Abstract:
:Lyme borreliosis (LB) causes a range of neurologic manifestations, the most common of which is facial nerve paralysis. To evaluate nervous system LB, we organized a neurologic collaborative study group in Suffolk County, NY, a region of high LB incidence. Between July and September 1989, LB serologies were performed on all patients with new-onset Bell's palsy. Seven of 32 had serologic evidence of LB at onset. One, initially seronegative, was highly seropositive 5 weeks later. In the five in whom we examined CSF, there was no evidence of intrathecal synthesis of specific antibody. In highly endemic areas, LB may be responsible for 1/4 of cases of Bell's palsy. Rarely, the palsy may occur prior to the development of a measurable antibody response, indicating a need for follow-up serologic testing.
journal_name
Neurologyjournal_title
Neurologyauthors
Halperin JJ,Golightly Mdoi
10.1212/wnl.42.7.1268subject
Has Abstractpub_date
1992-07-01 00:00:00pages
1268-70issue
7eissn
0028-3878issn
1526-632Xjournal_volume
42pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::The objective of this study was to clarify the clinical and radiologic features, risk factors, and prognosis of basilar embolism without permanent basilar artery occlusion. Forty-five patients (mean age, 59 years) with basilar artery embolism participated in the study. Patients with basilar artery occlusion were exclu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.5.1346
更新日期:1997-11-01 00:00:00
abstract::The malformation of inverse cerebellum and occipital encephalocele is situated morphologically between the Arnold-Chiari and Dandy-Walker malformations. In the three reported cases, hydrocephalus was not present, concomitant malformations of the lamina terminalis were present in two, and polymicrogyria was found in al...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.3.246
更新日期:1977-03-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to determine whether environmental and genetic alterations of neuronal aldehyde dehydrogenase (ALDH) enzymes were associated with increased Parkinson disease (PD) risk in an epidemiologic study. METHODS:A novel ex vivo assay was developed to identify pesticides that can inhibi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000083
更新日期:2014-02-04 00:00:00
abstract::Acute myopathy and myoglobinuria with markedly elevated creatine kinase (CK) activity developed in an 18-year-old boy on two occasions after gasoline sniffing. No signs of CNS involvement were seen, and the symptoms receded in a few days. The amount of lead in blood and urine exceeded the reference value for subjects ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.5.629
更新日期:1983-05-01 00:00:00
abstract:OBJECTIVE:This prospective, randomized, controlled study was designed to investigate the safety, feasibility, and preliminary efficacy of long-term CSF drainage via a low-flow ventriculoperitoneal shunt in subjects suffering from AD. METHODS:Twenty-nine subjects selected for probable AD (National Institute of Neurolog...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000031794.42077.a1
更新日期:2002-10-22 00:00:00
abstract:OBJECTIVE:To evaluate the area of the midbrain and pons on mid-sagittal MRI in patients with progressive supranuclear palsy (PSP), Parkinson disease (PD), and multiple-system atrophy of the Parkinson type (MSA-P), compare these appearances and values with those of normal control subjects, and establish diagnostic MRI c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000165960.04422.D0
更新日期:2005-06-28 00:00:00
abstract::One hundred and eight patients with independent, multifocal, spike discharges in the EEG were studied. The abnormality occurred at all ages but was more frequent between 4 and 7 years. The basic EEG activity in wake tracing was invariably slow for the age of the patient. The majority of the patients with independent m...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.7.667
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare multisystem disorder associated with plasma cell dyscrasia. There is increasing evidence that high-dose chemotherapy with autologous peripheral blood stem cell transplantation (Auto-PBSCT) is an efficacious t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000323811.42080.a4
更新日期:2008-11-18 00:00:00
abstract:OBJECTIVE:To analyze the frequency of neurologic events during commercial airline flights and to assess whether onboard emergency medical kits are adequate for in-flight neurologic emergencies. METHODS:Collaboration of the Mayo Clinic's Departments of Emergency Medicine and Medical Transportation Service and the Divis...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.58.12.1739
更新日期:2002-06-25 00:00:00
abstract:OBJECTIVE:To describe the detection frequency and clinical associations of immunoglobulin G (IgG) targeting dipeptidyl-peptidase-like protein-6 (DPPX), a regulatory subunit of neuronal Kv4.2 potassium channels. METHODS:Specimens from 20 patients evaluated on a service basis by tissue-based immunofluorescence yielded a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000991
更新日期:2014-11-11 00:00:00
abstract::Early motor manifestations are the main components of focal seizures involving the frontal lobe. We examined the relationship between the initial ictal motor manifestations and interictal abnormalities of cerebral glucose consumption (rCMRGlc) as assessed by PET in 48 consecutive patients with focal seizures of neocor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.2.341
更新日期:1997-08-01 00:00:00
abstract:OBJECTIVE:To assess the safety, tolerability, and biological activity of glial cell line-derived neurotrophic factor (GDNF) administered by an implanted intracerebroventricular (ICV) catheter and access port in advanced PD. BACKGROUND:GDNF is a peptide that promotes survival of dopamine neurons. It improved 6-OHDA- or...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.60.1.69
更新日期:2003-01-14 00:00:00
abstract:BACKGROUND:Campylobacter jejuni enteritis is the predominant bacterial infection preceding Guillain-Barré syndrome (GBS), an acute postinfectious immune-mediated polyradiculoneuropathy. The purpose of this study was to define the clinical phenotype of GBS and the relation with preceding C jejuni infections in Banglades...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181cff735
更新日期:2010-02-16 00:00:00
abstract::A 61-year-old woman presented with two paraneoplastic neurologic disorders--Lambert-Eaton myasthenic syndrome (LEMS) and subacute cerebellar degeneration (SCD)--that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficia...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1682
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVE:We aimed to assess the innervation density of dermal nerves in human skin biopsies by bright-field immunohistochemistry. METHODS:The size of dermal area where nerve length was quantified was validated in 30 skin biopsy sections (5 controls and 5 patients with small-fiber neuropathy [SFN]). It was obtained di...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318225ab51
更新日期:2011-07-19 00:00:00
abstract::The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient (ADC) in all patients, with correspon...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000218207.18707.f4
更新日期:2006-06-13 00:00:00
abstract::Autonomic functions were studied after withdrawal of all medication in parkinsonian out-patients with short and long duration of disease and in age-matched healthy control subjects. Vagal heart control and noradrenergic response to standing were impaired and related to duration of symptoms of idiopathic parkinsonism. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.7.1173
更新日期:1987-07-01 00:00:00
abstract::The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000125693.59817.31
更新日期:2004-05-11 00:00:00
abstract:OBJECTIVE:The diagnosis of psychogenic nonepileptic seizures (PNES) can be challenging. In the absence of a gold standard to verify the reliability of the diagnosis by EEG-video, we sought to assess the interrater reliability of the diagnosis using EEG-video recordings. METHODS:Patient samples consisted of 22 unselect...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181b78425
更新日期:2009-09-15 00:00:00
abstract::Motivationally responsive motor deficits may occur in isolation or as part of more general neglect syndromes. We describe three patients with two discrete syndromes of isolated motor neglect, differentiated primarily by their performance in motor tasks enacted within or toward the contralesional hemispace. The lesions...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.3.525
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVES:To test the hypothesis that neuropsychiatric symptomatology is predictive of the success of seizure control in patients newly treated with antiepileptic drugs (AEDs), and that this predictive value adds to that provided by other clinical, imaging, and genomic factors in a multivariate model. METHODS:One hun...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181f25b16
更新日期:2010-09-14 00:00:00
abstract::We review adjunctive ketogenic diet (KD) and modified Atkins diet (MAD) treatment of refractory epilepsy in adults. Only a few studies have been published, all open-label. Because of the disparate, uncontrolled nature of the studies, we analyzed all studies individually, without a meta-analysis. Across all studies, 32...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000001004
更新日期:2014-11-18 00:00:00
abstract:OBJECTIVES:To determine the prognostic role of late auditory (N100) and cognitive evoked potentials (MMN) for awakening in a cohort of comatose patients categorized by etiology. METHODS:The authors prospectively studied a series of 346 comatose patients. Coma was caused by stroke (n = 125), trauma (n = 96), anoxia (n ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000134670.10384.e2
更新日期:2004-08-24 00:00:00
abstract::Proteins from single frozen sections of human muscle were separated by two-dimensional gel electrophoresis and detected by fluorography or Coomassie Blue staining. The major proteins were identical in different normal muscles obtained from either sex at different ages, and in Duchenne and myotonic dystrophy samples. C...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.9.1152
更新日期:1983-09-01 00:00:00
abstract::We studied a family in which the father and 7 of 10 children had episodes of Bell's palsy. Five of the eight affected family members also had ocular motor palsies. Facial nerve and blink reflex studies in four affected siblings demonstrated asymmetrically reduced amplitude of evoked responses without delayed conductio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.8.1369
更新日期:1987-08-01 00:00:00
abstract::The Finnish Twin Cohort includes all Finnish same-sexed twins born before 1958 and alive in 1967; the number of individuals alive in 1975 was 33,247. We performed a search for cases with Parkinson's disease among this cohort by linking the Twin Cohort Register with the Finnish Hospital Discharge Register and the Finni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.8.1217
更新日期:1988-08-01 00:00:00
abstract::The authors describe an infant with vanishing white matter disease with demyelinating peripheral neuropathy. Sequence analysis of EIF2B5 gene showed that the patient was a double heterozygote, with novel missense mutation CGA-->CAA in codon 269 of exon 6, resulting in the replacement of an arginine residue with glutam...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000225077.40532.a5
更新日期:2006-07-25 00:00:00
abstract:OBJECTIVE:To evaluate an observational-behavioral pain tool among individuals with acute poststroke aphasia. METHODS:We performed a randomized, double-blind, controlled study of experimental pain assessment among 36 adult patients with acute poststroke aphasia. Patients were administered 3 levels of mechanical pain, i...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000006081
更新日期:2018-08-28 00:00:00
abstract:OBJECTIVE:We sought to determine the association of dietary factors and risk of cognitive decline in a population at high risk of cardiovascular disease. METHODS:Baseline dietary intake and measures of the Mini-Mental State Examination were recorded in 27,860 men and women who were enrolled in 2 international parallel...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000001638
更新日期:2015-06-02 00:00:00
abstract:OBJECTIVE:To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD). METHODS:Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007968
更新日期:2019-08-20 00:00:00