Abstract:
:Childhood absence epilepsy (CAE) is defined by absence seizures in a normally developing child, with onset between 4 and 10 years of age.(1) Typical absence seizures consist of behavioral arrest with or without automatisms, usually last 30-60 seconds, and demonstrate a characteristic 3-Hz generalized spike-wave (GSW) pattern on EEG, often in response to hyperventilation.(2) Children may have hundreds of episodes daily, many of them subclinical, which can impair sustained attention and memory processing. There is a strong association between CAE and disorders of attention and executive function. This association persists even when seizures are well-controlled. An underlying structural or functional abnormality of the brain has been postulated to explain both observations.(3,4) This article by Dlugos et al.(5) is a post hoc analysis of a randomized, double-blinded trial(6) that seeks to characterize the relationship between EEG characteristics prior to treatment, measures of attention, and the outcome of initial antiepileptic treatment.
journal_name
Neurologyjournal_title
Neurologyauthors
Bernson-Leung ME,Mazumdar Mdoi
10.1212/WNL.0000000000000380subject
Has Abstractpub_date
2014-05-06 00:00:00pages
e158-60issue
18eissn
0028-3878issn
1526-632Xpii
82/18/e158journal_volume
82pub_type
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