Abstract:
:Increased urinary levels of the polyamines, putrescine, spermidine, and spermine are present in Duchenne muscular dystrophy (DMD) patients. Alterations in excretion are detectable when based on nanomoles per milligram creatinine, micromoles per 24-hour urine collection, or nanomoles per kilogram body weight per 24-hour urine collection. Evaluation of creatinine levels in spot collections of urine versus 24-hour collections suggests a more consistent urinary creatinine in spot urines from DMD patients and normals, with wider variability in 24-hour specimens. We postulate that polyamines may be useful markers to evaluate disease activity and to screen for drug efficacy, as they have proved useful in cancer patients in assessing alterations in tumor kinetic parameters.
journal_name
Neurologyjournal_title
Neurologyauthors
Russell DH,Stern LZsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
80-3issue
1eissn
0028-3878issn
1526-632Xjournal_volume
31pub_type
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