Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage.

abstract：OBJECTIVE:This prospective, randomized, controlled study was designed to investigate the safety, feasibility, and preliminary efficacy of long-term CSF drainage via a low-flow ventriculoperitoneal shunt in subjects suffering from AD. METHODS:Twenty-nine subjects selected for probable AD (National Institute of Neurolog...

journal_title：Neurology

authors： Silverberg GD,Levinthal E,Sullivan EV,Bloch DA,Chang SD,Leverenz J,Flitman S,Winn R,Marciano F,Saul T,Huhn S,Mayo M,McGuire D

更新日期：2002-10-22 00:00:00

abstract：:Machado-Joseph disease is a dominantly inherited, multisystem, degenerative disorder that lacks a proven genetic marker. Peripheral nerve conduction-refractory period, sensory evoked potentials, and quantified oculomotor recordings were studied in nine patients affected with this disease to look for a potential physio...

journal_title：Neurology

authors： Hotson JR,Langston EB,Louis AA,Rosenberg RN

更新日期：1987-01-01 00:00:00

abstract：:Hemorrhage complicating acute carbon monoxide poisoning is usually confined to the basal ganglia. The authors report three people with acute carbon monoxide poisoning manifesting selective or prominent white matter involvement complicated by hemorrhagic infarction on CT and MRI in one and by subcortical T2*-weighted M...

journal_title：Neurology

authors： Finelli PF,DiMario FJ Jr

更新日期：2004-09-28 00:00:00

abstract：OBJECTIVE:To determine the clinical value of JC virus (JCV) detection in various anatomic compartments for the diagnosis of progressive multifocal leukoencephalopathy (PML). METHODS:CSF, peripheral blood mononuclear cells (PBMC), plasma, and urine samples were evaluated from HIV-infected and uninfected individuals. JC...

journal_title：Neurology

authors： Koralnik IJ,Boden D,Mai VX,Lord CI,Letvin NL

更新日期：1999-01-15 00:00:00

abstract：:Many new treatments under development for Alzheimer disease (AD) will be disease-modifying rather than symptomatic. Clinical evaluation of these treatments will require primary and secondary prevention trials. We describe some of the methodologic challenges in designing primary prevention trials for AD and illustrate ...

journal_title：Neurology

authors： Green RC,DeKosky ST

更新日期：2006-11-14 00:00:00

abstract：OBJECTIVE:To assess whether genetic subgroups in recent amyotrophic lateral sclerosis (ALS) trials responded to treatment with lithium carbonate, but that the treatment effect was lost in a large cohort of nonresponders. METHODS:Individual participant data were obtained from 3 randomized trials investigating the effic...

journal_title：Neurology

authors： van Eijk RPA,Jones AR,Sproviero W,Shatunov A,Shaw PJ,Leigh PN,Young CA,Shaw CE,Mora G,Mandrioli J,Borghero G,Volanti P,Diekstra FP,van Rheenen W,Verstraete E,Eijkemans MJC,Veldink JH,Chio A,Al-Chalabi A,van den Berg

更新日期：2017-10-31 00:00:00

abstract：OBJECTIVE:To assess the potential relationship of ultraviolet B radiation (UVB) and Epstein-Barr virus (EBV) exposure in explaining the period prevalence of multiple sclerosis (MS) in England. METHODS:English national Hospital Episode Statistics covering all admissions to National Health Service hospitals in England i...

journal_title：Neurology

authors： Ramagopalan SV,Handel AE,Giovannoni G,Rutherford Siegel S,Ebers GC,Chaplin G

更新日期：2011-04-19 00:00:00

abstract：OBJECTIVE:This study aimed to determine the frequency of CNS infection by dengue virus (DENV) in individuals with fatal outcomes. METHODS:Samples of 150 individuals suspect of an infection disease and with fatal outcomes were investigated for evidence of the presence of DENV. The sampling was made up of 150 CSF, 120 t...

journal_title：Neurology

authors： Araújo FM,Araújo MS,Nogueira RM,Brilhante RS,Oliveira DN,Rocha MF,Cordeiro RA,Araújo RM,Sidrim JJ

更新日期：2012-03-06 00:00:00

abstract：OBJECTIVES:To estimate the risk to public safety posed by drivers with epilepsy, the authors compared annual totals and disease-specific risk for fatal crashes associated with seizures and other medical conditions. They compared individual risks for fatal crashes due to seizures and other causes of mortality in patient...

journal_title：Neurology

authors： Sheth SG,Krauss G,Krumholz A,Li G

更新日期：2004-09-28 00:00:00

abstract：OBJECTIVE:To analyze the oral motor, speech, and language phenotype in 20 children and adults with Dravet syndrome (DS) associated with mutations in SCN1A. METHODS:Fifteen verbal and 5 minimally verbal DS patients with SCN1A mutations (aged 15 months-28 years) underwent a tailored assessment battery. RESULTS:Speech w...

journal_title：Neurology

authors： Turner SJ,Brown A,Arpone M,Anderson V,Morgan AT,Scheffer IE

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:Although the APOE epsilon 4 allele increases the risk of developing AD, the effects of the epsilon 4 allele on brain atrophy in clinical AD patients are controversial. OBJECTIVE:To investigate a possible relationship between the genetic variants of APOE and brain atrophy in patients with AD. METHODS:Using ...

journal_title：Neurology

authors： Hashimoto M,Yasuda M,Tanimukai S,Matsui M,Hirono N,Kazui H,Mori E

更新日期：2001-10-23 00:00:00

abstract：:We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 ...

journal_title：Neurology

authors： Leone MA,Solari A,Beghi E,FIRST Group.

更新日期：2006-12-26 00:00:00

abstract：BACKGROUND:Many studies have examined the role of APOE genotype in the development of dementia, specifically Alzheimer disease (AD). The APOE epsilon4 allele (APOE4) is a risk factor for both clinical and neuropathologic AD whereas the APOE epsilon2 allele (APOE2) seems to be protective. This would predict, even with a...

journal_title：Neurology

authors： Berlau DJ,Corrada MM,Head E,Kawas CH

更新日期：2009-03-03 00:00:00

abstract：OBJECTIVE:To better understand the epileptogenesis of symptomatic generalized epilepsy in patients with hypothalamic hamartoma and intractable epilepsy, many of whom experience remission of generalized seizures and slow spike-wave discharges following surgery. METHODS:The authors documented the evolution of symptomati...

journal_title：Neurology

authors： Freeman JL,Harvey AS,Rosenfeld JV,Wrennall JA,Bailey CA,Berkovic SF

更新日期：2003-03-11 00:00:00

abstract：OBJECTIVE:Evidence of a relation between use of lipid lowering drugs and cognitive outcomes is mixed. This study aimed to test the association between use of statins and incidence of dementia and cognitive impairment without dementia (CIND) over 5 years of follow-up. METHODS:Data were from a population-based cohort st...

journal_title：Neurology

authors： Cramer C,Haan MN,Galea S,Langa KM,Kalbfleisch JD

更新日期：2008-07-29 00:00:00

abstract：:The authors report two cases of patients with word deafness. The word deafness occurred after a head injury for the first patient and after an arterio venous malformation embolization for the second patient. MRI demonstrated bilateral lesions of the inferior colliculi but brainstem auditory-evoked potentials (BAEP) we...

journal_title：Neurology

authors： Vitte E,Tankéré F,Bernat I,Zouaoui A,Lamas G,Soudant J

更新日期：2002-03-26 00:00:00

abstract：OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESUL...

journal_title：Neurology

authors： Hu G,Jousilahti P,Nissinen A,Antikainen R,Kivipelto M,Tuomilehto J

更新日期：2006-12-12 00:00:00

abstract：OBJECTIVE:-To determine whether pre-treatment cerebral microbleeds (CMBs) presence and burden are correlated with an increased risk of intracranial hemorrhage (ICH) or poor functional outcome following endovascular thrombectomy (EVT) for acute ischemic stroke (AIS). METHODS:-Consecutive patients treated by EVT for ant...

journal_title：Neurology

authors： Derraz I,Cagnazzo F,Gaillard N,Morganti R,Dargazanli C,Ahmed R,Pierre-Henri L,Riquelme C,Mourand I,Gascou G,Bonafe A,Arquizan C,Costalat V

更新日期：2021-01-25 00:00:00

abstract：:Four patients with primary writing tremor had a focal, task-specific tremor that responded to anticholinergic drugs. Physiologic features included EMG activity alternating in antagonist muscles, 5- to 20-microV cerebral potentials evoked by stretch of pronator teres, and no C-reflexes. Another patient had myoclonic je...

journal_title：Neurology

authors： Ravits J,Hallett M,Baker M,Wilkins D

更新日期：1985-09-01 00:00:00

abstract：:In this study, the 24-hour pattern of blood pressure (BP), heart rate, and urinary catecholamine (CA) excretion and the response of BP and plasma CA to the tilt test have been investigated in 13 untreated patients affected by Parkinson's disease (PD) and in 11 age-matched healthy controls. Seven of the 13 PD subjects ...

journal_title：Neurology

authors： Micieli G,Martignoni E,Cavallini A,Sandrini G,Nappi G

更新日期：1987-03-01 00:00:00

abstract：:A 41-year-old man presented with bilateral posterior cerebral artery infarcts. He had visual object agnosia and prosopagnosia with preservation of reading abilities. There was also defective visual memory, topographic orientation, and color perception, as well as simultanagnosia. From the clinical facts and CT finding...

journal_title：Neurology

authors： Gomori AJ,Hawryluk GA

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:The annual relapse rate has been commonly used as a primary efficacy endpoint in phase III multiple sclerosis (MS) clinical trials. The aim of this study was to determine the relative contribution of different possible prognostic factors available at baseline to the on-study relapse rate in MS. METHODS:A to...

journal_title：Neurology

authors： Held U,Heigenhauser L,Shang C,Kappos L,Polman C,Sylvia Lawry Centre for MS Research.

更新日期：2005-12-13 00:00:00

abstract：:Malformations of cortical development (MCD) account for a high proportion of medically resistant partial seizures in children and figure prominently in pediatric surgical series. In contrast to the results of epilepsy surgery for postnatally acquired lesions, seizure freedom in patients with MCD is less certain owing ...

journal_title：Neurology

authors： Duchowny M,Jayakar P,Levin B

更新日期：2000-08-08 00:00:00

abstract：OBJECTIVE:APOE ε2 and ε4 alleles have been associated with lobar intracerebral hemorrhage (ICH) in predominately white populations; we sought to evaluate whether this held true among black and Hispanic populations. METHODS:The Ethnic/Racial Variations of Intracerebral Hemorrhage study is a prospective, multicenter cas...

journal_title：Neurology

authors： Sawyer RP,Sekar P,Osborne J,Kittner SJ,Moomaw CJ,Flaherty ML,Langefeld CD,Anderson CD,Rosand J,Woo D

更新日期：2018-07-31 00:00:00

abstract：OBJECTIVE:To assess the inpatient hospitalization burden and costs of patients with autoimmune encephalitis (AE) at a tertiary care institution. METHODS:Adult inpatients with AE were identified retrospectively from July 1, 2005, to June 30, 2015. Demographic and clinical data were collected and analyzed. Billing data ...

journal_title：Neurology

authors： Cohen J,Sotoca J,Gandhi S,Yeshokumar AK,Gordon-Lipkin E,Geocadin RG,Frick KD,Probasco JC,Venkatesan A

更新日期：2019-02-26 00:00:00

abstract：:Migration from an area where MS is common to an area where it is rare (and vice versa) affects the risk of MS, provided migration occurs in childhood. A childhood infection might explain this effect. Therefore, the age pattern of infectious diseases in different regions was examined. A higher proportion of children sh...

journal_title：Neurology

authors： Alter M,Zhang ZX,Davanipour Z,Sobel E,Zibulewski J,Schwartz G,Friday G

更新日期：1986-10-01 00:00:00

abstract：:Human cytomegalovirus and herpes simplex virus DNA probes were labeled in vitro and hybridized to the DNA extracted from brains of patients with multiple sclerosis (MS) to detect the presence of genetic information related to these viruses. We were unable to detect any virus-related genetic information complementary t...

journal_title：Neurology

authors： Aulakh GS,Albrecht P,Tourtellotte WW

更新日期：1980-05-01 00:00:00

abstract：:Recent evidence suggests that the vasopressin analogue desglycinamide-arginine8-vasopressin (DGAVP) might specifically benefit mild brain trauma patients. We investigated the effect of intranasal DGAVP treatment in 32 patients who had sustained a mild head injury for 3 months in a double-blind, placebo-controlled, mat...

journal_title：Neurology

authors： Bohnen NI,Twijnstra A,Jolles J

更新日期：1993-01-01 00:00:00

abstract：:In two patients, a sensory neuronopathy was the initial presentation of Sjögren's syndrome. There was no systemic or peripheral nerve vasculitis. Immunochemical studies failed to demonstrate specific antibodies against the nervous system. These features suggest that the damage to the sensory neurons might not be media...

journal_title：Neurology

authors： Graus F,Pou A,Kanterewicz E,Anderson NE

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVE:To examine the role of mutations in GABRB3 encoding the β3 subunit of the GABAA receptor in individual patients with epilepsy with regard to causality, the spectrum of genetic variants, their pathophysiology, and associated phenotypes. METHODS:We performed massive parallel sequencing of GABRB3 in 416 patient...

journal_title：Neurology

authors： Møller RS,Wuttke TV,Helbig I,Marini C,Johannesen KM,Brilstra EH,Vaher U,Borggraefe I,Talvik I,Talvik T,Kluger G,Francois LL,Lesca G,de Bellescize J,Blichfeldt S,Chatron N,Holert N,Jacobs J,Swinkels M,Betzler C,Syr

更新日期：2017-01-31 00:00:00