Abstract:
:Prompted by the observation that a fellow medical student sneezed at about the same time in class every morning, we recorded the time of each of the 118 sneezes she made on 69 days over a 6.5-month period. Analysis of the sneeze times with the goodness-of-fit test revealed a highly nonuniform distribution (p < 0.0001) with a significantly increased probability of sneeze production within a small time interval centered at 8:20 AM. After ruling out the known causes of sneezing, we propose that the subject had a circadian fluctuation in her sneeze threshold independent of any immediate external stimulus. We compare this circadian rhythm to other periodic phenomena such as cyclic esotropia and rapid-cycling bipolar disease as well as to illnesses such as the periodic paralyses in which rapid and reversible changes occur in the neuromuscular system, and we discuss the peculiar circumstances favorable to documenting a circadian sneeze.
journal_name
Neurologyjournal_title
Neurologyauthors
Grant AC,Roter EPdoi
10.1212/wnl.44.3_part_1.369subject
Has Abstractpub_date
1994-03-01 00:00:00pages
369-75issue
3 Pt 1eissn
0028-3878issn
1526-632Xjournal_volume
44pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity. The only factor that seemed to correlate with seizures was a se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.12.1769
更新日期:1985-12-01 00:00:00
abstract::Since a parental sex effect has been reported in Huntington's disease, we looked to see whether a similar effect is apparent in adult (autosomal dominant) familial ALS. We analyzed the data for 145 patients, with an onset age range of 20 to 68 years and a known affected parent (AP), from 52 families described in the l...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.41.8.1292
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVES:Functional neuroimaging has shown that the absence of externally observable signs of consciousness and cognition in severely brain-injured patients does not necessarily indicate the true absence of such abilities. However, relative to traumatic brain injury, nontraumatic injury is known to be associated with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318249f764
更新日期:2012-03-13 00:00:00
abstract::The authors estimated the sample sizes needed for exploratory trials of MS assessing the efficacy of new treatments in reducing the number of new enhancing lesions vs those of interferon-beta or glatiramer acetate. The sample sizes per arm ranged from 868 (effect: 20%) to 94 (effect: 50%) for patients with relapsing-r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.10.1883
更新日期:2001-11-27 00:00:00
abstract::A 41-year-old man presented with bilateral posterior cerebral artery infarcts. He had visual object agnosia and prosopagnosia with preservation of reading abilities. There was also defective visual memory, topographic orientation, and color perception, as well as simultanagnosia. From the clinical facts and CT finding...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.7.947
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Hereditary spastic paraplegia (HSP) are classified clinically as pure when progressive spasticity occurs in isolation or complicated when other neurologic abnormalities are present. At least 22 genetic loci have been linked to HSP, 8 of which are autosomal recessive (ARHSP). HSP complicated with the presence...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000208501.52849.dd
更新日期:2006-04-25 00:00:00
abstract:OBJECTIVE:It has been suggested that anemia may be a risk factor for dementia, for restless legs syndrome, and for Parkinson disease (PD). Thus, we investigated the association of anemia with the subsequent risk of PD using a case-control study design. METHODS:We used the medical records-linkage system of the Rocheste...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181bd80c1
更新日期:2009-10-27 00:00:00
abstract::Behavioral psychophysical techniques were used to obtain strength-duration curves for the ulnar nerve at both threshold and suprathreshold levels. The functions well match those obtained with electrophysiologic procedures, but overcome many of the difficulities associated with traditional electrodiagnosis. An alternat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.4.339
更新日期:1975-04-01 00:00:00
abstract:OBJECTIVE:To investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD). METHODS:This was a la...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008696
更新日期:2020-01-07 00:00:00
abstract:BACKGROUND:Using a stereologic approach, the density of nerve fibers innervating sweat gland (SG) fragments in patients with diabetes mellitus (DM) and healthy controls using protein gene product (PGP), tyrosine hydroxylase (TH), and vasoactive intestinal peptide (VIP) was measured to determine which marker best detect...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001488
更新日期:2015-04-21 00:00:00
abstract::This multicenter, double-blind, crossover study compared Tegretol-XR and Tegretol tablets with respect to trough plasma carbamazepine (CBZ) concentrations, seizure control, tolerability, and safety. We randomized 96 patients with epilepsy to 56-day monotherapy with their usual daily CBZ dose administered as (1) Tegret...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.45.9.1703
更新日期:1995-09-01 00:00:00
abstract::There is now increasing use of dopamine agonists as effective early monotherapy in the treatment of Parkinson's disease (PD). Dopamine agonists can induce an antiparkinsonian effect through actions on either D(1)-like or D(2)-like dopamine receptors, and the multiple receptor subtypes present in the brain may provide ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.58.suppl_1.s1
更新日期:2002-02-26 00:00:00
abstract:OBJECTIVE:We performed a longitudinal cohort study of infants with tuberous sclerosis complex (TSC), with the overarching goal of defining early clinical, behavioral, and biological markers of autism spectrum disorder (ASD) in this high-risk population. METHODS:Infants with TSC and typically developing controls were r...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000568
更新日期:2014-07-08 00:00:00
abstract:OBJECTIVE:To examine the influence of birthdays on the onset and course of vascular events such as stroke, TIA, and acute myocardial infarction (AMI). METHODS:This population-based study included all emergency department (ED) admissions due to ischemic stroke, TIA, or AMI from April 2002 to March 2004 in Ontario, Cana...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000217915.06544.aa
更新日期:2006-07-25 00:00:00
abstract:BACKGROUND:Cerebral microbleeds are known to be indicative of bleeding-prone microangiopathy and may predict incident intracerebral hemorrhage (ICH). In this study, we investigated whether microbleeds are associated with the incidence of warfarin-related ICH. METHODS:Twenty-four patients with ICH while on outpatient t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000339060.11702.dd
更新日期:2009-01-13 00:00:00
abstract::Over the past 5 years, and especially within the last year, there has been a rapid expansion of vagus nerve stimulation (VNS)-related preclinical research, as well as clinical studies in indications other than epilepsy. The research advances in understanding VNS are occurring in the midst of a blossoming of other form...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.59.6_suppl_4.s56
更新日期:2002-09-24 00:00:00
abstract::Family studies of primary torsion dystonia have used the diagnostic categories of definite, probable, and possible dystonia for gene mapping and identification, but the validity of this hierarchical classification is not known. The authors assessed 147 DYT1 GAG deletion carriers and 113 blood-related noncarriers from ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000035630.12515.e0
更新日期:2002-12-10 00:00:00
abstract:OBJECTIVE:To test the hypothesis that concussion-related brain alterations seen at symptomatic injury and medical clearance to return to play (RTP) will have dissipated by 1 year after RTP. METHODS:For this observational study, 24 athletes with concussion were scanned longitudinally within 1 week after injury, at RTP,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008523
更新日期:2019-11-19 00:00:00
abstract::The administration of lecithin has failed to improve memory in aged or demented individuals. We studied the effect of lecithin on another cholinergic function, REM sleep latency. Intravenous doses of physostigmine shortened the latency to the first REM sleep period, but oral lecithin did not. In contrast to physostigm...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.36.8.1079
更新日期:1986-08-01 00:00:00
abstract::The authors found serum immunoglobulin M (IgM) autoantibody in a patient with typical acute cerebellar ataxia (ACA) and identified the antigen molecule as triosephosphate isomerase (TPI). TPI antigenicity to the patient's antibody was the highest in the cerebellar tissue. Eight of 23 patients with ACA had increased Ig...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000178802.38268.1e
更新日期:2005-10-11 00:00:00
abstract:OBJECTIVE:To assess the clinical, urodynamic, and neurophysiologic features of patients with persisting bladder, bowel, and sexual dysfunction after transverse myelitis in myelin oligodendrocyte glycoprotein antibody (MOG-Ab) disease. METHODS:Patients with a history of MOG-Ab disease-related transverse myelitis seen p...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011030
更新日期:2020-11-24 00:00:00
abstract::A striking behavioral abnormality is described in three individuals who had severe head trauma. At a point when general mnestic capabilities had returned to a near normal level, the patients persistently relocated the hospital at another geographical site, even in the face of compelling counter-evidence. The strong pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.2.147
更新日期:1976-02-01 00:00:00
abstract::Described are the clinical, EEG, MR, and genetic characteristics of 106 members of a family with autosomal dominant temporal lobe epilepsy (TLE) and febrile seizures (FS), with 22 affected individuals. Eleven patients had a history of FS, and 10 patients had TLE. EEG showed epileptic activity in five. None had hippoca...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.9.1429
更新日期:2002-05-14 00:00:00
abstract:OBJECTIVE:To combine MRI-based cortical morphometry and diffusion white matter tractography to describe the anatomical correlates of repetition deficits in patients with primary progressive aphasia (PPA). METHODS:The traditional anatomical model of language identifies a network for word repetition that includes Wernic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008746
更新日期:2020-02-11 00:00:00
abstract::The authors interviewed 53 cluster headache patients who had used psilocybin or lysergic acid diethylamide (LSD) to treat their condition. Twenty-two of 26 psilocybin users reported that psilocybin aborted attacks; 25 of 48 psilocybin users and 7 of 8 LSD users reported cluster period termination; 18 of 19 psilocybin ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000219761.05466.43
更新日期:2006-06-27 00:00:00
abstract::We present a method for graphically reporting the results of brainstem auditory evoked response examinations on the basis of multiple parameters. The method is based on a transform that normalizes the many latency and amplitude measures obtained from the averaged evoked responses of normal subjects tested under standa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.242
更新日期:1979-02-01 00:00:00
abstract:OBJECTIVE:To determine the effect of interferon-beta-1b (IFNbeta-1b) treatment on total contrast-enhancing lesions (CEL), white matter lesion load (WMLL), and cerebral atrophy (CA) in patients with relapsing-remitting multiple sclerosis (RRMS) using serial monthly MRI. METHODS:An open-label baseline-vs-treatment cross...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000113765.75855.19
更新日期:2004-03-09 00:00:00
abstract::Cisternography and ventriculography were performed in five normal anesthetized dogs to study the dynamics of tracer dispersal. Indium 111-diethylenetriaminepentaacetic acid was injected into lateral ventricles, cisterna magna, thoracic subarachnoid space, and lumbar sac. The patterns of dispersal from each injection s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.3.254
更新日期:1976-03-01 00:00:00
abstract::We analyzed our experience with cough, exertional, and vascular sexual headaches, evaluated the interrelationships among them, and examined the possible symptomatic cases. Seventy-two patients consulted us because of headaches precipitated by coughing (n = 30), physical exercise (n = 28), or sexual excitement (n = 14)...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.46.6.1520
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:To verify whether the change in L-dopa plasma levels after a single dose of carbidopa/L-dopa 50/200 (controlled-release) transiently modifies frontal components of somatosensory evoked potentials (SEPs) in patients with PD in parallel with improvement of motor performance. BACKGROUND:Apomorphine, a potent do...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1451
更新日期:1999-10-22 00:00:00