Abstract:
:The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations between 10 to 20 mg per liter, the average t50% (18.6 hours) was approximately 58% as long as the average in adults with comparable concentrations. Whereas the t50% correlated with the initial PHT concentrations, there was no correlation overall between t50% and age, size, or number of other antiepileptic medications taken. The concentration-dependence of the t50% provided the basis for less frequent dosing than one would expect from previous studies of PHT half-life in children with low concentrations.
journal_name
Neurologyjournal_title
Neurologyauthors
Dodson WEdoi
10.1212/wnl.30.2.196subject
Has Abstractpub_date
1980-02-01 00:00:00pages
196-9issue
2eissn
0028-3878issn
1526-632Xjournal_volume
30pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.1.263
更新日期:1997-01-01 00:00:00
abstract::I studied vimentin and desmin immunoreactivities in the skeletal muscle of 30 human fetuses and children ranging from 8 weeks' gestation to 2 years of age, and in 45 infants and children and five adults with developmental neuromuscular diseases. Acridine orange-RNA fluorescence also identified regenerating myofibers i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.8.1616
更新日期:1992-08-01 00:00:00
abstract::The authors report seven patients from six neuro-ophthalmology referral centers who developed pseudo-tumor cerebri during treatment with doxycycline. All four female patients and one of three male patients were obese. Vision was minimally affected in most patients, but two had substantial visual acuity or visual field...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.62.12.2297
更新日期:2004-06-22 00:00:00
abstract:OBJECTIVE:To investigate the relationship between the presence of a circadian body temperature rhythm and behaviorally assessed consciousness levels in patients with disorders of consciousness (DOC; i.e., vegetative state/unresponsive wakefulness syndrome or minimally conscious state). METHODS:In a cross-sectional stu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003942
更新日期:2017-05-16 00:00:00
abstract::The defect occurring when a patient fails to report a visual stimulus presented in a visual half-field may be attributed to hemianopia (deafferentation) caused by a geniculocalcarine lesion. However, failure to report a stimulus presented in a visual field may also be caused by hemispatial visual inattention. We repor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.8.1125
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE:To develop evidence-based recommendations for complementary and alternative medicine (CAM) in multiple sclerosis (MS). METHODS:We searched the literature (1970-March 2011; March 2011-September 2013 MEDLINE search), classified articles, and linked recommendations to evidence. RESULTS AND RECOMMENDATIONS:Clin...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0000000000000250
更新日期:2014-03-25 00:00:00
abstract::In the same family, the generalized or infantile form of acid maltase deficiency (glycogenosis type II, Pompe disease) and the muscular or adult-onset form affected different individuals. Autosomal-recessive inheritance for the two clinical forms was demonstrated in this family by assay of acid alpha-glucosidase in mu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.10.1209
更新日期:1981-10-01 00:00:00
abstract:OBJECTIVE:To investigate the presenting characteristics of new-onset afebrile seizures in infants (age 1-24 months) and the yield of neuroimaging. METHODS:Prospective data were obtained from a standardized evaluation and management plan mandated by a critical care pathway. A total of 317 infants presented with new-ons...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c91847
更新日期:2010-01-12 00:00:00
abstract::To evaluate the potential for clinical application, the reputed protective action of barbiturates in cerebral ischemia was tested in a controlled study after segmental middle cerebral artery occlusion in primates. Surviving treated animals promptly recovered consciousness, locomotion, and feeding behavior despite pers...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.9.870
更新日期:1975-09-01 00:00:00
abstract:OBJECTIVE:To study the accuracy of the ABCD2 score in predicting early stroke risk following TIA and to model post-test probability of stroke for varying cutoff scores and baseline stroke risk. METHODS:Medline, PubMed, Embase, conference proceedings, and manuscript references up to October 2010 were searched for studi...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/WNL.0b013e31825f9d02
更新日期:2012-09-04 00:00:00
abstract::We performed an open-label study testing the effects of GM1 ganglioside on 10 Parkinson's disease (PD) patients. Patients received 1,000 mg of GM1 by IV infusion after the last of three baseline functional assessments. Patients then self-administered GM1 at a dose of 200 mg/d, by subcutaneous injection, for 18 weeks. ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.45.6.1149
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Although about 7 million people in the US population use marijuana at least weekly, there is a paucity of scientific data on persistent neurocognitive effects of marijuana use. OBJECTIVE:To determine if neurocognitive deficits persist in 28-day abstinent heavy marijuana users and if these deficits are dose-...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000031422.66442.49
更新日期:2002-11-12 00:00:00
abstract::We report the clinical and neuroimaging findings of a mother and daughter with seizure disorders and band heterotopias seen on magnetic resonance imaging studies. These clinicoradiologic findings simulate those for a diagnosis of tuberous sclerosis complex. Clinicians should be aware of this migrational anomaly and it...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.7.1424
更新日期:1993-07-01 00:00:00
abstract::Thyrotropin-releasing hormone (TRH) exerts many effects upon spinal cord function in animals, and may also play a role in human spinal cord function. We have used the technique of quantitative autoradiography to anatomically localize specific receptors for TRH within human spinal cord. Highest concentrations of TRH re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.3.328
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:To validate the ability of a specifically developed cognitive risk score to identify patients at risk of poststroke neurocognitive disorders (NCDs) who are eligible for a comprehensive cognitive assessment. METHODS:After assessing 404 patients (infarct 91.3%) in the Groupe de Réflexion pour l'Evaluation Cogn...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006544
更新日期:2018-11-20 00:00:00
abstract:BACKGROUND:Pharmacologic interventions (e.g., beta blockers) and thalamic lesions have failed to alter the pathophysiology of essential tremor (ET) beyond a reduction in tremor amplitude. Deep brain stimulation (DBS) of the ventral intermediate (VIM) nucleus of the thalamus successfully reduces tremor rating scores. It...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000086371.78447.d2
更新日期:2003-10-14 00:00:00
abstract:OBJECTIVE:To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD). METHODS:Twenty-year follow-up data from the Kuopio Osteoporosis Risk Factor and Prevention study cohort were used. Self-administered questionnaires were sent to all women aged 47-56 years, residing in Kuopio Pr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003696
更新日期:2017-03-14 00:00:00
abstract::We identified seven patients with refractory partial epilepsy and sleep apnea. Treatment of the sleep apnea with nasal continuous positive airway pressure (CPAP), protriptyline, trazodone, acetazolamide, or tracheostomy reduced seizure frequency and severity in six patients. Success with CPAP depended largely on compl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.11.2060
更新日期:1994-11-01 00:00:00
abstract::Although Parkinson's disease has a definite neurologic basis, patients and relatives experience a multitude of stresses, only partly related to motor symptoms. Subjective and behavioral problems may be regarded as secondary disease symptoms. In an integrated approach, patients and relatives receive psychological couns...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::Postmortem studies of patients with progressive supranuclear palsy (PSP) have demonstrated loss of cholinergic neurons in the striatum, nucleus basalis of Meynert, and the pedunculopontine nucleus. These findings suggest that cholinergic drugs might be an effective treatment for this disease. We studied the efficacy o...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.39.2.257
更新日期:1989-02-01 00:00:00
abstract::We treated 64 emergency room patients with a primary vascular headache with dihydroergotamine (DHE), meperidine, or butorphanol. Post-treatment pain scores were lowest in the DHE group (p less than 0.01). Eight of 21 patients receiving DHE had greater than 90% reduction in pain compared with three of 19 patients recei...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.39.4.590
更新日期:1989-04-01 00:00:00
abstract::This is a case study of a patient with the clinical diagnosis of meningoencephalitis. It demonstrates the in vivo development of plasma cells in the central nervous system. All the stages of in vitro mitogen-induced lymphocyte transformation previously described by light and electron microscopy are recapitulated in th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.5.448
更新日期:1977-05-01 00:00:00
abstract:OBJECTIVE:To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). BACKGROUND:LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. METHOD:The authors evaluated the brains of 72 consecutive cases of pathologically conf...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.9.1675
更新日期:2001-11-13 00:00:00
abstract:OBJECTIVE:To assess the frequency of mutations in C19orf12 in the greater neurodegeneration with brain iron accumulation (NBIA) population and further characterize the associated phenotype. METHODS:Samples from 161 individuals with idiopathic NBIA were screened, and C19orf12 mutations were identified in 23 subjects. D...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827e07be
更新日期:2013-01-15 00:00:00
abstract:OBJECTIVE:We aimed to perform an observational study of age at loss of independent ambulation (LoA) and side-effect profiles associated with different glucocorticoid corticosteroid (GC) regimens in Duchenne muscular dystrophy (DMD). METHODS:We studied 340 participants in the Cooperative International Neuromuscular Res...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001950
更新日期:2015-09-22 00:00:00
abstract:OBJECTIVE:Based on previous findings implicating abnormalities of cortico-striatal-thalamo-cortical circuitry in Tourette syndrome (TS), the authors performed a volumetric analysis of frontal and nonfrontal tissue (gray + white matter) in boys with TS, with and without attention deficit hyperactivity disorder (ADHD). ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.1.85
更新日期:2002-01-08 00:00:00
abstract:OBJECTIVE:To investigate the involvement of the epidermal small sensory fibers in the neurodegenerative process in amyotrophic lateral sclerosis (ALS). METHODS:In the present study, skin biopsies of 28 patients with ALS were obtained at an average of 34 months after disease onset by history. Protein gene product 9.5 (...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31821e553a
更新日期:2011-06-07 00:00:00
abstract::A 16-year-old male with a 9-year history of spontaneously arrested hydrocephalus was noted to have hydrosyringomyelia and increased intracranial pressure shortly after sustaining minor head trauma. His symptoms resolved completely following ventriculoperitoneal shunt replacement. Hydrosyringomyelia may occur in the se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.4.652
更新日期:1988-04-01 00:00:00
abstract::In 2001, the authors described the clinical features of a genetically distinct autosomal dominant limb-girdle muscular dystrophy (LGMD; LGMD 1F). Using a genome-wide screen with more than 400 microsatellite markers, the authors identified a novel LGMD disease locus at chromosome 7q32.1-32.2. Within this chromosomal re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073984.46546.4f
更新日期:2003-08-12 00:00:00
abstract:OBJECTIVE:To determine the stage of training at which neurology residents should achieve individual elements of the Accreditation Council for Graduate Medical Education neurology Milestones and to examine the relationship between perceived importance of Milestones and the stage by which they should be achieved. METHOD...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006361
更新日期:2018-10-16 00:00:00