Abstract:
BACKGROUND:Hereditary spastic paraplegia (HSP) are classified clinically as pure when progressive spasticity occurs in isolation or complicated when other neurologic abnormalities are present. At least 22 genetic loci have been linked to HSP, 8 of which are autosomal recessive (ARHSP). HSP complicated with the presence of thin corpus callosum (HSP-TCC) is a common subtype of HSP. One genetic locus has been identified on chromosome 15q13-q15 (SPG11) for HSP-TCC, but some HSP-TCC families have not been linked to this locus. METHODS:The authors characterized two families clinically and radiologically and performed a genome-wide scan and linkage analysis. RESULTS:The two families had complicated ARHSP. The affected individuals in Family A had thin corpus callosum and mental retardation, whereas in Family B two of three affected individuals had epilepsy. In both families linkage analysis identified a locus on chromosome 8 between markers D8S1820 and D8S532 with the highest combined lod score of 7.077 at marker D8S505. This 9 cM interval located on 8p12-p11.21 represents a new locus for ARHSP-TCC. Neuregulin and KIF13B genes, located within this interval, are interesting functional candidate genes for this HSP form. CONCLUSION:Two consanguineous families with complicated autosomal recessive hereditary spastic paraplegia were clinically characterized and genetically mapped to a new locus on 8p12-p11.21.
journal_name
Neurologyjournal_title
Neurologyauthors
Al-Yahyaee S,Al-Gazali LI,De Jonghe P,Al-Barwany H,Al-Kindi M,De Vriendt E,Chand P,Koul R,Jacob PC,Gururaj A,Sztriha L,Parrado A,Van Broeckhoven C,Bayoumi RAdoi
10.1212/01.wnl.0000208501.52849.ddsubject
Has Abstractpub_date
2006-04-25 00:00:00pages
1230-4issue
8eissn
0028-3878issn
1526-632Xpii
66/8/1230journal_volume
66pub_type
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