Abstract:
OBJECTIVES:To examine the illusional sensation of movement evoked by vibration of an immobilized arm. METHODS:Patients with idiopathic focal dystonia were compared with those with idiopathic PD and with patients with dystonia secondary to PD. A 100-Hz transcutaneous vibratory stimulus was applied to the biceps brachii tendon to elicit an illusional sensation of arm extension. Blindfolded patients were instructed to copy any perceived movement of the vibrated arm with the opposite (tracking) arm. By recording movement of reflective markers on the tracking arm using infrared video cameras, the change in elbow angle was quantified over 45 seconds. The effect of treatment with botulinum toxin was examined by retesting previously untreated patients after commencing therapy. These results were also compared with patients with hemifacial spasm who had ongoing treatment with botulinum toxin. RESULTS:Vibration of the biceps in dystonic patients produced a smaller sensation of arm extension than in control subjects unaffected by botulinum toxin treatment. There were no differences between the types of idiopathic focal dystonia examined, including patients with dystonia in sites other than the arm. Those with idiopathic PD and hemifacial spasm did not differ from healthy control subjects. Patients with dystonia secondary to PD showed a unilateral abnormality on the side of dystonic symptoms. CONCLUSION:Bilateral abnormal perception of the illusion of vibration-induced movement is a feature of idiopathic focal dystonia but not idiopathic PD, and is independent of treatment with botulinum toxin. Unilateral, abnormal sensorimotor integration is implicated in dystonia secondary to PD. These results may reflect abnormal sensorimotor integration of Ia afferent activity.
journal_name
Neurologyjournal_title
Neurologyauthors
Rome S,Grünewald RAdoi
10.1212/wnl.53.8.1794subject
Has Abstractpub_date
1999-11-10 00:00:00pages
1794-800issue
8eissn
0028-3878issn
1526-632Xjournal_volume
53pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Changes in estrogen levels at menarche, menstruation, pregnancy, and menopause may trigger or change the prevalence of migraine. The fall in estrogen that occurs with menstruation is the trigger for menstrual migraine, whereas the sustained high estrogen levels during pregnancy frequently result in headache relief. Es...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVE:To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). BACKGROUND:LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. METHOD:The authors evaluated the brains of 72 consecutive cases of pathologically conf...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.9.1675
更新日期:2001-11-13 00:00:00
abstract:OBJECTIVE:To investigate the temporal relationship between inflammation and cerebral atrophy in a longitudinal study of 19 patients with relapsing-remitting multiple sclerosis (RRMS) using serial monthly contrast enhanced MRI examinations and monthly measurements of brain fractional volume (BFV) for an average of 4 (ra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000197982.78063.06
更新日期:2006-02-28 00:00:00
abstract:BACKGROUND:Transcranial contrast Doppler studies have shown an increased prevalence of right-to-left shunts in patients with migraine with aura compared with controls. The anatomy and size of these right-to-left shunts have never been directly assessed. METHODS:In a cross-sectional case-control study, the authors perf...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000179800.73706.20
更新日期:2005-11-08 00:00:00
abstract::The authors sequenced the entire mitochondrial DNA coding region in a group of 19 patients with non-arteritic anterior ischemic optic neuropathy (NAION) and in 100 controls. Synonymous and nonsynonymous nucleotide changes were more common in NAION patients (p < 0.001). Twelve of these (11 novel) were potentially patho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000140696.34117.95
更新日期:2004-10-12 00:00:00
abstract::Cisternography and ventriculography were performed in five normal anesthetized dogs to study the dynamics of tracer dispersal. Indium 111-diethylenetriaminepentaacetic acid was injected into lateral ventricles, cisterna magna, thoracic subarachnoid space, and lumbar sac. The patterns of dispersal from each injection s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.3.254
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:The head impulse test (HIT) is a useful bedside test to identify peripheral vestibular deficits. However, such a deficit of the vestibulo-ocular reflex (VOR) may not be diagnosed because corrective saccades cannot always be detected by simple observation. The scleral search coil technique is the gold standar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181bacf85
更新日期:2009-10-06 00:00:00
abstract::CSF lymphocyte subpopulations of eight patients with neurosarcoidosis were examined. CSF or CT was abnormal in all. The CSF T4/T8 (helper/suppressor) ratio was elevated at 6.8 and 7.6 in two patients; in one, there were only CSF T4 cells. The ratio was normal in five patients. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.5.878
更新日期:1987-05-01 00:00:00
abstract::T, B, and "null" lymphocytes were determined in peripheral blood obtained from 24 control subjects and 15 multiple sclerosis patients. The total number of lymphocytes and T lymphocytes were reduced significantly in multiple sclerosis patients as compared with those of controls. Although the percentage of B lymphocytes...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.10.997
更新日期:1976-10-01 00:00:00
abstract:OBJECTIVE:To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS:We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP),...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000238511.72927.3c
更新日期:2006-10-10 00:00:00
abstract::The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000174432.87383.87
更新日期:2005-09-13 00:00:00
abstract::The technique of intrathecal enhancement using metrizamide (Amipaque) combined with CT imaging enables both the morphologic and dynamic (serial) evaluation of the intracranial cerebrospinal fluid pathways. Three distinct metrizamide CT cisternographic patterns (delayed, intermediate, and normal) emerge in pediatric pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.1.71
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of acetyl-l-carnitine (ALCAR) on the rate of decline in early-onset AD patients. METHODS:A 1-year, multicenter, double-blind, placebo-controlled, randomized trial was conducted. Subjects were 45 to 65 years old, with a diagnosis of probable AD according to National Institute of Neur...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.55.6.805
更新日期:2000-09-26 00:00:00
abstract:OBJECTIVE:Evidence of a relation between use of lipid lowering drugs and cognitive outcomes is mixed. This study aimed to test the association between use of statins and incidence of dementia and cognitive impairment without dementia (CIND) over 5 years of follow-up. METHODS:Data were from a population-based cohort st...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000319647.15752.7b
更新日期:2008-07-29 00:00:00
abstract:OBJECTIVE:Motor signs are functionally disabling features of Huntington disease. Characteristic motor signs define disease manifestation. Their severity and onset are assessed by the Total Motor Score of the Unified Huntington's Disease Rating Scale, a categorical scale limited by interrater variability and insensitivi...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e3182020123
更新日期:2010-12-14 00:00:00
abstract::Migraine and the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome have some clinical features in common. First, cerebral infarctions, most often in the posterior cerebral regions, which are a main symptom of MELAS, may complicate migraine. Second, migrainous headache w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.6.1735
更新日期:1996-06-01 00:00:00
abstract::Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000083992.28066.7e
更新日期:2003-10-14 00:00:00
abstract:BACKGROUND:To assess the temporal trend in multiple sclerosis (MS) onset during the last 50 years in Sardinia, Italy. METHODS:The authors used a cohort study to assess age at onset in 1,513 MS patients at the MS clinic in Cagliari, all born and living in Sardinia. They also assessed age at onset in 41 pairs of familia...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000125194.27381.d4
更新日期:2004-05-25 00:00:00
abstract:OBJECTIVE:To describe a large series of BIN1 patients, in which a novel founder mutation in the Roma population of southern Spain has been identified. METHODS:Patients diagnosed with centronuclear myopathy (CNM) at 5 major reference centers for neuromuscular disease in Spain (n = 53) were screened for BIN1 mutations. ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000005862
更新日期:2018-07-24 00:00:00
abstract::We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.59.1.123
更新日期:2002-07-09 00:00:00
abstract::Three children with cerebral oligodendrogliomas causing partial complex or generalized seizures presented with completely normal neurologic examinations. CT showed low-density, nonenhancing surface lesions. Although these CT features are usually associated with infarcts or cysts, neoplasm was suspected because of irre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.6.806
更新日期:1983-06-01 00:00:00
abstract::We identified 53 patients with non-neoplastic cysts of the pineal gland. In contrast to patients with pineal neoplasms, pineal cysts are usually asymptomatic. They infrequently obstruct the aqueduct to cause hydrocephalus or compress the tectum to produce the neuro-ophthalmologic signs of dorsal midbrain dysfunction. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.7.1034
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:To characterize patterns of cognitive functioning in a well-defined group of patients with MRI-identified coexisting left temporal lobe developmental malformations (TLDM) and mesial temporal sclerosis (MTS), and to examine neuropsychological outcome in this dual-pathology group following epilepsy surgery. ME...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.4.709
更新日期:1999-09-11 00:00:00
abstract:OBJECTIVE:Based on the theories of brain reserve and cognitive reserve, we investigated whether larger maximal lifetime brain growth (MLBG) and/or greater lifetime intellectual enrichment protect against cognitive decline over time. METHODS:Forty patients with multiple sclerosis (MS) underwent baseline and 4.5-year fo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000433
更新日期:2014-05-20 00:00:00
abstract:OBJECTIVE:To study the attributes of quantitative strength testing using hand-held dynamometry (HHD) as an efficacy measure in 2 large phase 3 amyotrophic lateral sclerosis (ALS) trials. METHODS:In the phase 3 trials of ceftriaxone and dexpramipexole, 513 and 943 patients, respectively, were enrolled in double-blind, ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000002941
更新日期:2016-08-09 00:00:00
abstract:OBJECTIVE:To conduct a systematic review on the association between tetanus vaccination and the risk of multiple sclerosis (MS). METHODS:The authors searched the databases Medline, LILACS, EMBASE, and Science Citation Index including the period 1966 to September 1, 2005. Eligible studies had to meet the following incl...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000225079.51201.f9
更新日期:2006-07-25 00:00:00
abstract:OBJECTIVES:To assess the therapeutic efficacy, required dose, and tolerability of pregabalin in patients with idiopathic restless legs syndrome (RLS). METHODS:This was a double-blind, placebo-controlled trial with polysomnographic control, providing Class II evidence. Ninety-eight patients underwent a 2-week single-bl...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0b013e3181e1ce73
更新日期:2010-06-08 00:00:00
abstract::We investigated the prevalence of Parkinson's disease and other types of parkinsonism in a Sicilian population using a door-to-door two-phase approach. This design called for the administration of a brief screening instrument to all subjects who, on November 1, 1987, were residents of Terrasini (Palermo Province), San...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.10.1901
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD). METHODS:Nine hundred eighteen older Catholic clergy participating in the Religious Orders Study without dementia at baseline were studied. Outcome measures were the clinical diagnosis of AD and change in cognit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000176061.33817.90
更新日期:2005-09-27 00:00:00
abstract:OBJECTIVE:To determine the effect of injections of botulinum toxin on simple motor tics. BACKGROUND:Case series with unblinded assessments have reported improvement in tic frequency and associated urge with botulinum toxin. METHODS:Patients with suitable simple motor tics were randomized to receive botulinum toxin an...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.56.5.605
更新日期:2001-03-13 00:00:00