Abstract:
:A subset of human B lymphocytes expresses Leu-1 (CD5), a pan-T cell marker, which is the equivalent of the murine Lyt-1 molecule. CD5+ B cells produce autoantibodies in vitro; therefore, they may play a role in the pathogenesis of autoimmune disorders. In myasthenia gravis (MG), autoantibodies are directed against the nicotinic acetylcholine receptor (AChR) at the neuromuscular junction. We examined the peripheral blood leukocytes of MG patients (n = 21) and controls (n = 15) for the presence of Leu-1+ B lymphocytes. A fraction of B-1 (CD20)+ cells expressed Leu-1 at a low density. There was a statistically significant difference in the frequency of Leu-1+ B cells between patients and controls. We observed 2 frequency ranges of Leu-1+ B cells (0 to 30% and above 30%), which were not related to the total percentage of B-1+ cells in the blood. Fifty-seven percent of MG patients had a high frequency of Leu-1+ B cells compared with 13% of controls.
journal_name
Neurologyjournal_title
Neurologyauthors
Ragheb S,Lisak RPdoi
10.1212/wnl.40.7.1120subject
Has Abstractpub_date
1990-07-01 00:00:00pages
1120-4issue
7eissn
0028-3878issn
1526-632Xjournal_volume
40pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To report eight cases of sensory Guillain-Barré syndrome (GBS). BACKGROUND:The concept of sensory equivalent to ascending paralysis of GBS was raised in 1958, and the diagnostic criteria for a sensory loss and areflexia variant of GBS were proposed in 1981. However, clinical cases meeting these criteria have...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.56.1.82
更新日期:2001-01-09 00:00:00
abstract::This study examined the frequency of epilepsy in a consecutive series of patients who received a definitive diagnosis of psychogenic nonepileptic seizures (PNES) after completing inpatient video-EEG (VEEG) monitoring. Of the 1,590 patients receiving definitive diagnosis, 514 (32.3%) were diagnosed with PNES. Twenty-ni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000098890.13946.f5
更新日期:2003-12-23 00:00:00
abstract::The pathologic substrate of essential tremor (ET) remains unknown. The authors studied 10 patients with ET and 10 volunteers using a multislice MR spectroscopy imaging sequence. Left and right cerebellar hemisphere NAA/CR and NAA/Cho ratios were significantly smaller in the ET patients than healthy subjects. The autho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000065885.15875.0d
更新日期:2003-04-22 00:00:00
abstract:BACKGROUND:Previous studies have examined the role of APOE variation in multiple sclerosis (MS), but have lacked the statistical power to detect modest genetic influences on risk and disease severity. The meta- and pooled analyses presented here utilize the largest collection, to date, of MS cases, controls, and famili...
journal_title:Neurology
pub_type: 杂志文章,meta分析
doi:10.1212/01.wnl.0000210531.19498.3f
更新日期:2006-05-09 00:00:00
abstract::Six patients with Parkinson's disease, six patients with essential or intention tremor, and nine controls were tested on a step-tracking task using a joystick control and oscilloscope display. Tremor subjects resembled controls in making an initial ballistic movement followed by (defective) corrections, and took longe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.5.413
更新日期:1975-05-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of acetyl-l-carnitine (ALCAR) on the rate of decline in early-onset AD patients. METHODS:A 1-year, multicenter, double-blind, placebo-controlled, randomized trial was conducted. Subjects were 45 to 65 years old, with a diagnosis of probable AD according to National Institute of Neur...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.55.6.805
更新日期:2000-09-26 00:00:00
abstract:OBJECTIVE:To examine the efficacy of rizatriptan and the consistency of treatment response in migraine attacks of children and adolescents. METHODS:We conducted a double-blind, placebo-controlled three-way crossover trial in patients ages 6 to 17 years diagnosed with migraine in two pediatric hospital outpatient clini...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000238179.79888.44
更新日期:2006-10-10 00:00:00
abstract::The predictive value of CSF oligoclonal banding for the development of clinically definite MS (CDMS) within 5 years after optic neuritis was assessed in 76 patients enrolled in the Optic Neuritis Treatment Trial. The presence of oligoclonal bands was associated with the development of CDMS (p = 0.02). However, the res...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.3.885
更新日期:1998-09-01 00:00:00
abstract::We present a patient with levodopa-resistant parkinsonism due to basal ganglia calcification related to surgically-induced hypoparathyroidism. The calcification was seen on computerized axial tomography but not on skull x-rays. Such calcification should be looked for in all cases of levodopa-resistant parkinsonism, si...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.3.221
更新日期:1976-03-01 00:00:00
abstract:OBJECTIVES:Functional neuroimaging has shown that the absence of externally observable signs of consciousness and cognition in severely brain-injured patients does not necessarily indicate the true absence of such abilities. However, relative to traumatic brain injury, nontraumatic injury is known to be associated with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318249f764
更新日期:2012-03-13 00:00:00
abstract::Early motor manifestations are the main components of focal seizures involving the frontal lobe. We examined the relationship between the initial ictal motor manifestations and interictal abnormalities of cerebral glucose consumption (rCMRGlc) as assessed by PET in 48 consecutive patients with focal seizures of neocor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.2.341
更新日期:1997-08-01 00:00:00
abstract::A 16-year-old male with a 9-year history of spontaneously arrested hydrocephalus was noted to have hydrosyringomyelia and increased intracranial pressure shortly after sustaining minor head trauma. His symptoms resolved completely following ventriculoperitoneal shunt replacement. Hydrosyringomyelia may occur in the se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.4.652
更新日期:1988-04-01 00:00:00
abstract::The incidence of MS in the Orkney Islands has been updated from 1941 to September 21, 1983. Since 1965, MS incidence rates have fallen significantly when compared with those for 1941 to 1964. Alterations in age-specific prevalence, mean duration of illness, and mean age of the MS population are consistent with the dec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.4.545
更新日期:1985-04-01 00:00:00
abstract::A randomized trial was completed to assess the feasibility of a 2-year education rehabilitation program for students with sickle cell disease and memory deficits. Eleven students were assigned to tutoring with or without memory training for 2 years. Eighty-two percent completed the program. Evidence of improvement in ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.wnl.0000264421.24415.16
更新日期:2007-06-05 00:00:00
abstract:BACKGROUND AND OBJECTIVES:A number of familial temporal lobe epilepsies (TLE) have been recently recognized. Mutations in LGI1 (leucine-rich, glioma-inactivated 1 gene) have been found in a few families with the syndrome of autosomal dominant partial epilepsy with auditory features (ADPEAF). The authors aimed to determ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000118213.94650.81
更新日期:2004-04-13 00:00:00
abstract:BACKGROUND:To date, there is no accepted clinical diagnostic test for Parkinson disease (PD) that is based on biochemical analysis of blood or CSF. The discovery of mutations in the SNCA gene encoding α-synuclein in familial parkinsonism and the accumulation of α-synuclein in the PD brain suggested a critical role for ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e3181fd613b
更新日期:2010-11-16 00:00:00
abstract:OBJECTIVE:To validate the ability of a specifically developed cognitive risk score to identify patients at risk of poststroke neurocognitive disorders (NCDs) who are eligible for a comprehensive cognitive assessment. METHODS:After assessing 404 patients (infarct 91.3%) in the Groupe de Réflexion pour l'Evaluation Cogn...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006544
更新日期:2018-11-20 00:00:00
abstract:BACKGROUND:Brodmann brain maps, assembled in 1909, are still in use, but understanding of their animal-human homology is uncertain. Furthermore, in 1909, Brodmann did not identify human area 12 (BA12), a location now important to understanding of frontotemporal lobar degeneration (FTLD). METHODS:We re-examined Brodman...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0b013e3182190cd8
更新日期:2011-05-03 00:00:00
abstract::We present a method for graphically reporting the results of brainstem auditory evoked response examinations on the basis of multiple parameters. The method is based on a transform that normalizes the many latency and amplitude measures obtained from the averaged evoked responses of normal subjects tested under standa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.2.242
更新日期:1979-02-01 00:00:00
abstract::Surgery is a safe and effective treatment for patients with temporal lobe epilepsy (TLE) who do not respond adequately to anticonvulsant medication and in whom the seizure generator can be identified and safely removed. Proton MR spectroscopic imaging (MRSI) can image and quantify neuronal damage in patients with TLE ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.6.1525
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between CSF creatine kinase BB isoenzyme activity (CSF CKBB) and neurologic outcome after cardiac arrest in clinical practice. BACKGROUND:CSF CKBB reflects the extent of brain damage following cardiac arrest. METHODS:To help with prognosis, treating physicians ordered CSF CKBB tes...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.2.352
更新日期:1997-02-01 00:00:00
abstract::A 64-year-old man with diffuse atherosclerosis developed an organic mental syndrome, followed by hypothalamic symptoms. Autopsy showed an old large cystic infarct involving the left temporal lobe including the hippocampus, and atrophy of the ipsilateral fornix, mammillary body, hypothalamus, mammillothalamic tract, an...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.12.1157
更新日期:1977-12-01 00:00:00
abstract:OBJECTIVES:SCN1A mutations were recently reported in several patients with severe myoclonic epilepsy in infancy (SMEI). The authors analyzed SCN1A mutations in 93 patients with SMEI and made genotype-phenotype correlation to clarify the role of this gene in the etiology of SMEI. METHODS:All patients fulfilled the crit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000069463.41870.2f
更新日期:2003-06-24 00:00:00
abstract:OBJECTIVE:To investigate whether the correlation of age and sex with the risk of recurrence and death seen in patients with previous ischemic stroke is also evident in patients with embolic stroke of undetermined source (ESUS). METHODS:We pooled datasets of 11 stroke registries from Europe and America. ESUS was define...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004199
更新日期:2017-08-08 00:00:00
abstract::This study investigates the histories and the clinical course of 111 patients who had nonlesional temporal lobe epilepsy. We compared 61 patients with unilateral hippocampal sclerosis (UHS group) and 50 patients with minimal change (MRI negative group) assessed on the basis of MRI. In agreement with previous reports, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.5.1199
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Over 50% of persons with idiopathic REM sleep behavior disorder (RBD) will develop Parkinson disease (PD) or dementia. At present, there is no way to predict who will develop disease. Since polysomnography is performed in all patients with idiopathic RBD at diagnosis, there is an opportunity to analyze if ba...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181ca0166
更新日期:2010-01-19 00:00:00
abstract:OBJECTIVE:To determine whether, and to what degree, preclinical Alzheimer disease (AD) confounds studies of healthy aging where "healthy" is based on cognitive normality alone. METHODS:We examined the effects of preclinical AD in cognitively normal older individuals using resting-state functional connectivity MRI. We ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000939
更新日期:2014-10-28 00:00:00
abstract::Essential tremor (ET) is a common movement disorder that often causes functional disability, potentially leading to physical and emotional difficulties. The paucity of data available regarding the underlying pathophysiologic mechanism of ET hinders the development of innovative approaches to pharmacotherapeutic treatm...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:Circulating endothelial progenitor cells (EPC) are markers of vascular injury and their numbers decrease in acute stroke. However, the relation of EPC levels to stroke severity has not been quantified. MRI measurements of lesion volume provide an objective method for stroke severity assessment and outcome pr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318200d741
更新日期:2010-12-07 00:00:00
abstract:OBJECTIVE:To distinguish, in patients with Korsakoff syndrome (KS), the structural brain abnormalities shared with alcoholic patients without KS (AL), from those specific to KS. METHODS:MRI data were collected in 11 alcoholic patients with KS, 34 alcoholic patients without KS, and 25 healthy control subjects (CS). Gra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318251834e
更新日期:2012-04-24 00:00:00