Autoantibodies in postinfectious acute cerebellar ataxia.

Abstract:

:The authors found serum immunoglobulin M (IgM) autoantibody in a patient with typical acute cerebellar ataxia (ACA) and identified the antigen molecule as triosephosphate isomerase (TPI). TPI antigenicity to the patient's antibody was the highest in the cerebellar tissue. Eight of 23 patients with ACA had increased IgM anti-TPI antibody titers vs those of healthy controls. Preceding Epstein-Barr virus infection was confirmed serologically in all 8 patients. Anti-TPI antibody decreased with clinical improvement.

journal_name

Neurology

journal_title

Neurology

authors

Uchibori A,Sakuta M,Kusunoki S,Chiba A

doi

10.1212/01.wnl.0000178802.38268.1e

subject

Has Abstract

pub_date

2005-10-11 00:00:00

pages

1114-6

issue

7

eissn

0028-3878

issn

1526-632X

pii

65/7/1114

journal_volume

65

pub_type

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