Pemoline-induced chorea.

Abstract:

:Acute chorea in a child followed ingestion of pemoline mesylate. In guinea pigs, in an experimental model of chorea, chronic administration of pemoline induced behavioral supersensitivity to other dopaminergic agonists. Pemoline is similar to both d-amphetamine and methylphenidate in altering central dopaminergic sensitivity, and may cause chorea by similar mechanisms. Chronic pemoline therapy may offer no significant advantage over therapy with other indirect dopamine agonists.

journal_name

Neurology

journal_title

Neurology

authors

Nausieda PA,Koller WC,Weiner WJ,Klawans HL

doi

10.1212/wnl.31.3.256

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

356-60

issue

3

eissn

0028-3878

issn

1526-632X

journal_volume

31

pub_type

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