Abstract:
:Eighty-eight multiple sclerosis case-friend pairs were interviewed by telephone to elicit information about early-life exposures. Available mothers were also interviewed. Risk factors included childhood diseases, exposures to animals, and residence. We found a positive association between MS and having measles at a later than usual age. Analysis of the data in the literature showed that this was the third statistically significant association between MS and later age for measles. This is consistent with the hypothesis that the pathogenesis of MS includes an age-dependent host response to measles.
journal_name
Neurologyjournal_title
Neurologyauthors
Sullivan CB,Visscher BR,Detels Rdoi
10.1212/wnl.34.9.1144subject
Has Abstractpub_date
1984-09-01 00:00:00pages
1144-8issue
9eissn
0028-3878issn
1526-632Xjournal_volume
34pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:This study correlated the extent of abnormalities detected by different magnetic resonance imaging (MRI) techniques [proton density (PD)-weighted, T1-weighted, and magnetization transfer imaging (MTI)] with the overall cognitive, frontal lobe, and memory impairments in patients with MS. PATIENTS:There were 3...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.6.1601
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:Optical coherence tomography (OCT) noninvasively quantifies retinal nerve fiber layer (RNFL) thickness. Studies show RNFL thinning in multiple sclerosis (MS), and we assessed its association with brain atrophy. METHODS:RNFL thickness was measured in 40 patients with MS and 15 controls. Brain parenchymal frac...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000295995.46586.ae
更新日期:2007-10-16 00:00:00
abstract:OBJECTIVE:In families with autosomal dominant partial epilepsy with auditory features (ADPEAF) with mutations in the LGI1 gene, we evaluated clustering of mutations within the gene and associations of penetrance and phenotypic features with mutation location and predicted effect (truncation or missense). METHODS:We ab...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318247ccbf
更新日期:2012-02-21 00:00:00
abstract:BACKGROUND:Abnormal insulin metabolism may contribute to the clinical symptoms and pathophysiology of AD. In vitro studies show that insulin enhances the release of beta-amyloid protein (Abeta) or inhibits its degradation, either of which might increase amyloid burden. METHODS:On separate mornings, 16 healthy older ad...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000065916.25128.25
更新日期:2003-06-24 00:00:00
abstract:OBJECTIVE:The authors imaged the medial longitudinal fasciculus (MLF) in 58 patients with MS and chronic internuclear ophthalmoparesis (INO) to determine which MRI technique best shows the characteristic lesion associated with this ocular motor syndrome. METHODS:Using quantitative infrared oculography, the authors det...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.5.762
更新日期:2001-09-11 00:00:00
abstract::A striking behavioral abnormality is described in three individuals who had severe head trauma. At a point when general mnestic capabilities had returned to a near normal level, the patients persistently relocated the hospital at another geographical site, even in the face of compelling counter-evidence. The strong pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.2.147
更新日期:1976-02-01 00:00:00
abstract::The "modified host protein" model of scrapie proposes that the transmissible agent is composed of the degradation-resistant protein, Sp33-37, and that clinical and pathologic signs result from neurotoxic accumulations of this protein. Sp33-37 is an abnormal, amyloidogenic isoform of the normally occurring cellular pro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.1.149
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Long-term treatment with valproate (VPA) or carbamazepine (CBZ) may induce reproductive endocrine disorders in patients with epilepsy. METHODS:Serum concentrations of reproductive hormones were studied in 17 women and 22 men with recently diagnosed epilepsy before they started either VPA or CBZ medication, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.3.440
更新日期:2001-08-14 00:00:00
abstract:OBJECTIVE:To investigate specificity and significance of dynamic changes of the cervical dural sac and spinal cord during neck flexion in juvenile muscular atrophy of the distal upper extremity. BACKGROUND:The disorder affects young people-predominantly men-and is progressive for several years. One autopsy case showed...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.10.1922
更新日期:2000-05-23 00:00:00
abstract:OBJECTIVE:To examine the association between cognitive function and dementia with vitamin D concentration in adults. METHODS:Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of glo...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0b013e31826c197f
更新日期:2012-09-25 00:00:00
abstract::To determine the extent that different dopamine (DA) neuronal markers provide similar estimates of striatal (caudate and putamen) DA nerve terminal loss in idiopathic Parkinson's disease (PD), we compared, in postmortem striatum of 12 patients with PD and 10 matched controls, levels of five different DA neuronal marke...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.3.718
更新日期:1996-09-01 00:00:00
abstract::Among 22 patients with human T-lymphotropic virus type I (HTLV-I)-associated chronic progressive myelopathy, agarose isoelectric focusing (AIF) revealed oligoclonal IgG bands in 21: in 3 in CSF only; in 11 in CSF and to some extent in serum; and in 7, identical patterns in CSF and serum. By immunoblot after AIF of CSF...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.12.1566
更新日期:1989-12-01 00:00:00
abstract::Seronegative (SN) patients with myasthenia gravis (MG) have clinical and electrophysiologic features similar to those of seropositive (SP) patients, and they respond to the same therapeutic measures. However, because SN patients lack detectable (by standard radioimmunoassays) serum antibodies to acetylcholine receptor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.6.1638
更新日期:1997-06-01 00:00:00
abstract::The incidence of contrast-induced nephropathy was examined in 1,075 patients receiving routine CT angiography and CT perfusion brain imaging at a single institution. Fifty-two patients had a creatinine rise of > or =0.5 mg/dL. In four patients (0.37%), the administration of IV contrast medium possibly contributed to r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000161845.69114.62
更新日期:2005-05-24 00:00:00
abstract::We performed serial baseline and gadolinium (Gd)-DTPA-enhanced MRI in 4 patients with definite multiple sclerosis. Studies were performed every month for a total of 4 scans. We obtained short TR/short TE sequences at 10 and 60 minutes after Gd-DTPA injection. All patients had multiple hyperintense lesions seen on base...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.4.591
更新日期:1990-04-01 00:00:00
abstract:OBJECTIVE:To compare access to caregiving between men and women with Parkinson disease (PD). METHODS:This was a cross-sectional and longitudinal study among participants with PD enrolled in the National Parkinson Foundation Parkinson's Outcomes Project from 2009 to 2014 at 21 international sites. The primary outcome m...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004764
更新日期:2018-01-02 00:00:00
abstract::Phenotypic heterogeneity of sporadic Creutzfeldt-Jakob disease (CJD) has been linked to biochemically distinct types of the protease-resistant form of the prion protein (type 1 and type 2 PrP(Sc)). We investigated 14 cases of sporadic CJD and found that both type 1 and type 2 PrP(Sc) coexisted in 5 subjects. The disti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.9.2173
更新日期:1999-12-10 00:00:00
abstract:OBJECTIVE:To characterize presenting symptomatology in patients with semantic dementia (SD) and to investigate whether left and right temporal variants of the disease have distinct behavioral and cognitive profiles. METHODS:Retrospective examination of case notes was performed in 47 consecutive referrals of patients w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000091868.28557.b8
更新日期:2003-11-11 00:00:00
abstract::Using data from the compulsory Medical Birth Registry of Norway, the authors investigated the effect of maternal multiple sclerosis (MS) on pregnancy, delivery, and birth outcome in 649 births by MS mothers and 2.1 million control births. The mothers with MS had a higher proportion of neonates small for gestational ag...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000188898.02018.95
更新日期:2005-12-27 00:00:00
abstract::We used proton magnetic resonance spectroscopy (1H MRS) to investigate the temporal lobes of 25 patients with temporal lobe epilepsy. Spectra were obtained from 2 x 2 x 2 cm cubes in the medial region of the temporal lobe, and were analyzed on the basis of signals from N-acetylaspartate (NAA), creatine + phosphocreati...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.8.1411
更新日期:1994-08-01 00:00:00
abstract::The association of APOE genotypes with cerebral microbleeds (CMBs) was examined on the basis of the location of CMBs in 414 patients who were admitted primarily because of stroke. With respect to possession of the epsilon2 or epsilon4 allele, the adjusted odds ratio was 1.94 (1.05 to 3.58) for lobar CMBs but 1.21 (0.6...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000183311.48144.7f
更新日期:2005-11-08 00:00:00
abstract:OBJECTIVES:The aim of this study was to identify risk factors for rupture of unruptured cerebral aneurysms (UCAs) in elderly Japanese patients aged 70 years or older. METHODS:The participants included all patients 70 years of age or older in 3 prospective studies in Japan (the Unruptured Cerebral Aneurysm Study of Jap...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002149
更新日期:2015-11-24 00:00:00
abstract::We report longitudinal data on a group of 29 male patients 50 years of age or older who were initially diagnosed as having idiopathic REM sleep behavior disorder (RBD) after extensive polysomnographic and neurologic evaluations. Thirty-eight percent (11/29) were eventually diagnosed as having a parkinsonian disorder (...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.2.388
更新日期:1996-02-01 00:00:00
abstract::Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000129543.46734.c0
更新日期:2004-08-10 00:00:00
abstract::To determine whether the complete correction of hyperglycemia of diabetes can rapidly improve abnormal peripheral nerve function, eight hyperglycemic insulin-requiring diabetics underwent 3 days of glucose control with an artificial endocrine pancreas, the BIOSTATOR Glucose Controller. Comparison of neurologic assessm...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.31.11.1375
更新日期:1981-11-01 00:00:00
abstract::A 50-year-old woman with a history of metastatic malignant thymoma presented with diffuse neuropathic pain involving the extremities and torso prior to chemotherapy and radiation. She also developed episodic diarrhea, diaphoresis, fevers, insomnia, and encephalopathy. Examination revealed rippling muscles (video on th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0fa1
更新日期:2013-01-29 00:00:00
abstract:OBJECTIVES:There is currently much interest in biomarkers of disease activity in frontotemporal lobar degeneration (FTLD). We assessed MRI and behavioral measures of progression in a longitudinal FTLD cohort. METHODS:Thirty-two patients with FTLD (11 behavioral variant frontotemporal dementia [bvFTD], 11 semantic deme...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181d1a879
更新日期:2010-02-23 00:00:00
abstract::Two cases of ischemic stroke due to carotid artery dissection occurring during wind instrument playing, probably caused by increased intrathoracic and subsequent intrapharyngeal pressure, are presented. A review of the literature revealed three similar patients with other types of cerebrovascular events, such as parad...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.6.865
更新日期:2000-09-26 00:00:00
abstract::Charcot-Marie-Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP) are inherited peripheral neuropathies. In most cases these disorders are caused by either the duplication (in CMT1A) or the deletion (in HNPP) of a 1.5-megabase DNA fragment on chromosome 17p11.2, which cont...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.3.760
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To investigate whether sex and race differences exist in dementia diagnosis risk associated with traumatic brain injury (TBI) among older veterans. METHODS:Using Fine-Gray regression models, we investigated incident dementia diagnosis risk with TBI exposure by sex and race. RESULTS:After the exclusion of ba...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010617
更新日期:2020-09-29 00:00:00