Abstract:
:We present four patients with typical neonatal onset non-ketotic hyperglycinemia (NKH) who developed hydrocephalus requiring shunting in early infancy. Brain imaging revealed acute hydrocephalus, a megacisterna magna or posterior fossa cyst, pronounced atrophy of the white matter, and an extremely thin corpus callosum in all. The three older patients had profound developmental disabilities. This suggests that the development of hydrocephalus in NKH is an additional poor prognostic sign.
journal_name
Neurologyjournal_title
Neurologyauthors
Van Hove JL,Kishnani PS,Demaerel P,Kahler SG,Miller C,Jaeken J,Rutledge SLdoi
10.1212/wnl.54.3.754subject
Has Abstractpub_date
2000-02-08 00:00:00pages
754-6issue
3eissn
0028-3878issn
1526-632Xjournal_volume
54pub_type
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