Abstract:
:Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of frontotemporal dementia (FTD), a heterogeneous group of disorders, 18 brain autopsy cases previously diagnosed as HSD were re-evaluated. In 11 cases, ubiquitinated neuronal inclusions, similar to those of motor neuron disease inclusion dementia (MNDID), were found. Brain levels of soluble and insoluble tau were normal. Most patients with pathologic findings of HSD may actually have the MNDID variant of FTD.
journal_name
Neurologyjournal_title
Neurologyauthors
Hatanpaa KJ,Blass DM,Pletnikova O,Crain BJ,Bigio EH,Hedreen JC,White CL 3rd,Troncoso JCdoi
10.1212/01.wnl.0000129543.46734.c0subject
Has Abstractpub_date
2004-08-10 00:00:00pages
538-42issue
3eissn
0028-3878issn
1526-632Xpii
63/3/538journal_volume
63pub_type
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