Abstract:
:Morphologic findings of thymuses from 32 anti-acetylcholine receptor (AChR)-negative myasthenia gravis patients, 12 with and 20 without antibodies against the muscle-specific kinase (MuSK), were compared with those from 30 AChR-positive subjects. In contrast with the high frequency of thymic hyperplastic changes in AChR-positive patients, in MuSK-positive subjects histologic alterations were minimal, arguing against an intrathymic disease pathogenesis. Since hyperplastic changes were seen in 35% of MuSK-negative patients, the thymus could be involved in some of these cases.
journal_name
Neurologyjournal_title
Neurologyauthors
Lauriola L,Ranelletti F,Maggiano N,Guerriero M,Punzi C,Marsili F,Bartoccioni E,Evoli Adoi
10.1212/01.WNL.0000150587.71497.B6subject
Has Abstractpub_date
2005-02-08 00:00:00pages
536-8issue
3eissn
0028-3878issn
1526-632Xpii
64/3/536journal_volume
64pub_type
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