl.59.9_suppl_5.s34

    authors: Schachter SC

    更新日期:2002-11-12 00:00:00

  • Brain-behavior correlations in hemispatial neglect using CT and SPECT: the Sunnybrook Stroke Study.

    abstract:OBJECTIVE:Structural and functional lesion localization in patients with hemispatial neglect. DESIGN:Location and severity of brain damage on CT and SPECT correlated with neglect performance as assessed with a battery of drawings, line bisection, and line and shape cancellation subtests. PATIENTS:Participants include...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.50.4.901

    authors: Leibovitch FS,Black SE,Caldwell CB,Ebert PL,Ehrlich LE,Szalai JP

    更新日期:1998-04-01 00:00:00

  • Severe dysarthria with right hemisphere stroke.

    abstract::Ten patients are presented with severe dysarthria from a right hemisphere stroke, 4 with autopsies, emphasizing that this lesion alone is compatible with severely slurred speech. Most had oropharyngeal weakness; the accompanying hemiparesis was of variable severity. Superficial or deep infarctions were responsible, th...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.37.6.1061

    authors: Ropper AH

    更新日期:1987-06-01 00:00:00

  • Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology.

    abstract:OBJECTIVE:To examine the relation of nonsteroidal anti-inflammatory drugs (NSAIDs) to incident Alzheimer disease (AD), change in cognition, and AD pathology. METHODS:Participants were 1,019 older Catholic clergy followed up annually for up to 12 years (mean baseline age = 75.0 years, education = 18.1 years, Mini-Menta...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000313813.48505.86

    authors: Arvanitakis Z,Grodstein F,Bienias JL,Schneider JA,Wilson RS,Kelly JF,Evans DA,Bennett DA

    更新日期:2008-06-03 00:00:00

  • The Tourette syndrome diagnostic confidence index: development and clinical associations.

    abstract:BACKGROUND:The clinical characteristics of Tourette syndrome (TS) present challenges for the systematic determination of whether individuals are affected and severity. Vocal and motor tics wax and wane, decrease over time, and may be voluntarily suppressible, and therefore may be absent at interview. Current instrument...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.53.9.2108

    authors: Robertson MM,Banerjee S,Kurlan R,Cohen DJ,Leckman JF,McMahon W,Pauls DL,Sandor P,van de Wetering BJ

    更新日期:1999-12-10 00:00:00

  • Readmission to a different hospital following acute stroke is associated with worse outcomes.

    abstract:OBJECTIVE:There is a high risk of readmission within 30 days of index acute ischemic stroke (AIS), but effect of readmission to a different hospital is not known. We performed a retrospective cohort study to assess our hypothesis that 30-day readmission outcomes after AIS are worse for those readmitted to another hospi...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000008446

    authors: Stein LK,Agarwal P,Thaler A,Kwon CS,Jette N,Dhamoon MS

    更新日期:2019-11-12 00:00:00

  • Long-term survival and neurologic status after resuscitation from out-of-hospital cardiac arrest.

    abstract::Thirty-eight survivors from among 117 patients hospitalized after out-of-hospital cardiac arrest were evaluated approximately 3 1/2 years later. Twenty patients were living; 18 had died. Fifty-three percent had resumed independent social activities, but only 32% had returned to work. Eight of 14 patients tested were n...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.30.12.1298

    authors: Earnest MP,Yarnell PR,Merrill SL,Knapp GL

    更新日期:1980-12-01 00:00:00