Interferon beta in the treatment of multiple sclerosis: mechanisms of action.

abstract：:We investigated the status of the apolipoprotein E allele in 538 participants in the incidence phase of the ongoing Shanghai Survey of Dementia, including 103 demented subjects, 72 with mild cognitive impairment and 363 cognitively normal. The apo E epsilon 4 allele was present in 10.2% of control subjects and the all...

journal_title：Neurology

authors： Katzman R,Zhang MY,Chen PJ,Gu N,Jiang S,Saitoh T,Chen X,Klauber M,Thomas RG,Liu WT,Yu ES

更新日期：1997-09-01 00:00:00

abstract：:Four patients developed postural tremor after ingestion of sodium valproate. The tremor was recorded by a variable-capacitance transducer and was of the "benign essential" type. The dosages of sodium valproate varied between 1000 mg and 2000 mg daily and serum levels were between 34.9 microgram per milliliter and 154....

journal_title：Neurology

authors： Hyman NM,Dennis PD,Sinclair KG

更新日期：1979-08-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess the prevalence of and to identify epidemiologic, genetic, electrophysiologic, and neuroanatomic risk factors for autism spectrum disorders (ASD) in a cohort of patients with tuberous sclerosis complex (TSC). METHODS:A total of 103 patients with TSC were evaluated for A...

journal_title：Neurology

authors： Numis AL,Major P,Montenegro MA,Muzykewicz DA,Pulsifer MB,Thiele EA

更新日期：2011-03-15 00:00:00

abstract：:We performed magnetic resonance imaging (MRI), before and after the administration of gadolinium-DTPA (Gd-DTPA), in 23 patients with medically refractory partial epilepsy who subsequently had surgical treatment for their seizure disorder. In most patients, 61%, unenhanced and enhanced MRI studies were negative. In 26%...

journal_title：Neurology

authors： Cascino GD,Hirschorn KA,Jack CR,Sharbrough FW

更新日期：1989-08-01 00:00:00

abstract：OBJECTIVE:To describe neurodevelopment and head growth in HIV-1-infected and exposed uninfected infants with and without in utero exposure to opiates and cocaine. METHODS:Using data from a multicenter cohort study of HIV-1-infected women and their children, the authors fit repeated measures regression models to estima...

journal_title：Neurology

authors： Macmillan C,Magder LS,Brouwers P,Chase C,Hittelman J,Lasky T,Malee K,Mellins CA,Velez-Borras J

更新日期：2001-10-23 00:00:00

abstract：:We detected 29 conduction blocks in 12 patients with hereditary neuropathy and liability to pressure palsies. The blocks occurred at entrapment sites, most often the ulnar nerve at the elbow. Some had lasted for several years. This kind of block seems to be characteristic of the neuropathy, and may be related to the l...

journal_title：Neurology

authors： Magistris MR,Roth G

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:Prospective memory (PM) describes the ability to fulfill previously planned intentions and is highly dependent on executive functions. Previous studies have shown deficits in executive functions in patients with juvenile myoclonic epilepsy (JME) and in their unaffected siblings. JME has a strong genetic predi...

journal_title：Neurology

authors： Wandschneider B,Kopp UA,Kliegel M,Stephani U,Kurlemann G,Janz D,Schmitz B

更新日期：2010-12-14 00:00:00

abstract：OBJECTIVE:To assess the recovery process in patients after an acute optic neuritis (ON) attack, comparing static and dynamic visual functions. METHODS:In this prospective controlled study, 21 patients with unilateral, first-ever ON were followed over the course of 1 year. Standard visual tests, visual evoked potential...

journal_title：Neurology

authors： Raz N,Dotan S,Benoliel T,Chokron S,Ben-Hur T,Levin N

更新日期：2011-06-14 00:00:00

abstract：OBJECTIVE:To test the hypothesis that concussion-related brain alterations seen at symptomatic injury and medical clearance to return to play (RTP) will have dissipated by 1 year after RTP. METHODS:For this observational study, 24 athletes with concussion were scanned longitudinally within 1 week after injury, at RTP,...

journal_title：Neurology

authors： Churchill NW,Hutchison MG,Graham SJ,Schweizer TA

更新日期：2019-11-19 00:00:00

abstract：BACKGROUND:Krabbe disease (globoid cell leukodystrophy [GLD]) is an autosomal recessive lysosomal disorder affecting the central and peripheral nervous system. The authors performed MRS to characterize metabolic alterations and their regional variation in brain tissue in GLD in vivo. METHODS:Abnormalities of cerebral ...

journal_title：Neurology

authors： Brockmann K,Dechent P,Wilken B,Rusch O,Frahm J,Hanefeld F

更新日期：2003-03-11 00:00:00

abstract：:Forty-seven consecutive patients presenting acutely with repetitive symptoms indicative of anterior circulation ischemia ("crescendo" transient ischemic attacks) were evaluated to identify clinical features that might reliably predict the presence of significant stenosis, ulceration, or both in the presumably symptoma...

journal_title：Neurology

authors： Rothrock JF,Lyden PD,Yee J,Wiederholt WC

更新日期：1988-02-01 00:00:00

abstract：OBJECTIVE:To examine the association of change in body mass index (BMI) with risk of Alzheimer disease (AD). METHODS:Nine hundred eighteen older Catholic clergy participating in the Religious Orders Study without dementia at baseline were studied. Outcome measures were the clinical diagnosis of AD and change in cognit...

journal_title：Neurology

authors： Buchman AS,Wilson RS,Bienias JL,Shah RC,Evans DA,Bennett DA

更新日期：2005-09-27 00:00:00

abstract：BACKGROUND:Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins, are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine whether patterns of gray matter atrophy from antemortem MRI correlate with Braak staging of NFT pathology. METHODS:Eighty-three subjects with Bra...

journal_title：Neurology

authors： Whitwell JL,Josephs KA,Murray ME,Kantarci K,Przybelski SA,Weigand SD,Vemuri P,Senjem ML,Parisi JE,Knopman DS,Boeve BF,Petersen RC,Dickson DW,Jack CR Jr

更新日期：2008-09-02 00:00:00

abstract：:In a double-blind, placebo-controlled, parallel-group, randomized clinical trial, we studied the efficacy of long-term (1-year) oral treatment with acetyl-L-carnitine in 130 patients with a clinical diagnosis of Alzheimer's disease. We employed 14 outcome measures to assess functional and cognitive impairment. After 1...

journal_title：Neurology

authors： Spagnoli A,Lucca U,Menasce G,Bandera L,Cizza G,Forloni G,Tettamanti M,Frattura L,Tiraboschi P,Comelli M

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:To characterize children with new-onset seizures presenting as status epilepticus at a tertiary care children's hospital. METHODS:Prospectively collected data were reviewed from a database derived from a mandated critical care pathway. A total of 1,382 patients presented with new-onset seizures between 2001 ...

journal_title：Neurology

authors： Singh RK,Stephens S,Berl MM,Chang T,Brown K,Vezina LG,Gaillard WD

更新日期：2010-02-23 00:00:00

abstract：OBJECTIVE:To determine the relationship between hippocampal, amygdalar, and entorhinal cortex atrophy and duration of epilepsy, presence of secondary generalized seizures, and prolonged childhood febrile convulsions in patients with pharmacologically intractable temporal lobe epilepsy (TLE). METHODS:Volumetric MRI of ...

journal_title：Neurology

authors： Bernasconi N,Natsume J,Bernasconi A

更新日期：2005-07-26 00:00:00

abstract：:Although the long-term effects of acute anoxia have been studied, the effects of chronic hypoxia on the developing human brain have received little attention. We studied children with a cyanotic congenital heart defect to assess the impact of chronic hypoxia by eight measures: neurologic examination, visual evoked res...

journal_title：Neurology

authors： O'Dougherty M,Wright FS,Loewenson RB,Torres F

更新日期：1985-01-01 00:00:00

abstract：:We report the clinical and pathologic features of a patient with peripheral neuropathy that was the first clinical expression of cholesterol emboli syndrome (CES). Biopsy of skeletal muscle and peripheral nerve revealed cholesterol clefts in lumens of small arteries, necrotizing arteritis, and severe degeneration of p...

journal_title：Neurology

authors： Bendixen BH,Younger DS,Hair LS,Gutierrez C,Meyers ML,Homma S,Jaffe IA

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that physical activity modifies the association between white matter hyperintensity (WMH) burden and motor function in healthy older persons without dementia. METHODS:Total daily activity (exercise and nonexercise physical activity) was measured for up to 11 days with actigraphy (Actic...

journal_title：Neurology

authors： Fleischman DA,Yang J,Arfanakis K,Arvanitakis Z,Leurgans SE,Turner AD,Barnes LL,Bennett DA,Buchman AS

更新日期：2015-03-31 00:00:00

abstract：OBJECTIVE:To determine whether comorbidity is associated with clinical (relapses, disability worsening) and MRI outcomes in multiple sclerosis (MS) by conducting a secondary analysis of the CombiRx clinical trial. METHODS:CombiRx compared interferon beta-1a, glatiramer acetate, and the combination of these agents. For...

journal_title：Neurology

authors： Salter A,Kowalec K,Fitzgerald KC,Cutter G,Marrie RA

更新日期：2020-08-04 00:00:00

abstract：OBJECTIVE:To improve our understanding of early β-amyloid (Aβ) accumulation processes using florbetapir-PET scan in 20- to 60-year-old individuals. METHODS:Seventy-six cognitively normal individuals aged 20 to 60 years, 57 cognitively normal older individuals (61-84 years old), and 70 patients with mild cognitive impa...

journal_title：Neurology

authors： Gonneaud J,Arenaza-Urquijo EM,Mézenge F,Landeau B,Gaubert M,Bejanin A,de Flores R,Wirth M,Tomadesso C,Poisnel G,Abbas A,Desgranges B,Chételat G

更新日期：2017-12-12 00:00:00

abstract：:Cytoplasmic inclusion bodies are found in fibers of superior rectus muscle of the eye. They occur in middle-aged and old individuals dying with various unrelated diseases not affecting muscle and in patients with myotonic dystrophy. With light microscopy they can be observed in fibers with pathologic changes, and with...

journal_title：Neurology

authors： Culebras A,Merk FB

更新日期：1975-05-01 00:00:00

abstract：OBJECTIVE:To assess whether genetic subgroups in recent amyotrophic lateral sclerosis (ALS) trials responded to treatment with lithium carbonate, but that the treatment effect was lost in a large cohort of nonresponders. METHODS:Individual participant data were obtained from 3 randomized trials investigating the effic...

journal_title：Neurology

authors： van Eijk RPA,Jones AR,Sproviero W,Shatunov A,Shaw PJ,Leigh PN,Young CA,Shaw CE,Mora G,Mandrioli J,Borghero G,Volanti P,Diekstra FP,van Rheenen W,Verstraete E,Eijkemans MJC,Veldink JH,Chio A,Al-Chalabi A,van den Berg

更新日期：2017-10-31 00:00:00

abstract：:Since a parental sex effect has been reported in Huntington's disease, we looked to see whether a similar effect is apparent in adult (autosomal dominant) familial ALS. We analyzed the data for 145 patients, with an onset age range of 20 to 68 years and a known affected parent (AP), from 52 families described in the l...

journal_title：Neurology

authors： Leone M

更新日期：1991-08-01 00:00:00

abstract：:Migration from an area where MS is common to an area where it is rare (and vice versa) affects the risk of MS, provided migration occurs in childhood. A childhood infection might explain this effect. Therefore, the age pattern of infectious diseases in different regions was examined. A higher proportion of children sh...

journal_title：Neurology

authors： Alter M,Zhang ZX,Davanipour Z,Sobel E,Zibulewski J,Schwartz G,Friday G

更新日期：1986-10-01 00:00:00

abstract：:We measured the cerebral metabolic rate for glucose (CMRglc) with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in a 47-year-old man with trisomy 21 Down's syndrome (DS) and autopsy-confirmed Alzheimer's disease. Dementia was evident from a confirmed history of cognitive decline, memory loss, and pe...

journal_title：Neurology

authors： Schapiro MB,Ball MJ,Grady CL,Haxby JV,Kaye JA,Rapoport SI

更新日期：1988-06-01 00:00:00

abstract：:Spontaneous arm levitation (SAL) is well-recognized in cortical-basal ganglionic degeneration, but not in other neurodegenerative diseases. We report six cases of progressive supranuclear palsy (PSP) with SAL. Pathologic examination in four revealed the classic features of PSP with additional areas of focal cortical d...

journal_title：Neurology

authors： Barclay CL,Bergeron C,Lang AE

更新日期：1999-03-10 00:00:00

abstract：OBJECTIVE:To evaluate the prospective association of long-term intake of vegetables and fruits with late-life subjective cognitive function (SCF). METHODS:Among 27,842 men with a mean age of 51 years in 1986, we used multinomial logistic regression to examine the relation of vegetable and fruit consumption to future S...

journal_title：Neurology

authors： Yuan C,Fondell E,Bhushan A,Ascherio A,Okereke OI,Grodstein F,Willett WC

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the integrity of the dorsal striatal dopaminergic innervation in rigid and choreic Huntington disease (HD). BACKGROUND:Some patients with HD have an akinetic-rigid phenotype. It has been suggested that nigrostriatal in addition to striatal pathology is present in this subgroup. The authors sought...

journal_title：Neurology

authors： Bohnen NI,Koeppe RA,Meyer P,Ficaro E,Wernette K,Kilbourn MR,Kuhl DE,Frey KA,Albin RL

更新日期：2000-05-09 00:00:00

abstract：OBJECTIVE:To characterize the present state of brain death (BD) determination in actual practice relative to contemporary American Academy of Neurology (AAN) guidelines. METHODS:We reviewed the charts of all adult (16 years and older) BD organ donors during 2011 from 68 heterogeneous hospitals in the Midwest United St...

journal_title：Neurology

authors： Shappell CN,Frank JI,Husari K,Sanchez M,Goldenberg F,Ardelt A

更新日期：2013-12-03 00:00:00