Improvement of motor function in early Parkinson disease by safinamide.

abstract：:Large doses of phenytoin were administered on 159 occasions to 139 adult patients. Most patients had had more than three seizures or were in status epilepticus. Based on response to treatment, patients could be divided into two groups. Those with excellent response (recurrent seizures, 10%; mortality, 1%) included kno...

journal_title：Neurology

authors： Cranford RE,Leppik IE,Patrick B,Anderson CB,Kostick B

更新日期：1979-11-01 00:00:00

abstract：:We review adjunctive ketogenic diet (KD) and modified Atkins diet (MAD) treatment of refractory epilepsy in adults. Only a few studies have been published, all open-label. Because of the disparate, uncontrolled nature of the studies, we analyzed all studies individually, without a meta-analysis. Across all studies, 32...

journal_title：Neurology

authors： Klein P,Tyrlikova I,Mathews GC

更新日期：2014-11-18 00:00:00

abstract：:Eighty-eight multiple sclerosis case-friend pairs were interviewed by telephone to elicit information about early-life exposures. Available mothers were also interviewed. Risk factors included childhood diseases, exposures to animals, and residence. We found a positive association between MS and having measles at a la...

journal_title：Neurology

authors： Sullivan CB,Visscher BR,Detels R

更新日期：1984-09-01 00:00:00

abstract：:The clinical and genetic findings are described for 16 patients from a large Italian family with a variant form of hereditary spastic paraplegia and congenital arachnoid cysts inherited as an autosomal dominant trait. A molecular study has revealed a novel missense mutation, T614I, in exon 17 of SPG4, which may play a...

journal_title：Neurology

authors： Orlacchio A,Gaudiello F,Totaro A,Floris R,St George-Hyslop PH,Bernardi G,Kawarai T

更新日期：2004-05-25 00:00:00

abstract：:Rare reflex epilepsies are a clinical curiosity but may also give insight into neurocognitive processes. The authors present a patient whose seizures were precipitated by drawing but not by writing. This dissociation complements previous reports on selective impairment of writing. EEG revealed a focus in the right fro...

journal_title：Neurology

authors： Kho KH,van den Bergh WM,Spetgens WP,Leijten FS

更新日期：2006-03-14 00:00:00

abstract：OBJECTIVE:To test the diagnostic accuracy of the horizontal head impulse test (h-HIT) of vestibulo-ocular reflex (VOR) function in distinguishing acute peripheral vestibulopathy (APV) from stroke. Most patients with acute vertigo, nausea/vomiting, and unsteady gait have benign APV (vestibular neuritis or labyrinthitis)...

journal_title：Neurology

authors： Newman-Toker DE,Kattah JC,Alvernia JE,Wang DZ

更新日期：2008-06-10 00:00:00

abstract：:Malformations of cortical development (MCD) account for a high proportion of medically resistant partial seizures in children and figure prominently in pediatric surgical series. In contrast to the results of epilepsy surgery for postnatally acquired lesions, seizure freedom in patients with MCD is less certain owing ...

journal_title：Neurology

authors： Duchowny M,Jayakar P,Levin B

更新日期：2000-08-08 00:00:00

abstract：:A 15-year-old girl with a 3-year history of Rasmussen syndrome (RS) underwent left functional hemispherectomy by central disconnection. Clinical seizures then ceased. Five months postoperatively, ictal EEG discharges were associated with focal hyperperfusion on SPECT within the disconnected hypoperfused left hemispher...

journal_title：Neurology

authors： Thomas P,Zifkin B,Ghetâu G,Delalande O

更新日期：2003-01-14 00:00:00

abstract：:Serum levels of creatine phosphokinase (CPK) and pyruvic kinase (PK) were determined in 42 controls, 57 patients with various neuromuscular disorders, and 23 female relatives of Duchenne dystrophy patients. CPK and PK enzyme activities were increased in comparable numbers of muscle disease patients and female carriers...

journal_title：Neurology

authors： Seay AR,Ziter FA,Wu LH,Wu JT

更新日期：1978-10-01 00:00:00

abstract：:The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilept...

journal_title：Neurology

authors： Mula M,Trimble MR,Yuen A,Liu RS,Sander JW

更新日期：2003-09-09 00:00:00

abstract：:There are several reports of a defect of complex I in the substantia nigra (SN) of Parkinson's disease (PD) patients. To evaluate whether this is specific to dopaminergic neurons or the phenotypically relevant consequence of a widespread failure of the mitochondrial oxidative phosphorylation (OXPHOS) system, we measur...

journal_title：Neurology

authors： DiDonato S,Zeviani M,Giovannini P,Savarese N,Rimoldi M,Mariotti C,Girotti F,Caraceni T

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of early blood pressure (BP) changes on diffusion-weighted imaging (DWI) lesion evolution and clinical outcome in patients with stroke treated with IV tissue plasminogen activator (tPA). METHODS:We prospectively evaluated 80 patients with stroke with a documented middle cerebral artery...

journal_title：Neurology

authors： Delgado-Mederos R,Ribo M,Rovira A,Rubiera M,Munuera J,Santamarina E,Delgado P,Maisterra O,Alvarez-Sabin J,Molina CA

更新日期：2008-08-19 00:00:00

abstract：:Cerebral cholesterol metabolism has been linked with production of amyloid peptide (Abeta) crucial in AD. The association between use of cholesterol-lowering drugs (statins) and AD disease is currently being intensely discussed. In this case-control study on elderly nondemented subjects, the authors provide the first ...

journal_title：Neurology

authors： Fassbender K,Stroick M,Bertsch T,Ragoschke A,Kuehl S,Walter S,Walter J,Brechtel K,Muehlhauser F,Von Bergmann K,Lütjohann D

更新日期：2002-10-22 00:00:00

abstract：OBJECTIVES:To determine the relative utility of 1H MRSI and hippocampal volumetry for the lateralization of mesial temporal lobe epilepsy (MTLE) in patients with intractable epilepsy. BACKGROUND:MTLE is the most common partial-onset seizure disorder in patients undergoing temporal lobe epilepsy surgery. MR volumetry a...

journal_title：Neurology

authors： Kuzniecky R,Hugg JW,Hetherington H,Butterworth E,Bilir E,Faught E,Gilliam F

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Pompe disease (acid maltase deficiency, glycogen storage disease type II; OMIM 232300) is an autosomal recessive lysosomal storage disorder characterized by acid alpha-glucosidase deficiency due to mutations in the GAA gene. Progressive skeletal muscle weakness affects motor and respiratory functions and is ...

journal_title：Neurology

authors： Kroos MA,Pomponio RJ,Hagemans ML,Keulemans JL,Phipps M,DeRiso M,Palmer RE,Ausems MG,Van der Beek NA,Van Diggelen OP,Halley DJ,Van der Ploeg AT,Reuser AJ

更新日期：2007-01-09 00:00:00

abstract：:Plasma levels of six short-chain fatty acids (SCFA) were measured in 23 Reye's syndrome patients. In sequential measurements, only propionic acid correlated closely with neurologic severity. Although admission SCFA levels were slightly elevated, there were no significant differences between patients grouped by severit...

journal_title：Neurology

authors： McArthur B,Sarnaik AP,Mitchell RA

更新日期：1984-06-01 00:00:00

abstract：:Eighty-five healthy elderly subjects were prospectively evaluated for 3 years to determine motor differences between those who remain cognitively intact and those who developed cognitive impairment during prospective follow-up. The 18 subjects who developed cognitive impairment had slower finger tapping and took longe...

journal_title：Neurology

authors： Camicioli R,Howieson D,Oken B,Sexton G,Kaye J

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:To describe clinical characteristics, imaging findings, morbidity, and mortality in a single-center cohort of 12 pediatric cavernous sinus thrombosis cases and to review all cases available in recent English literature. METHODS:Clinical data and radiographic studies on 12 cases from our institution were anal...

journal_title：Neurology

authors： Smith DM,Vossough A,Vorona GA,Beslow LA,Ichord RN,Licht DJ

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To examine the relation of nonsteroidal anti-inflammatory drugs (NSAIDs) to incident Alzheimer disease (AD), change in cognition, and AD pathology. METHODS:Participants were 1,019 older Catholic clergy followed up annually for up to 12 years (mean baseline age = 75.0 years, education = 18.1 years, Mini-Menta...

journal_title：Neurology

authors： Arvanitakis Z,Grodstein F,Bienias JL,Schneider JA,Wilson RS,Kelly JF,Evans DA,Bennett DA

更新日期：2008-06-03 00:00:00

abstract：BACKGROUND:Because of the relatively poor results of frontal lobe epilepsy (FLE) surgery, identification of prognostic factors for surgical outcome is of great importance. METHODS:To identify predictive factors for FLE surgery, we analyzed the data of 61 patients (mean age at surgery 19.2) who had undergone presurgica...

journal_title：Neurology

authors： Janszky J,Jokeit H,Schulz R,Hoppe M,Ebner A

更新日期：2000-04-11 00:00:00

abstract：:The motor effects of direct agonists which act selectively on certain dopamine receptors were studied in monkeys rendered hemiparkinsonian by unilateral intracarotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The D-2 dopamine agonist, LY 171555, but not the D-1 agonist, SKF 38393, reduced parkin...

journal_title：Neurology

authors： Barone P,Bankiewicz KS,Corsini GU,Kopin IJ,Chase TN

更新日期：1987-10-01 00:00:00

abstract：:Tizanidine, an imidazoline that acts as an agonist at alpha 2-adrenergic receptors, has been shown to be effective in reducing spasticity caused by MS. This multicenter study (14 sites) assessed the efficacy and safety of oral tizanidine in patients who had spinal cord injury of > 12 months' duration. Of the 124 patie...

journal_title：Neurology

authors： Nance PW,Bugaresti J,Shellenberger K,Sheremata W,Martinez-Arizala A

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer's disease (AD) using a community-dwelling cohort of women (aged 70-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). METHOD...

journal_title：Neurology

authors： Younan D,Wang X,Casanova R,Barnard R,Gaussoin SA,Saldana S,Petkus AJ,Beavers DP,Resnick SM,Manson JE,Serre ML,Vizuete W,Henderson VW,Sachs BC,Salinas JA,Gatz M,Espeland MA,Chui HC,Shumaker SA,Rapp SR,Chen JC,Wom

更新日期：2020-11-18 00:00:00

abstract：OBJECTIVE:To examine the severity of impairments in the decision-making abilities (understanding, appreciation, reasoning, and choice) and competency to make a decision to use an Alzheimer disease (AD)-slowing medication in patients with AD and the relationships between these impairments, insight, and overall cognition...

journal_title：Neurology

authors： Karlawish JH,Casarett DJ,James BD,Xie SX,Kim SY

更新日期：2005-05-10 00:00:00

abstract：OBJECTIVES:To correlate the two types of early ischemic change on noncontrast CT (NCCT) (parenchymal hypoattenuation [PH] and isolated focal swelling [IFS]) with concurrent assessment of cerebral perfusion and to compare their rates of progression to infarction. METHODS:We assessed cortical regions on NCCT for early i...

journal_title：Neurology

authors： Parsons MW,Pepper EM,Bateman GA,Wang Y,Levi CR

更新日期：2007-03-06 00:00:00

abstract：:Coenzyme Q10 (CoQ10) transfers electrons from complexes I and II of the mitochondrial respiratory chain to complex III. There is one published report of human CoQ10 deficiency describing two sisters with encephalopathy, proximal weakness, myoglobinuria, and lactic acidosis. We report a patient who had delayed motor mi...

journal_title：Neurology

authors： Sobreira C,Hirano M,Shanske S,Keller RK,Haller RG,Davidson E,Santorelli FM,Miranda AF,Bonilla E,Mojon DS,Barreira AA,King MP,DiMauro S

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To assess the predominant type of cerebral small vessel disease (SVD) and recurrence risk in patients who present with a combination of lobar and deep intracerebral hemorrhage (ICH)/microbleed locations (mixed ICH). METHODS:Of 391 consecutive patients with primary ICH enrolled in a prospective registry, 75 (...

journal_title：Neurology

authors： Pasi M,Charidimou A,Boulouis G,Auriel E,Ayres A,Schwab KM,Goldstein JN,Rosand J,Viswanathan A,Pantoni L,Greenberg SM,Gurol ME

更新日期：2018-01-09 00:00:00

abstract：:We report two conjugal cases of amyotrophic lateral sclerosis (ALS) occurring between 1977 and 1991 in southern France (Languedoc-Roussillon). Although conjugal ALS may occur by chance, the description of two cases in the same area points to a role of environmental or genetic factors in the etiology of the disease. ...

journal_title：Neurology

authors： Camu W,Cadilhac J,Billiard M

更新日期：1994-03-01 00:00:00

abstract：:Four patients with presumed Tolosa-Hunt syndrome ultimately proved to have a parasellar tumor. All four had manifestations of a cavernous sinus syndrome, normal radiologic and medical investigations, and response to steroid therapy. The Tolosa-Hunt syndrome is a diagnosis of exclusion; many other lesions can simulate ...

journal_title：Neurology

authors： Spector RH,Fiandaca MS

更新日期：1986-02-01 00:00:00

abstract：:We surveyed 297 patients with Parkinson disease (PD) with systematic screens and rigorous definitional criteria. Pathologic hypersexuality lifetime prevalence was 2.4%. Compulsive shopping was 0.7%. Combined with our pathologic gambling data, the lifetime prevalence of these behaviors was 6.1% and increases to 13.7% i...

journal_title：Neurology

authors： Voon V,Hassan K,Zurowski M,de Souza M,Thomsen T,Fox S,Lang AE,Miyasaki J

更新日期：2006-10-10 00:00:00