Abstract:
:Acute chorea in a child followed ingestion of pemoline mesylate. In guinea pigs, in an experimental model of chorea, chronic administration of pemoline induced behavioral supersensitivity to other dopaminergic agonists. Pemoline is similar to both d-amphetamine and methylphenidate in altering central dopaminergic sensitivity, and may cause chorea by similar mechanisms. Chronic pemoline therapy may offer no significant advantage over therapy with other indirect dopamine agonists.
journal_name
Neurologyjournal_title
Neurologyauthors
Nausieda PA,Koller WC,Weiner WJ,Klawans HLdoi
10.1212/wnl.31.3.256subject
Has Abstractpub_date
1981-03-01 00:00:00pages
356-60issue
3eissn
0028-3878issn
1526-632Xjournal_volume
31pub_type
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