A new SPG4 mutation in a variant form of spastic paraplegia with congenital arachnoid cysts.

abstract：OBJECTIVE:To determine the efficacy of acetyl-l-carnitine (ALCAR) on the rate of decline in early-onset AD patients. METHODS:A 1-year, multicenter, double-blind, placebo-controlled, randomized trial was conducted. Subjects were 45 to 65 years old, with a diagnosis of probable AD according to National Institute of Neur...

journal_title：Neurology

authors： Thal LJ,Calvani M,Amato A,Carta A

更新日期：2000-09-26 00:00:00

abstract：:The most consistent electroencephalographic finding in 16 cases of Sturge-Weber syndrome was a unilateral reduction of background amplitude in the waking record. Comparable asymmetries were noted in those patients in whom sleep recording also was done. Physiologic responses (to hyperventilation and photic driving) usu...

journal_title：Neurology

authors： Brenner RP,Sharbrough FW

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:Progressive brain atrophy in multiple sclerosis (MS) may reflect neuroaxonal and myelin loss and MRI measures of brain tissue loss are used as outcome measures in MS treatment trials. This study investigated sample sizes required to demonstrate reduction of brain atrophy using three outcome measures in a par...

journal_title：Neurology

authors： Altmann DR,Jasperse B,Barkhof F,Beckmann K,Filippi M,Kappos LD,Molyneux P,Polman CH,Pozzilli C,Thompson AJ,Wagner K,Yousry TA,Miller DH

更新日期：2009-02-17 00:00:00

abstract：:We describe a familial disorder consisting of sleep apnea, anosmia, colorblindness, partial complex seizures, and cognitive dysfunction. The phenotypic expression of the syndrome suggests an autosomal dominant inheritance with incomplete penetrance. ...

journal_title：Neurology

authors： Manon-Espaillat R,Gothe B,Adams N,Newman C,Ruff R

更新日期：1988-02-01 00:00:00

abstract：OBJECTIVE:To discuss the indications and timing for resective surgery in patients with Sturge-Weber syndrome (SWS) and medication-resistant epilepsy. BACKGROUND:SWS that causes epilepsy severe enough to merit surgery is rare. Because of the variable natural history of the disease, it is difficult to establish clear-cu...

journal_title：Neurology

authors： Arzimanoglou AA,Andermann F,Aicardi J,Sainte-Rose C,Beaulieu MA,Villemure JG,Olivier A,Rasmussen T

更新日期：2000-11-28 00:00:00

abstract：BACKGROUND:The probability of hearing loss during cerebellopontine angle (CPA) surgery can be reduced by using brainstem auditory evoked potential (BAEP) intraoperative monitoring (IOM). A wave V latency prolongation of 1.0 milliseconds or amplitude decrement of greater than 50% is arbitrarily considered the point when...

journal_title：Neurology

authors： James ML,Husain AM

更新日期：2005-11-22 00:00:00

abstract：BACKGROUND:Sleep-disordered breathing (SDB) and respiratory failure (RF) are complications of acid maltase deficiency (AMD), a rare hereditary myopathy. OBJECTIVE:To define the relationship between lung and respiratory muscle function, to establish incidence and patterns of SDB, and to determine daytime predictors of ...

journal_title：Neurology

authors： Mellies U,Ragette R,Schwake C,Baethmann M,Voit T,Teschler H

更新日期：2001-10-09 00:00:00

abstract：:Four patients with primary writing tremor had a focal, task-specific tremor that responded to anticholinergic drugs. Physiologic features included EMG activity alternating in antagonist muscles, 5- to 20-microV cerebral potentials evoked by stretch of pronator teres, and no C-reflexes. Another patient had myoclonic je...

journal_title：Neurology

authors： Ravits J,Hallett M,Baker M,Wilkins D

更新日期：1985-09-01 00:00:00

abstract：:The mechanism by which prednisone improves muscle strength and function in Duchenne muscular dystrophy (DMD) is unknown. We addressed the possibility that clinical improvement was related to prednisone-induced alterations in skeletal muscle dystrophin. We performed muscle biopsies on patients at the conclusion of a ra...

journal_title：Neurology

authors： Burrow KL,Coovert DD,Klein CJ,Bulman DE,Kissel JT,Rammohan KW,Burghes AH,Mendell JR

更新日期：1991-05-01 00:00:00

abstract：:Using an antibody against choline acetyltransferase (ChAT), mesencephalic cholinergic cell nuclei were studied in autopsy material from 3 cases of progressive supranuclear palsy (PSP) and 4 controls. ChAT-immunoreactive neurons were quantified in sections that spanned the rostrocaudal extent of each nucleus. In PSP, t...

journal_title：Neurology

authors： Juncos JL,Hirsch EC,Malessa S,Duyckaerts C,Hersh LB,Agid Y

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:We aimed to perform an observational study of age at loss of independent ambulation (LoA) and side-effect profiles associated with different glucocorticoid corticosteroid (GC) regimens in Duchenne muscular dystrophy (DMD). METHODS:We studied 340 participants in the Cooperative International Neuromuscular Res...

journal_title：Neurology

authors： Bello L,Gordish-Dressman H,Morgenroth LP,Henricson EK,Duong T,Hoffman EP,Cnaan A,McDonald CM,CINRG Investigators.

更新日期：2015-09-22 00:00:00

abstract：OBJECTIVE:To describe a large series of BIN1 patients, in which a novel founder mutation in the Roma population of southern Spain has been identified. METHODS:Patients diagnosed with centronuclear myopathy (CNM) at 5 major reference centers for neuromuscular disease in Spain (n = 53) were screened for BIN1 mutations. ...

journal_title：Neurology

authors： Cabrera-Serrano M,Mavillard F,Biancalana V,Rivas E,Morar B,Hernández-Laín A,Olive M,Muelas N,Khan E,Carvajal A,Quiroga P,Diaz-Manera J,Davis M,Ávila R,Domínguez C,Romero NB,Vílchez JJ,Comas D,Laing NG,Laporte J,Ka

更新日期：2018-07-24 00:00:00

abstract：BACKGROUND:The relationship between age-related memory decline and hippocampal anatomic changes is a matter of debate. OBJECTIVES:To investigate the relationship between age-related memory decline and MRI hippocampal anatomic changes in a cohort of healthy individuals. METHODS:In this cross-sectional study, 76 health...

journal_title：Neurology

authors： Carlesimo GA,Cherubini A,Caltagirone C,Spalletta G

更新日期：2010-01-19 00:00:00

abstract：:A 33-year-old man with complex partial seizures developed de novo hypertension after the initiation of carbamazepine, which resolved on discontinuation. Although rare, a variety of cardiovascular effects including hypertension have been reported with carbamazepine. Numerous mechanisms may be responsible; however, shar...

journal_title：Neurology

authors： Jette N,Veregin T,Guberman A

更新日期：2002-07-23 00:00:00

abstract：OBJECTIVE:To survey brain death criteria throughout the world. BACKGROUND:The clinical diagnosis of brain death allows organ donation or withdrawal of support. Declaration of brain death follows a certain set of examinations. The code of practice throughout the world has not been systematically investigated. METHODS:...

journal_title：Neurology

authors： Wijdicks EF

更新日期：2002-01-08 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of headaches in a Chinese elderly population. BACKGROUND:There are few headache surveys in the elderly. Previous studies have shown a low headache prevalence in Chinese. METHODS: TARGET POPULATION:eligible registered residents > or = 65 years old (N = 2,003) in two townships o...

journal_title：Neurology

authors： Wang SJ,Liu HC,Fuh JL,Liu CY,Lin KP,Chen HM,Lin CH,Wang PN,Hsu LC,Wang HC,Lin KN

更新日期：1997-07-01 00:00:00

abstract：:Motivationally responsive motor deficits may occur in isolation or as part of more general neglect syndromes. We describe three patients with two discrete syndromes of isolated motor neglect, differentiated primarily by their performance in motor tasks enacted within or toward the contralesional hemispace. The lesions...

journal_title：Neurology

authors： Simon ES,Hegarty AM,Mehler MF

更新日期：1995-03-01 00:00:00

abstract：:Patients, clinicians, and hospitals have undergone monumental changes during the coronavirus disease 2019 (COVID-19) pandemic. This crisis has forced us to consider the obligations that we neurologists have to our individual patients as well as the greater community. By returning to our fundamental understanding of th...

journal_title：Neurology

authors： Rubin MA,Bonnie RJ,Epstein L,Hemphill C,Kirschen M,Lewis A,Suarez JI,Ethics, Law, and Humanities Committee, a joint committee of the American Academy of Neurology, American Neurological Association, and Child Neurology Society; in collabor

更新日期：2020-07-28 00:00:00

abstract：:Weight gain has been recognized as an adverse effect of valproic acid therapy, but there are are no data about serum leptin levels in patients receiving this drug. To evaluate if valproic acid treatment in epileptic patients in whom obesity develops modifies serum levels of insulin and leptin, 40 female patients with ...

journal_title：Neurology

authors： Verrotti A,Basciani F,Morresi S,de Martino M,Morgese G,Chiarelli F

更新日期：1999-07-13 00:00:00

abstract：:Pergolide, a long-acting central dopamine agonist, was used as monotherapy in 16 parkinsonian patients. A mean daily dose of 6.3 mg resulted in 73% improvement of parkinsonian disability. Clinical improvement after acute administration of one dose of pergolide was similar to that observed after levodopa plus a periphe...

journal_title：Neurology

authors： Mear JY,Barroche G,de Smet Y,Weber M,Lhermitte F,Agid Y

更新日期：1984-07-01 00:00:00

abstract：:We evaluated a new magnetic resonance (MR)-based technique for performing volumetric measurements of temporal lobe structures. The technique was designed to assist in making the clinical diagnosis of dementia of the Alzheimer type (DAT). We chose specific anatomic regions of interest because of their known involvement...

journal_title：Neurology

authors： Jack CR Jr,Petersen RC,O'Brien PC,Tangalos EG

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:To describe clinical-radiologic characteristics in a prospective series of patients having both confirmed reversible cerebral vasoconstriction syndrome (RCVS) and cervical artery dissection (CeAD). METHODS:From January 2004 to December 2011, from our prospective cohorts of RCVS and CeAD, we studied patients...

journal_title：Neurology

authors： Mawet J,Boukobza M,Franc J,Sarov M,Arnold M,Bousser MG,Ducros A

更新日期：2013-08-27 00:00:00

abstract：OBJECTIVE:To validate the ability of a specifically developed cognitive risk score to identify patients at risk of poststroke neurocognitive disorders (NCDs) who are eligible for a comprehensive cognitive assessment. METHODS:After assessing 404 patients (infarct 91.3%) in the Groupe de Réflexion pour l'Evaluation Cogn...

journal_title：Neurology

authors： Godefroy O,Yaïche H,Taillia H,Bompaire F,Nédélec-Ciceri C,Bonnin C,Varvat J,Vincent-Grangette F,Diouf M,Mas JL,Canaple S,Lamy C,Arnoux A,Leclercq C,Tasseel-Ponche S,Roussel M,Barbay M,GRECogVASC Study Group.

更新日期：2018-11-20 00:00:00

abstract：OBJECTIVE:To investigate the pathogenesis of proximal diabetic neuropathy (PDN) with nerve and muscle biopsies. BACKGROUND:Recent evidence suggests that nerve ischemia secondary to immune-mediated vasculopathy rather than diabetic microangiopathy may be responsible for PDN. METHOD:- Fifteen patients with PDN and two ...

journal_title：Neurology

authors： Kelkar P,Masood M,Parry GJ

更新日期：2000-07-12 00:00:00

abstract：OBJECTIVE:To report outcomes of pregnancies that occurred during the fingolimod clinical development program. METHODS:Pregnancy outcomes from phase II, phase III, and phase IV clinical studies (with optional extensions) were reported by clinical trial investigators. Fingolimod exposure in utero was defined as fingolim...

journal_title：Neurology

authors： Karlsson G,Francis G,Koren G,Heining P,Zhang X,Cohen JA,Kappos L,Collins W

更新日期：2014-02-25 00:00:00

abstract：OBJECTIVE:To clarify the clinical and neurophysiologic spectrum of myoclonus-dystonia patients with mutations of the SGCE gene. METHODS:We prospectively studied 41 consecutive patients from 22 families with documented mutations of the SGCE gene. The patients had a standardized interview, neurologic examination, and de...

journal_title：Neurology

authors： Roze E,Apartis E,Clot F,Dorison N,Thobois S,Guyant-Marechal L,Tranchant C,Damier P,Doummar D,Bahi-Buisson N,André-Obadia N,Maltete D,Echaniz-Laguna A,Pereon Y,Beaugendre Y,Dupont S,De Greslan T,Jedynak CP,Ponsot G,D

更新日期：2008-03-25 00:00:00

abstract：OBJECTIVE:To examine the relationship of migraine and other severe headaches with panic disorder. METHODS:Representative samples of persons with migraine, non-migrainous severe headaches, and controls with no history of severe headaches, identified by a telephone survey, were interviewed in person, using a standardize...

journal_title：Neurology

authors： Breslau N,Schultz LR,Stewart WF,Lipton R,Welch KM

更新日期：2001-02-13 00:00:00

abstract：OBJECTIVE:To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. METHODS:Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who...

journal_title：Neurology

authors： Arrambide G,Espejo C,Eixarch H,Villar LM,Alvarez-Cermeño JC,Picón C,Kuhle J,Disanto G,Kappos L,Sastre-Garriga J,Pareto D,Simon E,Comabella M,Río J,Nos C,Tur C,Castilló J,Vidal-Jordana A,Galán I,Arévalo MJ,Auger C

更新日期：2016-09-13 00:00:00

abstract：:Cerebrospinal fluid (CSF) pressure was measured in four groups of patients: 116 with acute pseudotumor cerebri, 18 with chronic pseudotumor cerebri, 41 obese and 15 nonobese normal patients undergoing spinal anesthesia. Spinal fluid pressure between 200 and 250 mm H2O was found in members of each group. This suggests ...

journal_title：Neurology

authors： Corbett JJ,Mehta MP

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess the relation of retinal microvascular signs and incident stroke and stroke mortality in an older population. METHODS:The authors took retinal photographs on baseline participants (3,654 patients aged 49+ years) of the Blue Mountains Eye Study (1992 to 1994). They asses...

journal_title：Neurology

authors： Mitchell P,Wang JJ,Wong TY,Smith W,Klein R,Leeder SR

更新日期：2005-10-11 00:00:00