Abstract:
:A 48-year-old man presented with progressive spastic paraparesis and diffuse white matter involvement on neuroimaging that suggested a primary demyelinating disease. Brain biopsy 3 years after onset of symptoms demonstrated idiopathic granulomatous angiitis. In patients with MRI features of diffuse white matter disease of uncertain etiology, open brain biopsy of leptomeninges and parenchyma should be considered to exclude idiopathic granulomatous angiitis of the CNS.
journal_name
Neurologyjournal_title
Neurologyauthors
Finelli PF,Onyiuke HC,Uphoff DFdoi
10.1212/wnl.49.6.1696subject
Has Abstractpub_date
1997-12-01 00:00:00pages
1696-9issue
6eissn
0028-3878issn
1526-632Xjournal_volume
49pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To conduct a validation study of 123I-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (123I-FP-CIT) SPECT dopaminergic imaging in the clinical diagnosis of dementia with Lewy bodies (DLB) with autopsy as the gold standard. METHODS:Patients >60 years of age with dementia who had undergone 123I-FP-...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003512
更新日期:2017-01-17 00:00:00
abstract:BACKGROUND:X-linked adrenoleukodystrophy (X-ALD) has variants with widely different outcomes, hampering clinical counseling and evaluation of therapies. OBJECTIVE:To evaluate the degree to which MRI patterns can predict lesion progression. METHODS:Two hundred six boys and men with cerebral X-ALD (median age 12.2 year...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000079050.91337.83
更新日期:2003-08-12 00:00:00
abstract::To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.51.2.583
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:In patients with active epilepsy, adverse medication effects and severity of depression are correlated with health-related quality of life, but seizure frequency is not. We sought to examine if the same pattern exists in patients with psychogenic nonepileptic seizures (PNES). METHODS:We administered seizure...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181b04c83
更新日期:2009-08-04 00:00:00
abstract::We studied two families with an unusual variant of neurofibromatosis (NF). The first family had spinal neurofibromas and café au lait spots (CLS), the second spinal neurofibromas without CLS. Other signs of NF1 or NF2, such as cutaneous tumors, Lisch nodules, or acoustic tumors, were absent. The inheritance pattern in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.12.1923
更新日期:1991-12-01 00:00:00
abstract::Increased urinary levels of the polyamines, putrescine, spermidine, and spermine are present in Duchenne muscular dystrophy (DMD) patients. Alterations in excretion are detectable when based on nanomoles per milligram creatinine, micromoles per 24-hour urine collection, or nanomoles per kilogram body weight per 24-hou...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract:OBJECTIVES:To describe clinical-radiologic characteristics in a prospective series of patients having both confirmed reversible cerebral vasoconstriction syndrome (RCVS) and cervical artery dissection (CeAD). METHODS:From January 2004 to December 2011, from our prospective cohorts of RCVS and CeAD, we studied patients...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a2cbe2
更新日期:2013-08-27 00:00:00
abstract::Cytolytic T lymphocyte precursors (CTL-p) and natural killer precursors (NK-p) in the CSF of 15 MS patients and 11 patients with other neurologic disorders (OND) were quantitatively assessed, using a T-lymphocyte microculture system that allows clonal expansion of all human T cells. CSF CTL-p and NK-p frequencies were...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.3.419
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between hippocampal, amygdalar, and entorhinal cortex atrophy and duration of epilepsy, presence of secondary generalized seizures, and prolonged childhood febrile convulsions in patients with pharmacologically intractable temporal lobe epilepsy (TLE). METHODS:Volumetric MRI of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000169066.46912.fa
更新日期:2005-07-26 00:00:00
abstract:OBJECTIVE:This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men. METHODS:Forty-two 40- to 60-year-old cognitively normal women ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004425
更新日期:2017-09-26 00:00:00
abstract:OBJECTIVE:To assess resting cerebral blood flow (CBF) in the whole-brain and cerebral white matter (WM) and gray matter (GM) of adults with Fabry disease (FD), using arterial spin labeling (ASL) MRI, and to investigate CBF correlations with WM hyperintensity (WMH) volume and the circulating biomarker lyso-Gb3. METHODS...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005330
更新日期:2018-04-17 00:00:00
abstract:OBJECTIVE:To identify regional metabolic brain networks related specifically to the presence of tremor in PD. BACKGROUND:The pathophysiology of parkinsonian tremor is unknown. Because tremor in PD occurs mainly in repose, we used resting state PET with 18F-fluorodeoxyglucose (FDG) to identify specific metabolic brain ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.3.803
更新日期:1998-09-01 00:00:00
abstract::The occurrence of Creutzfeldt-Jakob disease (CJD) among American Indians and Alaska Natives in the United States was evaluated using national multiple cause-of-death data and medical information obtained from state health departments. Twelve CJD deaths were identified for 1981 through 2002, and the average annual age-...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000196473.46805.61
更新日期:2006-02-14 00:00:00
abstract::Sensory disturbance in the unilateral hand and ipsilateral mouth region, the cheiro-oral syndrome, may be due to cortical, thalamic, or brainstem lesions. We report five patients with this syndrome due to infarction at the border of the posterior limb of the internal capsule and the corona radiata. The sensory fibers ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.1_part_1.51
更新日期:1993-01-01 00:00:00
abstract::The local cerebral metabolic rate for glucose (1=CMRg) was computed in rats with methylphenidate-induced stereotypy using the quantitative 14C-2-deoxyglucose (2-DG) technique. Four rats received methylphenidate 15 mg per kilogram IP. Compared to five control animals, treated rats showed statistically significant (p le...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.4.377
更新日期:1982-04-01 00:00:00
abstract:BACKGROUND:Muscle channelopathies such as paramyotonia, hyperkalemic periodic paralysis, and potassium-aggravated myotonia are caused by gain-of-function Na+ channel mutations. METHODS:Methods: Implementation of a three-dimensional radial 23Na magnetic resonance (MR) sequence with ultra-short echo times allowed the au...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000233841.75824.0f
更新日期:2006-10-10 00:00:00
abstract:OBJECTIVE:To evaluate changes from baseline in patient-reported outcomes for measures of functioning and disability among patients with migraine treated with galcanezumab or placebo. METHODS:Patients with episodic migraine (4-14 monthly migraine headache days) were treated with either galcanezumab (Evaluation of LY295...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000007856
更新日期:2019-07-30 00:00:00
abstract:BACKGROUND:In patients with trigeminal neuralgia, results of clinical examination of sensory function are normal. Reflex and evoked potential studies have already provided information on large-afferent (non-nociceptive) function. Using laser-evoked potentials (LEP), the authors sought information on small-afferent (noc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.12.1722
更新日期:2001-06-26 00:00:00
abstract:BACKGROUND:Hematopoietic stem cell transplantation (HSCT) may slow the progression of Krabbe disease (KD) if performed early in the disease. The authors' studies indicate that more than 90% of patients with KD have severe abnormalities in peripheral nerve conduction. OBJECTIVE:To assess the effect of HSCT on nerve con...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000230156.01228.33
更新日期:2006-07-25 00:00:00
abstract::Rats were intoxicated with acrylamide monomer at 50 mg per kilogram per day; lumbar dorsal root ganglia and distal sural and tibial nerves were studied morphologically. At the sixth day of intoxication, large and small neuronal cell bodies showed a spectrum of remodeling changes that included nuclear eccentricity, cyt...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.9.1023
更新日期:1982-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of amyloid imaging on clinical decision making. METHODS:We conducted a retrospective analysis of 140 cognitively impaired patients (mean age 65.0 years, 46% primary β-amyloid (Aβ) diagnosis, mean Mini-Mental State Examination 22.3) who underwent amyloid (Pittsburgh compound B [PiB]) PE...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000032
更新日期:2014-01-21 00:00:00
abstract:PURPOSE:To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques. METHODS:Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004197
更新日期:2017-08-08 00:00:00
abstract:OBJECTIVE:To determine whether the cytokine tumor necrosis factor alpha (TNF-alpha) acts as a pain mediator in neuropathic pain in humans. BACKGROUND:In animal models, inflammatory cytokines such as TNF-alpha have been shown to facilitate neuropathic pain. METHODS:The expression of TNF-alpha was analyzed immunohistoc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.10.1371
更新日期:2001-05-22 00:00:00
abstract::Epilepsy is common in people with intellectual and developmental disabilities (IDD). In adulthood, patients with IDD and epilepsy (IDD-E) have neurologic, psychiatric, medical, and social challenges compounded by fragmented and limited care. With increasing neurologic disability, there is a higher frequency of epileps...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000002060
更新日期:2015-10-27 00:00:00
abstract:BACKGROUND:Chronic cerebrospinal venous insufficiency (CCSVI) was proposed as the causal trigger for developing multiple sclerosis (MS). However, current data are contradictory and a gold standard for venous flow assessment is missing. OBJECTIVE:To compare structural magnetic resonance venography (MRV) and dynamic ext...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318236f0ea
更新日期:2011-11-08 00:00:00
abstract::In 2001, the authors described the clinical features of a genetically distinct autosomal dominant limb-girdle muscular dystrophy (LGMD; LGMD 1F). Using a genome-wide screen with more than 400 microsatellite markers, the authors identified a novel LGMD disease locus at chromosome 7q32.1-32.2. Within this chromosomal re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073984.46546.4f
更新日期:2003-08-12 00:00:00
abstract::Parry-Romberg syndrome (PRS) is a rare neurocutaneous disorder characterized by progressive facial hemiatrophy. In this study, 205 patients with PRS were surveyed using the Internet. Estimates of the frequency of limb involvement (19%), epilepsy (11%), and other clinical and etiologic features were obtained. There was...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.61.5.674
更新日期:2003-09-09 00:00:00
abstract::The syndrome of increased intracranial pressure without hydrocephalus or mass lesion and with normal CSF composition, previously referred to as pseudotumor cerebri, is a diagnosis of exclusion now termed idiopathic intracranial hypertension (IIH). Diagnostic criteria of this disorder have not been updated since the Mo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000029570.69134.1b
更新日期:2002-11-26 00:00:00
abstract:BACKGROUND:Frontotemporal dementia (FTD) is currently distinguished from AD primarily on the basis of behavioral features because studies of cognition have shown negligible or inconsistent differences. However, the poor discriminability of cognitive measures may relate to reliance on imprecise clinically diagnosed grou...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.12.1801
更新日期:2002-06-25 00:00:00
abstract:OBJECTIVE:The visual system has often been described to be sensitized in migraineurs, with light being perceived as aversive or even painful. One possible explanation for this altered perception is crosslinks between the visual and the trigeminonociceptive system. Visual stimulation in chronic migraineurs on the level ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005622
更新日期:2018-05-29 00:00:00