Abstract:
:The major glycoprotein P0 from human and bovine peripheral nerves carries the L2/HNK-1 and L3 carbohydrate epitopes and is recognized by serum from patients with IgM gammopathy and polyneuropathy. Only serum from patients with reactivity toward the myelin-associated glycoprotein (MAG) was reactive with P0, while serum that did not react with MAG also did not recognize P0. Furthermore, the neural adhesion molecules L1, N-CAM, and J1 were also recognized by the serum that reacted with MAG, while the L3 carbohydrate-carrying cell adhesion molecule AMOG was not recognized. These observations indicate a restricted specificity in carbohydrate reactivity of IgM paraproteins and implicate yet another and, for the first time, peripheral myelin-specific glycoprotein in the pathogenesis of demyelinating neuropathy.
journal_name
Neurologyjournal_title
Neurologyauthors
Bollensen E,Steck AJ,Schachner Mdoi
10.1212/wnl.38.8.1266subject
Has Abstractpub_date
1988-08-01 00:00:00pages
1266-70issue
8eissn
0028-3878issn
1526-632Xjournal_volume
38pub_type
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