Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging.

abstract：:Neurofibromatosis 2 (NF2), a dominantly inherited disorder, typically manifests as bilateral vestibular schwannomas and predisposes to other nervous system tumors. In this study, we present a large pedigree with a benign course of NF2 (mild Gardner type) characterized by slowly growing vestibular schwannomas but few o...

journal_title：Neurology

authors： Sainio M,Strachan T,Blomstedt G,Salonen O,Setälä K,Palotie A,Palo J,Pyykkö I,Peltonen L,Jääskeläinen J

更新日期：1995-07-01 00:00:00

abstract：:Rosenthal fibers are present in several neurologic disorders. Their occurrence in widespread subependymal, subpial, and perivascular locations is thought to be diagnostic of Alexander's disease, but they have also been reported in rare adult cases. Some of these patients were neurologically intact with severe systemic...

journal_title：Neurology

authors： Friedman JH,Ambler M

更新日期：1992-09-01 00:00:00

abstract：:We studied the effects of intravenous immunoglobulin (IVIg) in 12 patients with motor neuron syndromes associated with high titers of anti-GM1 antibodies. Five of the patients had conduction blocks. The study design was a double-blind, placebo-controlled, crossover trial with IVIg (0.4 g/kg body weight per day injecte...

journal_title：Neurology

authors： Azulay JP,Blin O,Pouget J,Boucraut J,Billé-Turc F,Carles G,Serratrice G

更新日期：1994-03-01 00:00:00

abstract：:Patients with Parkinson's disease (PD) commonly complain of impaired visual function and difficulty reading, despite normal visual acuity. Although previous studies have evaluated contrast sensitivity, color vision, visuospatial processing, visual hallucinations, and ocular movements, none has systematically evaluated...

journal_title：Neurology

authors： Biousse V,Skibell BC,Watts RL,Loupe DN,Drews-Botsch C,Newman NJ

更新日期：2004-01-27 00:00:00

abstract：OBJECTIVES:The objective of this study was to clarify the characteristic brain MRI findings for genetically diagnosed CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy). METHODS:Seven patients with CARASIL carrying HTRA1 mutations (representing 6 Japanese families) we...

journal_title：Neurology

authors： Nozaki H,Sekine Y,Fukutake T,Nishimoto Y,Shimoe Y,Shirata A,Yanagawa S,Hirayama M,Tamura M,Nishizawa M,Onodera O

更新日期：2015-08-04 00:00:00

abstract：:Interferon beta (IFN-beta) has been shown in several clinical trials to have efficacy in MS. Its mechanism of action, however, remains unclear. In this review, several biological activities of IFN-beta are highlighted, including its inhibitory effects on proliferation of leukocytes and antigen presentation. Furthermor...

journal_title：Neurology

authors： Yong VW,Chabot S,Stuve O,Williams G

更新日期：1998-09-01 00:00:00

abstract：:Eighty-five healthy elderly subjects were prospectively evaluated for 3 years to determine motor differences between those who remain cognitively intact and those who developed cognitive impairment during prospective follow-up. The 18 subjects who developed cognitive impairment had slower finger tapping and took longe...

journal_title：Neurology

authors： Camicioli R,Howieson D,Oken B,Sexton G,Kaye J

更新日期：1998-05-01 00:00:00

abstract：:Prompted by the observation that a fellow medical student sneezed at about the same time in class every morning, we recorded the time of each of the 118 sneezes she made on 69 days over a 6.5-month period. Analysis of the sneeze times with the goodness-of-fit test revealed a highly nonuniform distribution (p < 0.0001)...

journal_title：Neurology

authors： Grant AC,Roter EP

更新日期：1994-03-01 00:00:00

abstract：:The scanning electronmicroscope was used to study the development of anencephaly in an experimental model. Anencephaly was produced consistently, using vitamin A as the teratogen. Embryos destined to become anencephalic displayed failure of opposing sides of the rostral neural tube to fuse. Subsequently, the neural fo...

journal_title：Neurology

authors： Smith MT,Wood LR,Honig SR

更新日期：1982-09-01 00:00:00

abstract：:We describe three patients with acute chiasmal visual field loss caused by hemorrhage within an intrachiasmal arteriovenous malformation. One patient had five episodes; vision improved three times without treatment and twice after surgical decompression. Surgical intervention restored vision in two of the three patien...

journal_title：Neurology

authors： Lavin PJ,McCrary JA 3rd,Roessmann U,Ellenberger C Jr

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Posterior cortical atrophy (PCA) is a progressive dementia characterized by prominent disorders of higher visual processing, affecting both dorsal and ventral streams to cause Balint's syndrome, alexia, and visual agnosia. OBJECTIVE:To define the cognitive profile of PCA and compare to the typical, primary ...

journal_title：Neurology

authors： McMonagle P,Deering F,Berliner Y,Kertesz A

更新日期：2006-02-14 00:00:00

abstract：OBJECTIVE:We used transcranial magnetic stimulation to investigate the effect of diurnal variability on cortical excitability in patients with epilepsy. METHODS:Thirty drug-naive patients with epilepsy (20 idiopathic generalized epilepsy [IGE], including 10 juvenile myoclonic epilepsy [JME], and 10 focal epilepsy) and...

journal_title：Neurology

authors： Badawy RA,Macdonell RA,Jackson GD,Berkovic SF

更新日期：2009-07-21 00:00:00

abstract：OBJECTIVE:To examine whether the incidence, comorbidity, and mortality of first-time ischemic stroke changed in Denmark between 1996 and 2016 overall and according to age and sex using a nationwide cohort design. METHODS:In this cohort study, 224,617 individuals ≥18 years of age admitted with first-time ischemic strok...

journal_title：Neurology

authors： Yafasova A,Fosbøl EL,Christiansen MN,Vinding NE,Andersson C,Kruuse C,Johnsen SP,Gislason GH,Torp-Pedersen C,Køber L,Butt JH

更新日期：2020-10-27 00:00:00

abstract：:This study was undertaken to determine the amount and histologic appearance of the persistent thymic tissue removed post mortem from 20 patients over 60 years of age with myasthenia gravis. One patient died several days after thymectomy. No recognizable thymic tissue on gross examination was seen in any patient. On mi...

journal_title：Neurology

authors： Perlo VP,Arnason B,Castleman B

更新日期：1975-03-01 00:00:00

abstract：OBJECTIVE:Motor signs are functionally disabling features of Huntington disease. Characteristic motor signs define disease manifestation. Their severity and onset are assessed by the Total Motor Score of the Unified Huntington's Disease Rating Scale, a categorical scale limited by interrater variability and insensitivi...

journal_title：Neurology

authors： Bechtel N,Scahill RI,Rosas HD,Acharya T,van den Bogaard SJ,Jauffret C,Say MJ,Sturrock A,Johnson H,Onorato CE,Salat DH,Durr A,Leavitt BR,Roos RA,Landwehrmeyer GB,Langbehn DR,Stout JC,Tabrizi SJ,Reilmann R

更新日期：2010-12-14 00:00:00

abstract：OBJECTIVE:To determine the efficacy of acetyl-l-carnitine (ALCAR) on the rate of decline in early-onset AD patients. METHODS:A 1-year, multicenter, double-blind, placebo-controlled, randomized trial was conducted. Subjects were 45 to 65 years old, with a diagnosis of probable AD according to National Institute of Neur...

journal_title：Neurology

authors： Thal LJ,Calvani M,Amato A,Carta A

更新日期：2000-09-26 00:00:00

abstract：:We measured the concentrations of the monoamines, their precursors, and their metabolites, and the activity of choline acetyltransferase (ChAT) in basal ganglia and cortical regions of postmortem brains from cases with histologically verified pure Alzheimer's disease (AD), AD with diffusely distributed Lewy bodies (Le...

journal_title：Neurology

authors： Langlais PJ,Thal L,Hansen L,Galasko D,Alford M,Masliah E

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS:Patients with symptomatic nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic autonomic neuropathy underwent open-label droxidopa ...

journal_title：Neurology

authors： Kaufmann H,Freeman R,Biaggioni I,Low P,Pedder S,Hewitt LA,Mauney J,Feirtag M,Mathias CJ,NOH301 Investigators.

更新日期：2014-07-22 00:00:00

abstract：:We examined correlates of depression in patients whose onset of Parkinson's disease (PD) began before age 55 (early-onset group) compared with patients whose onset was after age 55 (late-onset group). The early-onset group showed a significantly higher frequency of depression than the late-onset group. When both group...

journal_title：Neurology

authors： Starkstein SE,Berthier ML,Bolduc PL,Preziosi TJ,Robinson RG

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Treatment of aneurysmal subarachnoid hemorrhage (SAH) has changed substantially over the last 25 years but there is a lack of reliable population-based data on whether case-fatality or functional outcomes have improved. METHODS:We determined changes in the standardized incidence and outcome of SAH in the sa...

journal_title：Neurology

authors： Lovelock CE,Rinkel GJ,Rothwell PM

更新日期：2010-05-11 00:00:00

abstract：OBJECTIVE:To determine the cumulative incidence of epilepsy in a population-based cohort of patients with multiple sclerosis (MS) and to investigate the association between epilepsy and clinical features of MS. METHODS:All available patients in the Swedish MS register (n = 14,545) and 3 age- and sex-matched controls p...

journal_title：Neurology

authors： Burman J,Zelano J

更新日期：2017-12-12 00:00:00

abstract：OBJECTIVE:To review clinical and electrodiagnostic features of the medial brachial fascial compartment syndrome, a complication of percutaneous axillary vessel puncture. METHODS:The authors reviewed electrodiagnostic examinations over a 20-year period. RESULTS:This syndrome presents with weakness, pain, and numbness ...

journal_title：Neurology

authors： Tsao BE,Wilbourn AJ

更新日期：2003-10-28 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of opicapone as add-on to levodopa and the effects of switching from entacapone over 1 year of treatment in patients with fluctuating Parkinson disease. METHODS:After completion of a placebo- and entacapone-controlled double-blind study of opicapone (5, 25, or 50 mg), 495 patien...

journal_title：Neurology

authors： Ferreira JJ,Lees AJ,Poewe W,Rascol O,Rocha JF,Keller B,Soares-da-Silva P

更新日期：2018-05-22 00:00:00

abstract：:Restless legs syndrome (RLS) involves abnormal limb sensations that diminish with motor activity, worsen at rest, have a circadian peak in expression in the evening and at night, and can severely disrupt sleep. Primary treatment is directed at CNS dopaminergic systems, particularly activation of D(2)-like (D(2), D(3),...

journal_title：Neurology

authors： Clemens S,Rye D,Hochman S

更新日期：2006-07-11 00:00:00

abstract：OBJECTIVE:To assess the effect of patient and drug characteristics on medication adherence in people with epilepsy (PWE) in a large cohort representative of the German population. METHODS:Information was obtained from the Disease Analyzer database that collects anonymous demographic and medical data from practice comp...

journal_title：Neurology

authors： Gollwitzer S,Kostev K,Hagge M,Lang J,Graf W,Hamer HM

更新日期：2016-08-02 00:00:00

abstract：BACKGROUND:Co-occurrence of Parkinson disease (PD) and melanoma has been reported in numerous studies. If this was due to common genetic mechanisms, a positive family history of melanoma would be associated with an excessive PD risk, independent of environmental risk factors for PD. METHODS:We prospectively examined a...

journal_title：Neurology

authors： Gao X,Simon KC,Han J,Schwarzschild MA,Ascherio A

更新日期：2009-10-20 00:00:00

abstract：:We investigated the possible role of potassium deficiency, a recognized cause of myopathy, in the pathogenesis of experimental acute alcoholic myopathy (EAM) in the rat. Alcohol-treated animals receiving the same dietary potassium as controls developed mild hypokalemia; however, muscle potassium was preserved or eleva...

journal_title：Neurology

authors： Haller RG,Carter NW,Ferguson E,Knochel JP

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVE:To investigate the feasibility, safety, and efficacy of a ketogenic diet (KD) for superrefractory status epilepticus (SRSE) in adults. METHODS:We performed a prospective multicenter study of patients 18 to 80 years of age with SRSE treated with a KD treatment algorithm. The primary outcome measure was signif...

journal_title：Neurology

authors： Cervenka MC,Hocker S,Koenig M,Bar B,Henry-Barron B,Kossoff EH,Hartman AL,Probasco JC,Benavides DR,Venkatesan A,Hagen EC,Dittrich D,Stern T,Radzik B,Depew M,Caserta FM,Nyquist P,Kaplan PW,Geocadin RG

更新日期：2017-03-07 00:00:00

abstract：:Unilateral ligation of a common carotid artery in gerbils causes a decreased rate of serotonin synthesis and degradation but an increased release of this monoamine. In the brain, reduction of cerebral serotonin content during ischemia is followed by accumulation of its main metabolite, 5-hydroxyindolacetic acid. These...

journal_title：Neurology

authors： Mrsulja BB,Mrsulja BJ,Spatz M,Klatzo I

更新日期：1976-08-01 00:00:00

abstract：:We studied a patient with autopsy-proven Hallervorden-Spatz syndrome (HSS) and the previously unreported finding of high-density lesions in the basal ganglia on CT. The diagnosis of HSS should be considered in a patient with dystonia and basal ganglia mineralization on CT. ...

journal_title：Neurology

authors： Tennison MB,Bouldin TW,Whaley RA

更新日期：1988-01-01 00:00:00