Abstract:
:In 2001, the authors described the clinical features of a genetically distinct autosomal dominant limb-girdle muscular dystrophy (LGMD; LGMD 1F). Using a genome-wide screen with more than 400 microsatellite markers, the authors identified a novel LGMD disease locus at chromosome 7q32.1-32.2. Within this chromosomal region, filamin C, a gene encoding actin binding protein highly expressed in muscle, was an obvious candidate gene; however, the authors did not detect any defects in filamin C or its protein product.
journal_name
Neurologyjournal_title
Neurologyauthors
Palenzuela L,Andreu AL,Gàmez J,Vilà MR,Kunimatsu T,Meseguer A,Cervera C,Fernandez Cadenas I,van der Ven PF,Nygaard TG,Bonilla E,Hirano Mdoi
10.1212/01.wnl.0000073984.46546.4fsubject
Has Abstractpub_date
2003-08-12 00:00:00pages
404-6issue
3eissn
0028-3878issn
1526-632Xjournal_volume
61pub_type
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