Relative utility of 1H spectroscopic imaging and hippocampal volumetry in the lateralization of mesial temporal lobe epilepsy.


OBJECTIVES:To determine the relative utility of 1H MRSI and hippocampal volumetry for the lateralization of mesial temporal lobe epilepsy (MTLE) in patients with intractable epilepsy. BACKGROUND:MTLE is the most common partial-onset seizure disorder in patients undergoing temporal lobe epilepsy surgery. MR volumetry and spectroscopy are reliable preoperative imaging techniques for the lateralization of MTLE. METHODS:We analyzed the 1H MRSI and hippocampal formation volumes preoperatively in 30 consecutive patients who had undergone temporal lobectomy. RESULTS:Volumetry correctly lateralized the side of surgery in 93% of patients and 1H MRSI did so in 97% of patients. Incorrect lateralization occurred by volumetry in two patients and by 1H MRSI in one patient. Concordance between all MRI modalities was 73%. Pearson's analysis revealed no correlation between the degree of hippocampal volume loss and the creatine-to-N-acetylated-compounds ratio. CONCLUSIONS:Volumetry and 1H MRSI correctly lateralized most patients with MTLE and complement each other in final lateralization. The lack of correlation between the severity of volume loss and the degree of metabolic disturbance suggests that the techniques examine distinct pathophysiologic processes in MTLE.






Kuzniecky R,Hugg JW,Hetherington H,Butterworth E,Bilir E,Faught E,Gilliam F




Has Abstract


1998-07-01 00:00:00












  • Novel missense mutation in the early growth response 2 gene associated with Dejerine-Sottas syndrome phenotype.

    abstract:BACKGROUND:Mutations in the early growth response 2 (EGR2) gene have recently been found in patients with congenital hypomyelinating neuropathy and Charcot-Marie-Tooth type 1 (CMT1) disease. OBJECTIVE:To determine the frequency of EGR2 mutations in patients with a diagnosis of CMT1, Dejerine-Sottas syndrome (DSS), or ...


    pub_type: 杂志文章


    authors: Timmerman V,De Jonghe P,Ceuterick C,De Vriendt E,Löfgren A,Nelis E,Warner LE,Lupski JR,Martin JJ,Van Broeckhoven C

    更新日期:1999-06-10 00:00:00

  • 'Crescendo' transient ischemic attacks: clinical and angiographic correlations.

    abstract::Forty-seven consecutive patients presenting acutely with repetitive symptoms indicative of anterior circulation ischemia ("crescendo" transient ischemic attacks) were evaluated to identify clinical features that might reliably predict the presence of significant stenosis, ulceration, or both in the presumably symptoma...


    pub_type: 杂志文章


    authors: Rothrock JF,Lyden PD,Yee J,Wiederholt WC

    更新日期:1988-02-01 00:00:00

  • Significance of circadian rhythms in severely brain-injured patients: A clue to consciousness?

    abstract:OBJECTIVE:To investigate the relationship between the presence of a circadian body temperature rhythm and behaviorally assessed consciousness levels in patients with disorders of consciousness (DOC; i.e., vegetative state/unresponsive wakefulness syndrome or minimally conscious state). METHODS:In a cross-sectional stu...


    pub_type: 杂志文章


    authors: Blume C,Lechinger J,Santhi N,del Giudice R,Gnjezda MT,Pichler G,Scarpatetti M,Donis J,Michitsch G,Schabus M

    更新日期:2017-05-16 00:00:00

  • Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus.

    abstract:OBJECTIVE:To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. METHODS:We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was signif...


    pub_type: 杂志文章,多中心研究


    authors: Cervenka MC,Hocker S,Koenig M,Bar B,Henry-Barron B,Kossoff EH,Hartman AL,Probasco JC,Benavides DR,Venkatesan A,Hagen EC,Dittrich D,Stern T,Radzik B,Depew M,Caserta FM,Nyquist P,Kaplan PW,Geocadin RG

    更新日期:2017-03-07 00:00:00

  • Patient-centered outcomes: translating clinical efficacy into benefits on health-related quality of life.

    abstract:BACKGROUND:Multiple sclerosis (MS) is a neurodegenerative disease associated with marked impairments in health-related quality of life (HRQoL). Although standard clinical end points such as the Expanded Disability Status Scale and annualized relapse rate remain useful in assessing MS activity and severity, these measur...


    pub_type: 杂志文章


    authors: Miller D,Rudick RA,Hutchinson M

    更新日期:2010-04-27 00:00:00

  • Hallucinations and sleep disturbances in Parkinson's disease.

    abstract::Visual hallucinations (VHs) occur frequently in Parkinson's disease (PD). VHs occur more frequently in elderly patients with longer duration of illness, cognitive impairment, and sleep disturbances. The relationship between the use of antiparkinsonian drugs and VHs is complicated, but most drugs used to treat parkinso...


    pub_type: 杂志文章,评审


    authors: Kulisevsky J,Roldan E

    更新日期:2004-10-26 00:00:00

  • Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures.

    abstract:BACKGROUND:Previous studies have suggested a variety of factors that may be associated with the presence of hippocampal formation (HF) atrophy in patients with complex partial seizures (CPS), including a history of complex or prolonged febrile seizures (FS), age at seizure onset, and epilepsy duration. OBJECTIVE:To de...


    pub_type: 杂志文章


    authors: Theodore WH,Bhatia S,Hatta J,Fazilat S,DeCarli C,Bookheimer SY,Gaillard WD

    更新日期:1999-01-01 00:00:00

  • Practice variability in brain death determination: a call to action.

    abstract:OBJECTIVE:To characterize the present state of brain death (BD) determination in actual practice relative to contemporary American Academy of Neurology (AAN) guidelines. METHODS:We reviewed the charts of all adult (16 years and older) BD organ donors during 2011 from 68 heterogeneous hospitals in the Midwest United St...


    pub_type: 杂志文章,多中心研究


    authors: Shappell CN,Frank JI,Husari K,Sanchez M,Goldenberg F,Ardelt A

    更新日期:2013-12-03 00:00:00

  • APOE epsilon4 and the cognitive genetics of multiple sclerosis.

    abstract:BACKGROUND:Evidence linking APOE to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggests that it may be relevant in multiple sclerosis (MS). The purpose of this study was to determine whether the epsilon4 allele of APOE is associated with cognitive deficits in patients with MS. METHOD:Using...


    pub_type: 杂志文章


    authors: Ghaffar O,Reis M,Pennell N,O'Connor P,Feinstein A

    更新日期:2010-05-18 00:00:00

  • Vestibular perception in patients with acquired ophthalmoplegia.

    abstract::Using a perceptual technique it is shown that patients with chronic external ophthalmoplegia have shortened vestibular responses. It is postulated that this is secondary to the retinal image slip experienced by these patients during head movements and a useful compensatory mechanism to suppress motion-induced sickness...


    pub_type: 杂志文章


    authors: Grunfeld EA,Shallo-Hoffmann JA,Cassidy L,Okada T,Faldon M,Acheson JF,Bronstein AM

    更新日期:2003-06-24 00:00:00

  • PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations.

    abstract::The authors performed linkage analysis in 39 families with autosomal recessive early-onset PD (AR-EOPD) negative for parkin and DJ-1 mutations. Eight families including three Japanese, two Taiwanese, one Turkish, one Israeli, and one Philippine showed evidence of linkage with PARK6 with multipoint log of the odds (lod...


    pub_type: 杂志文章


    authors: Hatano Y,Sato K,Elibol B,Yoshino H,Yamamura Y,Bonifati V,Shinotoh H,Asahina M,Kobayashi S,Ng AR,Rosales RL,Hassin-Baer S,Shinar Y,Lu CS,Chang HC,Wu-Chou YH,Ataç FB,Kobayashi T,Toda T,Mizuno Y,Hattori N

    更新日期:2004-10-26 00:00:00

  • Cognition in multiple sclerosis: State of the field and priorities for the future.

    abstract::Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis (MS), especially deficits in episodic memory and processing speed. The field aims to (1) incorporate cognitive assessment into standard clinical care and clinical trials, (2) utilize state-of-the-art neuroimaging to more thor...


    pub_type: 杂志文章,评审


    authors: Sumowski JF,Benedict R,Enzinger C,Filippi M,Geurts JJ,Hamalainen P,Hulst H,Inglese M,Leavitt VM,Rocca MA,Rosti-Otajarvi EM,Rao S

    更新日期:2018-02-06 00:00:00

  • Evidence report: Genetic and metabolic testing on children with global developmental delay: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.

    abstract:OBJECTIVE:To systematically review the evidence concerning the diagnostic yield of genetic and metabolic evaluation of children with global developmental delay or intellectual disability (GDD/ID). METHODS:Relevant literature was reviewed, abstracted, and classified according to the 4-tiered American Academy of Neurolo...


    pub_type: 杂志文章,评审


    authors: Michelson DJ,Shevell MI,Sherr EH,Moeschler JB,Gropman AL,Ashwal S

    更新日期:2011-10-25 00:00:00

  • Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes.

    abstract:OBJECTIVE:To determine whether exposure to repetitive head impacts over a single season negatively affects cognitive performance in collegiate contact sport athletes. METHODS:This is a prospective cohort study at 3 Division I National Collegiate Athletic Association athletic programs. Participants were 214 Division I ...


    pub_type: 杂志文章


    authors: McAllister TW,Flashman LA,Maerlender A,Greenwald RM,Beckwith JG,Tosteson TD,Crisco JJ,Brolinson PG,Duma SM,Duhaime AC,Grove MR,Turco JH

    更新日期:2012-05-29 00:00:00

  • Depressive symptoms and white matter dysfunction in retired NFL players with concussion history.

    abstract:OBJECTIVE:To determine whether correlates of white matter integrity can provide general as well as specific insight into the chronic effects of head injury coupled with depression symptom expression in professional football players. METHOD:We studied 26 retired National Football League (NFL) athletes who underwent dif...


    pub_type: 杂志文章


    authors: Strain J,Didehbani N,Cullum CM,Mansinghani S,Conover H,Kraut MA,Hart J Jr,Womack KB

    更新日期:2013-07-02 00:00:00

  • Idiopathic intracranial hypertension: relationship to depression, anxiety, and quality of life.

    abstract:OBJECTIVE:To explore the incidence of depression and anxiety and to measure quality of life in women with idiopathic intracranial hypertension (IIH), a matched group cross-sectional study was conducted. Women with IIH (n = 28) were compared with control groups of weight- and age-matched women not diagnosed with IIH (n ...


    pub_type: 杂志文章


    authors: Kleinschmidt JJ,Digre KB,Hanover R

    更新日期:2000-01-25 00:00:00

  • Hereditary neuropathy with upper motor-neuron, visual pathway, and autonomic disorders.

    abstract::A 42-year-old man had progressive distal weakness and muscle atrophy, stocking-type sensory loss, upper motor-neuron and visual pathway lesions, and dysautonomia. Electrodiagnostic tests revealed a generalized sensorimotor peripheral neuropathy that largely involved axons. Low recumbent and upright norepinephrine leve...


    pub_type: 杂志文章


    authors: Rechthand E,Reife R,Kaplan JG

    更新日期:1983-11-01 00:00:00

  • Relationship between Meige syndrome and alpha-methyldopa-induced parkinsonism.

    abstract::We studied two patients with Meige syndrome who developed alpha-methyldopa-induced parkinsonism. Opposite responses of parkinsonian and dystonic symptoms to antiparkinson drugs in some cases suggest a functionally reciprocal relationship between these disorders. ...


    pub_type: 杂志文章


    authors: Sechi GP,Demontis G,Rosati G

    更新日期:1985-11-01 00:00:00

  • Right hippocampal sclerosis is more common than left after febrile seizures.

    abstract::Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis (HS) and a history of febrile convulsions (HFC). The authors investigated 292 patients with TLE due to HS. Left HS occurred more frequently (57%) than right HS (43%, p = 0.01). Forty-seven percent of the patients had HFC. In patients with...


    pub_type: 临床试验,杂志文章


    authors: Janszky J,Woermann FG,Barsi P,Schulz R,Halász P,Ebner A

    更新日期:2003-04-08 00:00:00

  • Dantrolene sodium and hepatic injury.

    abstract::This is a report on hepatic adverse events associated with dantrolene therapy. All cases reported to the manufacturer are included, from all sources, through 1987. Of 122 cases containing sufficient data to analyze, 47 patients had asymptomatic transaminase elevations, 12 had additional mild (less than or equal to 2.5...


    pub_type: 杂志文章


    authors: Chan CH

    更新日期:1990-09-01 00:00:00

  • Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study.

    abstract:OBJECTIVE:The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. METHODS:To resolve this is...


    pub_type: 杂志文章


    authors: Robert GH,Le Jeune F,Lozachmeur C,Drapier S,Dondaine T,Péron J,Houvenaghel JF,Travers D,Sauleau P,Millet B,Vérin M,Drapier D

    更新日期:2014-10-28 00:00:00

  • Effect of diet on exercise tolerance in carnitine palmitoyltransferase II deficiency.

    abstract::It is generally believed that a diet high in carbohydrate improves exercise tolerance in patients with carnitine palmitoyltransferase II (CPT II) deficiency, but it has never been systematically investigated. The authors investigated the effect of a high- vs low-carbohydrate diet on exercise tolerance in four patients...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ørngreen MC,Ejstrup R,Vissing J

    更新日期:2003-08-26 00:00:00

  • Retinal pathology in idiopathic moyamoya angiopathy detected by optical coherence tomography.

    abstract:OBJECTIVE:To investigate whether patients with moyamoya angiopathy without obvious retinal pathologies such as retinal infarctions or the congenital morning glory anomaly may have subtle subclinical retinal changes. METHODS:In this cross-sectional study, spectral domain optical coherence tomography was used to analyze...


    pub_type: 杂志文章


    authors: Albrecht P,Blasberg C,Lukas S,Ringelstein M,Müller AK,Harmel J,Kadas EM,Finis D,Guthoff R,Aktas O,Hartung HP,Paul F,Brandt AU,Berlit P,Methner A,Kraemer M

    更新日期:2015-08-11 00:00:00

  • Semantic memory activation in individuals at risk for developing Alzheimer disease.

    abstract:OBJECTIVE:To determine whether whole-brain, event-related fMRI can distinguish healthy older adults with known Alzheimer disease (AD) risk factors (family history, APOE epsilon4) from controls using a semantic memory task involving discrimination of famous from unfamiliar names. METHODS:Sixty-nine cognitively asymptom...


    pub_type: 杂志文章


    authors: Seidenberg M,Guidotti L,Nielson KA,Woodard JL,Durgerian S,Antuono P,Zhang Q,Rao SM

    更新日期:2009-08-25 00:00:00

  • Reversible alexia, mitochondrial myopathy, and lactic acidemia.

    abstract::A 11-year-old boy of short stature had recurrent right temporal pounding headaches of 7 months' duration, and progressive visual loss for 3 days. There was a left hemianopia, alexia without agraphia, and diffuse muscle weakness. Investigation established the presence of a mitochondrial myopathy with pyruvate and lacti...


    pub_type: 杂志文章


    authors: Skoglund RR

    更新日期:1979-05-01 00:00:00

  • Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination.

    abstract:OBJECTIVE:We investigated mitochondrial DNA (mtDNA) variants in children with a first episode of acquired demyelinating syndromes (PD-ADS) of the CNS and their relationship to disease phenotype, including subsequent diagnosis of multiple sclerosis (MS). METHODS:This exploratory analysis included the initial 213 childr...


    pub_type: 杂志文章


    authors: Venkateswaran S,Zheng K,Sacchetti M,Gagne D,Arnold DL,Sadovnick AD,Scherer SW,Banwell B,Bar-Or A,Simon DK,Canadian Pediatric Demyelinating Disease Network.

    更新日期:2011-03-01 00:00:00

  • Proximal myotonic myopathy with MRI white matter abnormalities of the brain.

    abstract::Proximal myotonic myopathy (PROMM) is an autosomal dominantly inherited multisystemic disorder characterized by myotonia, proximal muscle weakness, and cataracts. This disorder is not linked to the gene locus of myotonic dystrophy (DM). We describe three new families with PROMM. In all patients, CTG repeats of the DM ...


    pub_type: 杂志文章


    authors: Hund E,Jansen O,Koch MC,Ricker K,Fogel W,Niedermaier N,Otto M,Kuhn E,Meinck HM

    更新日期:1997-01-01 00:00:00

  • The 5-year risk of MS after optic neuritis. Experience of the optic neuritis treatment trial.

    abstract::The objective of our study was to assess the 5-year risk of and prognostic factors for the development of clinically definite multiple sclerosis (CDMS) following optic neuritis. In a prospective cohort study design, 388 patients, who did not have probable or definite MS at study entry enrolled in the Optic Neuritis Tr...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Optic Neuritis Study Group.

    更新日期:1997-11-01 00:00:00

  • Summary of evidence-based guideline update: evaluation and management of concussion in sports: report of the Guideline Development Subcommittee of the American Academy of Neurology.

    abstract:OBJECTIVE:To update the 1997 American Academy of Neurology (AAN) practice parameter regarding sports concussion, focusing on 4 questions: 1) What factors increase/decrease concussion risk? 2) What diagnostic tools identify those with concussion and those at increased risk for severe/prolonged early impairments, neurolo...


    pub_type: 杂志文章,评审


    authors: Giza CC,Kutcher JS,Ashwal S,Barth J,Getchius TS,Gioia GA,Gronseth GS,Guskiewicz K,Mandel S,Manley G,McKeag DB,Thurman DJ,Zafonte R

    更新日期:2013-06-11 00:00:00

  • Homolateral ataxia and crural paresis: case report.

    abstract::Homolateral ataxia and crural paresis is a recognized vascular syndrome. However, confirmation of the causative lesion rests principally on one earlier case with multiple other infarcts. We studied a patient with the clinical syndrome; computerized tomography revealed a lucency that appeared within 1 week of the infar...


    pub_type: 杂志文章


    authors: Perman GP,Racy A

    更新日期:1980-09-01 00:00:00