Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes.


OBJECTIVE:To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes. METHODS:This is a prospective cohort study at 3 Division I National Collegiate Athletic Association athletic programs. Participants were 214 Division I college varsity football and ice hockey players who wore instrumented helmets that recorded the acceleration-time history of the head following impact, and 45 noncontact sport athletes. All athletes were assessed prior to and shortly after the season with a cognitive screening battery (ImPACT) and a subgroup of athletes also were assessed with 7 measures from a neuropsychological test battery. RESULTS:Few cognitive differences were found between the athlete groups at the preseason or postseason assessments. However, a higher percentage of the contact sport athletes performed more poorly than predicted postseason on a measure of new learning (California Verbal Learning Test) compared to the noncontact athletes (24% vs 3.6%; p < 0.006). On 2 postseason cognitive measures (ImPACT Reaction Time and Trails 4/B), poorer performance was significantly associated with higher scores on several head impact exposure metrics. CONCLUSION:Repetitive head impacts over the course of a single season may negatively impact learning in some collegiate athletes. Further work is needed to assess whether such effects are short term or persistent.






McAllister TW,Flashman LA,Maerlender A,Greenwald RM,Beckwith JG,Tosteson TD,Crisco JJ,Brolinson PG,Duma SM,Duhaime AC,Grove MR,Turco JH




Has Abstract


2012-05-29 00:00:00














  • Cerebrospinal fluid creatine kinase BB isoenzyme activity and neurologic prognosis after cardiac arrest.

    abstract:OBJECTIVE:To assess the relationship between CSF creatine kinase BB isoenzyme activity (CSF CKBB) and neurologic outcome after cardiac arrest in clinical practice. BACKGROUND:CSF CKBB reflects the extent of brain damage following cardiac arrest. METHODS:To help with prognosis, treating physicians ordered CSF CKBB tes...


    pub_type: 杂志文章


    authors: Tirschwell DL,Longstreth WT Jr,Rauch-Matthews ME,Chandler WL,Rothstein T,Wray L,Eng LJ,Fine J,Copass MK

    更新日期:1997-02-01 00:00:00

  • Demonstration of CSF gamma-globulin banding in presenile dementia.

    abstract::An improved agarose gel electrophoretic technique was used to fractionate serum and cerebrospinal fluid (CSF) proteins in patients with presenile dementia. The CSF electrophoretic patterns demonstrated three abnormal bands in the gamma-globulin region in five out of eight of these patients. ...


    pub_type: 杂志文章


    authors: Williams A,Papadopoulos N,Chase TN

    更新日期:1980-08-01 00:00:00

  • ANGPTL6 genetic variants are an underlying cause of familial intracranial aneurysms.

    abstract:PURPOSE:To understand the role of the angiopoietin-like 6 gene (ANGPTL6) in intracranial aneurysms (IAs), we investigated its role in a large cohort of familial IAs. METHODS:Individuals with family history of IA were recruited to the Genetic and Observational Subarachnoid Haemorrhage (GOSH) study. The ANGPTL6 gene was...


    pub_type: 杂志文章


    authors: Hostettler IC,O'Callaghan B,Bugiardini E,O'Connor E,Vandrovcova J,Davagnanam I,Alg V,Bonner S,Walsh D,Bulters D,Kitchen N,Brown MM,Grieve J,Werring DJ,Houlden H,Genetics and Observational Subarachnoid Haemorrhage (GOSH) Stu

    更新日期:2020-10-26 00:00:00

  • Linking MRI to daily life experience: the example of poststroke depression.

    abstract:OBJECTIVE:The state-of-the-art tools of neurology, in particular modern neuroimaging techniques, have yet to benefit from the revolution in mobile technologies that provide new insights into the mechanisms underlying clinical syndromes. This study demonstrates the manner in which mobile technologies may provide informa...


    pub_type: 杂志文章


    authors: Lassalle-Lagadec S,Allard M,Dilharreguy B,Schweitzer P,Swendsen J,Sibon I

    更新日期:2012-01-31 00:00:00

  • Partial pontine hematomas.

    abstract::Two hypertensive men presented clinically with small, largely unilateral hematomas of the pons and midbrain demonstrated by computerized tomography. Clinical manifestations included "ocular bobbing," complex forms of ophthalmoplegia, Cheyne-Stokes respiration, and pyramidal tract signs. The "typical" sings of massive ...


    pub_type: 杂志文章


    authors: Kase CS,Maulsby GO,Mohr JP

    更新日期:1980-06-01 00:00:00

  • Cortical dysplasia with angiodysgenesis and chronic inflammation in multifocal partial epilepsy.

    abstract::A 25-year-old man with a long history of temporal lobe epilepsy developed right occipital lobe seizures and a progressive right homonymous hemianopia. MRI showed diffuse enhancement of the left temporoparieto-occipital white matter and cortical thickening of the left medial temporal lobe. The resected temporal lobe re...


    pub_type: 杂志文章


    authors: Thom M,Moran NF,Plant GT,Stevens JM,Scaravilli F

    更新日期:1999-02-01 00:00:00

  • Long-term survival and neurologic status after resuscitation from out-of-hospital cardiac arrest.

    abstract::Thirty-eight survivors from among 117 patients hospitalized after out-of-hospital cardiac arrest were evaluated approximately 3 1/2 years later. Twenty patients were living; 18 had died. Fifty-three percent had resumed independent social activities, but only 32% had returned to work. Eight of 14 patients tested were n...


    pub_type: 杂志文章


    authors: Earnest MP,Yarnell PR,Merrill SL,Knapp GL

    更新日期:1980-12-01 00:00:00

  • The predictive value of CSF oligoclonal banding for MS 5 years after optic neuritis. Optic Neuritis Study Group.

    abstract::The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the res...


    pub_type: 杂志文章


    authors: Cole SR,Beck RW,Moke PS,Kaufman DI,Tourtellotte WW

    更新日期:1998-09-01 00:00:00

  • Invited article: changing concepts in Parkinson disease: moving beyond the decade of the brain.

    abstract::Recent years have seen major changes in our understanding of Parkinson disease (PD), challenging conventional wisdom, much of which was established during the Decade of the Brain. In this article, we highlight important changes in our understanding of PD in six general categories: definition, etiology, pathology, path...


    pub_type: 杂志文章,评审


    authors: Marras C,Lang A

    更新日期:2008-05-20 00:00:00

  • Markers of immune activation and viral load in HIV-associated sensory neuropathy.

    abstract:BACKGROUND:HIV infection is associated with a painful distal sensory polyneuropathy (DSP) that can severely limit the quality of life of affected subjects. The pathogenesis of DSP is unknown, although both HIV proteins and products of immune activation triggered by HIV infection have been implicated. OBJECTIVE:To asse...


    pub_type: 杂志文章


    authors: Schifitto G,McDermott MP,McArthur JC,Marder K,Sacktor N,McClernon DR,Conant K,Cohen B,Epstein LG,Kieburtz K,NEAD Consortium.

    更新日期:2005-03-08 00:00:00

  • MELAS: Clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy.

    abstract::We describe the clinical, imaging, and pathologic findings in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). The patient experienced her first stroke-like episode at age forty-four. Brain MRI, obtained at symptom onset, at 3 weeks, and at 1 year, revealed migr...


    pub_type: 杂志文章


    authors: Clark JM,Marks MP,Adalsteinsson E,Spielman DM,Shuster D,Horoupian D,Albers GW

    更新日期:1996-01-01 00:00:00

  • Observations on the short-term 'natural history' of probable Alzheimer's disease in a controlled clinical trial.

    abstract::We examined the performance of patients with probable Alzheimer's disease (AD) who participated in the placebo arm of a 12-week clinical trial. Assessments occurred at baseline and at 4, 6, 10, and 12 weeks after starting study medication. Patients received the Alzheimer's Disease Assessment Scale--Cognitive on all fi...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Knopman D,Gracon S

    更新日期:1994-02-01 00:00:00

  • Transient obstructive sleep apnea and asystole in association with presumed viral encephalopathy.

    abstract::Evidence suggests that untreated obstructive sleep apnea (OSA) can lead to hypertension, cardiovascular disease, and stroke. Conversely, the systemic effects of a wide variety of critical illnesses can lead to CNS dysfunction, which can precipitate respiratory failure. Reported is a patient in whom an acute encephalop...


    pub_type: 杂志文章


    authors: Dyken ME,Yamada T,Berger HA

    更新日期:2003-05-27 00:00:00

  • Inverse cerebellum and occipital encephalocele. A dorsal fusion defect uniting the Arnold-Chiari and Dandy-Walker spectrum.

    abstract::The malformation of inverse cerebellum and occipital encephalocele is situated morphologically between the Arnold-Chiari and Dandy-Walker malformations. In the three reported cases, hydrocephalus was not present, concomitant malformations of the lamina terminalis were present in two, and polymicrogyria was found in al...


    pub_type: 杂志文章


    authors: Smith MT,Huntington HW

    更新日期:1977-03-01 00:00:00

  • Associations with autoimmune disorders and HLA class I and II antigens in inclusion body myositis.

    abstract::Whether autoimmune mechanisms play a role in the pathogenesis of inclusion body myositis (IBM) is unknown. Human leukocyte antigen (HLA) analysis in 52 patients, including 17 with autoimmune disorders (AIDs), showed that patients were more likely to have antigens from the autoimmune-prone HLA-B8-DR3 ancestral haplotyp...


    pub_type: 杂志文章


    authors: Badrising UA,Schreuder GM,Giphart MJ,Geleijns K,Verschuuren JJ,Wintzen AR,Maat-Schieman ML,van Doorn P,van Engelen BG,Faber CG,Hoogendijk JE,de Jager AE,Koehler PJ,de Visser M,van Duinen SG,Dutch IBM Study Group.

    更新日期:2004-12-28 00:00:00

  • Neutralizing antibodies against HTLV-I in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients and asymptomatic carriers.

    abstract::We tested serum specimens from patients with HAM/TSP and asymptomatic HTLV-I carriers from endemic areas of Japan, Jamaica, Colombia, and Chile for neutralizing antibodies against HTLV-I. The data suggest a trend for neutralizing activity to be found more frequently in the sera from HAM/TSP patients than in sera from ...


    pub_type: 杂志文章


    authors: Minagawa H,Yoshida T,Itoyama Y,Mora CA,Albert P,Mori R

    更新日期:1992-11-01 00:00:00

  • Treatment of CNS sarcoidosis with infliximab and mycophenolate mofetil.

    abstract:OBJECTIVE:To describe the effects of the anti-tumor necrosis factor neutralizing antibody, infliximab, and the antiproliferative immunosuppressant, mycophenolate mofetil, in refractory neurosarcoidosis. METHODS:We treated patients with biopsy-proven sarcoidosis and CNS involvement, who had failed treatment with steroi...


    pub_type: 杂志文章


    authors: Moravan M,Segal BM

    更新日期:2009-01-27 00:00:00

  • Detection of Duchenne and Becker muscular dystrophy carriers by quantitative multiplex polymerase chain reaction analysis.

    abstract::We developed a method for the detection of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) carriers. The method is based on the quantitative analysis of the products of standard multiplex polymerase chain reaction (PCR) from 18 different exons of the dystrophin gene, and is designated "QM-PCR." W...


    pub_type: 杂志文章


    authors: Ioannou P,Christopoulos G,Panayides K,Kleanthous M,Middleton L

    更新日期:1992-09-01 00:00:00

  • Proportional anterior commissure area in humans and monkeys.

    abstract::Behavioral testing following division of the corpus callosum has shown that the anterior commissure can transfer information related to visual tasks interhemispherically in nonhuman primates but not in humans. We have found that the ratio of anterior commissure cross-sectional area to total neocortical commissural are...


    pub_type: 杂志文章


    authors: Foxman BT,Oppenheim J,Petito CK,Gazzaniga MS

    更新日期:1986-11-01 00:00:00

  • Interrater reliability of EEG-video monitoring.

    abstract:OBJECTIVE:The diagnosis of psychogenic nonepileptic seizures (PNES) can be challenging. In the absence of a gold standard to verify the reliability of the diagnosis by EEG-video, we sought to assess the interrater reliability of the diagnosis using EEG-video recordings. METHODS:Patient samples consisted of 22 unselect...


    pub_type: 杂志文章


    authors: Benbadis SR,LaFrance WC Jr,Papandonatos GD,Korabathina K,Lin K,Kraemer HC,NES Treatment Workshop.

    更新日期:2009-09-15 00:00:00

  • Saccadic duration and intrasaccadic fatigue in myasthenic and nonmyasthenic ocular palsies.

    abstract::We measured the duration and amplitude of saccades in three normal subjects, eight patients with myasthenia gravis, and eight patients with nonmyasthenic ocular palsies. Saccades were examined at the start of a repetitive saccade task, after 3 minutes of activity, and 1 minute after administration of edrophonium. The ...


    pub_type: 杂志文章


    authors: Barton JJ,Jama A,Sharpe JA

    更新日期:1995-11-01 00:00:00

  • Peripheral neuropathy in Krabbe disease: effect of hematopoietic stem cell transplantation.

    abstract:BACKGROUND:Hematopoietic stem cell transplantation (HSCT) may slow the progression of Krabbe disease (KD) if performed early in the disease. The authors' studies indicate that more than 90% of patients with KD have severe abnormalities in peripheral nerve conduction. OBJECTIVE:To assess the effect of HSCT on nerve con...


    pub_type: 杂志文章


    authors: Siddiqi ZA,Sanders DB,Massey JM

    更新日期:2006-07-25 00:00:00

  • Peripheral neuropathy in classic Niemann-Pick disease: ultrastructure of nerves and skeletal muscles.

    abstract::A patient with classic (type A) Niemann-Pick disease had the usual clinical signs of failure to thrive, hepatosplenomegaly, and intellectual deterioration in the first year of life. In addition, there was striking hypotonia, areflexia, and abnormal nerve conduction velocities. Pathologically, the Schwann cells were fi...


    pub_type: 杂志文章


    authors: Gumbinas M,Larsen M,Mei Liu H

    更新日期:1975-02-01 00:00:00

  • Amyotrophic lateral sclerosis: thyrotropin-releasing hormone and histidyl proline diketopiperazine in the spinal cord and cerebrospinal fluid.

    abstract::In spinal cords from seven amyotrophic lateral sclerosis (ALS) patients and four controls, we found no difference in thyrotropin-releasing hormone (TRH) concentration relative to protein content, but there was a reduction per tissue wet weight in ALS. Immunohistochemical localization of TRH in ALS cord was unaltered. ...


    pub_type: 杂志文章


    authors: Jackson IM,Adelman LS,Munsat TL,Forte S,Lechan RM

    更新日期:1986-09-01 00:00:00

  • The childhood type of dermatomyositis.

    abstract::The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, l...


    pub_type: 杂志文章


    authors: Carpenter S,Karpati G,Rothman S,Watters G

    更新日期:1976-10-01 00:00:00

  • Anti-neutral glycolipid antibodies in encephalomyeloradiculoneuropathy.

    abstract:OBJECTIVE:The aim of this study was to review 4 patients with encephalomyeloradiculoneuropathy (EMRN) and assess for autoantibodies against neutral glycolipids. METHODS:We studied the progression of clinical, radiologic, neurophysiologic, and CSF findings, as well as anti-neutral glycolipid antibodies in sera. RESULT...


    pub_type: 杂志文章


    authors: Shima S,Kawamura N,Ishikawa T,Masuda H,Iwahara C,Niimi Y,Ueda A,Iwabuchi K,Mutoh T

    更新日期:2014-01-14 00:00:00

  • A human brain network derived from coma-causing brainstem lesions.

    abstract:OBJECTIVE:To characterize a brainstem location specific to coma-causing lesions, and its functional connectivity network. METHODS:We compared 12 coma-causing brainstem lesions to 24 control brainstem lesions using voxel-based lesion-symptom mapping in a case-control design to identify a site significantly associated w...


    pub_type: 杂志文章


    authors: Fischer DB,Boes AD,Demertzi A,Evrard HC,Laureys S,Edlow BL,Liu H,Saper CB,Pascual-Leone A,Fox MD,Geerling JC

    更新日期:2016-12-06 00:00:00

  • Clinical and electrophysiologic correlates of elevated anti-GM1 antibody titers.

    abstract::We reviewed the clinical and electrophysiologic features of 36 patients with increased titers of IgM anti-GM1 antibodies. Mildly elevated titers of up to 3,200 were not associated with any particular clinical syndrome or disease. Clinically, 14 of 16 patients with highly elevated titers of 6,400 or higher had progress...


    pub_type: 杂志文章


    authors: Kinsella LJ,Lange DJ,Trojaborg W,Sadiq SA,Younger DS,Latov N

    更新日期:1994-07-01 00:00:00

  • Incidence of seizures with phenytoin toxicity.

    abstract::Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity. The only factor that seemed to correlate with seizures was a se...


    pub_type: 杂志文章


    authors: Stilman N,Masdeu JC

    更新日期:1985-12-01 00:00:00

  • Cholesterol emboli neuropathy.

    abstract::We report the clinical and pathologic features of a patient with peripheral neuropathy that was the first clinical expression of cholesterol emboli syndrome (CES). Biopsy of skeletal muscle and peripheral nerve revealed cholesterol clefts in lumens of small arteries, necrotizing arteritis, and severe degeneration of p...


    pub_type: 杂志文章


    authors: Bendixen BH,Younger DS,Hair LS,Gutierrez C,Meyers ML,Homma S,Jaffe IA

    更新日期:1992-02-01 00:00:00