Abstract:
:Sphingosine 1-phosphate receptors (S1PRs) are G protein-coupled receptors expressed by many cell types, including immune and neural cells. These receptors are promising targets for immunomodulatory and possibly neuromodulatory therapies. Fingolimod (FTY720) is a sphingosine analog that, when phosphorylated, becomes a prototypical S1PR modulator. It has recently been approved as the first oral treatment for relapsing forms of multiple sclerosis in some countries. Fingolimod has documented effects on lymphocyte egress, selectively retaining lymphocytes within the lymph nodes. In addition, fingolimod can enter the CNS and can act on S1PRs expressed by most neural lineages. In this article, we discuss recent results supporting the concept that S1PR modulators may exert neuroprotective and regenerative actions in the CNS as well as having anti-inflammatory effects.
journal_name
Neurologyjournal_title
Neurologyauthors
Soliven B,Miron V,Chun Jdoi
10.1212/WNL.0b013e31820d9507subject
Has Abstractpub_date
2011-02-22 00:00:00pages
S9-14issue
8 Suppl 3eissn
0028-3878issn
1526-632Xpii
76/8_Supplement_3/S9journal_volume
76pub_type
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