Treatment of Bell palsy with prednisone: a prospective, randomized study.

Abstract:

:Two hundred thirty-nine patients with Bell palsy were randomly distributed into prednisone-treated and control groups. Patients were followed until complete recovery or for 1 year. In the steroid-treated and control groups, respectively, incomplete recovery of facial strength occurred in 12 percent and 20 percent; motor synkinesis in 9 percent and 15 percent; autonomic synkinesis in 1 percent and 10 percent; and electromyographic evidence of severe denervation in 9 percent and 17 percent. The differences reached statistical significance only for autonomic synkinesis. In the total series recovery of facial strength was incomplete in 16 percent. Residual weakness was mild in 14 percent and moderate in 2 percent. No patient remained with severe weakness. Age, hyperacusis, and severity of the initial palsy were associated with an increased risk of poor outcome.

journal_name

Neurology

journal_title

Neurology

authors

Wolf SM,Wagner JH,Davidson S,Forsythe A

doi

10.1212/wnl.28.2.158

subject

Has Abstract

pub_date

1978-02-01 00:00:00

pages

158-61

issue

2

eissn

0028-3878

issn

1526-632X

journal_volume

28

pub_type

临床试验,杂志文章,随机对照试验
  • Lysine vasopressin in Alzheimer disease.

    abstract::The effects of lysine vasopressin on memory and cognitive deficits in Alzheimer disease was investigated. In a double-blind study, seven patients were given 16 units of lysine vasopressin per day for 10 days and were compared with seven different patients receiving placebo. No significant difference in performance bet...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.32.6.674

    authors: Durso R,Fedio P,Brouwers P,Cox C,Martin AJ,Ruggieri SA,Tamminga CA,Chase TN

    更新日期:1982-06-01 00:00:00

  • A prospective study of quality of life in ALS patients treated with noninvasive ventilation.

    abstract::Noninvasive positive pressure ventilation prolongs survival in ALS but its effect on quality of life is unknown. The authors prospectively studied quality of life using the SF-36 questionnaire in a cohort of 16 ventilated patients with ALS. Noninvasive positive pressure ventilation improved scores in the "Vitality" do...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.57.1.153

    authors: Lyall RA,Donaldson N,Fleming T,Wood C,Newsom-Davis I,Polkey MI,Leigh PN,Moxham J

    更新日期:2001-07-10 00:00:00

  • Reprogramming cells from Gulf War veterans into neurons to study Gulf War illness.

    abstract::Gulf War illness (GWI), which afflicts at least 25% of veterans who served in the 1990-1991 war in the Persian Gulf, is thought to be caused by deployment exposures to various neurotoxicants, including pesticides, anti-nerve gas pills, and low-level nerve agents including sarin/cyclosarin. GWI is a multisymptom disord...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003938

    authors: Qiang L,Rao AN,Mostoslavsky G,James MF,Comfort N,Sullivan K,Baas PW

    更新日期:2017-05-16 00:00:00

  • Prospective and longitudinal long-term employment outcomes after resective epilepsy surgery.

    abstract:OBJECTIVE:To investigate long-term employment outcomes after resective epilepsy surgery in a national population-based cohort of adults. METHODS:In the Swedish National Epilepsy Surgery Register, all adults who were operated with resective epilepsy surgery from 1995 to 2010 were identified. Two-year follow-up was avai...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000002069

    authors: Edelvik A,Flink R,Malmgren K

    更新日期:2015-10-27 00:00:00

  • Botulinum toxin for simple motor tics: a randomized, double-blind, controlled clinical trial.

    abstract:OBJECTIVE:To determine the effect of injections of botulinum toxin on simple motor tics. BACKGROUND:Case series with unblinded assessments have reported improvement in tic frequency and associated urge with botulinum toxin. METHODS:Patients with suitable simple motor tics were randomized to receive botulinum toxin an...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1212/wnl.56.5.605

    authors: Marras C,Andrews D,Sime E,Lang AE

    更新日期:2001-03-13 00:00:00

  • Apolipoprotein E and functional recovery from brain injury following postacute rehabilitation.

    abstract:OBJECTIVE:APOE epsilon4 has been associated with late-onset familial and sporadic AD and delayed recovery from head injury. The authors examined the relationship between functional recovery of patients with head injury and the APOE alleles. METHODS:Thirty-one patients with head injury who had completed the Acute Neuro...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.55.10.1536

    authors: Lichtman SW,Seliger G,Tycko B,Marder K

    更新日期:2000-11-28 00:00:00

  • Effect of insurance status on postacute care among working age stroke survivors.

    abstract:OBJECTIVE:Utilization of postacute care is associated with improved poststroke outcomes. However, more than 20% of American adults under age 65 are uninsured. We sought to determine whether insurance status is associated with utilization and intensity of institutional postacute care among working age stroke survivors. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3182563bf5

    authors: Skolarus LE,Meurer WJ,Burke JF,Prvu Bettger J,Lisabeth LD

    更新日期:2012-05-15 00:00:00

  • Erythrocyte thiolmethyltransferase: another failed marker for Alzheimer's and Parkinson's diseases.

    abstract::There are reports that patients with Parkinson's disease (PD) and Alzheimer's disease (AD) have reduced levels of thiolmethyltransferase (TMT) in erythrocyte membranes. TMT methylates thiols and thiocarbamates, thereby reducing their toxicity. We examined TMT levels in erythrocytes from patients with PD and AD and fro...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.45.10.1903

    authors: Hurwitz A,Hubble JP,Glatt SL,Koller WC,Pollack J

    更新日期:1995-10-01 00:00:00

  • HLA-DRB1*15 influences the development of brain tissue damage in early PPMS.

    abstract:OBJECTIVES:To investigate whether (1) there were differences between HLA-DRB1*15-positive and -negative patients at baseline, and (2) HLA-DRB1*15-positive patients showed a greater development of brain and spinal cord damage, as assessed by MRI, and greater progression of disability, during a 5-year follow-up, compared...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000000959

    authors: Tur C,Ramagopalan S,Altmann DR,Bodini B,Cercignani M,Khaleeli Z,Miller DH,Thompson AJ,Ciccarelli O

    更新日期:2014-11-04 00:00:00

  • Stroke with sensory symptoms mimicking myocardial ischemia.

    abstract:OBJECTIVE:To report five stroke patients with sensory deficits including prominent chest discomfort mimicking angina. BACKGROUND:Chest wall sensory discomfort, as a part of unilateral sensory dysfunction, has seldom been recognized as a potential imitator of cardiac ischemia. METHODS:A retrospective review of stroke ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.46.2.548

    authors: Gorson KC,Pessin MS,DeWitt LD,Caplan LR

    更新日期:1996-02-01 00:00:00

  • Evaluation of dysphagia by novel real-time MRI.

    abstract:OBJECTIVE:To assess safety and feasibility of real-time (RT) MRI for evaluation of dysphagia and to compare this technique to standard assessment by flexible endoscopic evaluation of swallowing (FEES) and videofluoroscopy (VF) in a cohort of patients with inclusion body myositis (IBM). METHODS:Using RT-MRI, FEES, and ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000003337

    authors: Olthoff A,Carstens PO,Zhang S,von Fintel E,Friede T,Lotz J,Frahm J,Schmidt J

    更新日期:2016-11-15 00:00:00

  • Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures.

    abstract:OBJECTIVE:To investigate the added value of hippocampal atrophy rates over whole brain volume measurements on MRI in patients with Alzheimer disease (AD), patients with mild cognitive impairment (MCI), and controls. METHODS:We included 64 patients with AD (67 +/- 9 years; F/M 38/26), 44 patients with MCI (71 +/- 6 yea...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000344568.09360.31

    authors: Henneman WJ,Sluimer JD,Barnes J,van der Flier WM,Sluimer IC,Fox NC,Scheltens P,Vrenken H,Barkhof F

    更新日期:2009-03-17 00:00:00

  • Neurologic autoimmunity and immune checkpoint inhibitors: Autoantibody profiles and outcomes.

    abstract:OBJECTIVE:To describe neural autoantibody profiles and outcomes in patients with neurologic autoimmunity associated with immune checkpoint inhibitor (ICI) cancer immunotherapy. METHODS:In this retrospective descriptive study, 63 patients with ICI-related neurologic autoimmunity were included: 39 seen at the Mayo Clini...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000010632

    authors: Sechi E,Markovic SN,McKeon A,Dubey D,Liewluck T,Lennon VA,Lopez-Chiriboga AS,Klein CJ,Mauermann M,Pittock SJ,Flanagan EP,Zekeridou A

    更新日期:2020-10-27 00:00:00

  • Lambert-Eaton syndrome IgG inhibits transmitter release via P/Q Ca2+ channels.

    abstract:OBJECTIVE:To determine whether immunoglobulin G (IgG) from patients with Lambert-Eaton myasthenic syndrome (LEMS) decreases action potential–evoked synaptic vesicle exocytosis,and whether the effect is mediated by P/Q-type voltage-gated calcium channels (VGCCs). METHODS:IgG was obtained from 4 patients with LEMS (3 ma...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0000000000001225

    authors: Spillane J,Ermolyuk Y,Cano-Jaimez M,Lang B,Vincent A,Volynski KE,Kullmann DM

    更新日期:2015-02-10 00:00:00

  • Seeing ophthalmologic problems in Parkinson disease: Results of a visual impairment questionnaire.

    abstract:OBJECTIVE:To determine the prevalence and clinical effect of ophthalmologic symptoms in patients with Parkinson disease (PD), compared with controls, using a standardized questionnaire. METHODS:In this observational, cross-sectional, multicenter study, 848 patients with PD and 250 healthy controls completed the Visual...

    journal_title:Neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1212/WNL.0000000000009214

    authors: Borm CDJM,Visser F,Werkmann M,de Graaf D,Putz D,Seppi K,Poewe W,Vlaar AMM,Hoyng C,Bloem BR,Theelen T,de Vries NM

    更新日期:2020-04-07 00:00:00

  • Relationship between Meige syndrome and alpha-methyldopa-induced parkinsonism.

    abstract::We studied two patients with Meige syndrome who developed alpha-methyldopa-induced parkinsonism. Opposite responses of parkinsonian and dystonic symptoms to antiparkinson drugs in some cases suggest a functionally reciprocal relationship between these disorders. ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.35.11.1668

    authors: Sechi GP,Demontis G,Rosati G

    更新日期:1985-11-01 00:00:00

  • Evaluation of sleep and daytime somnolence in spinocerebellar ataxia type 6 (SCA6).

    abstract::To determine the frequency of subjective sleep problems in spinocerebellar ataxia type 6 (SCA6), the authors surveyed 25 patients and 25 age-matched controls with the Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI). The ESS was higher in patients with SCA6 (9.12 +/- 5.80; CI: 2.28) than in con...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/01.wnl.0000210485.37521.0b

    authors: Howell MJ,Mahowald MW,Gomez CM

    更新日期:2006-05-09 00:00:00

  • Functional deficits in patients with mild cognitive impairment: prediction of AD.

    abstract:OBJECTIVE:To evaluate the predictive utility of self-reported and informant-reported functional deficits in patients with mild cognitive impairment (MCI) for the follow-up diagnosis of probable AD. METHODS:The Pfeffer Functional Activities Questionnaire (FAQ) and Lawton Instrumental Activities of Daily Living (IADL) S...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.58.5.758

    authors: Tabert MH,Albert SM,Borukhova-Milov L,Camacho Y,Pelton G,Liu X,Stern Y,Devanand DP

    更新日期:2002-03-12 00:00:00

  • IgG Fc-receptor polymorphisms in Guillain-Barré syndrome.

    abstract::The authors studied immunoglobulin G (IgG) Fc receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms in 62 patients with Guillain-Barré syndrome (GBS) and in 89 healthy controls. The FcgammaR genotypes and allele frequencies did not differ significantly between the patients with GBS and the controls. Patients homozygou...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.55.5.705

    authors: Vedeler CA,Raknes G,Myhr KM,Nyland H

    更新日期:2000-09-12 00:00:00

  • Hippocampal mean diffusivity and memory in healthy elderly individuals: a cross-sectional study.

    abstract:BACKGROUND:The relationship between age-related memory decline and hippocampal anatomic changes is a matter of debate. OBJECTIVES:To investigate the relationship between age-related memory decline and MRI hippocampal anatomic changes in a cohort of healthy individuals. METHODS:In this cross-sectional study, 76 health...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181cb3e39

    authors: Carlesimo GA,Cherubini A,Caltagirone C,Spalletta G

    更新日期:2010-01-19 00:00:00

  • Orthostatic hypotension in familial amyloid polyneuropathy: treatment with DL-threo-3,4-dihydroxyphenylserine.

    abstract::We measured plasma norepinephrine levels in patients with familial amyloid polyneuropathy. Patients with orthostatic hypotension had low basal plasma norepinephrine levels, which did not increase after postural change. On the basis of biochemical findings that suggest depletion of peripheral norepinephrine, DL-threo-3...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.31.10.1323

    authors: Suzuki T,Higa S,Sakoda S,Hayashi A,Yamamura Y,Takaba Y,Nakajima A

    更新日期:1981-10-01 00:00:00

  • Subacute sclerosing panencephalitis: measles virus matrix protein nucleic acid sequences detected by in situ hybridization.

    abstract::Subacute sclerosing panencephalitis (SSPE) is characterized by a hyperimmune state toward the polypeptides of measles virus except the matrix (M) protein. Using cloned (3H)-labeled complementary DNA probes for in situ hybridization, we found the M protein and nucleocapsid (NP) protein nucleotide sequences in glial cel...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.35.11.1605

    authors: Shapshak P,Tourtellotte WW,Nakamura S,Graves MC,Darvish M,Hoffman D,Walsh MJ,Fareed GC,Schmid P,Heinzmann C

    更新日期:1985-11-01 00:00:00

  • Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS.

    abstract:OBJECTIVE:To investigate the possible association of persistent enterovirus (EV) infection with the development of ALS. BACKGROUND:Although ALS is a clinically well-defined motor neuron disease, little is known about the etiology and pathogenesis of the sporadic cases. Among the different causes that have been hypothe...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.1.20

    authors: Berger MM,Kopp N,Vital C,Redl B,Aymard M,Lina B

    更新日期:2000-01-11 00:00:00

  • Cerebral microembolism in symptomatic and asymptomatic high-grade internal carotid artery stenosis.

    abstract::Using transcranial Doppler (TCD) ultrasonography in patients with high-grade (> or = 70%) internal carotid artery (ICA) stenosis, we examined the relation between the rate of TCD-detected silent microembolism of the ipsilateral middle cerebral artery and a history of recent (< 121 days) ischemic symptoms attributable ...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.44.4.615

    authors: Siebler M,Kleinschmidt A,Sitzer M,Steinmetz H,Freund HJ

    更新日期:1994-04-01 00:00:00

  • Subacute necrotizing encephalopathy: oxidative phosphorylation defects and the ATPase 6 point mutation.

    abstract::Subacute necrotizing encephalopathy (SNE) or Leigh's disease is associated with various defects in oxidative phosphorylation (OXPHOS). However, the relationships between these OXPHOS defects and nuclear DNA or mitochondrial DNA (mtDNA) mutations is still unclear. We evaluated three SNE pedigrees (two singleton cases a...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.42.11.2168

    authors: Shoffner JM,Fernhoff PM,Krawiecki NS,Caplan DB,Holt PJ,Koontz DA,Takei Y,Newman NJ,Ortiz RG,Polak M

    更新日期:1992-11-01 00:00:00

  • A reliable method for localizing deep intracranial sources of the EEG.

    abstract::We have demonstrated the reliability of a noninvasive method for successfully localizing the intracranial origin of the EEG. The dipole localization method (DLM) is a computer-assisted, mathematical method based on electrical field theory and is similar to localization methods currently used by electrocardiologists. I...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.35.12.1702

    authors: Smith DB,Sidman RD,Flanigin H,Henke J,Labiner D

    更新日期:1985-12-01 00:00:00

  • Spinal muscular atrophy is not the result of mutations at the beta-hexosaminidase or GM2-activator locus.

    abstract::The disease locus for the clinically heterogeneous childhood spinal muscular atrophies (SMA) maps to the chromosome 5 subregion, 5q11.2-13.3. The beta-subunit of beta-D-N-acetylhexosaminidase (hexosaminidase) (EC 3.2.1.52) (Hex B) maps to the same region, and the protein required for substrate recognition by this enzy...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.41.9.1418

    authors: Kleyn PW,Brzustowicz LM,Wilhelmsen KC,Freimer NB,Miller JM,Munsat TL,Gilliam TC

    更新日期:1991-09-01 00:00:00

  • Acute hydrocephalus in nonketotic hyperglycinemia.

    abstract::We present four patients with typical neonatal onset non-ketotic hyperglycinemia (NKH) who developed hydrocephalus requiring shunting in early infancy. Brain imaging revealed acute hydrocephalus, a megacisterna magna or posterior fossa cyst, pronounced atrophy of the white matter, and an extremely thin corpus callosum...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/wnl.54.3.754

    authors: Van Hove JL,Kishnani PS,Demaerel P,Kahler SG,Miller C,Jaeken J,Rutledge SL

    更新日期:2000-02-08 00:00:00

  • Interrater reliability of EEG-video monitoring.

    abstract:OBJECTIVE:The diagnosis of psychogenic nonepileptic seizures (PNES) can be challenging. In the absence of a gold standard to verify the reliability of the diagnosis by EEG-video, we sought to assess the interrater reliability of the diagnosis using EEG-video recordings. METHODS:Patient samples consisted of 22 unselect...

    journal_title:Neurology

    pub_type: 杂志文章

    doi:10.1212/WNL.0b013e3181b78425

    authors: Benbadis SR,LaFrance WC Jr,Papandonatos GD,Korabathina K,Lin K,Kraemer HC,NES Treatment Workshop.

    更新日期:2009-09-15 00:00:00

  • Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD.

    abstract:BACKGROUND:Abeta42-immunization reduces plaque burden and improves cognition in transgenic mouse models of Alzheimer disease (AD). This phase 1 study evaluated the safety, tolerability, and immunogenicity of AN1792 (human aggregated Abeta42) in patients with mild to moderate AD. METHODS:Twenty patients were enrolled i...

    journal_title:Neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1212/01.WNL.0000148604.77591.67

    authors: Bayer AJ,Bullock R,Jones RW,Wilkinson D,Paterson KR,Jenkins L,Millais SB,Donoghue S

    更新日期:2005-01-11 00:00:00