Abstract:
:There are reports that patients with Parkinson's disease (PD) and Alzheimer's disease (AD) have reduced levels of thiolmethyltransferase (TMT) in erythrocyte membranes. TMT methylates thiols and thiocarbamates, thereby reducing their toxicity. We examined TMT levels in erythrocytes from patients with PD and AD and from age-matched controls. Specific activities of TMT were 564 +/- 199 U/mg protein in PD (n = 32), 513 +/- 118 in AD (n = 13), and 565 +/- 183 in controls (n = 35). There was no difference between any of the groups (p = 0.64). We failed to confirm TMT as a marker for neurodegenerative diseases or for this metabolic defect predisposing to susceptibility to neurotoxins.
journal_name
Neurologyjournal_title
Neurologyauthors
Hurwitz A,Hubble JP,Glatt SL,Koller WC,Pollack Jdoi
10.1212/wnl.45.10.1903subject
Has Abstractpub_date
1995-10-01 00:00:00pages
1903-6issue
10eissn
0028-3878issn
1526-632Xjournal_volume
45pub_type
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