Abstract:
:The authors describe a case of neurologic involvement in mild hyperphenylalaninemia (HPA), not due to tetrahydrobiopterin (BH(4)) deficiency, with low levels of monoamine neurotransmitter metabolites in CSF. The combined BH(4)-Phe loading test suggested a BH(4) response, confirmed by clinical improvement after BH(4) therapy. Molecular study revealed a compound heterozygosity of the phenylalanine hydroxylase alleles: a mild HPA-associated mutation (T380M) and the new mutation D151E. This case demonstrates that even mild HPA, generally considered a benign disorder, may present neurologic impairment.
journal_name
Neurologyjournal_title
Neurologyauthors
Bonafé L,Blau N,Burlina AP,Romstad A,Güttler F,Burlina ABdoi
10.1212/wnl.57.5.908subject
Has Abstractpub_date
2001-09-11 00:00:00pages
908-11issue
5eissn
0028-3878issn
1526-632Xjournal_volume
57pub_type
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