Abstract:
BACKGROUND:To date, there is no accepted clinical diagnostic test for Parkinson disease (PD) that is based on biochemical analysis of blood or CSF. The discovery of mutations in the SNCA gene encoding α-synuclein in familial parkinsonism and the accumulation of α-synuclein in the PD brain suggested a critical role for this protein in PD etiology. METHODS:We investigated total and α-synuclein oligomers levels in CSF from patients clinically diagnosed with PD, progressive supranuclear palsy (PSP), or Alzheimer disease (AD), and age-matched controls, using ELISA developed in our laboratory. RESULTS:The levels of α-synuclein oligomers and oligomers/total-α-synuclein ratio in CSF were higher in the PD group (n = 32; p < 0.0001, Mann-Whitney U test) compared to the control group (n = 28). The area under the receiver operating characteristic curve (AUC) indicated a sensitivity of 75.0% and a specificity of 87.5%, with an AUC of 0.859 for increased CSF α-synuclein oligomers in clinically diagnosed PD cases. However, when the CSF oligomers/total-α-synuclein ratio was analyzed, it provided an even greater sensitivity of 89.3% and specificity of 90.6%, with an AUC of 0.948. In another cross-sectional pilot study, we confirmed that the levels of CSF α-synuclein oligomers were higher in patients with PD (n = 25) compared to patients with PSP (n = 18; p < 0.05) or AD (n = 35; p < 0.001) or control subjects (n = 43; p < 0.05). CONCLUSION:Our results demonstrate that levels of α-synuclein oligomers in CSF and the oligomers/total-α-synuclein ratio can be useful biomarkers for diagnosis and early detection of PD.
journal_name
Neurologyjournal_title
Neurologyauthors
Tokuda T,Qureshi MM,Ardah MT,Varghese S,Shehab SA,Kasai T,Ishigami N,Tamaoka A,Nakagawa M,El-Agnaf OMdoi
10.1212/WNL.0b013e3181fd613bsubject
Has Abstractpub_date
2010-11-16 00:00:00pages
1766-72issue
20eissn
0028-3878issn
1526-632Xpii
WNL.0b013e3181fd613bjournal_volume
75pub_type
杂志文章,随机对照试验相关文献
NEUROLOGY文献大全abstract::Magnetic resonance images (MRI), evoked responses (ER), and CSF findings were compared in 39 patients with possible, probable, or definite MS. MRI disclosed multiple lesions (72%) more often than ERs (55%) in the total group of patients. In possible MS, MRI showed multiple lesions in 71%, and ER abnormalities were fou...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.6.828
更新日期:1986-06-01 00:00:00
abstract::Using a crossed-response task, monkeys with neglect induced by frontal lesions appear to have motor rather than sensory neglect. However, the crossed-response task may not reveal sensory neglect (inattention) if no perceptual discrimination is required. We therefore trained two monkeys in a perceptually complex crosse...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.6.1205
更新日期:1995-06-01 00:00:00
abstract:OBJECTIVE:To investigate the cognitive skills of patients with relapsing remitting multiple sclerosis (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS) relative to healthy control subjects and to assess whether there is heterogeneity in the type of cognitive disabilities demonstrated by patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000129828.03714.90
更新日期:2004-07-27 00:00:00
abstract::Mammalian spinal neurons grown in tissue culture were used to study the effects of the four convulsants-penicillin, pentylenetetrazol, picrotoxin, and bicuculline-on these neurons' responses to amino acids. Bath application of all four convulsants produced paroxysmal depolarizing events in the neurons; iontophoresis o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.4.325
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:Although hospital-outcome relationships have been explored for a variety of procedures and interventions, little is known about the association between annual stroke admission volumes and stroke mortality. Our aim was to determine whether facility type and hospital volume was associated with stroke mortality...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000268485.93349.58
更新日期:2007-09-11 00:00:00
abstract:OBJECTIVE:To investigate the role of alcohol as a causal factor for intracerebral hemorrhage (ICH) and whether its effects might vary according to the pathogenic mechanisms underlying cerebral bleeding. METHODS:We performed a case-control analysis, comparing a cohort of consecutive white patients with ICH aged 55 year...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000005814
更新日期:2018-07-17 00:00:00
abstract::The authors report a patient with chorea and multifocal neurologic abnormalities associated with a small-cell lung carcinoma. A previously unreported antibody directed at a 76-kD neuronal protein antigen was identified in both serum and CSF. Antitumor treatment resulted in dramatic and sustained clinical neurologic an...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.57.4.719
更新日期:2001-08-28 00:00:00
abstract:OBJECTIVE:To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas. METHODS:This was a retrospective cohort study of US veterans ≥65 years of age with type 2 diabetes who were new users of metformin or a sulfonylurea and had no dementia. Follow-up began after 2 years of therap...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004586
更新日期:2017-10-31 00:00:00
abstract::MRI in five term children with congenital hemiplegia without clinically apparent prenatal or perinatal difficulties showed a focal or porencephalic enlargement of the lateral ventricle and periventricular T2 prolongation, which were identical to findings of periventricular venous infarction seen in preterm children. S...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000079370.28310.ea
更新日期:2003-08-26 00:00:00
abstract:OBJECTIVE:To test the hypothesis that brain pathology is associated with total daily physical activity proximate to death in older adults. METHODS:We studied brain autopsies from 428 decedents of the Rush Memory and Aging Project. The quantity of all physical activity was measured continuously for up to 10 days with a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005552
更新日期:2018-05-22 00:00:00
abstract:OBJECTIVE:To identify presurgical and postsurgical factors that are independently predictive of the outcome of anterior temporal lobectomy (ATL) for intractable epilepsy. BACKGROUND:There have been reports of prognostic factors in epilepsy surgery, but little is known about factors that independently predict outcome o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.2.465
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To verify whether the change in L-dopa plasma levels after a single dose of carbidopa/L-dopa 50/200 (controlled-release) transiently modifies frontal components of somatosensory evoked potentials (SEPs) in patients with PD in parallel with improvement of motor performance. BACKGROUND:Apomorphine, a potent do...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1451
更新日期:1999-10-22 00:00:00
abstract::This single case report describes a large (giant) left internal carotid aneurysm that showed a very marked decrease in the size of its lumen on reevaluation 5 days after the initial arteriogram. A review of the literature found only 5 cases of spontaneous thrombosis documented by arteriography and only one involved a ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.4.334
更新日期:1976-04-01 00:00:00
abstract:OBJECTIVE:To determine the associations between amyloid-PET, tau-PET, and atrophy with the behavioral/dysexecutive presentation of Alzheimer disease (AD), how these differ from amnestic AD, and how they correlate to clinical symptoms. METHODS:We assessed 15 patients with behavioral/dysexecutive AD recruited from a ter...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011081
更新日期:2021-01-05 00:00:00
abstract::It is not known whether the antiepileptic drug (AED) levetiracetam can be used safely in human pregnancy. As part of a study to determine the risks of major congenital malformations (MCMs) for infants exposed to AEDs in utero, we identified all cases exposed to levetiracetam. Three of 117 exposed pregnancies had an MC...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000244491.48937.55
更新日期:2006-11-28 00:00:00
abstract:OBJECTIVE:Development of an easy to administer, low-cost test of vestibular function. METHODS:Members of the NIH Toolbox Sensory Domain Vestibular, Vision, and Motor subdomain teams collaborated to identify 2 tests: 1) Dynamic Visual Acuity (DVA), and 2) the Balance Accelerometry Measure (BAM). Extensive work was comp...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182872c6a
更新日期:2013-03-12 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of eptinezumab, a humanized anti-calcitonin gene-related peptide monoclonal antibody, in the preventive treatment of chronic migraine (CM). METHODS:The Prevention of Migraine via Intravenous ALD403 Safety and Efficacy-2 (PROMISE-2) study was a phase 3, multicenter, randomi...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000009169
更新日期:2020-03-31 00:00:00
abstract::Permanent paralysis was induced in dogs by a 500 gram centimeter force injury on the spinal cord, and drug treatments were given 1 hour after injury and were continued for 3 days. Dogs were evaluated for 90 days. Isotonic saline or mannitol administration were ineffective in reversing the paralysis. In dogs receiving ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.6.508
更新日期:1975-06-01 00:00:00
abstract::Treatment of functional symptoms has a long history, and interventions were often used in soldiers returning from battle. On the 75th anniversary of the end of the Second World War, I review the portrayal of neurology in documentary film. Two documentaries were released in 1946 and 1948 (Let There Be Light and Shades ...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0000000000009593
更新日期:2020-06-09 00:00:00
abstract::We describe three patients with acute chiasmal visual field loss caused by hemorrhage within an intrachiasmal arteriovenous malformation. One patient had five episodes; vision improved three times without treatment and twice after surgical decompression. Surgical intervention restored vision in two of the three patien...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.8.1007
更新日期:1984-08-01 00:00:00
abstract:OBJECTIVE:To investigate the genetic and physiologic basis of the neuromuscular symptoms of hypotonia-cystinuria syndrome (HCS) and isolated PREPL deficiency, and their response to therapy. METHODS:We performed molecular genetic, histochemical, immunoblot, and ultrastructural studies, investigated neuromuscular transm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000295
更新日期:2014-04-08 00:00:00
abstract::The authors describe two patients with clinical manifestations of the osmotic demyelination syndrome (ODS) and unusual MRI findings of gadolinium-enhancing peripheral cortical abnormalities. They propose that these represent extrapontine manifestations of ODS because neither patient had a notable hypoxic-ischemic insu...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.7.1048
更新日期:2000-10-10 00:00:00
abstract::In the past, stereotactic surgery was a regular treatment for prominent unilateral tremor in Parkinson's disease (PD), but follow-up studies were usually short-term and always unblinded. We examined 17 PD patients in long-term follow-up (mean, 10.9 years after surgery) and used videotapes and the Unified Parkinson's D...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.7.1311
更新日期:1992-07-01 00:00:00
abstract::Childhood absence epilepsy (CAE) is defined by absence seizures in a normally developing child, with onset between 4 and 10 years of age.(1) Typical absence seizures consist of behavioral arrest with or without automatisms, usually last 30-60 seconds, and demonstrate a characteristic 3-Hz generalized spike-wave (GSW) ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000000380
更新日期:2014-05-06 00:00:00
abstract::Although neurophysiologic doctrine has traditionally referred to "the" voltage-gated sodium channel, it is now clear that there are at least nine genes that encode molecularly and physiologically distinct sodium channels. Mutations of sodium channel genes provide a basis for genetic channelopathies. Dysregulated expre...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.56.12.1621
更新日期:2001-06-26 00:00:00
abstract::Eighty-one percent (47/58) of private-sector neurologists in Colorado responded to a mail survey of practice patterns. We evaluated patient load, degree of principal versus consultative care, and use of neurodiagnostic tests. Broad areas of neurologic education that were perceived to have been lacking during residency...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.2.287
更新日期:1987-02-01 00:00:00
abstract::We used [18F]-2-fluoro-2-deoxy-D-glucose (FDG) and PET to study regional cerebral glucose utilization in seven patients with fatal familial insomnia (FFI), an inherited prion disease with a mutation at codon 178 of the prion protein gene. Four patients were methionine/methionine homozygotes at codon 129 (symptom durat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.1.126
更新日期:1997-07-01 00:00:00
abstract::We investigated the influence of age on the occurrence of cognitive disturbances in Parkinson's disease (PD), by evaluating neuropsychological performances in early- and late-onset groups of patients (less than 45 and greater than 65 years, respectively), individually paired for all the variables of parkinsonism and c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.1.38
更新日期:1990-01-01 00:00:00
abstract::A patient presented with bilateral brachial plexus neuropathy which 2 weeks later evolved into a polyneuropathy involving all four extremities. On further investigation, the patient was found to have systemic lupus erythematosus. Treatment with steroids was accompanied by complete resolution of the neurologic findings...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.12.1633-a
更新日期:1979-12-01 00:00:00
abstract::Interferon beta (IFN-beta) has been shown in several clinical trials to have efficacy in MS. Its mechanism of action, however, remains unclear. In this review, several biological activities of IFN-beta are highlighted, including its inhibitory effects on proliferation of leukocytes and antigen presentation. Furthermor...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.51.3.682
更新日期:1998-09-01 00:00:00