The frequency of CD5+ B lymphocytes in the peripheral blood of patients with myasthenia gravis.

Abstract:

:A subset of human B lymphocytes expresses Leu-1 (CD5), a pan-T cell marker, which is the equivalent of the murine Lyt-1 molecule. CD5+ B cells produce autoantibodies in vitro; therefore, they may play a role in the pathogenesis of autoimmune disorders. In myasthenia gravis (MG), autoantibodies are directed against the nicotinic acetylcholine receptor (AChR) at the neuromuscular junction. We examined the peripheral blood leukocytes of MG patients (n = 21) and controls (n = 15) for the presence of Leu-1+ B lymphocytes. A fraction of B-1 (CD20)+ cells expressed Leu-1 at a low density. There was a statistically significant difference in the frequency of Leu-1+ B cells between patients and controls. We observed 2 frequency ranges of Leu-1+ B cells (0 to 30% and above 30%), which were not related to the total percentage of B-1+ cells in the blood. Fifty-seven percent of MG patients had a high frequency of Leu-1+ B cells compared with 13% of controls.

journal_name

Neurology

journal_title

Neurology

authors

Ragheb S,Lisak RP

doi

10.1212/wnl.40.7.1120

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

1120-4

issue

7

eissn

0028-3878

issn

1526-632X

journal_volume

40

pub_type

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