Abstract:
BACKGROUND:Cerebral microbleeds are known to be indicative of bleeding-prone microangiopathy and may predict incident intracerebral hemorrhage (ICH). In this study, we investigated whether microbleeds are associated with the incidence of warfarin-related ICH. METHODS:Twenty-four patients with ICH while on outpatient treatment with warfarin were selected from a consecutive cohort. Control, warfarin-using subjects with no history of ICH were randomly selected during the same time period (n = 48). We compared demographic factors, vascular risk factors, laboratory findings, and radiologic findings including microbleeds between the groups. RESULT:There were more cases of patients with microbleeds in the ICH than control group (79.2% vs 22.9%: p < 0.001), and the number of microbleeds was much higher for the ICH group (9.0 +/- 26.8 vs 0.5 +/- 1.03: p < 0.001). Moreover, the number of microbleeds was significantly correlated with the presence of warfarin-related ICH (r = 0.299; p < 0.001). Conditional logistic regression analysis showed that increased prothrombin time and the presence of microbleeds were independently related to the incidence of warfarin-related ICH (microbleeds: adjusted OR, 83.12). CONCLUSION:This study suggests that underlying microbleeds are independently associated with an incidence of warfarin-related intracerebral hemorrhage. Future research should focus on elucidating the risks and benefits of warfarin medication in patients with microbleeds.
journal_name
Neurologyjournal_title
Neurologyauthors
Lee SH,Ryu WS,Roh JKdoi
10.1212/01.wnl.0000339060.11702.ddsubject
Has Abstractpub_date
2009-01-13 00:00:00pages
171-6issue
2eissn
0028-3878issn
1526-632Xpii
72/2/171journal_volume
72pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. METHODS:Data were acquired from 2 CIS cohorts. The screening phase evaluated patients developing clinically definite MS (CIS-CDMS) and patients who...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003085
更新日期:2016-09-13 00:00:00
abstract::Regional cerebral glucose metabolism was studied in 16 patients with idiopathic torticollis, using positron emission tomography. Analysis of subcortical regions revealed no consistent focal abnormality of cerebral metabolic rate for glucose, but there was a bilateral breakdown of the normal relationships between the t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.5.653
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:Alzheimer disease (AD) risk factors are present throughout the lifespan. This randomized controlled trial evaluated the effectiveness of various online education strategies concerning AD risk reduction and brain health in younger populations. METHOD:High school and college students were recruited via social ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000009859
更新日期:2020-10-20 00:00:00
abstract::We present an 11-year-old girl in whom high field strength MRI performed 2 1/2 years and 6 months before her death showed prominent hypointensity in the globus pallidus and substantia nigra consistent with iron deposition. This finding suggested Hallervorden-Spatz disease, which was confirmed at autopsy. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.3.440
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:To explore alterations in gray matter volume in patients with functional movement disorders. METHODS:We obtained T1-weighted MRI on 48 patients with clinically definite functional movement disorders, a subset of functional neurologic symptom disorder characterized by abnormal involuntary movements, and on 55...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006514
更新日期:2018-11-13 00:00:00
abstract::Electrophysiologic studies were carried out on 11 patients with Holmes-Adie syndrome, 8 of whom had reduced or absent ankle jerks. Conduction velocities and evoked nerve and muscle compound action potentials in the peroneal, posterior tibial, and sural nerves were normal. The H reflex was absent (or virtually absent) ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.2.262
更新日期:1988-02-01 00:00:00
abstract:OBJECTIVE:The 36-item Short Form Health Survey Questionnaire (SF-36) is a widely used generic health status measure. Recently it has been adapted to produce a disease-specific measure for MS-the 54-item Multiple Sclerosis Quality of Life Scale (MSQOL-54)-composed of five unchanged SF-36 scales; three altered SF-36 scal...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.1.68
更新日期:2001-07-10 00:00:00
abstract:OBJECTIVE:To examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis (ALS). METHODS:We measured Nf light chain (NfL) and phosphorylated Nf heavy chain (pNfH) CSF and NfL serum levels in patients with ALS with first symptom onset...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000004761
更新日期:2018-01-02 00:00:00
abstract:OBJECTIVE:The study aims to examine α-synuclein in the CSF of patients with severe traumatic brain injury (TBI) and its relationship with clinical characteristics and long-term outcomes. METHODS:This prospective case-control study enrolled patients with severe TBI (Glasgow Coma Score ≤ 8) who underwent ventriculostomy...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182904d43
更新日期:2013-04-30 00:00:00
abstract:BACKGROUND:Infection with HIV can result in a debilitating CNS disorder known as HIV dementia (HIV-D). Since the advent of highly active antiretroviral therapy (HAART), the incidence of HIV-D has declined, but the prevalence continues to increase. In this new era of HIV-D, traditional biomarkers such as CSF viral load ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000260610.79853.47
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:The natural history of succinic semialdehyde dehydrogenase (SSADH) deficiency in adulthood is unknown; we elucidate the clinical manifestations of the disease later in life. METHODS:A 63-year-old man with long-standing intellectual disability was diagnosed with SSADH deficiency following hospitalization for ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001906
更新日期:2015-09-08 00:00:00
abstract::Despite recent advances in the molecular genetics of Alzheimer's disease (AD), several fundamental questions concerning risk of illness are unresolved, namely, if Mendelian factors account for the incidence of the disease, and if AD is an inevitable consequence of the aging process. This study was designed to address ...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/wnl.46.3.641
更新日期:1996-03-01 00:00:00
abstract::INeuro@neurolist.mcg. edu: An e-mail discussion list for neurologists Neuro@neurolist.mcg.edu (Neurolist) is a discussion list for neurologists. This Internet tool, established in 1994, allows the worldwide community of neurologists to communicate quickly and efficiently using e-mail, web browsers, and newsreaders. Ne...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.9.1891
更新日期:1999-06-10 00:00:00
abstract:OBJECTIVE:To report the development of CNS vasculitis in a patient with multiple sclerosis (MS) treated with daclizumab. METHODS:This report includes clinical, MRI, immunologic, and pathology data and CSF analysis. RESULTS:After completing a phase II daclizumab monotherapy study with an optimal response as evidenced ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0f42
更新日期:2013-01-29 00:00:00
abstract::Twenty-seven patients with static or worsening chronic inflammatory-demyelinating polyradiculoneuropathy were randomly assigned to alternate day decremental prednisone therapy alone or with azathioprine (2 mg/kg) for 9 months. No statistically significant alterations were demonstrated between these treatment schedules...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.35.8.1173
更新日期:1985-08-01 00:00:00
abstract::Self-reported versus informant-reported memory problems in nondemented elderly adults and in individuals with very mild and mild dementia of the Alzheimer type (DAT) were correlated with cognitive outcomes. No significant correlations were found between self-reported memory complaints and cognitive performance or (in ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.11.1724
更新日期:2000-12-12 00:00:00
abstract::Increased urinary levels of the polyamines, putrescine, spermidine, and spermine are present in Duchenne muscular dystrophy (DMD) patients. Alterations in excretion are detectable when based on nanomoles per milligram creatinine, micromoles per 24-hour urine collection, or nanomoles per kilogram body weight per 24-hou...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVES:To assess the association of primary retinal inflammation, namely retinal periphlebitis (RP) and microcystic macular edema, with clinical, brain, and retinal imaging biomarkers of multiple sclerosis (MS) severity. METHODS:One hundred patients with MS underwent a neurologic and ophthalmic examination, MRI, a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a3525e
更新日期:2013-09-03 00:00:00
abstract::Duchenne muscular dystrophy manifested in one of girl twins. The twins were monozygous on the basis of red cell and HL antigens and skin graft compatibility. Karyotyping, including banding techniques, showed a normal number of chromosomes and a normal configuration of the X-chromosome in both twins. The twins were ide...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.6.537
更新日期:1977-06-01 00:00:00
abstract::Fasciculations and cramps may occur in motor neuron disease or as part of a more benign syndrome. A man with apparently benign fasciculations and cramps for 4 years developed progressive muscle weakness and wasting. Such a previously undocumented evolution of benign fasciculations and cramps to motor neuron disease ma...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.7.997
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVE:To preliminarily assess the safety and efficacy of transdermal nicotine therapy on cognitive performance and clinical status in subjects with mild cognitive impairment (MCI). METHODS:Nonsmoking subjects with amnestic MCI were randomized to transdermal nicotine (15 mg per day or placebo) for 6 months. Primary...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/WNL.0b013e31823efcbb
更新日期:2012-01-10 00:00:00
abstract:OBJECTIVE:Dravet syndrome is a rare neurodevelopmental disorder characterized by seizures and other neurologic problems. SCN1A mutations account for ∼80% of cases. Animal studies have implicated mutation-related dysregulated cortical inhibitory networks in its pathophysiology. We investigated such networks in people wi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003868
更新日期:2017-04-25 00:00:00
abstract::The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations betw...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.196
更新日期:1980-02-01 00:00:00
abstract:OBJECTIVE:To characterize the prevalence and prognostic significance of major driver molecular alterations in adult midline diffuse gliomas (MLG). METHODS:Adults with histologically proven MLG diagnosed between 1996 and 2017 were identified from our tumor bank, systematically reviewed, and reclassified according to WH...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005658
更新日期:2018-06-05 00:00:00
abstract::The author describes a distinct clinical syndrome in six patients with autonomic failure who manifested habitual, voluntary, transiently suppressible, yet irresistible leg movements occurring only in the sitting position. Keeping the legs still brought on vague symptoms of fatigue, lightheadedness, or apprehension. Re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.12.1923
更新日期:2000-12-26 00:00:00
abstract::Four patients with a clinical syndrome closely resembling amyotrophic lateral sclerosis recovered completely, without treatment, 5 to 12 months after onset. Electrodiagnostic tests revealed acute and chronic denervation, with normal motor and sensory nerve conduction studies. The CSF was normal, and tests for paraprot...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.10.1541
更新日期:1991-10-01 00:00:00
abstract:OBJECTIVE:Subjects with diabetes are reported to have an increased risk of dementia and cognitive impairment. However, the underlying causes remain unknown. We investigated the longitudinal associations between midlife insulin secretion, glucose metabolism, and the subsequent development of Alzheimer disease (AD) and d...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000310646.32212.3a
更新日期:2008-09-30 00:00:00
abstract::Acute chorea in a child followed ingestion of pemoline mesylate. In guinea pigs, in an experimental model of chorea, chronic administration of pemoline induced behavioral supersensitivity to other dopaminergic agonists. Pemoline is similar to both d-amphetamine and methylphenidate in altering central dopaminergic sens...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.3.256
更新日期:1981-03-01 00:00:00
abstract:OBJECTIVE:The assessment of behavioral disturbances in amyotrophic lateral sclerosis (ALS) is important because of the overlap with the behavioral variant of frontotemporal dementia (ALS-bvFTD). Motor symptoms and dysarthria are not taken into account in currently used behavioral questionnaires. We examined the clinime...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826c1aa1
更新日期:2012-09-25 00:00:00
abstract:OBJECTIVE:To localize a gene predisposing to benign epilepsy of childhood with centrotemporal spikes (BECTS). BACKGROUND:BECTS, or rolandic epilepsy, is the most prevalent idiopathic epilepsy syndrome in childhood. Functional relevant defects in the alpha 4 subunit of the neuronal nicotinic acetylcholine receptor (ACh...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.6.1608
更新日期:1998-12-01 00:00:00