Relative utility of 1H spectroscopic imaging and hippocampal volumetry in the lateralization of mesial temporal lobe epilepsy.


OBJECTIVES:To determine the relative utility of 1H MRSI and hippocampal volumetry for the lateralization of mesial temporal lobe epilepsy (MTLE) in patients with intractable epilepsy. BACKGROUND:MTLE is the most common partial-onset seizure disorder in patients undergoing temporal lobe epilepsy surgery. MR volumetry and spectroscopy are reliable preoperative imaging techniques for the lateralization of MTLE. METHODS:We analyzed the 1H MRSI and hippocampal formation volumes preoperatively in 30 consecutive patients who had undergone temporal lobectomy. RESULTS:Volumetry correctly lateralized the side of surgery in 93% of patients and 1H MRSI did so in 97% of patients. Incorrect lateralization occurred by volumetry in two patients and by 1H MRSI in one patient. Concordance between all MRI modalities was 73%. Pearson's analysis revealed no correlation between the degree of hippocampal volume loss and the creatine-to-N-acetylated-compounds ratio. CONCLUSIONS:Volumetry and 1H MRSI correctly lateralized most patients with MTLE and complement each other in final lateralization. The lack of correlation between the severity of volume loss and the degree of metabolic disturbance suggests that the techniques examine distinct pathophysiologic processes in MTLE.






Kuzniecky R,Hugg JW,Hetherington H,Butterworth E,Bilir E,Faught E,Gilliam F




Has Abstract


1998-07-01 00:00:00












  • Sodium valproate: serial monitoring of EEG and serum levels.

    abstract::The clinical and electroencephalographic (EEG) effects of sodium valproate were studied in four patients by means of serial 24-hour EEG recordings and simultaneous hourly determinations of serum drug concentrations. The patients all had frequent clinical seizures and generalized spike-wave discharges. Valproate appear...


    pub_type: 杂志文章


    authors: Rowan AJ,Binnie CD,de Beer-Pawlikowski NK,Goedhart DM,Gutter T,van der Geest P,Meinardi H,Meijer JW

    更新日期:1979-11-01 00:00:00

  • Leigh-type neuropathology in Pearson syndrome associated with impaired ATP production and a novel mtDNA deletion.

    abstract::Pearson syndrome is a systemic disorder of oxidative phosphorylation in infants, predominantly affecting the bone marrow and exocrine pancreas and associated with single deletions in mitochondrial DNA (mtDNA). CNS involvement may occur in patients who survive the infantile hematopoietic disorder. We describe a Pearson...


    pub_type: 杂志文章


    authors: Santorelli FM,Barmada MA,Pons R,Zhang LL,DiMauro S

    更新日期:1996-11-01 00:00:00

  • Mechanisms of action of anticonvulsant agents.

    abstract::Systematic screening of many compounds in animal models led to identification of the established antiepileptic drugs (AEDs). By contrast, the newer AEDs were specifically designed to enhance an inhibitory process or to inhibit a specific excitatory pathway. However, it was later discovered that some of the designed dr...


    pub_type: 杂志文章,评审


    authors: Moshé SL

    更新日期:2000-01-01 00:00:00

  • Not paralysis, but dystonia causes stridor in multiple system atrophy.

    abstract::Electromyography (EMG) was performed in 10 patients with multiple system atrophy, laryngeal or pharyngeal symptoms, or both. In patients with stridor, EMG during quiet breathing revealed persistent tonic activity in both abductor and adductor vocal cord muscles. In patients with dysphagia, the cricopharyngeal muscle s...


    pub_type: 杂志文章


    authors: Merlo IM,Occhini A,Pacchetti C,Alfonsi E

    更新日期:2002-02-26 00:00:00

  • Adult fucosidosis: histochemical and ultrastructural studies of rectal mucosa biopsy.

    abstract::Three sisters with adult fucosidosis showed prominent psychomotor retardation, gargoyle features, and angiokeratoma corporis diffusum, meeting the criteria for type II fucosidosis. By histochemical and ultrastructural studies, biopsy of rectal mucosa revealed many abnormal macrophages that were filled with fucose-rich...


    pub_type: 杂志文章


    authors: Ikeda S,Kondo K,Oguchi K,Yanagisawa N,Horigome R,Murata F

    更新日期:1984-04-01 00:00:00

  • Short-chain fatty acids and encephalopathy of Reye's syndrome.

    abstract::Plasma levels of six short-chain fatty acids (SCFA) were measured in 23 Reye's syndrome patients. In sequential measurements, only propionic acid correlated closely with neurologic severity. Although admission SCFA levels were slightly elevated, there were no significant differences between patients grouped by severit...


    pub_type: 杂志文章


    authors: McArthur B,Sarnaik AP,Mitchell RA

    更新日期:1984-06-01 00:00:00

  • Factors influencing sweat gland innervation in diabetes.

    abstract:BACKGROUND:Using a stereologic approach, the density of nerve fibers innervating sweat gland (SG) fragments in patients with diabetes mellitus (DM) and healthy controls using protein gene product (PGP), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP) was measured to determine which marker best detect...


    pub_type: 杂志文章


    authors: Liu Y,Billiet J,Ebenezer GJ,Pan B,Hauer P,Wei J,Polydefkis M

    更新日期:2015-04-21 00:00:00

  • Chronic polyradiculoneuropathy of infancy. A report of three cases with familial incidence.

    abstract::Two siblings and a third child exhibited a syndrome of progressive muscular weakness and wasting, closely resembling Werdnig-Hoffmann's disease. Autopsy of one of the siblings and the third child showed nearly total absence of myelin sheaths in the cranial and spinal nerve roots, relative preservation of axons, and no...


    pub_type: 杂志文章


    authors: Kasman M,Bernstein L,Schulman S

    更新日期:1976-06-01 00:00:00

  • Thalamic deep brain stimulation for tremor in Parkinson disease, essential tremor, and dystonia.

    abstract:OBJECTIVE:To report on the long-term outcomes of deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (VIM) in Parkinson disease (PD), essential tremor (ET), and dystonic tremor. METHODS:One hundred fifty-nine patients with PD, ET, and dystonia underwent VIM DBS due to refractory tremor at the Gre...


    pub_type: 杂志文章


    authors: Cury RG,Fraix V,Castrioto A,Pérez Fernández MA,Krack P,Chabardes S,Seigneuret E,Alho EJL,Benabid AL,Moro E

    更新日期:2017-09-26 00:00:00

  • Minimal thyroid ophthalmopathy.

    abstract::We studied six patients with the clinical, sonographic, CT, and biochemical profile of minimal euthyroid Graves' disease (MEGD). This syndrome was characterized clinically by small but obtrusive and measurable amounts of diplopia related to endocrine ophthalmopathy and the conspicuous absence of systemic or laboratory...


    pub_type: 杂志文章


    authors: Spector RH,Carlisle JA

    更新日期:1987-11-01 00:00:00

  • Ictal SPECT during autonomic crisis in familial dysautonomia.

    abstract::The authors report results of SPECT cerebral perfusion studies in two patients with familial dysautonomia (FD) during dysautonomic crises and when clinically stable. SPECT imaging studies used 99mTc ethylene cysteine dimer. During dysautonomic crises, regions in the temporoparietal and frontal lobes had increased upta...


    pub_type: 杂志文章


    authors: Axelrod FB,Zupanc M,Hilz MJ,Kramer EL

    更新日期:2000-07-12 00:00:00

  • Central nervous system involvement in dengue: a study in fatal cases from a dengue endemic area.

    abstract:OBJECTIVE:This study aimed to determine the frequency of CNS infection by dengue virus (DENV) in individuals with fatal outcomes. METHODS:Samples of 150 individuals suspect of an infection disease and with fatal outcomes were investigated for evidence of the presence of DENV. The sampling was made up of 150 CSF, 120 t...


    pub_type: 杂志文章


    authors: Araújo FM,Araújo MS,Nogueira RM,Brilhante RS,Oliveira DN,Rocha MF,Cordeiro RA,Araújo RM,Sidrim JJ

    更新日期:2012-03-06 00:00:00

  • Alternating episodes of vestibular nerve excitation and failure.

    abstract::Recurrent episodes of oscillopsia, rotational vertigo, and postural imbalance were elicited and modulated by changing the horizontal head positions of a patient with an arachnoid cyst in the right cerebellopontine angle that distorted the vestibulocochlear nerve. Oculomotor analysis revealed two different types of att...


    pub_type: 杂志文章


    authors: Arbusow V,Strupp M,Dieterich M,Jäger L,Hischa A,Schulz P,Brandt T

    更新日期:1998-11-01 00:00:00

  • A study of congenital nystagmus: waveforms.

    abstract::Eighteen patients with congenital nystagmus were studied with the techniques of electronystagmography and computer analysis. We found several complex wave forms of congenital nystagmus in the primary position of gaze above those of jerk and pendular nystagmus as defined clinically. An etiologic classification of motor...


    pub_type: 杂志文章


    authors: Yee RD,Wong EK,Baloh RW,Honrubia V

    更新日期:1976-04-01 00:00:00

  • Juvenile-onset glycogen storage disease type II with novel mutations in acid alpha-glucosidase gene.

    abstract::The authors describe two novel mutations of the acid alpha-glucosidase gene, P361L and R437C, which define the juvenile-onset glycogen storage disease type II (GSDII) in a 16-year-old Chinese patient. The asymptomatic 13-year-old brother of the proband is also a compound heterozygote of the two mutations. These result...


    pub_type: 杂志文章


    authors: Lam CW,Yuen YP,Chan KY,Tong SF,Lai CK,Chow TC,Lee KC,Chan YW,Martiniuk F

    更新日期:2003-02-25 00:00:00

  • Noninvasive diagnosis of extracranial cerebrovascular disease: oculoplethysmography-phonoangiography and directional Doppler ultrasonography.

    abstract::The ability of two noninvasive diagnostic methods--oculoplethysmography-carotid phonoangiography (OPG/CPA) and directional Doppler ultrasonography--to detect extracranial cerebrovascular disease was examined in 400 consecutive studies. Cerebral arteriography was performed in 74 patients. Transient ischemic attack was ...


    pub_type: 杂志文章


    authors: Ginsberg MD,Greenwood SA,Goldberg HI

    更新日期:1979-05-01 00:00:00

  • Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies.

    abstract:OBJECTIVE:To determine the rate of progression of mild cognitive impairment (MCI) to dementia with Lewy bodies (DLB). METHODS:We followed 337 patients with MCI in the Mayo Alzheimer's Disease Research Center (range 2-12 years). Competing risks survival models were used to examine the rates of progression to clinically...


    pub_type: 杂志文章


    authors: Ferman TJ,Smith GE,Kantarci K,Boeve BF,Pankratz VS,Dickson DW,Graff-Radford NR,Wszolek Z,Van Gerpen J,Uitti R,Pedraza O,Murray ME,Aakre J,Parisi J,Knopman DS,Petersen RC

    更新日期:2013-12-03 00:00:00

  • The predictive value of CSF oligoclonal banding for MS 5 years after optic neuritis. Optic Neuritis Study Group.

    abstract::The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the res...


    pub_type: 杂志文章


    authors: Cole SR,Beck RW,Moke PS,Kaufman DI,Tourtellotte WW

    更新日期:1998-09-01 00:00:00

  • Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage.

    abstract::An infant with Pena-Shokeir phenotype was born to a cocaine-using mother. The pathologic findings included polyhydramnios, facial anomalies, arthrogryposis, camptodactyly, pulmonary hypoplasia, and tetralogy of Fallot. The neuropathologic findings were diffuse brainstem and spinal cord neuronal degeneration and focal ...


    pub_type: 杂志文章


    authors: Lavi E,Montone KT,Rorke LB,Kliman HJ

    更新日期:1991-09-01 00:00:00

  • Distinguishing between extrinsic and intrinsic tongue muscle weakness in unilateral hypoglossal palsy.

    abstract::A 53-year-old man presented with multiple right cranial nerve palsies that included the tongue. When the tongue was protruded, it deviated to the right. However, when the tongue was not protruded, he could readily turn the tip of the tongue to the left, but not to the right. Protrusion of the tongue requires the actio...


    pub_type: 杂志文章


    authors: Riggs JE

    更新日期:1984-10-01 00:00:00

  • The value of informant versus individual's complaints of memory impairment in early dementia.

    abstract::Self-reported versus informant-reported memory problems in nondemented elderly adults and in individuals with very mild and mild dementia of the Alzheimer type (DAT) were correlated with cognitive outcomes. No significant correlations were found between self-reported memory complaints and cognitive performance or (in ...


    pub_type: 杂志文章


    authors: Carr DB,Gray S,Baty J,Morris JC

    更新日期:2000-12-12 00:00:00

  • Traumatic brainstem deafness with normal brainstem auditory evoked potentials.

    abstract::A 48-year-old woman became totally deaf after a head injury. Magnetic resonance imaging showed bilateral contusions around the inferior colliculi and the brainstem auditory evoked potentials (BAEP) failed to show any abnormality. This case demonstrates that small, symmetrical, bilateral lesions around the inferior col...


    pub_type: 杂志文章


    authors: Hu CJ,Chan KY,Lin TJ,Hsiao SH,Chang YM,Sung SM

    更新日期:1997-05-01 00:00:00

  • Dystrophin expression and somatic reversion in prednisone-treated and untreated Duchenne dystrophy. CIDD Study Group.

    abstract::The mechanism by which prednisone improves muscle strength and function in Duchenne muscular dystrophy (DMD) is unknown. We addressed the possibility that clinical improvement was related to prednisone-induced alterations in skeletal muscle dystrophin. We performed muscle biopsies on patients at the conclusion of a ra...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Burrow KL,Coovert DD,Klein CJ,Bulman DE,Kissel JT,Rammohan KW,Burghes AH,Mendell JR

    更新日期:1991-05-01 00:00:00

  • Subacute sclerosing panencephalitis: clinical and immunologic study of 23 patients.

    abstract::Lymphocyte subpopulations ("active' T cells, total T cells, and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, and C4), and immune complexes in serum and cerebrospinal fluid were studied in 23 patients with subacute sclerosing panencephalitis. The percentage of active T cells was norm...


    pub_type: 杂志文章


    authors: Derakhshan I,Massoud A,Foroozanfar N,Nikbin B,Lotfi J,Shakib N,Ala F

    更新日期:1981-02-01 00:00:00

  • Effect of intellectual enrichment on AD biomarker trajectories: Longitudinal imaging study.

    abstract:OBJECTIVE:To investigate the effect of age, sex, APOE4 genotype, and lifestyle enrichment (education/occupation, midlife cognitive activity, and midlife physical activity) on Alzheimer disease (AD) biomarker trajectories using longitudinal imaging data (brain β-amyloid load via Pittsburgh compound B PET and neurodegene...


    pub_type: 杂志文章


    authors: Vemuri P,Lesnick TG,Przybelski SA,Knopman DS,Machulda M,Lowe VJ,Mielke MM,Roberts RO,Gunter JL,Senjem ML,Geda YE,Rocca WA,Petersen RC,Jack CR Jr

    更新日期:2016-03-22 00:00:00

  • A pilot randomized education rehabilitation trial is feasible in sickle cell and strokes.

    abstract::A randomized trial was completed to assess the feasibility of a 2-year education rehabilitation program for students with sickle cell disease and memory deficits. Eleven students were assigned to tutoring with or without memory training for 2 years. Eighty-two percent completed the program. Evidence of improvement in ...


    pub_type: 杂志文章,随机对照试验


    authors: King AA,White DA,McKinstry RC,Noetzel M,Debaun MR

    更新日期:2007-06-05 00:00:00

  • The biphasic pattern of age-specific malignant brain tumor mortality rates.

    abstract::Many aging-associated neurologic disorders, including primary malignant brain tumors (MBT), share a common biphasic age-specific mortality rate pattern: initially increasing exponentially with age, and then declining. A modeling study using MBT mortality was conducted to determine if the observed biphasic pattern of M...


    pub_type: 杂志文章,评审


    authors: Riggs JE

    更新日期:2000-09-26 00:00:00

  • Tissue inhibitor metalloproteinase-1 and clinical outcomes after acute ischemic stroke.

    abstract:OBJECTIVE:To prospectively investigate the relationships between serum tissue inhibitor metalloproteinase-1 (TIMP-1) and clinical outcomes in patients with acute ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline serum TIMP-1 concentrations were measured i...


    pub_type: 杂志文章


    authors: Zhong C,Wang G,Xu T,Zhu Z,Guo D,Zheng X,Wang A,Bu X,Peng H,Chen J,Xu T,Peng Y,Li Q,Ju Z,Geng D,He J,Zhang Y

    更新日期:2019-10-29 00:00:00

  • Analysis of MRI patterns aids prediction of progression in X-linked adrenoleukodystrophy.

    abstract:BACKGROUND:X-linked adrenoleukodystrophy (X-ALD) has variants with widely different outcomes, hampering clinical counseling and evaluation of therapies. OBJECTIVE:To evaluate the degree to which MRI patterns can predict lesion progression. METHODS:Two hundred six boys and men with cerebral X-ALD (median age 12.2 year...


    pub_type: 杂志文章


    authors: Loes DJ,Fatemi A,Melhem ER,Gupte N,Bezman L,Moser HW,Raymond GV

    更新日期:2003-08-12 00:00:00

  • Quantifying physical decline in juvenile neuronal ceroid lipofuscinosis (Batten disease).

    abstract:OBJECTIVE:To use the Unified Batten Disease Rating Scale (UBDRS) to measure the rate of decline in physical and functional capability domains in patients with juvenile neuronal ceroid lipofuscinosis (JNCL) or Batten disease, a neurodegenerative lysosomal storage disorder. We have evaluated the UBDRS in subjects with JN...


    pub_type: 杂志文章


    authors: Kwon JM,Adams H,Rothberg PG,Augustine EF,Marshall FJ,Deblieck EA,Vierhile A,Beck CA,Newhouse NJ,Cialone J,Levy E,Ramirez-Montealegre D,Dure LS,Rose KR,Mink JW

    更新日期:2011-11-15 00:00:00