Predictors of incident epilepsy in older adults: The Cardiovascular Health Study.


OBJECTIVE:To determine the prevalence, incidence, and predictors of epilepsy among older adults in the Cardiovascular Health Study (CHS). METHODS:We analyzed data prospectively collected in CHS and merged with data from outpatient Medicare administrative claims. We identified cases with epilepsy using self-report, antiepileptic medication, hospitalization discharge ICD-9 codes, and outpatient Medicare ICD-9 codes. We used Cox proportional hazards regression to identify factors independently associated with incident epilepsy. RESULTS:At baseline, 42% of the 5,888 participants were men and 84% were white. At enrollment, 3.7% (215 of 5,888) met the criteria for prevalent epilepsy. During 14 years of follow-up totaling 48,651 person-years, 120 participants met the criteria for incident epilepsy, yielding an incidence rate of 2.47 per 1,000 person-years. The period prevalence of epilepsy by the end of follow-up was 5.7% (335 of 5,888). Epilepsy incidence rates were significantly higher among blacks than nonblacks: 4.44 vs 2.17 per 1,000 person-years (p < 0.001). In multivariable analyses, risk of incident epilepsy was significantly higher among blacks compared to nonblacks (hazard ratio [HR] 4.04, 95% confidence interval [CI] 1.99-8.17), those 75 to 79 compared to those 65 to 69 years of age (HR 2.07, 95% CI 1.21-3.55), and those with history of stroke (HR 3.49, 95% CI 1.37-8.88). CONCLUSIONS:Epilepsy in older adults in the United States was common. Blacks, the very old, and those with history of stroke have a higher risk of incident epilepsy. The association with race remains unexplained.






Choi H,Pack A,Elkind MS,Longstreth WT Jr,Ton TG,Onchiri F




Has Abstract


2017-02-28 00:00:00














  • Tracheostomy can fatally exacerbate sleep-disordered breathing in multiple system atrophy.

    abstract::Tracheostomy has been employed to release the airway obstruction at the glottic level and to prevent sudden death in patients with multiple system atrophy (MSA). However, sudden death is possible even after tracheostomy. Nocturnal polysomnography showed that the apnea-hypopnea index became higher after tracheostomy, a...


    pub_type: 杂志文章


    authors: Jin K,Okabe S,Chida K,Abe N,Kimpara T,Ohnuma A,Nomura H,Itoyama Y,Onodera H

    更新日期:2007-05-08 00:00:00

  • Physical activity and the association with sporadic ALS.

    abstract:OBJECTIVE:To assess whether lifetime physical activity during work and leisure time is associated with an increased risk of developing ALS and to determine the association between physical activity and duration or age at onset of disease. METHODS:Patients referred to our clinic during the 1-year period 2001 to 2002 wh...


    pub_type: 杂志文章,评审


    authors: Veldink JH,Kalmijn S,Groeneveld GJ,Titulaer MJ,Wokke JH,van den Berg LH

    更新日期:2005-01-25 00:00:00

  • 'Sympathetically maintained pain.' I. Phentolamine block questions the concept.

    abstract::Patients with "reflex sympathetic dystrophy" or "causalgia" underwent sympathetic blocks. In protocol A (77 patients), we infused placebo (saline) for 30 minutes followed by phentolamine (35 mg). In protocol B (23 patients), the saline phase was followed by double-blind infusion of phentolamine or phenylephrine (500 m...


    pub_type: 临床试验,杂志文章


    authors: Verdugo RJ,Ochoa JL

    更新日期:1994-06-01 00:00:00

  • Levodopa-induced dyskinesia in Parkinson disease: A population-based cohort study.

    abstract:OBJECTIVE:To assess dyskinesia frequency in a population-based cohort of patients with Parkinson disease (PD). Dyskinesia complicates levodopa treatment and affects quality of life. METHODS:Utilizing the 1991-2010 population-based, parkinsonism-incident cohort of Olmsted County, MN (n = 669), accessed via the Rocheste...


    pub_type: 杂志文章


    authors: Turcano P,Mielke MM,Bower JH,Parisi JE,Cutsforth-Gregory JK,Ahlskog JE,Savica R

    更新日期:2018-12-11 00:00:00

  • Molecular basis of hypokalemic myopathy caused by 17alpha-hydroxylase/17,20-lyase deficiency.

    abstract::We describe a 28-year-old woman presenting with hypokalemic myopathy caused by 17alpha-hydroxylase/17,20-lyase deficiency caused by a homozygous mutation consisting of a G-to-C transition in the initiation codon in exon 1 of the CYP17 gene resulting in expression of an enzymatically inactive truncated P450c17 protein....


    pub_type: 杂志文章


    authors: Satoh J,Kuroda Y,Nawata H,Yanase T

    更新日期:1998-12-01 00:00:00

  • Pathologic findings in prospectively ascertained essential tremor subjects.

    abstract:OBJECTIVE:To assess pathologic changes in prospectively characterized subjects with essential tremor (ET). METHODS:Subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program were examined annually by a movement disorders neurologist, and semiannually by a behavioral neurologist and neuropsy...


    pub_type: 杂志文章


    authors: Shill HA,Adler CH,Sabbagh MN,Connor DJ,Caviness JN,Hentz JG,Beach TG

    更新日期:2008-04-15 00:00:00

  • Familial recurrent Bell's palsy with ocular motor palsies.

    abstract::We studied a family in which the father and 7 of 10 children had episodes of Bell's palsy. Five of the eight affected family members also had ocular motor palsies. Facial nerve and blink reflex studies in four affected siblings demonstrated asymmetrically reduced amplitude of evoked responses without delayed conductio...


    pub_type: 杂志文章


    authors: Aldrich MS,Beck RW,Albers JW

    更新日期:1987-08-01 00:00:00

  • 3-O-methyldopa and motor fluctuations in Parkinson's disease.

    abstract::High plasma levels of 3-O-methyldopa (OMD) were found in parkinsonian patients chronically treated with levodopa, particularly in those with on-off phenomenon. However, no relation could be established between circulating levels of the levodopa metabolite and the presence of motor response fluctuations at any stage of...


    pub_type: 杂志文章


    authors: Fabbrini G,Juncos JL,Mouradian MM,Serrati C,Chase TN

    更新日期:1987-05-01 00:00:00

  • Relationship of UV exposure to prevalence of multiple sclerosis in England.

    abstract:OBJECTIVE:To assess the potential relationship of ultraviolet B radiation (UVB) and Epstein-Barr virus (EBV) exposure in explaining the period prevalence of multiple sclerosis (MS) in England. METHODS:English national Hospital Episode Statistics covering all admissions to National Health Service hospitals in England i...


    pub_type: 杂志文章


    authors: Ramagopalan SV,Handel AE,Giovannoni G,Rutherford Siegel S,Ebers GC,Chaplin G

    更新日期:2011-04-19 00:00:00

  • Multifocal motor neuropathy: serum IgM binding to a GM1 ganglioside-containing lipid mixture but not to GM1 alone.

    abstract::IgM anti-GM1 antibodies are associated with motor neuropathy syndromes, including multifocal motor neuropathy (MMN). We compared the ability of serum IgM from patients with multifocal motor neuropathy to bind to GM1 ganglioside alone and to GM1 as a component of a lipid mixture that also contained galactocerebroside a...


    pub_type: 杂志文章


    authors: Pestronk A,Choksi R,Blume G,Lopate G

    更新日期:1997-04-01 00:00:00

  • Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies.

    abstract::The Israeli Teratogen Information Service prospectively followed up 210 pregnancies with first trimester carbamazepine exposure. Pregnancy outcome was compared with that of two overlapping controls, matched and general (n = 629), exposed to nonteratogenic agents. Our study suggests a twofold increase in the rate of ma...


    pub_type: 杂志文章


    authors: Diav-Citrin O,Shechtman S,Arnon J,Ornoy A

    更新日期:2001-07-24 00:00:00

  • Plasmapheresis in multiple sclerosis: prospective trial of pheresis and immunosuppression versus immunosuppression alone.

    abstract::A prospective trial of plasmapheresis and azathioprine or azathioprine alone was carrier out on 20 patients with chronic progressive MS. Seven of 10 patients in each group continued therapy for 12 months. When the groups were compared by disability ratings, the combination of plasmapheresis and azathioprine was no bet...


    pub_type: 杂志文章


    authors: Tindall RS,Walker JE,Ehle AL,Near L,Rollins J,Becker D

    更新日期:1982-07-01 00:00:00

  • Dementia in Down's syndrome: cerebral glucose utilization, neuropsychological assessment, and neuropathology.

    abstract::We measured the cerebral metabolic rate for glucose (CMRglc) with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in a 47-year-old man with trisomy 21 Down's syndrome (DS) and autopsy-confirmed Alzheimer's disease. Dementia was evident from a confirmed history of cognitive decline, memory loss, and pe...


    pub_type: 杂志文章


    authors: Schapiro MB,Ball MJ,Grady CL,Haxby JV,Kaye JA,Rapoport SI

    更新日期:1988-06-01 00:00:00

  • Treatment of sporadic inclusion body myositis with bimagrumab.

    abstract:OBJECTIVE:To study activin signaling and its blockade in sporadic inclusion body myositis (sIBM) through translational studies and a randomized controlled trial. METHODS:We measured transforming growth factor β signaling by SMAD2/3 phosphorylation in muscle biopsies of 50 patients with neuromuscular disease (17 with s...


    pub_type: 杂志文章,随机对照试验


    authors: Amato AA,Sivakumar K,Goyal N,David WS,Salajegheh M,Praestgaard J,Lach-Trifilieff E,Trendelenburg AU,Laurent D,Glass DJ,Roubenoff R,Tseng BS,Greenberg SA

    更新日期:2014-12-09 00:00:00

  • In vivo studies on striatal dopamine D1 and D2 site binding in L-dopa-treated Parkinson's disease patients with and without dyskinesias.

    abstract::Dyskinesias are usually seen in Parkinson's disease (PD) patients after several years of L-dopa therapy. Their presence has been attributed to supersensitivity of striatal D1 and D2 receptors. We have used PET to assess striatal D2 receptor binding in untreated PD patients and striatal D1 and D2 binding in L-dopa-trea...


    pub_type: 杂志文章


    authors: Turjanski N,Lees AJ,Brooks DJ

    更新日期:1997-09-01 00:00:00

  • Guillain-Barré syndrome after epidural anesthesia: direct nerve root damage may trigger disease.

    abstract::Guillain-Barré syndrome (GBS) appeared in four patients 1 to 2 weeks after epidural anesthesia. In all patients, clinical diagnosis was confirmed by CSF findings and nerve conduction velocity studies. Although epidural anesthesia has not been listed as an antecedent event in GBS, evidence for the relationship has been...


    pub_type: 杂志文章


    authors: Steiner I,Argov Z,Cahan C,Abramsky O

    更新日期:1985-10-01 00:00:00

  • Anti-neutral glycolipid antibodies in encephalomyeloradiculoneuropathy.

    abstract:OBJECTIVE:The aim of this study was to review 4 patients with encephalomyeloradiculoneuropathy (EMRN) and assess for autoantibodies against neutral glycolipids. METHODS:We studied the progression of clinical, radiologic, neurophysiologic, and CSF findings, as well as anti-neutral glycolipid antibodies in sera. RESULT...


    pub_type: 杂志文章


    authors: Shima S,Kawamura N,Ishikawa T,Masuda H,Iwahara C,Niimi Y,Ueda A,Iwabuchi K,Mutoh T

    更新日期:2014-01-14 00:00:00

  • Acoustic reflex abnormalities in cranial-cervical dystonia.

    abstract::Previous anatomic and physiologic studies suggest brainstem dysfunction in cranial-cervical dystonia. To further explore this, we studied suprathreshold acoustic reflex waveforms in 15 such patients. A unique feature of this technique is its ability to reject movement artifacts before averaging the acoustic reflex wav...


    pub_type: 杂志文章


    authors: Lew H,Jordan C,Jerger J,Jankovic J

    更新日期:1992-03-01 00:00:00

  • Cognitive training in Parkinson disease: cognition-specific vs nonspecific computer training.

    abstract:OBJECTIVE:In this study, we compared a cognition-specific computer-based cognitive training program with a motion-controlled computer sports game that is not cognition-specific for their ability to enhance cognitive performance in various cognitive domains in patients with Parkinson disease (PD). METHODS:Patients with...


    pub_type: 杂志文章


    authors: Zimmermann R,Gschwandtner U,Benz N,Hatz F,Schindler C,Taub E,Fuhr P

    更新日期:2014-04-08 00:00:00

  • The prevalence of MS in the United States: A population-based estimate using health claims data.

    abstract:OBJECTIVE:To generate a national multiple sclerosis (MS) prevalence estimate for the United States by applying a validated algorithm to multiple administrative health claims (AHC) datasets. METHODS:A validated algorithm was applied to private, military, and public AHC datasets to identify adult cases of MS between 200...


    pub_type: 杂志文章


    authors: Wallin MT,Culpepper WJ,Campbell JD,Nelson LM,Langer-Gould A,Marrie RA,Cutter GR,Kaye WE,Wagner L,Tremlett H,Buka SL,Dilokthornsakul P,Topol B,Chen LH,LaRocca NG,US Multiple Sclerosis Prevalence Workgroup.

    更新日期:2019-03-05 00:00:00

  • Cervical puncture to deliver nusinersen in patients with spinal muscular atrophy.

    abstract:OBJECTIVE:To report our experience delivering intrathecal nusinersen through cervical puncture in patients with spinal muscular atrophy (SMA) with no lumbar access. BACKGROUND:SMA is a neuromuscular disorder characterized by profound muscle weakness, atrophy, and paralysis due to degeneration of the anterior horn cell...


    pub_type: 杂志文章


    authors: Veerapandiyan A,Pal R,D'Ambrosio S,Young I,Eichinger K,Collins E,Westesson PL,Kwon J,Ciafaloni E

    更新日期:2018-08-14 00:00:00

  • Alteration of calcium transport in Duchenne erythrocytes.

    abstract::Erythrocyte calcium transport as a function of free [Ca++] was examined using inside-out vesicles from eight pairs of patients with Duchenne dystrophy and age- and sex-matched controls. The Km for Ca++ of the transport protein and the Vmax were higher in the Duchenne vesicles in seven of the eight pairs. The mean Km a...


    pub_type: 杂志文章


    authors: Mollman JE,Cardenas JC,Pleasure DE

    更新日期:1980-11-01 00:00:00

  • A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III).

    abstract:OBJECTIVE:To replicate the beneficial effect of brain-derived neurotrophic factor (BDNF) in 1,135 ALS patients in a multicenter trial. BACKGROUND:In a phase I through II study, BDNF appeared to increase survival and retard loss of pulmonary function in ALS patients. METHODS:Patients were randomized to placebo, or 25 ...


    pub_type: 临床试验,杂志文章,随机对照试验



    更新日期:1999-04-22 00:00:00

  • Firing rates of human motor units in partially denervated muscle.

    abstract::Single motor unit firing rates were measured from the first dorsal interosseous muscle (FDI) of normal subjects and patients with partial denervation of that muscle. Motor unit discharges were recorded at various levels of voluntary, stationary, isometric contraction of the FDI. The mean increase in firing rate associ...


    pub_type: 杂志文章


    authors: Miller RG,Sherratt M

    更新日期:1978-12-01 00:00:00

  • Incidence of acquired demyelination of the CNS in Canadian children.

    abstract:BACKGROUND:The incidence of acquired demyelination of the CNS (acquired demyelinating syndromes [ADS]) in children is unknown. It is important that physicians recognize the features of ADS to facilitate care and to appreciate the future risk of multiple sclerosis (MS). OBJECTIVE:To determine the incidence, clinical fe...


    pub_type: 杂志文章


    authors: Banwell B,Kennedy J,Sadovnick D,Arnold DL,Magalhaes S,Wambera K,Connolly MB,Yager J,Mah JK,Shah N,Sebire G,Meaney B,Dilenge ME,Lortie A,Whiting S,Doja A,Levin S,MacDonald EA,Meek D,Wood E,Lowry N,Buckley D,Yim

    更新日期:2009-01-20 00:00:00

  • Hyperglycemia predicts poststroke infections in acute ischemic stroke.

    abstract:OBJECTIVE:To investigate whether admission hyperglycemia predicts poststroke infections and, if so, whether poststroke infections modify the effect of admission hyperglycemia on functional outcome in ischemic stroke. METHODS:We used data from acute ischemic stroke patients in the Preventive Antibiotics in Stroke Study...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zonneveld TP,Nederkoorn PJ,Westendorp WF,Brouwer MC,van de Beek D,Kruyt ND,PASS Investigators.

    更新日期:2017-04-11 00:00:00

  • Meningeal involvement in Wegener's granulomatosis confirmed and monitored by positive circulating antineutrophil cytoplasm in cerebrospinal fluid.

    abstract::MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activ...


    pub_type: 杂志文章


    authors: Spranger M,Schwab S,Meinck HM,Tischendorf M,Sis J,Breitbart A,Andrassy K

    更新日期:1997-01-01 00:00:00

  • Lewy bodies are not increased in progressive supranuclear palsy compared with normal controls.

    abstract:OBJECTIVE:To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). BACKGROUND:LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. METHOD:The authors evaluated the brains of 72 consecutive cases of pathologically conf...


    pub_type: 杂志文章


    authors: Tsuboi Y,Ahlskog JE,Apaydin H,Parisi JE,Dickson DW

    更新日期:2001-11-13 00:00:00

  • HLA B*44: protective effects in MS susceptibility and MRI outcome measures.

    abstract:OBJECTIVE:In addition to the main multiple sclerosis (MS) major histocompatibility complex (MHC) risk allele (HLA DRB1*1501), investigations of the MHC have implicated several class I MHC loci (HLA A, HLA B, and HLA C) as potential independent MS susceptibility loci. Here, we evaluate the role of 3 putative protective ...


    pub_type: 杂志文章


    authors: Healy BC,Liguori M,Tran D,Chitnis T,Glanz B,Wolfish C,Gauthier S,Buckle G,Houtchens M,Stazzone L,Khoury S,Hartzmann R,Fernandez-Vina M,Hafler DA,Weiner HL,Guttmann CR,De Jager PL

    更新日期:2010-08-17 00:00:00

  • Friedreich's disease: V. Variant form with vitamin E deficiency and normal fat absorption.

    abstract::A 30-year-old woman was thought to have Friedreich's disease because of progressive ataxia, dysarthria, and titubation from age 3 years. Her diet was normal, and there were neither symptoms nor laboratory evidence of liver disease or fat malabsorption. Serum vitamin E content and the ratio of serum vitamin E to total ...


    pub_type: 杂志文章


    authors: Stumpf DA,Sokol R,Bettis D,Neville H,Ringel S,Angelini C,Bell R

    更新日期:1987-01-01 00:00:00