Sample sizes for brain atrophy outcomes in trials for secondary progressive multiple sclerosis.

abstract：:Nuclear magnetic resonance (NMR) imaging was superior to CT for imaging the brain lesions of 27 patients with MS. The incidence of abnormal examinations was 78% by NMR and 63% by CT. In cases in which both studies were abnormal, NMR usually demonstrated many more lesions and more extensive involvement than CT. The app...

journal_title：Neurology

authors： Jacobs L,Kinkel WR,Polachini I,Kinkel RP

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:We sought to identify rare variants influencing brain imaging phenotypes in the Framingham Heart Study by performing whole genome sequence association analyses within the Trans-Omics for Precision Medicine Program. METHODS:We performed association analyses of cerebral and hippocampal volumes and white matter...

journal_title：Neurology

authors： Sarnowski C,Satizabal CL,DeCarli C,Pitsillides AN,Cupples LA,Vasan RS,Wilson JG,Bis JC,Fornage M,Beiser AS,DeStefano AL,Dupuis J,Seshadri S,NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium.,TOPMed Neurocognitive W

更新日期：2018-01-16 00:00:00

abstract：PURPOSE:To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques. METHODS:Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole...

journal_title：Neurology

authors： Liu H,MacMillian EL,Jutzeler CR,Ljungberg E,MacKay AL,Kolind SH,Mädler B,Li DKB,Dvorak MF,Curt A,Laule C,Kramer JLK

更新日期：2017-08-08 00:00:00

abstract：:To test possible biochemical mechanisms by which L-tryptophan may reverse mental side effects of levodopa therapy in parkinsonism we administered levodopa, 250 mg per kilogram intraperitoneally, alone and with L-tryptophan, 500 mg per kilogram intraperitoneally, to rats pretreated with the peripheral dopa decarboxylas...

journal_title：Neurology

authors： Fahn S,Snider S,Prasad AL,Lane E,Makadon H

更新日期：1975-09-01 00:00:00

abstract：:This paper reviews the issue of hepatotoxicity with the use of the catechol-O-methly transferase (COMT) inhibitors tolcapone and entacapone. Neither drug caused hepatotoxicity in preclinical toxicity testing. However, in clinical trials of tolcapone, liver chemistry tests were elevated more than 3 times above the uppe...

journal_title：Neurology

authors： Watkins P

更新日期：2000-01-01 00:00:00

abstract：:Postprandial hypotension occurs commonly in patients with autonomic failure and may be due to attenuation of the normal sympathetic nervous system activation in response to meal ingestion. In a randomized, double-blind, placebo-controlled study, we investigated the therapeutic effect of the norepinephrine precursor 3,...

journal_title：Neurology

authors： Freeman R,Young J,Landsberg L,Lipsitz L

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:The epsilon 4 allele of the APOE gene (APOE) is more frequent in patients with AD than in the general population, but studies are inconclusive as to whether it affects rate of progression or survival. Because survival in AD is generally longer in women than in men, the authors investigated whether APOE affec...

journal_title：Neurology

authors： Dal Forno G,Carson KA,Brookmeyer R,Troncoso J,Kawas CH,Brandt J

更新日期：2002-04-09 00:00:00

abstract：:Despite strong evidence of the importance of hereditary factors in the etiology of Tourette's syndrome (TS), research findings have consistently pointed to a role of environmental influences. A recent line of research has suggested that tic disorders and associated behavioral disturbances, such as obsessive-compulsive...

journal_title：Neurology

authors： Kurlan R

更新日期：1998-06-01 00:00:00

abstract：:We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson's disease (5) and parkinsonism with dementia (PD) (5). We found similar, but less extensive, pathology in the substantia nigra of six of ni...

journal_title：Neurology

authors： McGeer PL,Itagaki S,Boyes BE,McGeer EG

更新日期：1988-08-01 00:00:00

abstract：:We investigated 185 families with ALS for evidence of anticipation and mitochondrial inheritance. Although initial analysis demonstrated significant anticipation of age at death between generations in patients with familial ALS, further analysis demonstrated features of regression to the mean, suggesting that the perc...

journal_title：Neurology

authors： Bradley M,Bradley L,de Belleroche J,Orrell RW

更新日期：2005-05-10 00:00:00

abstract：:The authors recorded the acoustic startle response in 32 patients with stroke, 6 patients with incomplete cervical cord lesions, and 26 controls. Increased startle occurred in about one quarter of both stroke and spinal cord injury patients. The response in biceps demonstrated the greatest deviation from normal, with ...

journal_title：Neurology

authors： Jankelowitz SK,Colebatch JG

更新日期：2004-01-13 00:00:00

abstract：OBJECTIVE:We developed the Recurrence and Recovery Questionnaire (RRQ) by converting the Pediatric Stroke Outcome Measure (PSOM) to a questionnaire for telephone interview and sought to validate the RRQ in a large cohort. METHOD:We analyzed parents' RRQ responses and same-day PSOM assessments for 232 children who had ...

journal_title：Neurology

authors： Lo WD,Ichord RN,Dowling MM,Rafay M,Templeton J,Halperin A,Smith SE,Licht DJ,Moharir M,Askalan R,Deveber G,International Pediatric Stroke Study (IPSS) Investigators.

更新日期：2012-08-28 00:00:00

abstract：OBJECTIVE:To investigate the temporal relationship between inflammation and cerebral atrophy in a longitudinal study of 19 patients with relapsing-remitting multiple sclerosis (RRMS) using serial monthly contrast enhanced MRI examinations and monthly measurements of brain fractional volume (BFV) for an average of 4 (ra...

journal_title：Neurology

authors： Richert ND,Howard T,Frank JA,Stone R,Ostuni J,Ohayon J,Bash C,McFarland HF

更新日期：2006-02-28 00:00:00

abstract：:Magnetic resonance images (MRI), evoked responses (ER), and CSF findings were compared in 39 patients with possible, probable, or definite MS. MRI disclosed multiple lesions (72%) more often than ERs (55%) in the total group of patients. In possible MS, MRI showed multiple lesions in 71%, and ER abnormalities were fou...

journal_title：Neurology

authors： Farlow MR,Markand ON,Edwards MK,Stevens JC,Kolar OJ

更新日期：1986-06-01 00:00:00

abstract：:E.C. Seguin was one of the early, influential 19th-century neurologists who participated in the development of neurology as a specialty in the United States. Born in France, but raised from early childhood in the United States, Seguin published widely, developed a high-profile New York City practice, and was named Cli...

journal_title：Neurology

authors： Goetz CG,Harter DH

更新日期：2013-04-30 00:00:00

abstract：OBJECTIVE:To investigate the pathogenesis of proximal diabetic neuropathy (PDN) with nerve and muscle biopsies. BACKGROUND:Recent evidence suggests that nerve ischemia secondary to immune-mediated vasculopathy rather than diabetic microangiopathy may be responsible for PDN. METHOD:- Fifteen patients with PDN and two ...

journal_title：Neurology

authors： Kelkar P,Masood M,Parry GJ

更新日期：2000-07-12 00:00:00

abstract：OBJECTIVE:The aims of this study were to examine executive dysfunction using an antisaccade (AS) task in normal elderly (NE) and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD) as well as to evaluate the relationship between AS performance and cortical thinning within AD-associated regions. ME...

journal_title：Neurology

authors： Heuer HW,Mirsky JB,Kong EL,Dickerson BC,Miller BL,Kramer JH,Boxer AL

更新日期：2013-10-01 00:00:00

abstract：:A 52-year-old woman had a fatal intracerebral hemorrhage after dental manipulation. Normotensive in the past, the initial blood pressure was high but rapidly returned to normal. Necropsy showed no vascular malformation or evidence of hypertensive vascular disease. Clinical and experimental data show that stimulation o...

journal_title：Neurology

authors： Barbas N,Caplan L,Baquis G,Adelman L,Moskowitz M

更新日期：1987-03-01 00:00:00

abstract：:We initiated a double-blind, placebo-controlled trial to test the efficacy and safety of branched-chain amino acids (BCAA) (L-leucine 12 g, L-isoleucine 6 g, and L-valine 6 g daily) in amyotrophic lateral sclerosis (ALS) patients. There was an excess mortality in subjects randomized to active treatment (24 BCAA, 13 pl...

journal_title：Neurology

authors：

更新日期：1993-12-01 00:00:00

abstract：:The administration of lecithin has failed to improve memory in aged or demented individuals. We studied the effect of lecithin on another cholinergic function, REM sleep latency. Intravenous doses of physostigmine shortened the latency to the first REM sleep period, but oral lecithin did not. In contrast to physostigm...

journal_title：Neurology

authors： Kapen S,Fleming PD,Drachman DA

更新日期：1986-08-01 00:00:00

abstract：:We studied electrically elicited blink reflex responses in patients with hemifacial spasm (HFS) by applying single isolated, as well as paired (conditioning and test), stimuli at both sides of the face. Responses after single stimuli were of larger size on the side of the spasm compared with the uninvolved side and co...

journal_title：Neurology

authors： Valls-Sole J,Tolosa ES

更新日期：1989-08-01 00:00:00

abstract：:Carbamazepine was compared with phenytoin in a double-blind study. Of 87 patients, data on 70 patients were complete and used for analysis. Thirty-five patients were treated with each drug. The incidence of major side effects, minor side effects, and complete control (85%) was the same in both groups. A mild but signi...

journal_title：Neurology

authors： Ramsay RE,Wilder BJ,Berger JR,Bruni J

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND:In patients with active epilepsy, adverse medication effects and severity of depression are correlated with health-related quality of life, but seizure frequency is not. We sought to examine if the same pattern exists in patients with psychogenic nonepileptic seizures (PNES). METHODS:We administered seizure...

journal_title：Neurology

authors： LaFrance WC Jr,Syc S

更新日期：2009-08-04 00:00:00

abstract：:Cerebral cavernous malformations (CCM) are CNS vascular anomalies associated with seizures, headaches, and hemorrhagic strokes. The CCM1 gene was screened in 35 sporadic cases with either single or multiple CCM. It was found that 29% of the individuals with multiple CCM have a CCM1 mutation, whereas cases with only on...

journal_title：Neurology

authors： Verlaan DJ,Laurent SB,Sure U,Bertalanffy H,Andermann E,Andermann F,Rouleau GA,Siegel AM

更新日期：2004-04-13 00:00:00

abstract：OBJECTIVE:To determine the incidence and clinical effects of antibodies that develop during treatment with natalizumab. METHODS:In two randomized, double-blind, placebo-controlled studies (natalizumab safety and efficacy in relapsing remitting multiple sclerosis [MS, AFFIRM] and safety and efficacy of natalizumab in c...

journal_title：Neurology

authors： Calabresi PA,Giovannoni G,Confavreux C,Galetta SL,Havrdova E,Hutchinson M,Kappos L,Miller DH,O'Connor PW,Phillips JT,Polman CH,Radue EW,Rudick RA,Stuart WH,Lublin FD,Wajgt A,Weinstock-Guttman B,Wynn DR,Lynn F,Panzar

更新日期：2007-10-02 00:00:00

abstract：OBJECTIVE:To compare the clinical features of patients with chronic daily headache (CDH) with idiopathic intracranial hypertension without papilledema (IIHWOP) to those with normal CSF pressure. METHODS:A case-control study was conducted at a tertiary headache center. Cases consisted of 25 consecutive patients (24 wom...

journal_title：Neurology

authors： Wang SJ,Silberstein SD,Patterson S,Young WB

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:To prospectively investigate the relationships between serum tissue inhibitor metalloproteinase-1 (TIMP-1) and clinical outcomes in patients with acute ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline serum TIMP-1 concentrations were measured i...

journal_title：Neurology

authors： Zhong C,Wang G,Xu T,Zhu Z,Guo D,Zheng X,Wang A,Bu X,Peng H,Chen J,Xu T,Peng Y,Li Q,Ju Z,Geng D,He J,Zhang Y

更新日期：2019-10-29 00:00:00

abstract：OBJECTIVES:To determine the sensitivity and specificity of B-mode ultrasound in the diagnosis of neuromuscular diaphragmatic dysfunction, including phrenic neuropathy. METHODS:A prospective study of patients with dyspnea referred to the EMG laboratory over a 2-year time frame for evaluation of neuromuscular respirator...

journal_title：Neurology

authors： Boon AJ,Sekiguchi H,Harper CJ,Strommen JA,Ghahfarokhi LS,Watson JC,Sorenson EJ

更新日期：2014-09-30 00:00:00

abstract：OBJECTIVE:We performed propensity score (PS) models to compare the outcome of patients with myasthenia gravis (MG) submitted to 2 different surgical approaches: extended transsternal (T-3b) or thoracoscopic extended thymectomy (VATET). METHODS:Patients' clinical data were retrieved from the MG database of the C. Besta...

journal_title：Neurology

authors： Brenna G,Antozzi C,Montomoli C,Baggi F,Mantegazza R,INCB-MG Group.

更新日期：2017-07-11 00:00:00

abstract：:Reflex sympathetic dystrophy (RSD) is a relatively common disabling disorder of unknown pathophysiology. From a cohort of 52 patients, carefully selected to fulfill the recently formulated diagnostic criteria for RSD, venous blood samples were taken for typing of class I and II major histocompatibility antigens. The f...

journal_title：Neurology

authors： Kemler MA,van de Vusse AC,van den Berg-Loonen EM,Barendse GA,van Kleef M,Weber WE

更新日期：1999-10-12 00:00:00