Abstract:
OBJECTIVE:To examine the efficacy of rizatriptan and the consistency of treatment response in migraine attacks of children and adolescents. METHODS:We conducted a double-blind, placebo-controlled three-way crossover trial in patients ages 6 to 17 years diagnosed with migraine in two pediatric hospital outpatient clinics. Two doses of rizatriptan and a matching placebo were administered at home during three attacks. Rizatriptan dose was 5 mg for those with a body weight of 20 to 39 kg, and 10 mg for those with a body weight of 40 kg or more. The primary efficacy endpoint was headache relief by two grades on a five-grade face scale at 2 hours. RESULTS:Ninety-six patients used all three treatments, 10 used two, and 10 only the first. At 2 hours, the primary endpoint was reached twice as often after both treatments of rizatriptan (first 74%, n = 71/96; second 73%, n = 70/96) as after placebo (36%, n = 35/96) (p < 0.001). Already at 1 hour, rizatriptan was clearly more effective as headache relief was reported by 50% (n = 48/96) and 55% (n = 53/96) of children after the first and the second dose of rizatriptan, compared to 29% (n = 28/96) after placebo (p = 0.004). Rizatriptan was superior at 3 and 4 hours, and the other endpoints also favored rizatriptan. Efficacy of rizatriptan was constant over the two treated attacks, and the findings were similar in children using the dose of 5 and 10 mg. No serious adverse effects were observed. CONCLUSIONS:Oral rizatriptan is effective and well-tolerated for migraine attacks in children over age 6 years.
journal_name
Neurologyjournal_title
Neurologyauthors
Ahonen K,Hämäläinen ML,Eerola M,Hoppu Kdoi
10.1212/01.wnl.0000238179.79888.44subject
Has Abstractpub_date
2006-10-10 00:00:00pages
1135-40issue
7eissn
0028-3878issn
1526-632Xpii
01.wnl.0000238179.79888.44journal_volume
67pub_type
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