Abstract:
OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESULTS:During a mean follow-up period of 18.8 years, 272 men and 254 women developed incident PD. After adjustment for confounding factors (age, study years, systolic blood pressure, total cholesterol, education, leisure-time physical activity, smoking, and alcohol, coffee, and tea consumption), the HRs of PD at different levels of BMI (<23, 23 to 24.9, 25 to 26.9, 27 to 29.9, and > or =30 kg/m(2)) were 1.00, 1.97 (95% CI: 1.21 to 3.22), 1.83 (95% CI: 1.12 to 2.99), 2.34 (95% CI: 1.45 to 3.78), and 2.44 (95% CI: 1.44 to 4.15) in men, and 1.00, 1.50 (95% CI: 0.95 to 2.37), 1.65 (95% CI: 1.05 to 2.59), 1.79 (95% CI: 1.15 to 2.80), and 1.77 (95% CI: 1.12 to 2.78) in women, and 1.00, 1.70 (95% CI: 1.23 to 2.37), 1.70 (95% CI: 1.23 to 2.37), 2.02 (95% CI: 1.46 to 2.79), and 2.03 (95% CI: 1.44 to 2.85) in men and women combined (adjusted also for sex). In both sexes combined, the multivariate-adjusted direct association between BMI and the risk of PD was present both in subjects aged 25 to 49 years and 50 to 59 years, in never smokers and smokers and in participants diagnosed PD before and after 65 years of age. CONCLUSION:Body mass index is associated with a risk of Parkinson disease. The effect is graded and independent of other risk factors.
journal_name
Neurologyjournal_title
Neurologyauthors
Hu G,Jousilahti P,Nissinen A,Antikainen R,Kivipelto M,Tuomilehto Jdoi
10.1212/01.wnl.0000247052.18422.e5subject
Has Abstractpub_date
2006-12-12 00:00:00pages
1955-9issue
11eissn
0028-3878issn
1526-632Xpii
67/11/1955journal_volume
67pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:BACKGROUND:The neurodegenerative process in Alzheimer's disease (AD) and in the Lewy body variant of AD (LBV) patients is characterized by cholinergic dysfunction and deposition of amyloid beta-peptide (Abeta) 1-40 and 1-42; however, the differential effects of Abeta species on the cholinergic system are not completely...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073987.79060.4b
更新日期:2003-07-22 00:00:00
abstract::We studied the effect of acetazolamide on plasma potassium in normals and in two patients with hyperkalemic periodic paralysis. Administration of acetazolamide for 48 hours lowered mean plasma potassium in normals from 4.01 to 3.56 mEq per liter (p less than 0.001) and in the patients from 4.55 to 4.00 mEq per liter (...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.6.725
更新日期:1981-06-01 00:00:00
abstract::Co-morbid conditions frequently occur in childhood epilepsy and may significantly affect epilepsy and its treatment. Similarly, epilepsy and antiepileptic drugs (AEDs) may affect these associated conditions. Co-morbidities that have a significant association with childhood epilepsy include attention-deficit/hyperactiv...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.62.5_suppl_2.s17
更新日期:2004-03-09 00:00:00
abstract::Quantitative studies of the afferent pathways from hollow viscera have been limited by the lack of an easily controlled, reproducible visceral stimulus. We adapted a slow distention device to allow for rapid distention to study the afferent pathways from the rectum. The device produced a pressure increase of 10 mm Hg ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.8.1510
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Findings from a small clinical study suggested that statins may counteract the therapeutic effects of interferon beta (IFNbeta) in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS:We conducted a post hoc analysis of data from the Safety and Efficacy of Natalizumab in Combination With IFN...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/WNL.0b013e3181a92b96
更新日期:2009-06-09 00:00:00
abstract::We present an 11-year-old girl in whom high field strength MRI performed 2 1/2 years and 6 months before her death showed prominent hypointensity in the globus pallidus and substantia nigra consistent with iron deposition. This finding suggested Hallervorden-Spatz disease, which was confirmed at autopsy. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.3.440
更新日期:1989-03-01 00:00:00
abstract::Machado-Joseph disease is a dominantly inherited, multisystem, degenerative disorder that lacks a proven genetic marker. Peripheral nerve conduction-refractory period, sensory evoked potentials, and quantified oculomotor recordings were studied in nine patients affected with this disease to look for a potential physio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.1.112
更新日期:1987-01-01 00:00:00
abstract::Proton nuclear magnetic resonance spectroscopy is a noninvasive technique allowing the localized, in vivo detection of proton-containing brain metabolites. We used this technique to study eight patients with cerebral infarction or ischemia. A stimulated echo-pulse sequence with chemical shift imaging was used to acqui...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.7.1408
更新日期:1992-07-01 00:00:00
abstract::The apolipoprotein E gene has been associated with various types of dementia. We studied the connection between the APOE gene and the risk and onset of disease in 34 patients with clinically diagnosed frontal lobe dementia (FLD) derived from a population-based study in the Netherlands. A significant increased risk of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.6.1526
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:To compare the prognostic accuracy of various acute stroke prognostic scales using a large, independent, clinical trials dataset. METHODS:We directly compared 8 stroke prognostic scales, chosen based on focused literature review (Acute Stroke Registry and Analysis of Lausanne [ASTRAL]; iSCORE; iSCORE-revised...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004332
更新日期:2017-09-05 00:00:00
abstract:OBJECTIVE:To investigate the genotype-phenotype correlation between neurofibromatosis 1 (NF1) germline mutations and imaging features of neurofibromas on whole-body MRI (WBMRI) by using radiomics image analysis techniques. MATERIALS AND METHODS:Twenty-nine patients with NF1 who had known germline mutations determined ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009490
更新日期:2020-06-16 00:00:00
abstract::About 9% of patients presenting to a Huntington disease (HD) clinic for evaluation of possible HD lacked a family history of the disorder. HD was the final diagnosis in 53 to 83% of these patients. As a group, HD-affected individuals without a family history of HD were older and had fewer CAG repeats than the average ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.6.1578
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:Guillain-Barré syndrome (GBS) is characterized by nerve infiltration of leukocytes and autoantibodies of the immunoglobulin G (IgG) isotype directed against nerve constituents. Leukocyte receptors for IgG (FcgammaR) constitute an important link between the humoral and cellular parts of the immune system and c...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.54.8.1661
更新日期:2000-04-25 00:00:00
abstract:OBJECTIVE:Glucocerebrosidase (GBA) gene mutations represent a strong risk factor for Parkinson disease (PD). PD penetrance in GBA mutation carriers, which represents a key issue for genetic counseling, especially for relatives of patients with Gaucher disease (GD), is unknown. Our objective was to estimate PD penetranc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318245f476
更新日期:2012-02-07 00:00:00
abstract:OBJECTIVE:To characterize prospectively the cognitive profile in ALS. METHODS:Clinically definite ALS patients (11 men, 2 women), age 39.9 to 74.0 years (mean age, 54.2 +/- 9.6 years; mean disease duration, 21.1 +/- 10.5 months) underwent neuropsychologic, language, and speech testing followed by MR 1H spectroscopy (4...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.8.1665
更新日期:1999-11-10 00:00:00
abstract:OBJECTIVE:To cross-sectionally compare the regional white matter fractional anisotropy (FA) of cognitively normal (CN) older individuals and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), separately focusing on the normal-appearing white matter (NAWM) and white matter hyperintensities (WMH), ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c33afb
更新日期:2009-11-24 00:00:00
abstract:OBJECTIVE:To determine whether 24 weeks of high-intensity progressive aerobic exercise (PAE) affects brain MRI measures in people with multiple sclerosis (MS). METHODS:We conducted a randomized, controlled, phase 2 trial (with a crossover follow-up) including an exercise group (supervised PAE followed by self-guided p...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000011241
更新日期:2021-01-12 00:00:00
abstract::We studied the effects of acute ethanol intoxication on platelet function, coagulation factors, and fibrinolytic activity in 12 healthy men. During the ethanol session, 10 of the 12 developed a transient decrease in fibrinolytic activity. Ethanol ingestion increased factor VIII coagulant activity. VIII-related antigen...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.3.381
更新日期:1983-03-01 00:00:00
abstract::This article presents the findings relating to the European subgroup of 91 patients in an international survey of the current diagnosis and treatment of patients with amyotrophic lateral sclerosis (ALS). The mean time between first symptoms and first consultation with a physician was 4.9 months, and mean delay in seei...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:The major histocompatibility complex (MHC) has been consistently associated with susceptibility to MS and the course of several other human autoimmune diseases. A putative association between the course and severity of MS and the MHC remains controversial. METHODS:DR and DQ genotyping by either restriction ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.3.742
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:X-linked adrenoleukodystrophy (X-ALD) has variants with widely different outcomes, hampering clinical counseling and evaluation of therapies. OBJECTIVE:To evaluate the degree to which MRI patterns can predict lesion progression. METHODS:Two hundred six boys and men with cerebral X-ALD (median age 12.2 year...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000079050.91337.83
更新日期:2003-08-12 00:00:00
abstract::We report the clinical and neuroimaging findings of a mother and daughter with seizure disorders and band heterotopias seen on magnetic resonance imaging studies. These clinicoradiologic findings simulate those for a diagnosis of tuberous sclerosis complex. Clinicians should be aware of this migrational anomaly and it...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.7.1424
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To assess the frequency of this finding in patients with minor stroke and TIAs compared to those with stroke mimics and to evaluate the level of agreement between examiners to detect an upgoing thumb sign. METHODS:We previously reported an upgoing thumb sign as a subtle clinical finding in patients with tran...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004157
更新日期:2017-07-25 00:00:00
abstract:BACKGROUND:Periodic paralyses and paramyotonia congenita are rare disorders causing disabling weakness and myotonia. Mutations in sodium, calcium, and potassium channels have been recognized as causing disease. OBJECTIVE:To analyze the clinical phenotype of patients with and without discernible genotype and to identif...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000143383.91137.00
更新日期:2004-11-09 00:00:00
abstract::CSF hypocretin-1 levels at 6 PM did not significantly differ between patients with restless legs syndrome (RLS) and control subjects as measured by direct radioimmunoassay and after acid extraction. The authors did not observe significant differences between early onset and late onset RLS. Hypocretin-1 levels did not ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000094196.50155.38
更新日期:2003-11-25 00:00:00
abstract:BACKGROUND:Patients with arm intention tremor due to multiple sclerosis (MS) often manifest eye movement deficits, illustrating the role of infratentorial brain in both ocular and manual movement control. Our previous study showed that both the amplitude of intention tremor and eye fixational movements were greatly enh...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000287071.51180.b1
更新日期:2008-01-08 00:00:00
abstract::A young girl who initially presented with jaw hypomobility at age 4 years subsequently developed signs of a slowly progressive myopathy. Rods were found in all sampled muscles, and were associated with fibrous contractures in the temporomandibular joint muscles. Rods in fibers undergoing necrosis displayed a pattern o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.9.971
更新日期:1980-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the muscle biopsy findings from 240 patients who had isolated muscle pain. METHODS:Histopathology, immunohistochemistry for dystrophin, dystrophin-related proteins, major histocompatibility complex type I, and biochemical analysis of glycolytic and mitochondrial respiratory chain enzymes were per...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000252252.29532.cc
更新日期:2007-01-16 00:00:00
abstract:BACKGROUND:UK veterans who were deployed to the Gulf in 1990 to 1991 reported higher prevalence of neuromuscular symptoms. OBJECTIVE:To investigate whether these Gulf War-related symptoms were associated with objective evidence of neuromuscular dysfunction. METHODS:Forty-nine Gulf War veterans with more than four neu...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000032755.27372.fc
更新日期:2002-11-26 00:00:00
abstract::The authors performed serial transcranial Doppler (TCD) and carbon dioxide reactivity (CO2R) testing in 20 aneurysmal subarachnoid hemorrhage patients to determine whether impaired cerebrovascular reactivity was associated with symptomatic vasospasm. Symptomatic vasospasm occurred in 9 of 14 patients with abnormal CO2...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000200777.96896.3d
更新日期:2006-03-14 00:00:00