Abstract:
BACKGROUND:Because of the relatively poor results of frontal lobe epilepsy (FLE) surgery, identification of prognostic factors for surgical outcome is of great importance. METHODS:To identify predictive factors for FLE surgery, we analyzed the data of 61 patients (mean age at surgery 19.2) who had undergone presurgical evaluation and resective surgery in the frontal lobe. Postoperative follow-up ranged from 0.5 to 5 years (mean 1.78). Fifty-nine patients had MRI-detectable lesions. Histopathologic examination showed dysplasia (57.4%), tumor (16.4%), or other lesions (26.2%). Thirty postoperatively seizure-free patients were compared with 31 non-seizure-free patients with respect to clinical history, seizure semiology, EEG and neuroimaging data, resected area, and postoperative data including histopathology. RESULTS:Three preoperative and two postoperative variables were related to poor outcome: generalized epileptiform discharges, generalized slowing, use of intracranial electrodes, incomplete resection detected by MRI, and postoperative epileptiform discharges. The only preoperative factor associated with seizure-free outcome was the absence of generalized EEG signs. Multivariate analysis showed that only the absence of generalized EEG signs predicts the outcome independently. Moreover, the occurrence of a somatosensory aura, secondarily generalized seizures, and negative MRI was identified as additional independent risk factors for poor surgical results. CONCLUSIONS:The absence of generalized EEG signs is the most predictive variable for a seizure-free outcome in FLE surgery. Furthermore, nonlesional MRI, somatosensory aura, and secondarily generalized seizures are risk factors for poor surgical results.
journal_name
Neurologyjournal_title
Neurologyauthors
Janszky J,Jokeit H,Schulz R,Hoppe M,Ebner Adoi
10.1212/wnl.54.7.1470subject
Has Abstractpub_date
2000-04-11 00:00:00pages
1470-6issue
7eissn
0028-3878issn
1526-632Xjournal_volume
54pub_type
临床试验,杂志文章相关文献
NEUROLOGY文献大全abstract::Dysfunction of NADH: ubiquinone oxidoreductase (complex I) of the mitochondrial electron transport chain has been linked to the pathogenesis of Parkinson's disease. While simple assays of complex I activity are unlikely to be useful in the preclinical detection of Parkinson's disease, other more sophisticated physical...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.41.5_suppl_2.34
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:To assess the effects of levodopa on resting-state brain metabolism in PD. BACKGROUND:In previous studies the authors used [18F] fluorodeoxyglucose (FDG) and PET to quantify regional metabolic abnormalities in PD. They found that this disease is characterized reproducibly by a specific abnormal PD-related pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.11.2083
更新日期:2001-12-11 00:00:00
abstract::"Healthy citizens are the greatest asset any country can have."-Sir Winston Churchill. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000053
更新日期:2014-01-28 00:00:00
abstract::We studied 20 patients with an acute parietal stroke with hemisensory disturbances but no visual field deficit and no or only slight motor weakness, without thalamic involvement on CT or MRI and found three main sensory syndromes. (1) The pseudothalamic sensory syndrome consists of a faciobrachiocrural impairment of e...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.10.1942
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:To examine the efficacy of rizatriptan and the consistency of treatment response in migraine attacks of children and adolescents. METHODS:We conducted a double-blind, placebo-controlled three-way crossover trial in patients ages 6 to 17 years diagnosed with migraine in two pediatric hospital outpatient clini...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000238179.79888.44
更新日期:2006-10-10 00:00:00
abstract::Normal human quadriceps muscle was transplanted into nude mice subcutaneously for periods of 1, 2, 3, 4, 6, and 8 weeks. At 1 week, there was myoblast and myotube formation with thin and thick filaments. After 2 weeks, there was myotube formation with partially cross-striated myofilaments, and formation of dyads or tr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.7.740
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the burden of deep and lobar lacunes differs between patients with intracerebral hemorrhage (ICH) with definite/probable cerebral amyloid angiopathy (CAA) per the Boston criteria and hypertensive small vessel disease (HTN-SVD; ICH in basal ganglia, thalami, brainstem). METHODS:We defined ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004007
更新日期:2017-06-06 00:00:00
abstract::We evaluated 85 patients with serologic evidence of Borrelia burgdorferi infection. Manifestations included encephalopathy (41), neuropathy (27), meningitis (2), multiple sclerosis (MS) (6), and psychiatric disorders (3). We performed lumbar punctures in 53, brain MRI in 33, and evoked potentials (EPs) in 33. Only pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.6.753
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Cerebral microbleeds are known to be indicative of bleeding-prone microangiopathy and may predict incident intracerebral hemorrhage (ICH). In this study, we investigated whether microbleeds are associated with the incidence of warfarin-related ICH. METHODS:Twenty-four patients with ICH while on outpatient t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000339060.11702.dd
更新日期:2009-01-13 00:00:00
abstract:BACKGROUND:There is evidence that angiotensin-converting enzyme inhibitors (ACEIs) reduce the risk of stroke. However, it is unclear whether ACEI use before stroke provides a vasoprotective effect resulting in less severe stroke. METHODS:We ascertained all strokes occurring in a defined population in Melbourne, Austra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000261914.18101.60
更新日期:2007-05-15 00:00:00
abstract:OBJECTIVE:To correlate muscle biopsy findings with prebiopsy and postbiopsy clinical course and response to therapy in polymyositis (PM) and sporadic inclusion body myositis (IBM). BACKGROUND:Existence of pure PM has recently been questioned; subsequently, the definition and criteria for diagnosing PM were debated. M...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000277527.69388.fe
更新日期:2008-02-05 00:00:00
abstract::Subacute sclerosing panencephalitis (SSPE) is characterized by a hyperimmune state toward the polypeptides of measles virus except the matrix (M) protein. Using cloned (3H)-labeled complementary DNA probes for in situ hybridization, we found the M protein and nucleocapsid (NP) protein nucleotide sequences in glial cel...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.11.1605
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:To establish a variant of sporadic prion disease as the sporadic form of fatal familial insomnia (FFI). BACKGROUND:FFI is a recently described prion disease characterized clinically by severe sleep impairment, dysautonomia, and motor signs, and pathologically by atrophy of thalamic nuclei, especially the med...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.9.1757
更新日期:1999-06-10 00:00:00
abstract:BACKGROUND:The Babinski sign is a well-known sign of upper motor neuron dysfunction that is widely considered an essential element of a complete neurologic examination. Little is known about reliability and validity of this sign. A less well-known sign of upper motor neuron dysfunction, decreased speed of foot tapping,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000180608.76190.10
更新日期:2005-10-25 00:00:00
abstract::Confusion, speech arrest, automatic behavior, and amnesia characterize the prolonged twilight states of both petit mal and psychomotor status. However, in psychomotor status two electroclinical phases were differentiated: (1) A continuous twilight state with partial responsiveness and reactive automatisms interrupted ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.3.239
更新日期:1978-03-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role in the origin of SVD markers on MRI. METHODS:We included 503 individuals with SVD from the Radboud University Nijmegen Diffusion Ten...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008364
更新日期:2019-10-22 00:00:00
abstract::Urinary incontinence (UI) after stroke is common and associated with overall poor functional outcomes. There is controversy regarding which factors contribute to incontinence after stroke and which factors may be predictive of recovery of continence. This study investigated consecutive stroke admissions to an inpatien...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.3.659
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:The Stroke-Thrombolytic Predictive Instrument (Stroke-TPI) predicts the probability of good and bad outcomes with and without recombinant tissue plasminogen activator (rtPA). We sought to rebuild and externally validate a simpler Stroke-TPI to support implementation in routine clinical care. METHODS:Using t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001925
更新日期:2015-09-15 00:00:00
abstract:BACKGROUND:Seven loci for autosomal dominant hereditary spastic paraplegia (ADHSP) have been mapped. To date, two families of SPG12 (chromosome 19q13) have been analyzed; however, there is not enough clinical information on SPG12 to establish locus-phenotype correlations. METHODS:The authors studied 60 individuals fro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000031423.43482.19
更新日期:2002-11-12 00:00:00
abstract::The authors used PET to show that the abnormal pattern of cerebral blood flow (CBF) activation described in PD is normalized by electrical stimulation of subthalamic nucleus. Improvement in bradykinesia correlated with increase in CBF due to stimulation in the supplementary motor area and anterior cingulate cortex. Co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000052691.48076.92
更新日期:2003-03-25 00:00:00
abstract::We evaluated the effects of isoniazid on tremor in 13 patients with MS. Patients were evaluated before treatment, after 1 month of therapy (1,000 mg daily), and 1 month after the last dose. Ten patients improved on at least one of three methods of evaluation. Transient side effects were common, possibly because there ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.35.12.1772
更新日期:1985-12-01 00:00:00
abstract::We studied two patients with Meige syndrome who developed alpha-methyldopa-induced parkinsonism. Opposite responses of parkinsonian and dystonic symptoms to antiparkinson drugs in some cases suggest a functionally reciprocal relationship between these disorders. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.11.1668
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:To assess alterations in brain metabolites of patients with Pelizaeus-Merzbacher disease (PMD) with the proteolipid protein gene 1 (PLP1) duplications using quantitative proton MRS. METHODS:Five unrelated male Japanese patients with PMD with PLP1 duplications were analyzed using automated proton brain examin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.2.237
更新日期:2002-01-22 00:00:00
abstract::This study examined the frequency of epilepsy in a consecutive series of patients who received a definitive diagnosis of psychogenic nonepileptic seizures (PNES) after completing inpatient video-EEG (VEEG) monitoring. Of the 1,590 patients receiving definitive diagnosis, 514 (32.3%) were diagnosed with PNES. Twenty-ni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000098890.13946.f5
更新日期:2003-12-23 00:00:00
abstract:OBJECTIVE:To investigate the association between early depressive behavior after stroke onset and occurrence of poststroke depression (PSD) at 3- and 12-month follow-up evaluations. METHODS:The study prospectively included 273 patients with first-ever single uncomplicated ischemic stroke. In the stroke unit, nurses sc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000150935.05940.2D
更新日期:2005-02-08 00:00:00
abstract::We tested the hypothesis that an anticardiolipin antibody (aCL) titer of > or = 10 IgG phospholipid (GPL) at the time of an index ischemic stroke is associated with an increased risk of subsequent thrombo-occlusive events or death. First-time ischemic stroke patients from the Antiphospholipid Antibodies and Stroke Stu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.1.91
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Whether recurrent epileptic seizures induce brain damage is debated. Disease progression in epilepsy has been evaluated only in a few community-based studies involving patients with seizures well controlled by medication. These studies concluded that epilepsy does not inevitably lead to global cerebral damag...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000345969.57574.f5
更新日期:2009-05-19 00:00:00
abstract::The authors sequenced the entire mitochondrial DNA coding region in a group of 19 patients with non-arteritic anterior ischemic optic neuropathy (NAION) and in 100 controls. Synonymous and nonsynonymous nucleotide changes were more common in NAION patients (p < 0.001). Twelve of these (11 novel) were potentially patho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000140696.34117.95
更新日期:2004-10-12 00:00:00
abstract:OBJECTIVE:Dominant, left anteromedial temporal lobe resection (AMTLR) for seizure control carries risks to verbal episodic memory and visual object naming. Consistent with traditional thinking, verbal memory decline is considered a consequence of hippocampal removal and naming decline has been attributed to lateral tem...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181dd40f0
更新日期:2010-05-11 00:00:00
abstract:OBJECTIVE:Several lines of evidence suggest that pathologic changes underlying Alzheimer disease (AD) begin years prior to the clinical expression of the disease, underscoring the need for studies of cognitively healthy adults to capture these early changes. The overall goal of the current study was to map the cortical...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318245d295
更新日期:2012-02-07 00:00:00