Abstract:
:We investigated potential risk factors for Alzheimer's disease (AD) in a clinicopathologic study of 407 patients with definite AD, 100 non-Alzheimer dementia patients, and 50 normal subjects. The AD patients had more first-degree relatives with dementia than the non-AD dementia group (odds ratio of 1.85, 95% confidence interval of 1.07-3.20) or the normal elderly (odds ratio of 3.60, 95% confidence interval of 1.50-8.64) but did not have significantly more head injuries, medical and psychiatric illnesses, or relatives with Down's syndrome. The AD patients with a family history of dementia had their dementia at a later age than those without an affected relative. These findings indicate a familial risk for AD that is greater than for other dementing illnesses and has age-related penetrance. This study does not support other putative risk factors for AD such as head trauma and familial Down's syndrome.
journal_name
Neurologyjournal_title
Neurologyauthors
Mendez MF,Underwood KL,Zander BA,Mastri AR,Sung JH,Frey WH 2nddoi
10.1212/wnl.42.4.770subject
Has Abstractpub_date
1992-04-01 00:00:00pages
770-5issue
4eissn
0028-3878issn
1526-632Xjournal_volume
42pub_type
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