Abstract:
:The authors found serum immunoglobulin M (IgM) autoantibody in a patient with typical acute cerebellar ataxia (ACA) and identified the antigen molecule as triosephosphate isomerase (TPI). TPI antigenicity to the patient's antibody was the highest in the cerebellar tissue. Eight of 23 patients with ACA had increased IgM anti-TPI antibody titers vs those of healthy controls. Preceding Epstein-Barr virus infection was confirmed serologically in all 8 patients. Anti-TPI antibody decreased with clinical improvement.
journal_name
Neurologyjournal_title
Neurologyauthors
Uchibori A,Sakuta M,Kusunoki S,Chiba Adoi
10.1212/01.wnl.0000178802.38268.1esubject
Has Abstractpub_date
2005-10-11 00:00:00pages
1114-6issue
7eissn
0028-3878issn
1526-632Xpii
65/7/1114journal_volume
65pub_type
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