Abstract:
:Proteins from single frozen sections of human muscle were separated by two-dimensional gel electrophoresis and detected by fluorography or Coomassie Blue staining. The major proteins were identical in different normal muscles obtained from either sex at different ages, and in Duchenne and myotonic dystrophy samples. Congenital myopathy, denervation atrophy, polymyositis, and Becker's muscular dystrophy samples, however, showed abnormal myosin light chain compositions, some with a decrease of fast-fiber myosin light chains and others with a decrease of slow-fiber light chains. These protein alterations did not correlate with any specific disease, and may be caused by generalized muscle-fiber damage.
journal_name
Neurologyjournal_title
Neurologyauthors
Giometti CS,Danon MJ,Anderson NGdoi
10.1212/wnl.33.9.1152subject
Has Abstractpub_date
1983-09-01 00:00:00pages
1152-6issue
9eissn
0028-3878issn
1526-632Xjournal_volume
33pub_type
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