Hemorrhagic infarction in white matter following acute carbon monoxide poisoning.


:Hemorrhage complicating acute carbon monoxide poisoning is usually confined to the basal ganglia. The authors report three people with acute carbon monoxide poisoning manifesting selective or prominent white matter involvement complicated by hemorrhagic infarction on CT and MRI in one and by subcortical T2*-weighted MRI abnormality in all three.






Finelli PF,DiMario FJ Jr




Has Abstract


2004-09-28 00:00:00














  • Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy.

    abstract::PET-demonstrated decreases in [11C]flumazenil binding occur in anterior mesial temporal structures on the side of epileptogenesis in unilateral mesial temporal lobe epilepsy. We performed quantitative autoradiography on anterior mesial and lateral temporal specimens from 11 subjects with unilateral mesial temporal lob...


    pub_type: 杂志文章


    authors: Burdette DE,Sakurai SY,Henry TR,Ross DA,Pennell PB,Frey KA,Sackellares JC,Albin RL

    更新日期:1995-05-01 00:00:00

  • Effect of anticonvulsants on sleep.

    abstract::The intensive study of seizures via serial 24-hour EEG-video monitoring has allowed enhanced observation of sleep patterns among epilepsy patients and has revealed that disturbed rest is common in this population. Previous work has shown that sleep deprivation of any type can exacerbate seizure activity, leading to sp...


    pub_type: 杂志文章,评审


    authors: Sammaritano M,Sherwin A

    更新日期:2000-01-01 00:00:00

  • Homolateral ataxia and crural paresis: case report.

    abstract::Homolateral ataxia and crural paresis is a recognized vascular syndrome. However, confirmation of the causative lesion rests principally on one earlier case with multiple other infarcts. We studied a patient with the clinical syndrome; computerized tomography revealed a lucency that appeared within 1 week of the infar...


    pub_type: 杂志文章


    authors: Perman GP,Racy A

    更新日期:1980-09-01 00:00:00

  • Correlating phenotype and genotype in the periodic paralyses.

    abstract:BACKGROUND:Periodic paralyses and paramyotonia congenita are rare disorders causing disabling weakness and myotonia. Mutations in sodium, calcium, and potassium channels have been recognized as causing disease. OBJECTIVE:To analyze the clinical phenotype of patients with and without discernible genotype and to identif...


    pub_type: 杂志文章


    authors: Miller TM,Dias da Silva MR,Miller HA,Kwiecinski H,Mendell JR,Tawil R,McManis P,Griggs RC,Angelini C,Servidei S,Petajan J,Dalakas MC,Ranum LP,Fu YH,Ptácek LJ

    更新日期:2004-11-09 00:00:00

  • Hereditary dystonia-parkinsonism syndrome of juvenile onset.

    abstract::We studied a family with an extrapyramidal disorder characterized by childhood onset of lower-limb and axial dystonia, followed by parkinsonism. Dramatic response to levodopa therapy and minimal progression in adult life was seen. The family included five generations of affected members of both sexes in an autosomal d...


    pub_type: 杂志文章


    authors: Nygaard TG,Duvoisin RC

    更新日期:1986-11-01 00:00:00

  • APOE epsilon4 is not a susceptibility gene in idiopathic or diabetic sensory neuropathy.

    abstract::The presence of an APOE epsilon4 allele may be a risk factor for neuropathy severity in diabetes. The authors assessed the frequency of APOE epsilon4 in patients presenting with sensory predominant neuropathy. APOE epsilon4 frequency among patients with early diabetic neuropathy and impaired glucose tolerance-associat...


    pub_type: 杂志文章


    authors: Zhou Z,Hoke A,Cornblath DR,Griffin JW,Polydefkis M

    更新日期:2005-01-11 00:00:00

  • Sex of parent transmission effect in Tourette's syndrome: evidence for earlier age at onset in maternally transmitted cases suggests a genomic imprinting effect.

    abstract::Parent of origin effects caused by genomic imprinting may influence the phenotypic expression of a number of heritable human disorders. To test this phenomenon in Tourette's syndrome (TS), we studied 437 first degree relatives systematically ascertained through 57 probands. We compared age at onset, age at diagnosis, ...


    pub_type: 杂志文章


    authors: Eapen V,O'Neill J,Gurling HM,Robertson MM

    更新日期:1997-04-01 00:00:00

  • Cardiac injury associated with neurogenic pulmonary edema following subarachnoid hemorrhage.

    abstract:OBJECTIVE:To describe the clinical features of cardiac injury associated with neurogenic pulmonary edema (NPE) in patients with acute subarachnoid hemorrhage (SAH). BACKGROUND:NPE is generally viewed as a form of noncardiogenic pulmonary edema related to massive sympathetic discharge. METHODS:Case series. RESULTS:We...


    pub_type: 杂志文章


    authors: Mayer SA,Fink ME,Homma S,Sherman D,LiMandri G,Lennihan L,Solomon RA,Klebanoff LM,Beckford A,Raps EC

    更新日期:1994-05-01 00:00:00

  • The natural history of asymptomatic meningiomas in Olmsted County, Minnesota.

    abstract::To define the natural history of asymptomatic meningioma found incidentally on a neuroimaging study, we performed a retrospective analysis of 35 such patients. There were 32 women and three men, with a mean age of 67 years and a mean follow-up of 74 months. Four tumors had progressed on subsequent imaging, and one pat...


    pub_type: 杂志文章


    authors: Go RS,Taylor BV,Kimmel DW

    更新日期:1998-12-01 00:00:00

  • Spatial disorientation in Alzheimer's disease: the remembrance of things passed.

    abstract:BACKGROUND:Patients with Alzheimer's disease (AD) and many older adults become lost even in familiar surroundings. This is commonly attributed to memory impairment, but it may reflect impaired spatial cognition. METHODS:The authors examined the role of memory, perceptual, and cognitive mechanisms in spatial disorienta...


    pub_type: 杂志文章


    authors: Monacelli AM,Cushman LA,Kavcic V,Duffy CJ

    更新日期:2003-12-09 00:00:00

  • Interictal, circulating sphingolipids in women with episodic migraine: A case-control study.

    abstract:OBJECTIVE:To evaluate interictal, circulating sphingolipids in women migraineurs. METHODS:In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n=52) and from controls (n=36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled wi...


    pub_type: 杂志文章


    authors: Peterlin BL,Mielke MM,Dickens AM,Chatterjee S,Dash P,Alexander G,Vieira RV,Bandaru VV,Dorskind JM,Tietjen GE,Haughey NH

    更新日期:2015-10-06 00:00:00

  • Psychometric evaluation of a new sensory scale in immune-mediated polyneuropathies. Inflammatory Neuropathy Cause and Treatment (INCAT) Group.

    abstract:OBJECTIVE:To perform a psychometric evaluation of the inflammatory neuropathy cause and treatment (INCAT) sensory sumscore (ISS) in sensory-motor immune-mediated polyneuropathies. This new sensory scale was evaluated to strive for uniformity in assessing sensory deficit in these disorders. METHODS:The ISS comprises vi...


    pub_type: 杂志文章


    authors: Merkies IS,Schmitz PI,van der Meché FG,van Doorn PA

    更新日期:2000-02-22 00:00:00

  • The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs.

    abstract:BACKGROUND:Extrapyramidal signs (EPS) are common in Alzheimer disease (AD) and increase in prevalence as AD advances. The neuropathologic substrate responsible for EPS in AD remains to be fully characterized. METHODS:Subjects had a clinical diagnosis of AD confirmed by neuropathologic examination. EPS during life were...


    pub_type: 杂志文章


    authors: Burns JM,Galvin JE,Roe CM,Morris JC,McKeel DW

    更新日期:2005-04-26 00:00:00

  • Clinical course correlates poorly with muscle pathology in nemaline myopathy.

    abstract:OBJECTIVE:To report pathologic findings in 124 Australian and North American cases of primary nemaline myopathy. METHODS:Results of 164 muscle biopsies from 124 Australian and North American patients with primary nemaline myopathy were reviewed, including biopsies from 19 patients with nemaline myopathy due to alpha-a...


    pub_type: 杂志文章


    authors: Ryan MM,Ilkovski B,Strickland CD,Schnell C,Sanoudou D,Midgett C,Houston R,Muirhead D,Dennett X,Shield LK,De Girolami U,Iannaccone ST,Laing NG,North KN,Beggs AH

    更新日期:2003-02-25 00:00:00

  • Repetitive TMS temporarily alters brain diffusion.

    abstract::The authors investigated whether repetitive transcranial magnetic stimulation (rTMS) at 1 Hz (12 minutes; 90% of motor threshold) to the primary motor cortex (M1) leads to changes in diffusion-weighted imaging (DWI). After the rTMS train, there was a temporary small restriction in diffusion within the targeted left M1...


    pub_type: 杂志文章


    authors: Mottaghy FM,Gangitano M,Horkan C,Chen Y,Pascual-Leone A,Schlaug G

    更新日期:2003-05-13 00:00:00

  • Age-associated leukoaraiosis and cortical cholinergic deafferentation.

    abstract:OBJECTIVE:To investigate the relationship between age-associated MRI leukoaraiosis or white matter hyperintensities (WMH) and cortical acetylcholinesterase (AChE) activity. BACKGROUND:One possible mechanism of cognitive decline in elderly individuals with leukoaraiosis is disruption of cholinergic fibers by strategica...


    pub_type: 杂志文章


    authors: Bohnen NI,Müller ML,Kuwabara H,Constantine GM,Studenski SA

    更新日期:2009-04-21 00:00:00

  • Cytoplasmic inclusion bodies in superior rectus muscle of the eye.

    abstract::Cytoplasmic inclusion bodies are found in fibers of superior rectus muscle of the eye. They occur in middle-aged and old individuals dying with various unrelated diseases not affecting muscle and in patients with myotonic dystrophy. With light microscopy they can be observed in fibers with pathologic changes, and with...


    pub_type: 杂志文章


    authors: Culebras A,Merk FB

    更新日期:1975-05-01 00:00:00

  • Creutzfeldt-Jakob disease associated with a deletion of two repeats in the prion protein gene.

    abstract::A two-octapeptide repeat deletion of the prion protein gene has been recently observed in a patient with a 2-year history of dementia and a clinical diagnosis of possible Creutzfeldt-Jakob disease (CJD). The authors report a similar deletion in a patient with a definitive diagnosis of CJD. Since the two-repeat deletio...


    pub_type: 杂志文章


    authors: Capellari S,Parchi P,Wolff BD,Campbell J,Atkinson R,Posey DM,Petersen RB,Gambetti P

    更新日期:2002-11-26 00:00:00

  • Persistence of ictal activity after functional hemispherectomy in Rasmussen syndrome.

    abstract::A 15-year-old girl with a 3-year history of Rasmussen syndrome (RS) underwent left functional hemispherectomy by central disconnection. Clinical seizures then ceased. Five months postoperatively, ictal EEG discharges were associated with focal hyperperfusion on SPECT within the disconnected hypoperfused left hemispher...


    pub_type: 杂志文章


    authors: Thomas P,Zifkin B,Ghetâu G,Delalande O

    更新日期:2003-01-14 00:00:00

  • Treatment of Rasmussen's syndrome with ganciclovir.

    abstract::Since cytomegalovirus (CMV) has been implicated in the pathogenesis of Rasmussen's syndrome, we treated four patients with ganciclovir, a potent anti-CMV drug. A 7-year-old girl with seizures escalating to 60/day over 3 months despite triple antiepileptic drug therapy became seizure-free 5 days after initiation of tre...


    pub_type: 杂志文章


    authors: McLachlan RS,Levin S,Blume WT

    更新日期:1996-10-01 00:00:00

  • Current treatment pathways in ALS: a European perspective.

    abstract::This article presents the findings relating to the European subgroup of 91 patients in an international survey of the current diagnosis and treatment of patients with amyotrophic lateral sclerosis (ALS). The mean time between first symptoms and first consultation with a physician was 4.9 months, and mean delay in seei...


    pub_type: 杂志文章


    authors: Dengler R

    更新日期:1999-01-01 00:00:00

  • Extracranial-intracranial bypass surgery: hemodynamic and metabolic effects.

    abstract::After superficial temporal artery-middle cerebral artery bypass, cerebral blood flow (CBF) in the operated hemisphere increased in 6 of 17 patients. Preoperatively, the symptomatic hemisphere showed lower CBF in all six, lower oxygen metabolism in five, higher blood volume in four, and higher oxygen extraction in two....


    pub_type: 杂志文章


    authors: Powers WJ,Martin WR,Herscovitch P,Raichle ME,Grubb RL Jr

    更新日期:1984-09-01 00:00:00

  • Failure of cholinergic agonist RS-86 to improve cognition and movement in PSP despite effects on sleep.

    abstract::Postmortem studies of patients with progressive supranuclear palsy (PSP) have demonstrated loss of cholinergic neurons in the striatum, nucleus basalis of Meynert, and the pedunculopontine nucleus. These findings suggest that cholinergic drugs might be an effective treatment for this disease. We studied the efficacy o...


    pub_type: 临床试验,杂志文章


    authors: Foster NL,Aldrich MS,Bluemlein L,White RF,Berent S

    更新日期:1989-02-01 00:00:00

  • A new SPG4 mutation in a variant form of spastic paraplegia with congenital arachnoid cysts.

    abstract::The clinical and genetic findings are described for 16 patients from a large Italian family with a variant form of hereditary spastic paraplegia and congenital arachnoid cysts inherited as an autosomal dominant trait. A molecular study has revealed a novel missense mutation, T614I, in exon 17 of SPG4, which may play a...


    pub_type: 杂志文章


    authors: Orlacchio A,Gaudiello F,Totaro A,Floris R,St George-Hyslop PH,Bernardi G,Kawarai T

    更新日期:2004-05-25 00:00:00

  • APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort.

    abstract:OBJECTIVE:To compare the proportion of APOE ε4 genotype carriers in aphasic vs amnestic variants of Alzheimer disease (AD). METHOD:The proportion of APOE ε4 carriers was compared among the following 3 groups: (1) 42 patients with primary progressive aphasia (PPA) and AD pathology (PPA/AD) enrolled in the Northwestern ...


    pub_type: 杂志文章


    authors: Weintraub S,Teylan M,Rader B,Chan KCG,Bollenbeck M,Kukull WA,Coventry C,Rogalski E,Bigio E,Mesulam MM

    更新日期:2020-02-11 00:00:00

  • Risk factors for Alzheimer's disease: a case-control study.

    abstract::A case-control study was conducted to assess personal and family medical history and the appearance of Alzheimer's disease. We compared 98 men with clinically diagnosed Alzheimer's disease and 162 controls, matched by sex, year of birth, and town of residence. Family history of dementia and personal history of depress...


    pub_type: 杂志文章


    authors: Shalat SL,Seltzer B,Pidcock C,Baker EL Jr

    更新日期:1987-10-01 00:00:00

  • Volumetric atrophy of the amygdala in Alzheimer's disease: quantitative serial reconstruction.

    abstract::The present study quantitatively assessed volumes of the amygdala and its subnuclei in autopsied cases of advanced Alzheimer's disease (AD) for comparison with age-matched controls. Amygdalar nuclei showed significant atrophy in AD with the exception of the paralaminar portion of the basal nucleus. The magnocellular r...


    pub_type: 杂志文章


    authors: Scott SA,DeKosky ST,Scheff SW

    更新日期:1991-03-01 00:00:00

  • Alexander disease: ventricular garlands and abnormalities of the medulla and spinal cord.

    abstract:BACKGROUND:Alexander disease is most commonly associated with macrocephaly and, on MRI, a leukoencephalopathy with frontal preponderance. The disease is caused by mutation of the GFAP gene. Clinical and MRI phenotypic variation have been increasingly recognized. METHODS:The authors studied seven patients with Alexande...


    pub_type: 杂志文章


    authors: van der Knaap MS,Ramesh V,Schiffmann R,Blaser S,Kyllerman M,Gholkar A,Ellison DW,van der Voorn JP,van Dooren SJ,Jakobs C,Barkhof F,Salomons GS

    更新日期:2006-02-28 00:00:00

  • Is prestroke use of angiotensin-converting enzyme inhibitors associated with better outcome?

    abstract:BACKGROUND:There is evidence that angiotensin-converting enzyme inhibitors (ACEIs) reduce the risk of stroke. However, it is unclear whether ACEI use before stroke provides a vasoprotective effect resulting in less severe stroke. METHODS:We ascertained all strokes occurring in a defined population in Melbourne, Austra...


    pub_type: 杂志文章


    authors: Chitravas N,Dewey HM,Nicol MB,Harding DL,Pearce DC,Thrift AG

    更新日期:2007-05-15 00:00:00

  • Inflammatory markers and cognition in well-functioning African-American and white elders.

    abstract:BACKGROUND:Several lines of evidence suggest that inflammatory mechanisms contribute to AD. OBJECTIVE:To examine whether several markers of inflammation are associated with cognitive decline in African-American and white well-functioning elders. METHODS:The authors studied 3,031 African-American and white men and wom...


    pub_type: 杂志文章


    authors: Yaffe K,Lindquist K,Penninx BW,Simonsick EM,Pahor M,Kritchevsky S,Launer L,Kuller L,Rubin S,Harris T

    更新日期:2003-07-08 00:00:00