Abstract:
:We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 to 86% at 10 years (p = NS). The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64% (p = NS). Early treatment does not affect the long-term prognosis of epilepsy.
journal_name
Neurologyjournal_title
Neurologyauthors
Leone MA,Solari A,Beghi E,FIRST Group.doi
10.1212/01.wnl.0000249309.80510.63subject
Has Abstractpub_date
2006-12-26 00:00:00pages
2227-9issue
12eissn
0028-3878issn
1526-632Xpii
67/12/2227journal_volume
67pub_type
杂志文章,多中心研究,随机对照试验相关文献
NEUROLOGY文献大全abstract::We assessed the ability to recognize epileptiform abnormalities on a video review of ambulatory cassette EEGs (A/EEG) by comparing two independent interpretations of an A/EEG to those derived from a routine recording and intensive monitoring by cable telemetry (C/EEG) of the same 40 patients. Both A/EEG readings concu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.7.853
更新日期:1983-07-01 00:00:00
abstract::We report the clinical and neuroimaging findings of a mother and daughter with seizure disorders and band heterotopias seen on magnetic resonance imaging studies. These clinicoradiologic findings simulate those for a diagnosis of tuberous sclerosis complex. Clinicians should be aware of this migrational anomaly and it...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.7.1424
更新日期:1993-07-01 00:00:00
abstract::We studied the effects of intravenous immunoglobulin (IVIg) in 12 patients with motor neuron syndromes associated with high titers of anti-GM1 antibodies. Five of the patients had conduction blocks. The study design was a double-blind, placebo-controlled, crossover trial with IVIg (0.4 g/kg body weight per day injecte...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.44.3_part_1.429
更新日期:1994-03-01 00:00:00
abstract::In Icelandic pedigrees a cystatin C mutation, glutamine 68 (L68Q), causes autosomal dominant cerebral amyloid angiopathy-related hemorrhage (CAAH). We examined 33 patients with sporadic CAAH for this mutation. None carried L68Q and, including this report, only one of 52 published cases of sporadic CAAH has had the cys...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.1.242
更新日期:2000-01-11 00:00:00
abstract::In a 20-year-old patient with the classic form of Pelizaeus-Merzbacher disease, electroencephalograms during wakefulness were moderately diffusely abnormal, and an overnight polygraphic sleep recording showed distorted nonrapid eye movement sleep patterns without vertex sharp waves, K-complexes, spindles, or positive ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.11.1042
更新日期:1976-11-01 00:00:00
abstract::Self-reported versus informant-reported memory problems in nondemented elderly adults and in individuals with very mild and mild dementia of the Alzheimer type (DAT) were correlated with cognitive outcomes. No significant correlations were found between self-reported memory complaints and cognitive performance or (in ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.11.1724
更新日期:2000-12-12 00:00:00
abstract:OBJECTIVE:Functional or psychogenic movement disorders (FMD) present a diagnostic challenge. To diagnose FMD, clinicians must have experience with signs typical of FMD and distinguishing features from other hyperkinetic disorders. The aim of this study was to clarify the decision-making process of expert clinicians whi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003479
更新日期:2017-01-10 00:00:00
abstract:OBJECTIVES:New data suggest that glioma stem-like cells (GSCs) and neural stem/progenitor cells (NSCs) may share common origins. GSCs drive tumor proliferation and appear to be resistant to classic chemotherapy, while the effects of chemotherapy on NSCs are not well studied. As the role of NSCs in learning and memory i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318212a89f
更新日期:2011-03-29 00:00:00
abstract:BACKGROUND:Microvascular brain injury, typically measured by extent of white matter hyperintensity (WMH) on MRI, is an important contributor to cognitive impairment in the elderly. Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease. METHODS:The auth...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000191403.95453.6a
更新日期:2006-01-10 00:00:00
abstract::The authors describe a novel pathogenic G5540A transition in the mitochondrial transfer RNA (tRNA)Trp gene of a sporadic encephalomyopathy characterized by spinocerebellar ataxia. Clinical features also included neurosensorial deafness, peripheral neuropathy, and dementia. Biochemistry revealed a severe reduction of c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.8.1693
更新日期:2000-04-25 00:00:00
abstract::There was a report of spongiform encephalopathy transmitted to Syrian hamsters by intracerebral inoculation with the blood buffy coat of patients with Alzheimer's disease (AD) and their unaffected first-degree relatives. We attempted to verify that report, taking measures to reduce the risk of contaminating samples wi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.6.1111
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVE:Because age affects hormonal production differently in women compared with men, we sought to define sex and age interactions across a multiracial/ethnic population after intracerebral hemorrhage (ICH) to uncover evidence that loss of gonadal hormone production would result in loss of the known neuroprotective...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000004255
更新日期:2017-09-05 00:00:00
abstract::First-degree relatives of narcoleptic subjects (probands) may have sleep pathology related to the transmission of the disorder through their family members. The authors examined four groups: probands (n = 96), first-degree relative (n = 337), environmental reference (n = 85), and general population (n = 6,694) groups....
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000229930.68094.48
更新日期:2006-08-22 00:00:00
abstract:OBJECTIVE:To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. METHODS:Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003085
更新日期:2016-09-13 00:00:00
abstract:OBJECTIVE:To validate, examine the internal validity, and adapt to children the electronic version of the composite cerebellar functional severity (CCFS) score. METHODS:In this multicenter study, we compared the validated manual device with the new electronic version (n = 46) and analyzed its kinetics in 146 patients ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000001403
更新日期:2015-03-24 00:00:00
abstract:OBJECTIVE:To determine serial MRI and CT abnormalities around calcified cysts due to cysticercosis in previously treated patients during periods of seizure activity. BACKGROUND:Some patients with calcified lesions due to cysticercosis have seizures. How and why seizures occur in this setting are unknown. METHODS:Thre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.4.777
更新日期:1999-09-11 00:00:00
abstract::The clinical and angiographic correlations of small deep infarcts seen on computed tomography (CT) scan were studied in 297 consecutive patients. Some of these showed the features described by Fisher as part of the lacunar syndrome. In a large number, a source of emboli from either a cardiac or a carotid source was hi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.10.1090
更新日期:1980-10-01 00:00:00
abstract::Successful screening for neuropathy in patients with diabetes is available using the 10 g Semmes-Weinstein monofilament (Mid-Delta Health Systems, Inc., Belzoni, MS) (touch/pressure sensation) and the Neurothesiometer (Horwell Scientific, London, UK; vibration perception threshold). In healthy volunteers and patients ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.59.4.611
更新日期:2002-08-27 00:00:00
abstract:OBJECTIVE:To evaluate the usefulness of a mismatch between the severity of acute clinical manifestations and the diffusion-weighted imaging (DWI) lesion in predicting early stroke outcome and infarct volume. METHODS:One hundred sixty-six patients with a hemispheric ischemic stroke of <12 hours' duration were studied. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000130570.41127.ea
更新日期:2004-06-22 00:00:00
abstract::Valproic acid (VPA) has been postulated to exert its anticonvulsant effects by interaction with the postsynaptic GABA receptor. To test that hypothesis, we applied VPA in clinically appropriate concentrations to cortical neurons in dissociated cell culture. VPA did not enhance the postsynaptic effect of GABA, but did ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.2.259
更新日期:1986-02-01 00:00:00
abstract:OBJECTIVE:To characterize the prevalence and prognostic significance of major driver molecular alterations in adult midline diffuse gliomas (MLG). METHODS:Adults with histologically proven MLG diagnosed between 1996 and 2017 were identified from our tumor bank, systematically reviewed, and reclassified according to WH...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005658
更新日期:2018-06-05 00:00:00
abstract::Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local tissue injury by generating an inflammatory response, mediated in part by the production of toxic oxygen metabolites. Corticosteroids are frequently and effectively used to ameliorate MS exacerbations, despite inadeq...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.2_part_1.297
更新日期:1991-02-01 00:00:00
abstract::A 50-year-old woman with a history of metastatic malignant thymoma presented with diffuse neuropathic pain involving the extremities and torso prior to chemotherapy and radiation. She also developed episodic diarrhea, diaphoresis, fevers, insomnia, and encephalopathy. Examination revealed rippling muscles (video on th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0fa1
更新日期:2013-01-29 00:00:00
abstract::Family studies of primary torsion dystonia have used the diagnostic categories of definite, probable, and possible dystonia for gene mapping and identification, but the validity of this hierarchical classification is not known. The authors assessed 147 DYT1 GAG deletion carriers and 113 blood-related noncarriers from ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000035630.12515.e0
更新日期:2002-12-10 00:00:00
abstract:OBJECTIVE:The NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox) is a comprehensive battery of brief assessment tools. The purpose of this article is to describe plans to establish normative reference values for the NIH Toolbox measures. METHODS:A large sample will be obtained from the US...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182872e70
更新日期:2013-03-12 00:00:00
abstract::A randomized trial was completed to assess the feasibility of a 2-year education rehabilitation program for students with sickle cell disease and memory deficits. Eleven students were assigned to tutoring with or without memory training for 2 years. Eighty-two percent completed the program. Evidence of improvement in ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000264421.24415.16
更新日期:2007-06-05 00:00:00
abstract:OBJECTIVE:To analyze the relationship between retinal thinning and nigral dopaminergic loss in de novo Parkinson disease (PD). METHODS:Forty-nine patients with PD and 54 age-matched controls were analyzed. Ophthalmologic examination and macula optical coherence tomography scans were performed with additional microperi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006157
更新日期:2018-09-11 00:00:00
abstract::In two patients, a sensory neuronopathy was the initial presentation of Sjögren's syndrome. There was no systemic or peripheral nerve vasculitis. Immunochemical studies failed to demonstrate specific antibodies against the nervous system. These features suggest that the damage to the sensory neurons might not be media...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.10.1637
更新日期:1988-10-01 00:00:00
abstract::Neurologic disorders are among the most frequent causes of morbidity and mortality in the United States. Moreover, the current shortfall of neurologists is expected to worsen over the coming decade. As a consequence, many patients with neurologic disorders will be treated by physicians and primary care providers witho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006716
更新日期:2019-01-22 00:00:00
abstract:OBJECTIVE:To evaluate urinary neurotrophin receptor p75 extracellular domain (p75ECD) levels as disease progression and prognostic biomarkers in amyotrophic lateral sclerosis (ALS). METHODS:The population in this study comprised 45 healthy controls and 54 people with ALS, 31 of whom were sampled longitudinally. Urinar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003741
更新日期:2017-03-21 00:00:00