Healthy eating and reduced risk of cognitive decline: A cohort from 40 countries.

Abstract:

OBJECTIVE:We sought to determine the association of dietary factors and risk of cognitive decline in a population at high risk of cardiovascular disease. METHODS:Baseline dietary intake and measures of the Mini-Mental State Examination were recorded in 27,860 men and women who were enrolled in 2 international parallel trials of the ONTARGET (Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial) and TRANSCEND (Telmisartan Randomised Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease) studies. We measured diet quality using the modified Alternative Healthy Eating Index. Cox proportional hazards regression was used to determine the association between diet quality and risk of ≥3-point decline in Mini-Mental State Examination score, and reported as hazard ratio with 95% confidence intervals with adjustment for covariates. RESULTS:During 56 months of follow-up, 4,699 cases of cognitive decline occurred. We observed lower risk of cognitive decline among those in the healthiest dietary quintile of modified Alternative Healthy Eating Index compared with lowest quintile (hazard ratio 0.76, 95% confidence interval 0.66-0.86, Q5 vs Q1). Lower risk of cognitive decline was consistent regardless of baseline cognitive level. CONCLUSION:We found that higher diet quality was associated with a reduced risk of cognitive decline. Improved diet quality represents an important potential target for reducing the global burden of cognitive decline.

journal_name

Neurology

journal_title

Neurology

authors

Smyth A,Dehghan M,O'Donnell M,Anderson C,Teo K,Gao P,Sleight P,Dagenais G,Probstfield JL,Mente A,Yusuf S,ONTARGET and TRANSCEND Investigators.

doi

10.1212/WNL.0000000000001638

subject

Has Abstract

pub_date

2015-06-02 00:00:00

pages

2258-65

issue

22

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000001638

journal_volume

84

pub_type

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