Abstract:
OBJECTIVE:To assess the potential relationship of ultraviolet B radiation (UVB) and Epstein-Barr virus (EBV) exposure in explaining the period prevalence of multiple sclerosis (MS) in England. METHODS:English national Hospital Episode Statistics covering all admissions to National Health Service hospitals in England in the 7 years from 1998 to 2005 were used to obtain the period prevalences of MS and infectious mononucleosis (IM) in England. The United States National Aeronautics and Space Administration's data on UVB intensity for England from the Nimbus 7 satellite was collected. The relationships among the 3 variables (MS prevalence, IM prevalence, and UVB intensity) were investigated. RESULTS:The regression of MS against UVB intensity for all seasons had an r(2) of 0.61; when including the interaction of IM with seasonal UVB, the r(2) rose to 0.72. CONCLUSIONS:UVB exposure and IM together can explain a substantial proportion of the variance of MS. The effect of UVB on generating vitamin D seems the most likely candidate for explaining its relationship with MS. There is a pressing need to investigate the role of vitamin D and EBV and how they might interact to influence MS risk to identify potential prevention strategies.
journal_name
Neurologyjournal_title
Neurologyauthors
Ramagopalan SV,Handel AE,Giovannoni G,Rutherford Siegel S,Ebers GC,Chaplin Gdoi
10.1212/WNL.0b013e318216715esubject
Has Abstractpub_date
2011-04-19 00:00:00pages
1410-4issue
16eissn
0028-3878issn
1526-632Xpii
76/16/1410journal_volume
76pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To study the impact of negative expectation related to receiving a placebo (the "lessebo effect") on efficacy outcome measures of symptomatic treatments in Parkinson disease (PD). METHODS:We conducted meta-analyses of double-blind randomized controlled trials (RCTs) of dopamine agonists in PD and compared th...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0000000000000340
更新日期:2014-04-22 00:00:00
abstract::A patient with glioblastoma of the rostral brainstem and hypothalamus exhibited bilateral internuclear ophthalmoplegia and vertical nystagmus; he suffered episodes of cataplexy, narcolepsy, and sleep paralysis. A peculiar fluctuation of posture and tone ("limp man syndrome") proved to be a manifestation of continuous ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.10.1115
更新日期:1980-10-01 00:00:00
abstract::The objective of our study was to assess the 5-year risk of and prognostic factors for the development of clinically definite multiple sclerosis (CDMS) following optic neuritis. In a prospective cohort study design, 388 patients, who did not have probable or definite MS at study entry enrolled in the Optic Neuritis Tr...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.49.5.1404
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:The histopathology of AIDS-associated myelopathy (AM) closely resembles that of myelopathies due to cobalamin or folate deficiency, with white matter vacuolization in the spinal cord. The pathogenesis of AM appears unrelated to direct HIV infection of the spinal cord. There is abnormal trans-methylation meta...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000140469.18782.05
更新日期:2004-10-12 00:00:00
abstract::The American Academy of Neurology has published a comprehensive review and guidelines for the use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) for the first time since 2002. These guidelines represent the work of MS experts, patients, and guideline experts and are based on their review of randomize...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000005574
更新日期:2018-06-12 00:00:00
abstract::The P3 component of the auditory evoked potential has been shown to reflect "endogenous" processes related to cognition. This component was measured serially in seven patients who had confusional states or dementing illnesses that fluctuated in severity over time. The latency of P3 component reflected the clinical imp...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.9.1215
更新日期:1983-09-01 00:00:00
abstract:OBJECTIVE:Functional or psychogenic movement disorders (FMD) present a diagnostic challenge. To diagnose FMD, clinicians must have experience with signs typical of FMD and distinguishing features from other hyperkinetic disorders. The aim of this study was to clarify the decision-making process of expert clinicians whi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003479
更新日期:2017-01-10 00:00:00
abstract::We performed a prospective study of neuroimaging studies and temporal lobe pathology in 13 patients with facial asymmetry and intractable partial epilepsy of temporal lobe origin. The 13 patients, derived from 50 consecutive patients with nonlesional medically refractory partial epilepsy, were deemed appropriate candi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.4.725
更新日期:1993-04-01 00:00:00
abstract::About one-third of patients with acoustic tumor (AT) initially seek medical attention for nonaudiologic complaints. The nonspecific early symptoms of AT require the inclusion of AT in many neurologic differential diagnoses. Advances in electrophysiologic and radiographic tests have allowed earlier diagnosis of AT at a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.2.211
更新日期:1983-02-01 00:00:00
abstract:OBJECTIVE:To determine whether correlates of white matter integrity can provide general as well as specific insight into the chronic effects of head injury coupled with depression symptom expression in professional football players. METHOD:We studied 26 retired National Football League (NFL) athletes who underwent dif...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318299ccf8
更新日期:2013-07-02 00:00:00
abstract:OBJECTIVE:To assess neurodevelopmental outcome after endovascular treatment of vein of Galen malformations (VOGM). METHODS:Outcome of patients who underwent endovascular treatment for VOGM between 1983 and 2002 was assessed by chart review and parental questionnaires. Development was classified as normal, minor delay ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000094322.12621.02
更新日期:2003-11-25 00:00:00
abstract::We reviewed the outcome (developmental, neurologic, and seizure) and prognostic factors of 57 cases of infantile spasms (17 cryptogenic, 40 symptomatic). The mean developmental score of the cryptogenic group (71.2 +/- 24.2) was significantly higher than that of the symptomatic group (48.4 +/- 24.5), as assessed by the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.11.2322
更新日期:1993-11-01 00:00:00
abstract::A patient with PD who exhibited disabling tremor and prominent dyskinesia underwent deep brain stimulation (DBS) of the left thalamic ventral intermediate nucleus. The electrode migrated and was replaced but with suboptimal clinical response. Two years later, postmortem analysis found the second electrode tip had ente...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.11.1576
更新日期:2001-06-12 00:00:00
abstract::Our understanding of the pathogenesis of Alzheimer's disease (AD) had advanced rapidly, particularly in the area of genetics. Clinical trials of agents that offer the promise of going beyond symptomatic treatment to actually slowing the progression of disease, perhaps by enhancing the viability of neurons, are under w...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.48.5_suppl_7.2s
更新日期:1997-05-01 00:00:00
abstract::The local cerebral metabolic rate for glucose (1=CMRg) was computed in rats with methylphenidate-induced stereotypy using the quantitative 14C-2-deoxyglucose (2-DG) technique. Four rats received methylphenidate 15 mg per kilogram IP. Compared to five control animals, treated rats showed statistically significant (p le...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.4.377
更新日期:1982-04-01 00:00:00
abstract::We enrolled 11 patients with secondary progressive MS in a randomized single-masked cross-over study of plasma exchange (PE) in combination with azathioprine 2 mg/kg. PE was performed once a week for 4 weeks and thereafter every second week for 20 weeks (14 treatments). Eight patients completed the whole trial, and th...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.46.6.1620
更新日期:1996-06-01 00:00:00
abstract::Two patients with visual agnosia underwent visual recognition and neuropsychological tests to characterize their perceptual functioning. Both had an initial "apperceptive profile" and evolved from cortical blindness. One had carbon monoxide intoxication and incidental agenesis of the splenium of the corpus callosum; t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.11.1754
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:The APOE epsilon4 allele has emerged as a major genetic factor for Alzheimer disease (AD), and its presence has been associated with an increase in beta-amyloid senile plaques (SPs) and neuritic plaques (NPs). Whether it affects neurofibrillary tangle (NFT) accumulation or cholinergic losses in AD remains co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000128091.92139.0f
更新日期:2004-06-08 00:00:00
abstract::In a series of 100 patients exhibiting clinical and molecular features of facioscapulohumeral muscular dystrophy (FSHMD), five patients had conduction defects or arrhythmia in the absence of cardiovascular risk factors--namely, intraventricular conduction delay and supraventricular arrhythmia induced by electrophysiol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.5.1454
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:(1)H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether altered brain levels of mI and other metabolites occur in mild AD and whet...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.4.626
更新日期:2001-08-28 00:00:00
abstract::Titus Lucretius Carus was an ancient Roman philosopher of the Epicurean school whose epic poem On the Nature of Things described numerous aspects of the natural world. In fact, much contemporary scientific understanding is consistent with or inspired by his work. Among Lucretius's contributions to neurology were his d...
journal_title:Neurology
pub_type: 传,历史文章,杂志文章
doi:10.1212/WNL.0b013e31822cfa34
更新日期:2011-09-06 00:00:00
abstract::Central nervous system disorders may cause obstructive sleep apnea, but this sleep-related breathing disorder is rarely associated with a structural abnormality of the medulla. We present a patient with obstructive apnea resulting from autopsy-proven syringobulbia-myelia. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.8.1046
更新日期:1983-08-01 00:00:00
abstract::This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.3.294
更新日期:1975-03-01 00:00:00
abstract::In the present study we compared the efficacy and safety of the new dopamine agonist cabergoline (CBG) with bromocriptine (BCR) in Parkinson's disease (PD). CBG has a very long half-life and can be administered as a single daily dose. Forty-four PD patients with uncontrolled motor fluctuations participated in the stud...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.47.3.785
更新日期:1996-09-01 00:00:00
abstract::We present a case of uncontrolled temporal lobe epilepsy due to a focal left temporal neuronal heterotopia associated with the nevoid-basal-cell carcinoma syndrome. This is the first pathologically described lesion associated with temporal lobe epilepsy in this syndrome. Because the patient's seizures resolved after a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.2.574
更新日期:1996-02-01 00:00:00
abstract::An infant with transient neonatal myasthenia gravis had a double-blood-volume exchange transfusion because of maternal-fetal blood group incompatibility. This seemed to accelerate both decline in antiacetylcholine antibody titer and clinical improvement. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.7.911
更新日期:1981-07-01 00:00:00
abstract::Dopa-responsive dystonia (DRD) is an autosomal dominant disorder typically presenting as dystonia with diurnal variability. Described is an 8-year-old boy who had had waddling gait, generalized hypotonia, and proximal weakness since early childhood. He responded well to low-dose L-dopa. He had a point mutation of the ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.6.1121
更新日期:2001-09-25 00:00:00
abstract:OBJECTIVE:The aim of this study was to review 4 patients with encephalomyeloradiculoneuropathy (EMRN) and assess for autoantibodies against neutral glycolipids. METHODS:We studied the progression of clinical, radiologic, neurophysiologic, and CSF findings, as well as anti-neutral glycolipid antibodies in sera. RESULT...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000015
更新日期:2014-01-14 00:00:00
abstract::We performed brain MRIs on 21 patients with CNS sarcoidosis. Brain CTs were performed in 18 of these. Parenchymal lesions were seen in 17 of 21 with MRI, compared with 9 of 18 with CT. MRI detected a greater number of parenchymal lesions in cases where both CT and MRI were positive, and some lesions appeared more exte...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.3.378
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Krabbe disease (globoid cell leukodystrophy [GLD]) is an autosomal recessive lysosomal disorder affecting the central and peripheral nervous system. The authors performed MRS to characterize metabolic alterations and their regional variation in brain tissue in GLD in vivo. METHODS:Abnormalities of cerebral ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000049469.29011.e9
更新日期:2003-03-11 00:00:00