Abstract:
:We detected large numbers of HLA-DR-positive reactive microglia (macrophages), along with Lewy bodies and free melanin, in the substantia nigra of all cases studied with Parkinson's disease (5) and parkinsonism with dementia (PD) (5). We found similar, but less extensive, pathology in the substantia nigra of six of nine cases of dementia of the Alzheimer type (DAT) but in only one of 11 age-matched nonneurologic cases. All dementia cases with a premortem diagnosis of DAT or PD showed large numbers of HLA-DR-positive reactive microglia and significant plaque and tangle counts in the hippocampus, as well as reduced cortical choline acetyltransferase activity. One of 11 nondemented controls showed mild evidence of similar cortical pathology. These data indicate that HLA-DR-positive reactive microglia are a sensitive index of neuropathologic activity. They suggest a frequent coexistence of DAT- and Parkinson-type pathology in elderly patients.
journal_name
Neurologyjournal_title
Neurologyauthors
McGeer PL,Itagaki S,Boyes BE,McGeer EGdoi
10.1212/wnl.38.8.1285subject
Has Abstractpub_date
1988-08-01 00:00:00pages
1285-91issue
8eissn
0028-3878issn
1526-632Xjournal_volume
38pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::From 536 patients with the CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasis), seven were identified as having peripheral neuropathy not attributable to another cause. Peripheral neuropathy developed 0 to 25 years after their first symptoms of scleroderma. Unex...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.6.1641
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:To compare refractory convulsive status epilepticus (rSE) management and outcome in children with and without a prior diagnosis of epilepsy and with and without a history of status epilepticus (SE). METHODS:This was a prospective observational descriptive study performed from June 2011 to May 2016 on pediatr...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000003550
更新日期:2017-01-24 00:00:00
abstract:OBJECTIVE:To study the distribution of prior scoliosis among patients with primary adult-onset cervical dystonia (CD) and matched control subjects. METHODS:Case and control subjects were selected among consecutive outpatients attending four Italian centers. Control outpatients were matched for age (+/-5 years), sex, a...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/01.wnl.0000049932.22065.60
更新日期:2003-03-25 00:00:00
abstract:OBJECTIVE:To study the potential effect of the 2008 Institute of Medicine (IOM) work duty hour (WDH) recommendations on neurology residency programs. METHODS:This study evaluated resident sleepiness, personal study hours, quality of life, and satisfaction and faculty satisfaction during a control month using the Accre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31822c61c3
更新日期:2011-08-30 00:00:00
abstract::We enrolled 116 patients in a multicenter, randomized, double-blind controlled trial of an 8-week course of 11 plasma exchange (PE) treatments in exacerbations of MS. The control group received sham PE, and both groups received identical treatment with IM ACTH and oral cyclophosphamide. Serum IgG decreased in the PE a...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.39.9.1143
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVE:To investigate the prevalence of asymptomatic diffusion-weighted imaging-positive (DWI+) lesions in individuals with cerebral small vessel disease (SVD) and identify their role in the origin of SVD markers on MRI. METHODS:We included 503 individuals with SVD from the Radboud University Nijmegen Diffusion Ten...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008364
更新日期:2019-10-22 00:00:00
abstract::The motor effects of direct agonists which act selectively on certain dopamine receptors were studied in monkeys rendered hemiparkinsonian by unilateral intracarotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The D-2 dopamine agonist, LY 171555, but not the D-1 agonist, SKF 38393, reduced parkin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.10.1592
更新日期:1987-10-01 00:00:00
abstract:OBJECTIVE:To demonstrate noninvasive localization of cognitive cortical areas involved in language processing with magnetoencephalography (MEG) interpreted by multiresolution FOCUSS (MR-FOCUSS), a current density imaging technique. METHOD:MEG data were collected during verb-generation and picture-naming tasks from 18 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000130385.21160.7a
更新日期:2004-06-22 00:00:00
abstract::A number of high-quality studies have recently been published that examine the association between neuropathic pain and health-related quality of life (HRQoL). The current review identified 52 such studies in patients with six neuropathic pain conditions associated with lesions of either the peripheral (postsurgical n...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/01.wnl.0000259085.61898.9e
更新日期:2007-04-10 00:00:00
abstract::Generic substitution is practiced widely in both hospital and community settings. There have been several reports of reduced serum concentrations and seizure exacerbation following generic substitution of Tegretol. We describe the first 2 cases of carbamazepine toxicity resulting from the substitution of Tegretol with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.12.2696
更新日期:1993-12-01 00:00:00
abstract::We identified 53 patients with non-neoplastic cysts of the pineal gland. In contrast to patients with pineal neoplasms, pineal cysts are usually asymptomatic. They infrequently obstruct the aqueduct to cause hydrocephalus or compress the tectum to produce the neuro-ophthalmologic signs of dorsal midbrain dysfunction. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.7.1034
更新日期:1991-07-01 00:00:00
abstract:OBJECTIVE:To determine possible effects of prolonged marijuana use on the cerebrovascular system during a month of monitored abstinence and to assess how the intensity of current use might have influenced cerebrovascular perfusion in these marijuana users. METHOD:The authors recorded blood flow velocity in the anterio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000150882.69371.DD
更新日期:2005-02-08 00:00:00
abstract::A 50-year-old woman with a history of metastatic malignant thymoma presented with diffuse neuropathic pain involving the extremities and torso prior to chemotherapy and radiation. She also developed episodic diarrhea, diaphoresis, fevers, insomnia, and encephalopathy. Examination revealed rippling muscles (video on th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31827f0fa1
更新日期:2013-01-29 00:00:00
abstract::The incidence of MS in the Orkney Islands has been updated from 1941 to September 21, 1983. Since 1965, MS incidence rates have fallen significantly when compared with those for 1941 to 1964. Alterations in age-specific prevalence, mean duration of illness, and mean age of the MS population are consistent with the dec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.4.545
更新日期:1985-04-01 00:00:00
abstract::We performed a clinical study and linkage analysis on 278 subjects (66 affected) belonging to eight families with X-linked dominant Charcot-Marie-Tooth (CMT) neuropathy. This form affects 11.8% of CMT patients in Iowa. Motor nerve conduction velocities (MNCVs) were significantly slowed consistent with type 1 CMT. Fift...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.4.903
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Bilateral absent N20 responses of median nerve somatosensory evoked potentials (SEPs) reliably predict poor prognosis after cardiac arrest. However, the studies supporting this fact were carried out before hypothermia was established as standard treatment. Recent evidence suggests that hypothermia treatment ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181d5a631
更新日期:2010-03-23 00:00:00
abstract:BACKGROUND:About 20% of patients with familial hemiplegic migraine (FHM) develop progressive cerebellar signs. Genetic studies have established an association with mutations in the CACNA1A gene. However, the mechanisms underlying cerebellar involvement are largely unknown. OBJECTIVE:To use proton MR spectroscopy (1H-M...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000151855.98318.50
更新日期:2005-02-22 00:00:00
abstract::Guillain-Barré syndrome (GBS) appeared in four patients 1 to 2 weeks after epidural anesthesia. In all patients, clinical diagnosis was confirmed by CSF findings and nerve conduction velocity studies. Although epidural anesthesia has not been listed as an antecedent event in GBS, evidence for the relationship has been...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.10.1473
更新日期:1985-10-01 00:00:00
abstract::We describe the clinical, imaging, and pathologic findings in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). The patient experienced her first stroke-like episode at age forty-four. Brain MRI, obtained at symptom onset, at 3 weeks, and at 1 year, revealed migr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.1.223
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Periodic paralyses and paramyotonia congenita are rare disorders causing disabling weakness and myotonia. Mutations in sodium, calcium, and potassium channels have been recognized as causing disease. OBJECTIVE:To analyze the clinical phenotype of patients with and without discernible genotype and to identif...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000143383.91137.00
更新日期:2004-11-09 00:00:00
abstract::The authors identified a novel mtDNA mutation (T9176G) in the ATPase 6 gene in a family in which a 10-year-old girl had a severe neurodegenerative disorder, her elder sister had died of Leigh syndrome (LS), and a maternal uncle had a spinocerebellar disorder. Biochemical studies disclosed a reduced rate of ATP synthes...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.5.687
更新日期:2001-03-13 00:00:00
abstract:OBJECTIVES:To provide information on the effect of the coronavirus disease of 2019 (COVID-19) pandemic on people with epilepsy and provide consensus recommendations on how to provide the best possible care for people with epilepsy while avoiding visits to urgent care facilities and hospitalizations during the novel cor...
journal_title:Neurology
pub_type: 共识发展会议,杂志文章
doi:10.1212/WNL.0000000000009632
更新日期:2020-06-09 00:00:00
abstract::Neurologic complications of brain tissue-derived rabies vaccine may be chronic or progressive. Lymphocytes and serum from three patients with this form of encephalitis were studied. Two patients had positive lymphoproliferation to purified myelin, two had antibody to white matter, and one had antibody to myelin basic ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.1.42
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To distinguish, in patients with Korsakoff syndrome (KS), the structural brain abnormalities shared with alcoholic patients without KS (AL), from those specific to KS. METHODS:MRI data were collected in 11 alcoholic patients with KS, 34 alcoholic patients without KS, and 25 healthy control subjects (CS). Gra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318251834e
更新日期:2012-04-24 00:00:00
abstract:OBJECTIVE:APOE ε2 and ε4 alleles have been associated with lobar intracerebral hemorrhage (ICH) in predominately white populations; we sought to evaluate whether this held true among black and Hispanic populations. METHODS:The Ethnic/Racial Variations of Intracerebral Hemorrhage study is a prospective, multicenter cas...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005908
更新日期:2018-07-31 00:00:00
abstract::Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.12.1759
更新日期:2001-06-26 00:00:00
abstract:OBJECTIVE:We conducted a nationwide case-control study in Sweden to test the hypothesis that specific clinical characteristics are associated with increased risk of sudden unexpected death in epilepsy (SUDEP). METHODS:The study included 255 SUDEP cases (definite and probable) and 1,148 matched controls. Clinical infor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008741
更新日期:2020-01-28 00:00:00
abstract::Sorivudine provides a unique nucleoside analog with significantly enhanced both in vitro and in vitro activity and enhanced oral bioavailability. Early indications from controlled studies indicate that sorivudine therapy is superior to acyclovir for the treatment of localized zoster in individuals with HIV infection a...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.45.12_suppl_8.s73
更新日期:1995-12-01 00:00:00
abstract::Salla disease is a lysosomal storage disorder associated with increased urinary excretion of free sialic acid. The main clinical features in 34 patients were severe psychomotor retardation of early onset, ataxia, athetosis, rigidity, spasticity, and impaired speech. Growth retardation, thick calvarium, and exotropia w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.1.57
更新日期:1983-01-01 00:00:00
abstract::Two hundred thirty-nine patients with Bell palsy were randomly distributed into prednisone-treated and control groups. Patients were followed until complete recovery or for 1 year. In the steroid-treated and control groups, respectively, incomplete recovery of facial strength occurred in 12 percent and 20 percent; mot...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.28.2.158
更新日期:1978-02-01 00:00:00