Abstract:
:The motor effects of direct agonists which act selectively on certain dopamine receptors were studied in monkeys rendered hemiparkinsonian by unilateral intracarotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The D-2 dopamine agonist, LY 171555, but not the D-1 agonist, SKF 38393, reduced parkinsonian signs and induced rotation away from the side of the nigral lesion. When administered together, SKF 38393 diminished the LY 171555-induced turning in a dose-dependent manner. A selective D-1 antagonist, SCH 23390, induced mild and brief rotation when administered alone. These results suggest that D-2 receptor stimulation is necessary to ameliorate parkinsonism, but that pharmacologic manipulation of both D-1 and D-2 receptors may be required for an optimal therapeutic response.
journal_name
Neurologyjournal_title
Neurologyauthors
Barone P,Bankiewicz KS,Corsini GU,Kopin IJ,Chase TNdoi
10.1212/wnl.37.10.1592subject
Has Abstractpub_date
1987-10-01 00:00:00pages
1592-5issue
10eissn
0028-3878issn
1526-632Xjournal_volume
37pub_type
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