Autosomal-recessive juvenile parkinsonism in a Jewish Yemenite kindred: mutation of Parkin gene.

abstract：:(-)Deprenyl, a specific monoamine oxidase subtype B inhibitor (MAOI-B), has been reported to be a safe and valuable adjunct to conventional treatment of parkinsonism. A double-blind, clinical comparison of (-)deprenyl with placebo was undertaken in 11 parkinsonian patients; the efficacy of 10 mg daily was studied over...

journal_title：Neurology

authors： Eisler T,Teräväinen H,Nelson R,Krebs H,Weise V,Lake CR,Ebert MH,Whetzel N,Murphy DL,Kopin IJ,Calne DB

更新日期：1981-01-01 00:00:00

abstract：:A patient with classic (type A) Niemann-Pick disease had the usual clinical signs of failure to thrive, hepatosplenomegaly, and intellectual deterioration in the first year of life. In addition, there was striking hypotonia, areflexia, and abnormal nerve conduction velocities. Pathologically, the Schwann cells were fi...

journal_title：Neurology

authors： Gumbinas M,Larsen M,Mei Liu H

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:Serum copper not bound to ceruloplasmin ("free") appears slightly elevated in patients with Alzheimer disease (AD). We explored whether a deregulation of the free copper pool can predict AD clinical worsening. METHODS:We assessed levels of copper, iron, zinc, transferrin, ceruloplasmin, peroxides, total ant...

journal_title：Neurology

authors： Squitti R,Bressi F,Pasqualetti P,Bonomini C,Ghidoni R,Binetti G,Cassetta E,Moffa F,Ventriglia M,Vernieri F,Rossini PM

更新日期：2009-01-06 00:00:00

abstract：:The efficacy and safety of donepezil as a treatment for patients with mild to moderate Alzheimer's disease (AD) was investigated in a multicenter, double-blind study. Patients were randomly assigned to treatment with placebo (n = 162), 5 mg/d donepezil (n = 154), or 10 mg/d donepezil (n = 157) for 24 weeks followed by...

journal_title：Neurology

authors： Rogers SL,Farlow MR,Doody RS,Mohs R,Friedhoff LT

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:In a recent study, the authors found that blinks in healthy volunteers always triggered ocular torsion quick phases during dynamic roll movements of the head. On the basis of this observation, they hypothesized that blinks in patients with a vestibular tone imbalance would also trigger torsional quick phases...

journal_title：Neurology

authors： Schneider E,Glasauer S,Dieterich M,Kalla R,Brandt T

更新日期：2004-10-12 00:00:00

abstract：:We compared 42 myasthenia gravis (MG) patients with thymoma with 42 generalized MG patients without thymoma using a modified Osserman classification. The mean Osserman grades at diagnosis, 6 months, and 5 and 10 years post-thymectomy did not differ between groups. Our results indicate that thymoma is not a negative de...

journal_title：Neurology

authors： Bril V,Kojic J,Dhanani A

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To study the brain activation pattern of coexisting experimental ongoing pain and brush-evoked allodynia (pain evoked by innocuous brush) with the use of PET. BACKGROUND:Neuropathic pain usually has two essential phenomena: ongoing pain and brush-evoked allodynia, which coexist and may influence each other. ...

journal_title：Neurology

authors： Witting N,Kupers RC,Svensson P,Arendt-Nielsen L,Gjedde A,Jensen TS

更新日期：2001-11-27 00:00:00

abstract：:Motor axons supplying lumbrical muscles are less severely affected than axons supplying thenar muscles in the carpal tunnel syndrome; sometimes lumbrical motor fibers are less affected than digit 2 sensory fibers. This pattern is consistent with compression of both the anterior and posterior aspects of the median nerv...

journal_title：Neurology

authors： Logigian EL,Busis NA,Berger AR,Bruyninckx F,Khalil N,Shahani BT,Young RR

更新日期：1987-09-01 00:00:00

abstract：:A 14-year-old girl developed severe bilateral optic neuritis 1 week after the onset of chickenpox. Though previous case reports state that complete recovery is the rule, this child had a persistent decrease in visual acuity in the right eye and loss of color vision and defects in visual fields in both eyes. ...

journal_title：Neurology

authors： Purvin V,Hrisomalos N,Dunn D

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVES:Despite many neuropsychological studies to differentiate subcortical vascular dementia (SVaD) from Alzheimer disease (AD), previous studies did not eliminate confounding effects of mixed Alzheimer and vascular pathology. We aimed to investigate neuropsychological differences between patients with Pittsburgh ...

journal_title：Neurology

authors： Yoon CW,Shin JS,Kim HJ,Cho H,Noh Y,Kim GH,Chin JH,Oh SJ,Kim JS,Choe YS,Lee KH,Lee JH,Seo SW,Na DL

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:Because of the relatively poor results of frontal lobe epilepsy (FLE) surgery, identification of prognostic factors for surgical outcome is of great importance. METHODS:To identify predictive factors for FLE surgery, we analyzed the data of 61 patients (mean age at surgery 19.2) who had undergone presurgica...

journal_title：Neurology

authors： Janszky J,Jokeit H,Schulz R,Hoppe M,Ebner A

更新日期：2000-04-11 00:00:00

abstract：:A 35-year-old woman had cardiac arrest requiring treatment with a left ventricular assist device. After regaining consciousness, examination revealed upbeating nystagmus, otherwise normal bulbar function, left arm dysmetria, and numbness periorally and in areas she described as "a turtleneck of numbness with a T-shirt...

journal_title：Neurology

authors： Ryman DC,Ju YE

更新日期：2013-12-03 00:00:00

abstract：:Plasma exchange (PE) was shown in a previous double-blind randomized controlled study to confer significant additional benefit at 1 year upon patients with chronic progressive multiple sclerosis (CPMS) treated with immunosuppressive drug therapy (ISDT). Efficacy over an extended term, indications for retreatment, and ...

journal_title：Neurology

authors： Khatri BO,McQuillen MP,Hoffmann RG,Harrington GJ,Schmoll D

更新日期：1991-03-01 00:00:00

abstract：:Eighteen patients with congenital nystagmus were studied with the techniques of electronystagmography and computer analysis. We found several complex wave forms of congenital nystagmus in the primary position of gaze above those of jerk and pendular nystagmus as defined clinically. An etiologic classification of motor...

journal_title：Neurology

authors： Yee RD,Wong EK,Baloh RW,Honrubia V

更新日期：1976-04-01 00:00:00

abstract：:We investigated potential risk factors for Alzheimer's disease (AD) in a clinicopathologic study of 407 patients with definite AD, 100 non-Alzheimer dementia patients, and 50 normal subjects. The AD patients had more first-degree relatives with dementia than the non-AD dementia group (odds ratio of 1.85, 95% confidenc...

journal_title：Neurology

authors： Mendez MF,Underwood KL,Zander BA,Mastri AR,Sung JH,Frey WH 2nd

更新日期：1992-04-01 00:00:00

abstract：:Age at 1st risk for seizures may predict anomia following dominant anterior temporal lobectomy. We assessed confrontation naming before and 2 to 3 weeks after surgery in 45 right-handed patients grouped by side of focus and presence or absence of early (less than or equal to 5 years) risk factors. After left lobectomy...

journal_title：Neurology

authors： Stafiniak P,Saykin AJ,Sperling MR,Kester DB,Robinson LJ,O'Connor MJ,Gur RC

更新日期：1990-10-01 00:00:00

abstract：:Research and development of the adenosine A2A receptor selective antagonist KW6002 have focused on developing a novel nondopaminergic therapy for Parkinson's disease (PD). Salient pharmacologic features of KW6002 were investigated in several animal models of PD. In rodent and primate models, KW6002 provides symptomati...

journal_title：Neurology

authors： Kase H,Aoyama S,Ichimura M,Ikeda K,Ishii A,Kanda T,Koga K,Koike N,Kurokawa M,Kuwana Y,Mori A,Nakamura J,Nonaka H,Ochi M,Saki M,Shimada J,Shindou T,Shiozaki S,Suzuki F,Takeda M,Yanagawa K,Richardson PJ,Jenner P

更新日期：2003-12-09 00:00:00

abstract：:We analyzed the frequency of cardiac embolic sources in 62 patients with acute lacunar stroke vs 50 controls. In post hoc analysis, 11 patients with lacunar stroke having neither hypertension nor diabetes mellitus (non-HDM group) had a higher frequency of right-to-left shunt (RLS) (82%) than patients with risk factors...

journal_title：Neurology

authors： Ueno Y,Kimura K,Iguchi Y,Shibazaki K,Inoue T,Urabe T

更新日期：2007-02-13 00:00:00

abstract：:A wide variety of movement disorders are associated with alcohol abuse. Some idiopathic movement disorders are markedly improved by small amounts of alcohol and this response occasionally may lead to alcoholism. Alcohol abuse alone or combined with hepatic encephalopathy can cause various types of tremor, asterixis, a...

journal_title：Neurology

authors： Neiman J,Lang AE,Fornazzari L,Carlen PL

更新日期：1990-05-01 00:00:00

abstract：:In the past, stereotactic surgery was a regular treatment for prominent unilateral tremor in Parkinson's disease (PD), but follow-up studies were usually short-term and always unblinded. We examined 17 PD patients in long-term follow-up (mean, 10.9 years after surgery) and used videotapes and the Unified Parkinson's D...

journal_title：Neurology

authors： Diederich N,Goetz CG,Stebbins GT,Klawans HL,Nittner K,Koulosakis A,Sanker P,Sturm V

更新日期：1992-07-01 00:00:00

abstract：OBJECTIVE:To analyze the frequency of neurologic events during commercial airline flights and to assess whether onboard emergency medical kits are adequate for in-flight neurologic emergencies. METHODS:Collaboration of the Mayo Clinic's Departments of Emergency Medicine and Medical Transportation Service and the Divis...

journal_title：Neurology

authors： Sirven JI,Claypool DW,Sahs KL,Wingerchuk DM,Bortz JJ,Drazkowski J,Caselli R,Zanick D

更新日期：2002-06-25 00:00:00

abstract：:A cross-sectional survey and subsequent longitudinal study among diabetic residents of Rochester, MN--The Rochester Diabetic Neuropathy Study (RDNS)--is population-based and uses quantitative, validated, and unique end points to detect, classify, and stage neuropathy. Nondiabetic persons, drawn from the same populatio...

journal_title：Neurology

authors： Dyck PJ,Kratz KM,Lehman KA,Karnes JL,Melton LJ 3rd,O'Brien PC,Litchy WJ,Windebank AJ,Smith BE,Low PA

更新日期：1991-06-01 00:00:00

abstract：:In four patients who received periocular injections of botulinum toxin for blepharospasm, abnormal neuromuscular transmission was demonstrated by single-fiber EMG in arm muscles. The time course with which the abnormalities developed and cleared, as well as the inverse relationship between the neuromuscular jitter and...

journal_title：Neurology

authors： Sanders DB,Massey EW,Buckley EG

更新日期：1986-04-01 00:00:00

abstract：:We evaluated four formulas for estimating the intra-blood-brain barrier (IBBB) synthesis of IgG in a computer model of two types of BBB damage and in 1,629 consecutively received pairs of CSF and serum. These four formulas were the IgG synthesis rate (SR), IgG(loc) (ie, local), IgG index, and IgG extended index. Resul...

journal_title：Neurology

authors： Peter JB,Bowman RL

更新日期：1992-03-01 00:00:00

abstract：:Although Parkinson's disease has a definite neurologic basis, patients and relatives experience a multitude of stresses, only partly related to motor symptoms. Subjective and behavioral problems may be regarded as secondary disease symptoms. In an integrated approach, patients and relatives receive psychological couns...

journal_title：Neurology

authors： Ellgring H,Seiler S,Perleth B,Frings W,Gasser T,Oertel W

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:To determine if progressive brain atrophy could be detected over 1- and 2-year intervals in relapsing MS, based on annual MR studies from the Multiple Sclerosis Collaborative Research Group (MSCRG) trial of interferon beta-1a (Avonex). METHODS:All subjects had mild to moderate disability, with baseline expan...

journal_title：Neurology

authors： Simon JH,Jacobs LD,Campion MK,Rudick RA,Cookfair DL,Herndon RM,Richert JR,Salazar AM,Fischer JS,Goodkin DE,Simonian N,Lajaunie M,Miller DE,Wende K,Martens-Davidson A,Kinkel RP,Munschauer FE 3rd,Brownscheidle CM

更新日期：1999-07-13 00:00:00

abstract：OBJECTIVE:To study the distribution of prior scoliosis among patients with primary adult-onset cervical dystonia (CD) and matched control subjects. METHODS:Case and control subjects were selected among consecutive outpatients attending four Italian centers. Control outpatients were matched for age (+/-5 years), sex, a...

journal_title：Neurology

authors： Defazio G,Abbruzzese G,Girlanda P,Buccafusca M,Currà A,Marchese R,Martino D,Masi G,Mazzella L,Vacca L,Livrea P,Berardelli A

更新日期：2003-03-25 00:00:00

abstract：OBJECTIVE:To evaluate the relationship of white matter hyperintensities (WMH) with decline in lower extremity function (LEF) over approximately 3 years in dementia-free older adults with memory complaints. METHODS:We obtained brain MRI data from 458 community-dwelling adults, aged 70 years or over, at baseline, and fr...

journal_title：Neurology

authors： Moon SY,de Souto Barreto P,Rolland Y,Chupin M,Bouyahia A,Fillon L,Mangin JF,Andrieu S,Cesari M,Vellas B,MAPT\/DSA Study Group.

更新日期：2018-04-10 00:00:00

abstract：:The authors correlated neurologic features of rostral lateral pontine infarct (rLPI) with lesion location on MRI. rLPI is a motor-sensory stroke presenting as crural monoparesis or crural dominant hemiparesis and segmental superficial or deep sensory disturbances. The dorsolateral pontine base causes crural paresis wi...

journal_title：Neurology

authors： Kataoka S,Miaki M,Saiki M,Saiki S,Yamaya Y,Hori A,Hirose G

更新日期：2003-07-08 00:00:00

abstract：:Men and women with dementia of the Alzheimer type (DAT) had more brain atrophy and ventricular dilatation, measured by quantitative CT, than did respective age- and sex-matched healthy controls (p less than 0.05). The male DAT patients with mild dementia had a larger mean third ventricle volume, whereas male patients ...

journal_title：Neurology

authors： Creasey H,Schwartz M,Frederickson H,Haxby JV,Rapoport SI

更新日期：1986-12-01 00:00:00