Abstract:
:In this study, the 24-hour pattern of blood pressure (BP), heart rate, and urinary catecholamine (CA) excretion and the response of BP and plasma CA to the tilt test have been investigated in 13 untreated patients affected by Parkinson's disease (PD) and in 11 age-matched healthy controls. Seven of the 13 PD subjects showed a fall of supine systolic BP greater than that in controls (ie, exceeding 20% of the preprandial value). A significant relationship was found in the PD group between the degree of postprandial hypotension and the 24-hour mean value of dopamine excretion. Eight PD subjects also showed orthostatic hypotension during the tilt test (performed in the morning hours) and in the postprandial phase. Basal norepinephrine plasma levels of PD patients, as well as their percentage increases on standing, were within the range of the controls. These data suggest the existence of a subtype of PD patient, characterized by a widespread impairment of cardiovascular responsiveness and bordering on syndromes of autonomic failure such as progressive autonomic failure or multiple system atrophy, or both.
journal_name
Neurologyjournal_title
Neurologyauthors
Micieli G,Martignoni E,Cavallini A,Sandrini G,Nappi Gdoi
10.1212/wnl.37.3.386subject
Has Abstractpub_date
1987-03-01 00:00:00pages
386-93issue
3eissn
0028-3878issn
1526-632Xjournal_volume
37pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::An infant with Pena-Shokeir phenotype was born to a cocaine-using mother. The pathologic findings included polyhydramnios, facial anomalies, arthrogryposis, camptodactyly, pulmonary hypoplasia, and tetralogy of Fallot. The neuropathologic findings were diffuse brainstem and spinal cord neuronal degeneration and focal ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.9.1467
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Cross-sectional studies suggest gender differences in cognitive function and risk of AD in older persons. However, longitudinal studies comparing change in cognitive function and risk of AD in men and women have had mixed results. The authors investigated gender differences in rate of decline for different c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000065892.67099.2a
更新日期:2003-06-10 00:00:00
abstract:OBJECTIVE:To investigate the effect of optimal combination of evidence-based drug therapies including antihypertensive agents, lipid modifiers, and antithrombotic agents on risk of recurrent vascular events after stroke. METHODS:We analyzed the database of a multicenter trial involving 3,680 recent noncardioembolic st...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001099
更新日期:2015-01-06 00:00:00
abstract::Two patients with visual agnosia underwent visual recognition and neuropsychological tests to characterize their perceptual functioning. Both had an initial "apperceptive profile" and evolved from cortical blindness. One had carbon monoxide intoxication and incidental agenesis of the splenium of the corpus callosum; t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.11.1754
更新日期:1988-11-01 00:00:00
abstract::A patient with PD who exhibited disabling tremor and prominent dyskinesia underwent deep brain stimulation (DBS) of the left thalamic ventral intermediate nucleus. The electrode migrated and was replaced but with suboptimal clinical response. Two years later, postmortem analysis found the second electrode tip had ente...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.11.1576
更新日期:2001-06-12 00:00:00
abstract::We developed a method for the detection of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) carriers. The method is based on the quantitative analysis of the products of standard multiplex polymerase chain reaction (PCR) from 18 different exons of the dystrophin gene, and is designated "QM-PCR." W...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.9.1783
更新日期:1992-09-01 00:00:00
abstract::We analyzed the association of HLA-DR and -DQ haplotypes and alleles with multiple sclerosis (MS) in 91 patients and 91 controls from Iceland using the relative predispositional effect method. The aim was to establish whether there is heterogeneity in HLA associations with MS, whether there are both predispositional a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.4.1107
更新日期:1996-04-01 00:00:00
abstract::We investigated tyrosine-hydroxylase (TH)-immunoreactive neurons in the medulla oblongata corresponding to the A1 and A2 cell groups in autopsy tissue of patients with Parkinson's disease (PD) (n = 3), progressive supranuclear palsy (PSP) (n = 3), striatonigral degeneration (SND) (n = 2), and in controls (n = 4). The ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.11.1739
更新日期:1990-11-01 00:00:00
abstract::Two cases of giant-cell arteritis with cerebral arteritis are presented. The clinical situation and the suggestive but nonspecific angiographic features make the antemortem diagnosis possible. Greater awareness of this entity will facilitate its diagnosis and the institution of effective steroid therapy. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.8.794
更新日期:1977-08-01 00:00:00
abstract::The authors measured the association of early ischemic change on CT scan, measured using the Alberta Stroke Programme Early CT score (ASPECTS), and functional outcome in 825 patients with anterior circulation stroke treated with IV thrombolysis within 3 hours of onset. ASPECTS predicted outcome in a graded fashion (li...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000228221.44334.73
更新日期:2006-08-08 00:00:00
abstract:OBJECTIVE:To determine the rate of relapse occurrence during pregnancy and postpartum. METHODS:In a cross-sectional study using the national multiple sclerosis (MS) registry, pregnant women with relapsing MS were identified. Data on demographics, clinical characteristics, and disease-modifying therapies (DMTs), includ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005065
更新日期:2018-03-06 00:00:00
abstract:OBJECTIVE:To evaluate attention deficit in Alzheimer's disease (AD) and its relationship to attention deficits associated with aging and with medications altering alertness. METHODS:Ten patients with probable AD, 10 healthy old controls, and 15 young controls performed a covert orienting of spatial attention task. You...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.4.657
更新日期:1994-04-01 00:00:00
abstract:OBJECTIVE:The study aims to examine α-synuclein in the CSF of patients with severe traumatic brain injury (TBI) and its relationship with clinical characteristics and long-term outcomes. METHODS:This prospective case-control study enrolled patients with severe TBI (Glasgow Coma Score ≤ 8) who underwent ventriculostomy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182904d43
更新日期:2013-04-30 00:00:00
abstract:OBJECTIVE:We investigated mitochondrial DNA (mtDNA) variants in children with a first episode of acquired demyelinating syndromes (PD-ADS) of the CNS and their relationship to disease phenotype, including subsequent diagnosis of multiple sclerosis (MS). METHODS:This exploratory analysis included the initial 213 childr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820ee1bb
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:The aim of the current study was, first, to determine the critical causative vestibular areas that in exceptional cases manifest with transient vertigo or dizziness in acute strokes of the middle cerebral artery, and second, to try to explain why in most cases unilateral lesions of these areas manifest witho...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0000000000001501
更新日期:2015-04-21 00:00:00
abstract:BACKGROUND:Chronic cerebrospinal venous insufficiency (CCSVI) was proposed as the causal trigger for developing multiple sclerosis (MS). However, current data are contradictory and a gold standard for venous flow assessment is missing. OBJECTIVE:To compare structural magnetic resonance venography (MRV) and dynamic ext...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318236f0ea
更新日期:2011-11-08 00:00:00
abstract:OBJECTIVE:To test the hypothesis that patients with multiple sclerosis (MS) with intereye asymmetry on low contrast letter acuity, and thickness of the retinal nerve fiber layer (RNFL), would exhibit corresponding changes in cortical timing and amplitude responses on pattern reversal multifocal visual evoked potentials...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182661edc
更新日期:2012-08-21 00:00:00
abstract:OBJECTIVE:To compare the clinical features of patients showing a classical phenotype of facioscapulohumeral muscular dystrophy (FSHD) with genetic and epigenetic characteristics of the FSHD1 and FSHD2 loci D4Z4 and SMCHD1. METHODS:This is a national multicenter cohort study. We measured motor strength, motor function,...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000007456
更新日期:2019-05-07 00:00:00
abstract:OBJECTIVE:To investigate the association between EVT start time in acute ischemic stroke (AIS) and mid-term functional outcome. METHODS:This retrospective cohort study included all AIS cases treated with EVT from two stroke center registries from January 2012 to December 2018. The primary outcome was the score on the ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011449
更新日期:2021-01-04 00:00:00
abstract:OBJECTIVE:To clarify the possible relation between the extent of involvement of catecholaminergic neurons and the presence of alveolar hypoventilation in patients with myotonic dystrophy (MyD). BACKGROUND:Respiratory insufficiency has been reported frequently in MyD patients. Recent data support the hypothesis that th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.4.1121
更新日期:1998-10-01 00:00:00
abstract::In two patients, a sensory neuronopathy was the initial presentation of Sjögren's syndrome. There was no systemic or peripheral nerve vasculitis. Immunochemical studies failed to demonstrate specific antibodies against the nervous system. These features suggest that the damage to the sensory neurons might not be media...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.10.1637
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:To investigate the cognitive skills of patients with relapsing remitting multiple sclerosis (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS) relative to healthy control subjects and to assess whether there is heterogeneity in the type of cognitive disabilities demonstrated by patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000129828.03714.90
更新日期:2004-07-27 00:00:00
abstract:BACKGROUND:Hereditary neuralgic amyotrophy (HNA) is an autosomal-dominant disorder associated with recurrent, episodic, painful, brachial neuropathy. The gene for HNA has been mapped to chromosome 17q25. Characteristic features including hypotelorism, short stature, and cleft palate occur in some patients. OBJECTIVE:T...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.11.1963
更新日期:2001-12-11 00:00:00
abstract::We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. Orally administered THIP (4,5,6,7-tetrahydroisoxazolo-[5,4,-c] pyridin-3-ol), a novel GABA receptor agonist, failed to improve motor o...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.33.5.637
更新日期:1983-05-01 00:00:00
abstract::We evaluated cognitive outcome in a group of 37 patients who had undergone surgery for rupture and repair of a single intracranial aneurysm at least 6 months previously. We compared outcome--assessed by tests of intelligence, attention, executive functions sensitive to frontal lobe lesions, memory, neglect, and mood, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.5.876
更新日期:1995-05-01 00:00:00
abstract::This double-blind, placebo-controlled, crossover study of the acute treatment of migraine investigated the efficacy and tolerability of oral sumatriptan 100 mg (Imitrex) administered for up to nine attacks compared with placebo administered for up to three attacks. Patients were randomized to receive oral sumatriptan ...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-08-01 00:00:00
abstract:OBJECTIVE:This study prospectively examined the relationships among late night salivary cortisol (NSC) levels and depressive symptoms, memory performance, and hippocampal volumes in patients with medically intractable temporal lobe epilepsy (TLE) and the potential mediating effects of cortisol in the relationships betw...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824e8efb
更新日期:2012-04-03 00:00:00
abstract::Ten patients are presented with severe dysarthria from a right hemisphere stroke, 4 with autopsies, emphasizing that this lesion alone is compatible with severely slurred speech. Most had oropharyngeal weakness; the accompanying hemiparesis was of variable severity. Superficial or deep infarctions were responsible, th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.6.1061
更新日期:1987-06-01 00:00:00
abstract::Transcranial Doppler examinations (TCD) of 24 brain-dead adult patients demonstrated persistent movement of blood within the middle cerebral arteries in 21. The characteristic pattern of Doppler shift frequencies, seen in 14, was a sharply contoured, brief anterograde systolic envelope with reversed diastolic flow. Fi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.11.1733
更新日期:1987-11-01 00:00:00
abstract::We observed that patients with amnesia after cardiac arrest had preserved recognition memory despite profound loss of recall memory. In the present study, rate of forgetting was measured in six amnesic subjects for both recall and recognition memory of verbal material. The data show that recall decayed significantly f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.3.408
更新日期:1986-03-01 00:00:00