The in vivo development of plasma cells: a morphologic study of human cerebrospinal fluid.

abstract：BACKGROUND:Because of the relatively poor results of frontal lobe epilepsy (FLE) surgery, identification of prognostic factors for surgical outcome is of great importance. METHODS:To identify predictive factors for FLE surgery, we analyzed the data of 61 patients (mean age at surgery 19.2) who had undergone presurgica...

journal_title：Neurology

authors： Janszky J,Jokeit H,Schulz R,Hoppe M,Ebner A

更新日期：2000-04-11 00:00:00

abstract：:The authors measured the association of early ischemic change on CT scan, measured using the Alberta Stroke Programme Early CT score (ASPECTS), and functional outcome in 825 patients with anterior circulation stroke treated with IV thrombolysis within 3 hours of onset. ASPECTS predicted outcome in a graded fashion (li...

journal_title：Neurology

authors： Weir NU,Pexman JH,Hill MD,Buchan AM,CASES investigators.

更新日期：2006-08-08 00:00:00

abstract：:Morphologic findings of thymuses from 32 anti-acetylcholine receptor (AChR)-negative myasthenia gravis patients, 12 with and 20 without antibodies against the muscle-specific kinase (MuSK), were compared with those from 30 AChR-positive subjects. In contrast with the high frequency of thymic hyperplastic changes in AC...

journal_title：Neurology

authors： Lauriola L,Ranelletti F,Maggiano N,Guerriero M,Punzi C,Marsili F,Bartoccioni E,Evoli A

更新日期：2005-02-08 00:00:00

abstract：:Genetic factors clearly cause Lewy-body Parkinson's disease (PD) in a subset of autosomal-dominant families. However, most cases of PD are sporadic. The two most likely models of four discussed for sporadic PD are the reduced penetrance model and the multifactorial model. Sporadic PD is likely to be caused by the comb...

journal_title：Neurology

authors： Johnson WG

更新日期：1991-05-01 00:00:00

abstract：:The association of APOE genotypes with cerebral microbleeds (CMBs) was examined on the basis of the location of CMBs in 414 patients who were admitted primarily because of stroke. With respect to possession of the epsilon2 or epsilon4 allele, the adjusted odds ratio was 1.94 (1.05 to 3.58) for lobar CMBs but 1.21 (0.6...

journal_title：Neurology

authors： Kim M,Bae HJ,Lee J,Kang L,Lee S,Kim S,Lee JE,Lee KM,Yoon BW,Kwon O,Koo JS,Kim BK

更新日期：2005-11-08 00:00:00

abstract：OBJECTIVE:To localize a gene predisposing to benign epilepsy of childhood with centrotemporal spikes (BECTS). BACKGROUND:BECTS, or rolandic epilepsy, is the most prevalent idiopathic epilepsy syndrome in childhood. Functional relevant defects in the alpha 4 subunit of the neuronal nicotinic acetylcholine receptor (ACh...

journal_title：Neurology

authors： Neubauer BA,Fiedler B,Himmelein B,Kämpfer F,Lässker U,Schwabe G,Spanier I,Tams D,Bretscher C,Moldenhauer K,Kurlemann G,Weise S,Tedroff K,Eeg-Olofsson O,Wadelius C,Stephani U

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:To detect and quantify lesions of the small-caliber sural nerve (SN) in symptomatic and asymptomatic transthyretin familial amyloid polyneuropathy (TTR-FAP) by high-resolution magnetic resonance neurography (MRN) in correlation with electrophysiologic and histopathologic findings. METHODS:Twenty-five patient...

journal_title：Neurology

authors： Kollmer J,Sahm F,Hegenbart U,Purrucker JC,Kimmich C,Schönland SO,Hund E,Heiland S,Hayes JM,Kristen AV,Röcken C,Pham M,Bendszus M,Weiler M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Silent infarcts are commonly discovered on cranial MRI in the elderly. OBJECTIVE:To examine the association between risk of stroke and presence of silent infarcts, alone and in combination with other stroke risk factors. METHODS:Participants (3,324) in the Cardiovascular Health Study (CHS) without a histor...

journal_title：Neurology

authors： Bernick C,Kuller L,Dulberg C,Longstreth WT Jr,Manolio T,Beauchamp N,Price T,Cardiovascular Health Study Collaborative Reseach Group.

更新日期：2001-10-09 00:00:00

abstract：:We used the Mayo Clinic medical records linkage system to detect all cases of intracranial vascular malformation (IVM) among residents of Olmsted County, Minnesota from 1965 to 1992 and found 48 IVMs over the 27-year period, including four patients with IVM detected at autopsy, without prior symptoms. Twenty-nine of 4...

journal_title：Neurology

authors： Brown RD Jr,Wiebers DO,Torner JC,O'Fallon WM

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:To further investigate the basis of abnormal neuromuscular transmission in two patients with congenital myasthenic syndrome associated with episodic ataxia type 2 (EA2) using stimulated single fiber EMG (SFEMG) and in vitro microelectrode studies. METHODS:Two patients with genetically characterized EA2 previ...

journal_title：Neurology

authors： Maselli RA,Wan J,Dunne V,Graves M,Baloh RW,Wollmann RL,Jen J

更新日期：2003-12-23 00:00:00

abstract：OBJECTIVE:To describe the clinical characteristics of encounters with patients misdiagnosed with multiple sclerosis (MS). METHODS:A cross-sectional Internet-based physician survey of MS specialists was performed. RESULTS:The response rate for the survey was 50.4%. Of those who responded, the majority (95%) reported h...

journal_title：Neurology

authors： Solomon AJ,Klein EP,Bourdette D

更新日期：2012-06-12 00:00:00

abstract：OBJECTIVE:To estimate the US commercially insured multiple sclerosis (MS) annual prevalence from 2008 to 2012. METHODS:The study was a retrospective analysis using PharMetrics Plus, a nationwide claims database for over 42 million covered US representative lives. Annual point prevalence required insurance eligibility ...

journal_title：Neurology

authors： Dilokthornsakul P,Valuck RJ,Nair KV,Corboy JR,Allen RR,Campbell JD

更新日期：2016-03-15 00:00:00

abstract：OBJECTIVE:To assess the determinants of amyotrophic lateral sclerosis (ALS) phenotypes in a population-based cohort. METHODS:The study population included 2,839 patients with ALS diagnosed in Piemonte, Italy (1995-2015). Patients were classified according to motor (classic, bulbar, flail arm, flail leg, predominantly ...

journal_title：Neurology

authors： Chiò A,Moglia C,Canosa A,Manera U,D'Ovidio F,Vasta R,Grassano M,Brunetti M,Barberis M,Corrado L,D'Alfonso S,Iazzolino B,Peotta L,Sarnelli MF,Solara V,Zucchetti JP,De Marchi F,Mazzini L,Mora G,Calvo A

更新日期：2020-02-25 00:00:00

abstract：OBJECTIVE:To investigate the effect of age, sex, APOE4 genotype, and lifestyle enrichment (education/occupation, midlife cognitive activity, and midlife physical activity) on Alzheimer disease (AD) biomarker trajectories using longitudinal imaging data (brain β-amyloid load via Pittsburgh compound B PET and neurodegene...

journal_title：Neurology

authors： Vemuri P,Lesnick TG,Przybelski SA,Knopman DS,Machulda M,Lowe VJ,Mielke MM,Roberts RO,Gunter JL,Senjem ML,Geda YE,Rocca WA,Petersen RC,Jack CR Jr

更新日期：2016-03-22 00:00:00

abstract：:This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On mi...

journal_title：Neurology

authors： Perlo VP,Arnason B,Castleman B

更新日期：1975-03-01 00:00:00

abstract：OBJECTIVE:To perform an evidence-based review of the safety and efficacy of botulinum neurotoxin (BoNT) in the treatment of movement disorders. METHODS:A literature search was performed including MEDLINE and Current Contents for therapeutic articles relevant to BoNT and selected movement disorders. Authors reviewed, a...

journal_title：Neurology

authors： Simpson DM,Blitzer A,Brashear A,Comella C,Dubinsky R,Hallett M,Jankovic J,Karp B,Ludlow CL,Miyasaki JM,Naumann M,So Y,Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

更新日期：2008-05-06 00:00:00

abstract：:Automatisms are commonly seen in epilepsy, either ictally or postictally. However, most automatisms are simple, with hand movements, mouth smacking, nose-rubbing, repetition of a single word, or coughing, grunting, or screeching. Complex automatisms are less common and striking. The authors report two cases of seizure...

journal_title：Neurology

authors： Doherty MJ,Wilensky AJ,Holmes MD,Lewis DH,Rae J,Cohn GH

更新日期：2002-11-12 00:00:00

abstract：:A wide variety of movement disorders are associated with alcohol abuse. Some idiopathic movement disorders are markedly improved by small amounts of alcohol and this response occasionally may lead to alcoholism. Alcohol abuse alone or combined with hepatic encephalopathy can cause various types of tremor, asterixis, a...

journal_title：Neurology

authors： Neiman J,Lang AE,Fornazzari L,Carlen PL

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:To determine the association between hypertensive disorders of pregnancy (HDP) and cognitive impairment 15 years after pregnancy, we measured cognitive performance in 115 women with a history of HDP and in 481 women with a previous normotensive pregnancy. METHODS:This was a nested cohort study embedded in a ...

journal_title：Neurology

authors： Adank MC,Hussainali RF,Oosterveer LC,Ikram MA,Steegers EAP,Miller EC,Schalekamp-Timmermans S

更新日期：2021-02-02 00:00:00

abstract：:Five women are presented with a subacute pure pancerebellar syndrome of ataxia and dysarthria to emphasize that this illness may occur without anti-Purkinje-cell or anti-Yo antibodies, or associated systemic cancer. The syndrome evolved over weeks or less and stabilized in four of the patients. Three had had a precedi...

journal_title：Neurology

authors： Ropper AH

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) (gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, and zonisamide) in the treatment of children and adults with refractory partial and generalized epilepsies. METHODS:A ...

journal_title：Neurology

authors： French JA,Kanner AM,Bautista J,Abou-Khalil B,Browne T,Harden CL,Theodore WH,Bazil C,Stern J,Schachter SC,Bergen D,Hirtz D,Montouris GD,Nespeca M,Gidal B,Marks WJ Jr,Turk WR,Fischer JH,Bourgeois B,Wilner A,Faught R

更新日期：2004-04-27 00:00:00

abstract：:We performed a 3-month, double-blind, placebo-controlled trial of 300 mg of gangliosides (Cronassial) in 40 outpatients with amyotrophic lateral sclerosis (ALS). We evaluated drug effect through physical examinations and symptom scales. Though this dosage had no major toxic effect, Cronassial treatment did not signifi...

journal_title：Neurology

authors： Lacomblez L,Bouche P,Bensimon G,Meininger V

更新日期：1989-12-01 00:00:00

abstract：OBJECTIVE:To perform a systematic review and meta-analysis of studies reporting recurrent intracranial hemorrhage (ICH) and ischemic stroke (IS) in ICH survivors with atrial fibrillation (AF) during long-term follow-up. METHODS:A comprehensive literature search including MEDLINE, EMBASE, Cochrane library, clinical tri...

journal_title：Neurology

authors： Korompoki E,Filippidis FT,Nielsen PB,Del Giudice A,Lip GYH,Kuramatsu JB,Huttner HB,Fang J,Schulman S,Martí-Fàbregas J,Gathier CS,Viswanathan A,Biffi A,Poli D,Weimar C,Malzahn U,Heuschmann P,Veltkamp R

更新日期：2017-08-15 00:00:00

abstract：OBJECTIVES:To estimate patient-acceptable symptom state (PASS) cut points for myasthenia gravis (MG) health scales. METHODS:We conducted an electronic survey that included the Myasthenia Gravis Impairment Index (MGII), EuroQol 5-Dimension (EQ5D), and a simple PASS question. PASS-anchored thresholds were estimated for ...

journal_title：Neurology

authors： Mendoza M,Tran C,Bril V,Katzberg HD,Barnett C

更新日期：2020-09-22 00:00:00

abstract：OBJECTIVE:This study assessed the strength of military-related concussion-, psychological-, and behavioral-related measures to predict neurobehavioral symptom (NBS) reporting in order to help clarify the extent to which persistent NBS reflect lingering effects of concussion vs other psychological/behavioral factors amo...

journal_title：Neurology

authors： Andrews RJ,Fonda JR,Levin LK,McGlinchey RE,Milberg WP

更新日期：2018-08-21 00:00:00

abstract：:Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures. Sixty neonates (85%) had seizures controlled by phenobarbital alone. Effective plasma concentrations were 10.1 to 46.4 mg per liter. Although 36 neonates had seizures controlled by phenobarb...

journal_title：Neurology

authors： Gal P,Toback J,Boer HR,Erkan NV,Wells TJ

更新日期：1982-12-01 00:00:00

abstract：:Progressive supranuclear palsy (PSP) is a relatively common neurodegenerative tauopathy clinically characterized by parkinsonism, axial rigidity, and supranuclear gaze palsy. Pathologic findings of PSP are neuronal loss, gliosis, and neurofibrillary tangles in basal ganglia, diencephalon, and brainstem; there is incre...

journal_title：Neurology

authors： Fujioka S,Algom AA,Murray ME,Strongosky A,Soto-Ortolaza AI,Rademakers R,Ross OA,Wszolek ZK,Dickson DW

更新日期：2013-05-28 00:00:00

abstract：BACKGROUND:In patients with trigeminal neuralgia, results of clinical examination of sensory function are normal. Reflex and evoked potential studies have already provided information on large-afferent (non-nociceptive) function. Using laser-evoked potentials (LEP), the authors sought information on small-afferent (noc...

journal_title：Neurology

authors： Cruccu G,Leandri M,Iannetti GD,Mascia A,Romaniello A,Truini A,Galeotti F,Manfredi M

更新日期：2001-06-26 00:00:00

abstract：:A kindred is described with a dominantly inherited "pure" cerebellar ataxia in which the currently known spinocerebellar ataxias have been excluded. In the eight subjects studied, a notable clinical feature is slow progression, with the three least affected having only a mild degree of gait ataxia after three or more ...

journal_title：Neurology

authors： Storey E,Gardner RJ,Knight MA,Kennerson ML,Tuck RR,Forrest SM,Nicholson GA

更新日期：2001-11-27 00:00:00

abstract：OBJECTIVE:The relationship between relapses and long-term disability in multiple sclerosis (MS) remains to be fully elucidated. Current literature is conflicting and focused on early relapses. We investigated the effects of relapses at different stages on disability progression. METHODS:We conducted a retrospective re...

journal_title：Neurology

authors： Tremlett H,Yousefi M,Devonshire V,Rieckmann P,Zhao Y,UBC Neurologists.

更新日期：2009-11-17 00:00:00